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Vitaros Cream (Alprostadil)

Vitaros Cream (Alprostadil)

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  • ✔️ Treats erectile dysfunction with locally acting alprostadil 3mg/g
  • ✔️ Works within 5–30 minutes of topical application
  • ✔️ Suitable for men who cannot take oral ED tablets
  • ✔️ Avoids systemic side effects common with oral treatments
  • ✔️ Single-dose applicators for precise, hygienic use each time

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What Is Vitaros Cream and How Does It Treat ED?

 

Erectile dysfunction (ED) affects a significant number of men in the UK at some point in their lives. It can be caused by physical factors, psychological ones, or a combination of both. Vitaros cream is a topical treatment containing alprostadil 3mg/g, applied directly to the tip of the penis to help produce an erection. Unlike oral tablets, it works locally — which makes it a genuinely different option for men who cannot or prefer not to take pills. You can explore a wider range of products in our men's health collection.

Alprostadil is a synthetic version of prostaglandin E1, a naturally occurring substance in the body that plays a role in regulating blood flow. Vitaros cream is licensed in the UK for the treatment of erectile dysfunction in adult men and is available through registered online pharmacies following a clinical assessment.

 

How Does Vitaros Cream Work in the Body?

 

The mechanism behind Vitaros cream is straightforward once you understand the physiology of an erection. Alprostadil binds to specific receptors in the smooth muscle of the penile blood vessels, triggering a cascade that leads to relaxation and vasodilation.

  • Alprostadil stimulates adenylyl cyclase, increasing cyclic AMP (cAMP) levels in smooth muscle cells.
  • Raised cAMP causes smooth muscle relaxation in the corpus cavernosum.
  • Relaxed smooth muscle allows arterial blood to flow into the penis more freely.
  • Increased blood flow produces tumescence and, with stimulation, a full erection.

Because the cream is applied topically to the urethral meatus, absorption is localised. This means systemic side effects are generally less pronounced than with injected alprostadil formulations.

 

Who Is Vitaros Cream Suitable For?

 

Vitaros cream is intended for adult men diagnosed with erectile dysfunction. It is particularly useful for those who have not responded adequately to oral PDE5 inhibitors (such as sildenafil or tadalafil), or for whom those medicines are contraindicated — for example, men taking nitrate medications for heart conditions.

  • Adult men with ED of organic, psychogenic, or mixed origin.
  • Men who cannot tolerate or are contraindicated for oral ED treatments.
  • Men seeking a non-oral, locally acting alternative.
  • Men who prefer a treatment that does not require planning hours in advance.

It is not suitable for men under 18, men with penile anatomical deformities such as Peyronie's disease, or men with conditions that predispose them to priapism (prolonged erection), such as sickle cell anaemia.

 

How Does Vitaros Cream Compare to Other ED Treatments?

 

Feature Vitaros Cream (Alprostadil) Sildenafil (Viagra)
Route of administration Topical (urethral meatus) Oral tablet
Onset of action 5–30 minutes 30–60 minutes
Suitable if taking nitrates? Generally yes (seek advice) No — contraindicated
Systemic side effects Lower risk Headache, flushing common

 

Is Vitaros Cream Safe to Use and How Should It Be Stored?

 

Vitaros cream is a clinically evaluated treatment with a well-established safety profile when used as directed. Before dispensing, it must be stored in a refrigerator at 2°C–8°C. Once dispensed, it can be kept below 25°C and should be used within three months. Do not freeze it. Each applicator is single-use only — discard after use even if some cream remains.

If your partner is pregnant, a condom must be used during sexual activity when you have applied Vitaros cream, as alprostadil may affect foetal circulation. You should also browse our condoms and sexual health collection for suitable barrier contraception options.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Vitaros Cream (Alprostadil) specifications
Treatment category Erectile dysfunction
Active ingredient Alprostadil 3mg/g
Mechanism of action Prostaglandin E1 analogue — smooth muscle relaxation and vasodilation
Route of administration Topical (applied to urethral meatus)
Preparation Cream
Strengths 3mg/g
Pack sizes Single-dose applicators
Suitable for Adult men with erectile dysfunction
UK classification Prescription-only medicine (POM)
Drug class Prostaglandin / vasodilator
Effective Within 5–30 minutes of application

Specifications of Vitaros Cream (Alprostadil)

 

What Is Vitaros Cream and What Is It Used For?

 

Vitaros cream contains alprostadil 3mg/g as its active ingredient. It is used to treat erectile dysfunction (ED) — the inability to achieve or maintain an erection sufficient for satisfactory sexual activity — in adult men. Alprostadil is a prostaglandin E1 analogue that acts locally on penile tissue to increase blood flow. It is applied to the urethral meatus (the opening at the tip of the penis) using a single-dose applicator.

ED is a common condition. The NHS notes that it becomes more prevalent with age, though it can affect men of any age and often has both physical and psychological components. Vitaros cream offers an alternative route of treatment for men who cannot use or have not benefited from oral ED medicines.

 

What Do You Need to Know Before Using Vitaros Cream?

 

Do not use Vitaros cream if any of the following apply to you:

  • You are under 18 years of age.
  • You have a known hypersensitivity to alprostadil or any other ingredient in the cream.
  • You have a condition that predisposes you to priapism (prolonged erection), such as sickle cell anaemia, multiple myeloma, or leukaemia.
  • You have penile anatomical deformities, including Peyronie's disease.
  • You have been advised by a doctor to avoid sexual activity.
  • Your sexual partner is pregnant and you are not using a condom.

Tell your doctor or pharmacist if you are taking any of the following, as interactions may occur:

  • Antihypertensive medicines (blood pressure lowering drugs) — risk of additive hypotension.
  • Anticoagulants such as warfarin — may increase bleeding risk.
  • Other treatments for erectile dysfunction — do not use concurrently.
  • Sympathomimetic agents — may reduce the effect of alprostadil.

 

How Should You Use Vitaros Cream Correctly?

 

Always use Vitaros cream exactly as your prescriber or pharmacist has told you. The following steps describe the standard application method:

  1. Wash your hands thoroughly before handling the applicator.
  2. Remove the single-dose applicator from its packaging.
  3. Sit or stand comfortably and retract the foreskin if applicable.
  4. Apply the cream directly to the urethral meatus (the opening at the tip of the penis).
  5. Gently massage the tip of the penis for approximately one minute to aid absorption.
  6. Allow 5–30 minutes for the erection to develop before engaging in sexual activity.
  7. Discard the applicator after use — it is single-use only.
Indication Age Group Dose Frequency
Erectile dysfunction Adult men (18+) One 3mg/g applicator Once per 24 hours; max 2–3 times per week

Do not use more than one applicator in a 24-hour period. If you are unsure about the correct dose, speak to your pharmacist. You may also find it helpful to browse our creams and ointments section for guidance on topical medicine application.

 

What Are the Possible Side Effects of Vitaros Cream?

 

Like all medicines, Vitaros cream can cause side effects, although not everyone experiences them. Most side effects are localised to the application site.

Common side effects (may affect up to 1 in 10 people):

  • Penile pain or burning sensation after application.
  • Redness or erythema at the application site.
  • Warmth or tingling in the penis.

Less common side effects (may affect up to 1 in 100 people):

  • Dizziness or light-headedness.
  • Low blood pressure (hypotension).
  • Prolonged erection (priapism) — seek urgent medical attention if an erection lasts more than four hours.
  • Genital irritation in the sexual partner.
  • Urethral bleeding or spotting.

If you experience a prolonged or painful erection lasting more than four hours, seek emergency medical attention immediately. This is a medical emergency.

 

How Should You Store Vitaros Cream?

 

  • Before dispensing: store in a refrigerator at 2°C–8°C.
  • After dispensing: store below 25°C, away from direct heat and sunlight.
  • Use within 3 months of dispensing.
  • Do not freeze.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the packaging.
  • Dispose of used applicators safely — do not flush down the toilet.

For more information on managing your sexual health, visit our condoms and sexual health collection.

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Frequently Asked Questions

Where can I buy Vitaros cream online in the UK?

You can buy Vitaros cream online through Cured Pharmacy, a GPhC-registered online pharmacy. You will need to complete a short clinical questionnaire so a pharmacist can confirm the treatment is appropriate for you. Once approved, it is dispensed and delivered discreetly to your door. Browse our men's health collection for related products.

How does Vitaros cream work in the body?

Vitaros cream contains alprostadil, a prostaglandin E1 analogue that relaxes smooth muscle and dilates blood vessels in the penis, increasing blood flow to produce an erection. It is absorbed through the urethral meatus and acts locally rather than throughout the whole body. This localised action means it tends to cause fewer systemic side effects than oral ED treatments.

How do I use Vitaros cream step by step?

Wash your hands, open the single-dose applicator, and apply the cream directly to the urethral opening at the tip of the penis. Gently massage the area for around one minute to help absorption, then allow 5–30 minutes for the erection to develop before sexual activity. Discard the applicator after use — each one is for single use only.

What is the correct dose of Vitaros cream?

The standard dose is one 3mg/g single-dose applicator applied to the urethral meatus per occasion. You should not use more than one applicator in any 24-hour period, and use should generally be limited to two or three times per week. Always follow the instructions given by your prescriber or pharmacist.

When is the best time to use Vitaros cream?

Vitaros cream should be applied approximately 5–30 minutes before you intend to have sexual activity, as this is the typical time needed for the erection to develop. Unlike some oral ED tablets, it does not need to be taken hours in advance, which many men find more convenient. Apply it in a private, comfortable setting so you can follow the application steps correctly.

What are the side effects of Vitaros cream?

The most common side effects are localised to the application site and include penile pain, burning, or redness. Less commonly, some men experience dizziness or a drop in blood pressure. If you develop a prolonged erection lasting more than four hours (priapism), seek emergency medical attention immediately as this requires urgent treatment.

Who is eligible to use Vitaros cream?

Vitaros cream is suitable for adult men (aged 18 and over) with erectile dysfunction, particularly those who have not responded to or cannot take oral PDE5 inhibitors such as sildenafil. It is not suitable for men with penile anatomical deformities, conditions predisposing to priapism, or those advised to avoid sexual activity for medical reasons. A clinical assessment is required before it can be dispensed.

How does Vitaros cream compare to Viagra (sildenafil)?

Unlike Viagra, which is taken orally and works systemically, Vitaros cream is applied topically and acts locally in the penile tissue. This makes it a viable option for men who cannot take nitrate medications alongside oral ED treatments, as there is no significant interaction risk with nitrates. The onset of action is broadly similar, though individual responses vary.

Can I use Vitaros cream if I take blood pressure medication?

You should tell your prescriber or pharmacist if you are taking antihypertensive medicines before using Vitaros cream, as there is a potential for additive blood pressure lowering effects. In many cases it can still be used, but your suitability needs to be assessed individually. Never start or stop any medication without speaking to a healthcare professional first.

What happens if I use too much Vitaros cream?

Using more than the recommended dose increases the risk of side effects, including a prolonged erection (priapism), low blood pressure, and increased local irritation. If you accidentally use more than one applicator or experience a painful erection lasting over four hours, seek emergency medical attention immediately. Do not attempt to manage priapism at home.

Does my partner need to take any precautions when I use Vitaros cream?

If your partner is pregnant, you must use a condom during sexual activity after applying Vitaros cream, as alprostadil may affect foetal circulation. Female partners may occasionally experience genital irritation from contact with the cream. You can find suitable barrier options in our condoms and sexual health collection.

How long can I keep using Vitaros cream?

Vitaros cream can be used on an ongoing basis as long as it remains appropriate and effective for you, subject to regular review by your prescriber. There is no fixed maximum duration of treatment, but your doctor or pharmacist may periodically reassess whether it is still the right option. If you notice reduced effectiveness over time, discuss this with a healthcare professional.

What are the alternatives to Vitaros cream for erectile dysfunction?

Alternatives to Vitaros cream include oral PDE5 inhibitors such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra), as well as injectable alprostadil (Caverject) and vacuum erection devices. The right choice depends on your medical history, other medications, and personal preference. Your GP or pharmacist can help you weigh up the options.

How should Vitaros cream be stored at home?

After dispensing, Vitaros cream should be stored below 25°C, away from direct heat and sunlight, and used within three months. Before dispensing it must be kept refrigerated at 2°C–8°C. Do not freeze the product, and always keep it out of the reach of children.

What are the latest findings on alprostadil cream for erectile dysfunction?

Clinical studies have consistently shown that topical alprostadil is effective in producing erections sufficient for sexual intercourse in men with ED of various causes, including those with diabetes and cardiovascular disease. Research published in peer-reviewed urology journals supports its use as a second-line option when oral treatments are unsuitable. The NHS recognises alprostadil as an established treatment for erectile dysfunction.

How Should You Use Vitaros Cream?

Vitaros cream is applied topically to the urethral meatus — the small opening at the tip of the penis. It is important to follow the application steps carefully to ensure the cream is absorbed correctly and to minimise the risk of side effects. Always wash your hands before and after handling the applicator.

Do not insert the applicator deeply into the urethra. If you experience significant pain or burning that does not settle, stop use and speak to your pharmacist or GP.

What Is the Correct Dose of Vitaros Cream?

The recommended dose of Vitaros cream is one single-dose applicator (containing alprostadil 3mg/g) per occasion. Do not use more than one applicator within any 24-hour period, and limit use to no more than two or three times per week to reduce the risk of local side effects and tolerance.

When Is the Best Time to Use Vitaros Cream?

Apply Vitaros cream approximately 5–30 minutes before you intend to engage in sexual activity. This window allows sufficient time for alprostadil to be absorbed and for the erection to develop. Unlike some oral ED tablets that require planning an hour or more in advance, Vitaros cream offers a relatively short lead time, which many men find more natural and less disruptive.

Avoid applying the cream immediately before or after urination, as this may affect absorption. There is no restriction on the time of day — use it whenever it is most appropriate for you and your partner.

How Long Can You Use Vitaros Cream For?

There is no fixed maximum duration of treatment with Vitaros cream. It can be used on an ongoing basis provided it remains effective and appropriate for you. Your prescriber or pharmacist may periodically review your treatment to ensure it is still the right option. If you notice the cream becoming less effective over time, or if side effects become troublesome, discuss this with a healthcare professional rather than increasing the dose yourself.

Long-term use should always be monitored. Regular check-ins with your GP or pharmacist help ensure your erectile dysfunction is being managed safely and that no underlying causes are being overlooked.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Vitaros Cream?

Most side effects associated with Vitaros cream are localised to the area of application and are generally mild to moderate in severity. They tend to resolve on their own without the need for additional treatment.

  • Penile pain or aching after application.
  • Burning or stinging sensation at the urethral meatus.
  • Redness (erythema) of the penile skin.
  • Warmth or tingling in the penis.
  • Minor urethral discomfort.

These effects are usually short-lived. If the pain is severe or persists for more than a few hours after use, stop using the cream and speak to your pharmacist or GP.

What Are the Less Common Side Effects of Vitaros Cream?

Less common side effects occur in a smaller proportion of users but are still worth being aware of before you start treatment. Some of these relate to the mild systemic absorption of alprostadil.

  • Dizziness or light-headedness.
  • Low blood pressure (hypotension), particularly if you are also taking antihypertensive medicines.
  • Genital irritation or itching in your sexual partner.
  • Minor urethral bleeding or spotting.
  • Swelling of the penis or foreskin.

What Are the Serious Side Effects of Vitaros Cream?

Serious side effects are uncommon but require prompt medical attention if they occur. The most significant risk is priapism — a prolonged, painful erection that is not related to sexual stimulation and does not subside after orgasm.

If you experience an erection lasting more than four hours, seek emergency medical attention immediately. Priapism that is not treated promptly can cause permanent damage to penile tissue. Men with conditions such as sickle cell anaemia, leukaemia, or multiple myeloma are at higher risk and should not use Vitaros cream without specialist guidance.

What Should You Do If You Experience Side Effects?

For mild local side effects such as burning or redness, no specific treatment is usually needed — they typically resolve within a short time. Avoid using the cream again until the irritation has fully settled. If side effects are persistent, worsening, or causing significant distress, contact your pharmacist or GP for advice.

In the event of a serious allergic reaction — characterised by swelling of the face, lips, or throat, difficulty breathing, or a widespread rash — call 999 or go to your nearest A&E department immediately. Do not use Vitaros cream again until you have spoken to a doctor.

Can Vitaros Cream Interact With Other Medicines?

Vitaros cream can interact with certain other medicines, which may increase the risk of side effects or reduce its effectiveness. The most clinically relevant interactions include antihypertensive drugs (which may cause additive blood pressure lowering), anticoagulants such as warfarin (which may increase bleeding risk), and other erectile dysfunction treatments (which should not be used at the same time). Always tell your prescriber or pharmacist about all medicines, supplements, and herbal products you are taking before starting Vitaros cream.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question

Most men notice it starts to work within 5 to 30 minutes, and the effects can last for up to 2 hours. 

Using more than recommended can cause excessive burning, redness, or prolonged erection. Always use exactly one sachet per dose.

You can expect results to last for about 1 to 2 hours, depending on your body’s response and level of arousal.

No, you should only use one dose in 24 hours, and a maximum of two to three times per week. Overuse can increase irritation or discomfort.

No. You should never combine Vitaros with other ED medications. Stick to one treatment at a time to avoid side effects or overstimulation. 

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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How fast does Vitaros Cream work? 

Most men notice it starts to work within 5 to 30 minutes, and the effects can last for up to 2 hours. 

What happens if I apply too much? 

Using more than recommended can cause excessive burning, redness, or prolonged erection. Always use exactly one sachet per dose.

How long does the effect last?

You can expect results to last for about 1 to 2 hours, depending on your body’s response and level of arousal.

Can I use Vitaros every day?

No, you should only use one dose in 24 hours, and a maximum of two to three times per week. Overuse can increase irritation or discomfort.

Can I use Vitaros alongside ED tablets like Viagra or Cialis?  No. You should never combine Vitaros with other ED medications. Stick to one treatment at a time to avoid side effects or overstimulation.