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Dermol 500 Lotion - 500ml

Dermol 500 Lotion - 500ml

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  • ✔️ Soothes and moisturises dry, itchy, eczema-prone skin daily
  • ✔️ Dual antimicrobial action reduces bacterial skin colonisation
  • ✔️ Works as both a leave-on moisturiser and soap substitute
  • ✔️ Suitable for adults and children with eczema or dermatitis
  • ✔️ Paraffin-based formula locks in moisture and restores skin barrier

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What Is Dermol 500 Lotion and How Does It Help Dry Skin?

 

Living with dry, itchy, or inflamed skin can be genuinely exhausting. Whether it's eczema flaring up in winter or persistent dermatitis that just won't settle, finding a moisturiser that actually does the job matters. Dermol 500 lotion is an antimicrobial emollient that does two things at once — it moisturises and it helps protect the skin from bacterial colonisation, which is a known trigger for eczema flare-ups. Available from Cured Pharmacy for just £8.99, it's a clinically recognised option that dermatologists and GPs regularly recommend. You can explore our wider range of skin care products if you're looking for complementary treatments alongside this lotion.

Dry skin conditions affect millions of people across the UK. The NHS estimates that eczema alone affects around 1 in 5 children and 1 in 10 adults at some point in their lives. Emollients are the cornerstone of managing these conditions — they reduce water loss from the skin surface and help restore the protective barrier that keeps irritants out.

 

How Does Dermol 500 Lotion Work to Soothe and Protect Skin?

 

The lotion works through a dual-action formula. It contains two moisturising agents — liquid paraffin and isopropyl myristate — alongside two antimicrobial ingredients: benzalkonium chloride and chlorhexidine dihydrochloride. Here's how each component contributes:

  • Liquid paraffin (10%): Forms a protective film over the skin surface, locking in moisture and reducing transepidermal water loss.
  • Isopropyl myristate (10%): Helps soften and smooth the skin, improving texture and reducing the rough, scaly appearance associated with dry skin conditions.
  • Benzalkonium chloride (0.1%): An antiseptic agent that reduces bacterial load on the skin surface, particularly Staphylococcus aureus, which is commonly found in higher concentrations on eczema-affected skin.
  • Chlorhexidine dihydrochloride (0.1%): A second antimicrobial that works alongside benzalkonium chloride to provide broader protection against skin bacteria.

Together, these ingredients address both the dryness and the infection risk that often go hand in hand with conditions like atopic eczema and contact dermatitis.

 

Who Should Use Dermol 500 Lotion and Is It Right for You?

 

This lotion is suitable for a wide range of people dealing with dry or compromised skin. It can be used as a leave-on moisturiser or as a soap substitute — making it particularly versatile for those who find that regular soaps and shower gels aggravate their skin. It's suitable for:

  • Adults and children with atopic eczema or contact dermatitis
  • People with psoriasis who need regular moisturisation
  • Individuals with ichthyosis or other chronic dry skin conditions
  • Anyone whose skin is prone to bacterial infections alongside dryness

It is not recommended for people with known hypersensitivity to any of the active or excipient ingredients. Always check the full ingredient list before use, particularly if you have a history of contact allergies.

 

How Does Dermol 500 Lotion Compare to Other Emollients?

 

Feature Dermol 500 Lotion Diprobase Cream
Antimicrobial action Yes (benzalkonium chloride + chlorhexidine) No
Soap substitute use Yes No
Texture Light lotion Thick cream
Suitable for face Yes (avoid eyes) Yes

 

Is Dermol 500 Lotion Safe to Store and Use Long-Term?

 

Dermol 500 lotion should be stored below 25°C, away from direct sunlight, and kept out of reach of children. Once opened, use within the period indicated on the packaging. One important safety point that's easy to overlook: emollients — including this one — can make skin, clothing, and bedding flammable. Keep away from naked flames and do not smoke while applying. This is a well-documented risk highlighted by the NHS and MHRA for all paraffin-based emollients. If you're also managing related skin concerns, our creams and ointments collection includes a range of complementary topical treatments.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Dermol 500 Lotion 500ml specifications
Treatment category Emollient / Antimicrobial moisturiser
Mechanism of action Moisturises skin via occlusive agents; reduces bacterial colonisation via antiseptic ingredients
Effective for Dry skin, eczema, dermatitis, psoriasis, ichthyosis
Suitable for Adults and children (consult pharmacist for infants)
Active ingredients Benzalkonium chloride 0.1%, Chlorhexidine dihydrochloride 0.1%, Isopropyl myristate 10%, Liquid paraffin 10%
Pack size 500ml
UK classification P (Pharmacy medicine)
Drug class Emollient / Antiseptic
Preparation Lotion
Route of administration Topical (skin)

Specifications of Dermol 500 Lotion 500ml

 

What Is Dermol 500 Lotion and What Is It Used For?

 

Dermol 500 lotion is a topical emollient containing both moisturising and antimicrobial ingredients. It is used to manage dry skin conditions including atopic eczema, contact dermatitis, psoriasis, and ichthyosis. It can be applied directly to the skin as a leave-on moisturiser or used as a soap substitute during washing. The NHS recommends emollients as a first-line treatment for eczema and other chronic dry skin conditions, advising that they should be used regularly — even when the skin appears to be clear — to maintain the skin barrier and prevent flare-ups.

 

What Do You Need to Know Before Using Dermol 500 Lotion?

 

Before using this lotion, read the following carefully. There are some situations where you should not use it or should seek advice first.

Do not use Dermol 500 Lotion if you:

  • Are allergic to benzalkonium chloride, chlorhexidine, liquid paraffin, isopropyl myristate, or any other ingredient in the formulation
  • Have a known sensitivity to antiseptic agents

Warnings and precautions:

  • Emollients containing paraffin are flammable — keep away from naked flames, cigarettes, and open fires
  • Fabric (clothing, bedding, dressings) soaked with emollient can catch fire more easily — wash regularly
  • Avoid contact with the eyes
  • Do not apply to broken, infected, or weeping skin without medical advice
  • If your skin condition worsens after use, stop and consult your GP or pharmacist
  • Consult a healthcare professional before use in infants under 12 months

Drug interactions:

  • No significant drug interactions are currently known for topical use of this product
  • If you are using other topical medicines (e.g. topical corticosteroids), apply Dermol 500 Lotion first and allow it to absorb before applying the other product, or follow your prescriber's instructions

 

How Should You Use Dermol 500 Lotion Correctly?

 

Using an emollient correctly makes a real difference to how well it works. Apply generously and regularly — the NHS advises that emollients should be used at least twice daily, and more frequently during flare-ups. Here's how to use it:

  1. Wash your hands before applying the lotion
  2. Apply a generous amount to the affected area
  3. Smooth gently into the skin in the direction of hair growth — do not rub vigorously
  4. If using as a soap substitute, apply to wet skin, lather gently, and rinse off thoroughly
  5. Pat skin dry with a soft towel after washing — do not rub
  6. Reapply throughout the day as needed, especially after washing
Indication Age Group Dose Frequency
Dry skin / eczema (leave-on) Adults & children Apply liberally to affected area At least twice daily
Soap substitute (wash-off) Adults & children Apply to wet skin, rinse off Every time you wash
Severe flare-up Adults & children Apply liberally Up to 4–5 times daily

If you're managing eczema in a child, our baby and toddler range includes additional products suitable for younger skin.

 

What Are the Possible Side Effects of Dermol 500 Lotion?

 

Side effects from Dermol 500 lotion are uncommon, but it's important to know what to look out for. As with any topical product, individual skin reactions can vary.

Common side effects:

  • Mild stinging or tingling on first application, particularly on broken or sensitive skin
  • Temporary greasiness or residue on the skin surface

Less common side effects:

  • Skin redness or irritation at the application site
  • Contact dermatitis (allergic reaction to one of the ingredients)
  • Folliculitis (inflammation of hair follicles) — more likely if the product is applied against the direction of hair growth

If you experience any signs of a serious allergic reaction — such as swelling of the face, lips, or throat, difficulty breathing, or a widespread rash — stop using the product immediately and seek urgent medical attention.

 

How Should You Store Dermol 500 Lotion?

 

Correct storage keeps the product effective and safe to use. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the cap tightly closed when not in use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the bottle
  • Do not store near naked flames — the product is flammable

For a broader selection of topical treatments for skin conditions, browse our creams and ointments collection, where you'll find a range of options suited to different skin types and conditions.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Dermol 500 Lotion online in the UK?

You can buy Dermol 500 Lotion online in the UK directly from Cured Pharmacy, a GPhC-registered online pharmacy. It is available without a prescription as an over-the-counter emollient. At just £8.99 for a 500ml bottle, it offers excellent value for a clinically recognised antimicrobial moisturiser.

How does Dermol 500 Lotion work on dry and eczema-prone skin?

Dermol 500 lotion works through a dual-action formula combining moisturising oils — liquid paraffin and isopropyl myristate — with two antimicrobial agents, benzalkonium chloride and chlorhexidine dihydrochloride. The oils restore the skin's lipid barrier and reduce water loss, while the antimicrobials help reduce bacterial colonisation, particularly Staphylococcus aureus, which is commonly elevated in eczema-affected skin. This combination addresses both the dryness and the infection risk that often worsen flare-ups.

How do I use Dermol 500 Lotion step by step?

Apply a generous amount of the lotion to the affected area and smooth gently into the skin in the direction of hair growth. As a soap substitute, apply to wet skin, lather lightly, and rinse off thoroughly before patting dry. Use at least twice daily as a leave-on moisturiser, or every time you wash when using as a soap substitute.

Can Dermol 500 Lotion be used on children and babies?

Dermol 500 Lotion can be used on children, but you should consult your GP or pharmacist before using it on infants under 12 months. Always perform a small patch test on a discreet area of skin before applying more widely. If you're looking for products specifically designed for younger skin, our baby and toddler range may also be helpful.

What are the side effects of Dermol 500 Lotion?

Side effects are uncommon but may include mild stinging on first application, temporary skin redness, or irritation at the application site. In rare cases, an allergic contact reaction to one of the ingredients may occur — if this happens, stop use and speak to your pharmacist or GP. Signs of a serious allergic reaction, such as facial swelling or difficulty breathing, require immediate medical attention.

Is Dermol 500 Lotion safe to use during pregnancy?

Dermol 500 Lotion is generally considered safe for topical use during pregnancy, as systemic absorption from the skin is minimal. However, you should always speak to your GP or midwife before starting any new skincare product while pregnant or breastfeeding. They can advise on the most appropriate emollient for your individual circumstances.

What is the difference between Dermol 500 Lotion and Dermol 600 Shower Emollient?

Dermol 500 Lotion is designed for use as a leave-on moisturiser or soap substitute applied directly to the skin, while Dermol 600 Shower Emollient is specifically formulated for use in the bath or shower as a wash-off product. Both contain similar active ingredients but differ in their formulation, consistency, and intended method of application. Your pharmacist can help you decide which is more suitable for your routine.

How often should I apply Dermol 500 Lotion for eczema?

The NHS recommends applying emollients at least twice daily for eczema, even when the skin appears clear, to maintain the skin barrier and reduce the frequency of flare-ups. During a flare-up, you may need to apply it more frequently — up to four or five times a day. Consistency is key; regular use tends to produce better long-term results than applying only when symptoms appear.

Is Dermol 500 Lotion flammable?

Yes — like all paraffin-based emollients, Dermol 500 Lotion is flammable. The MHRA and NHS have issued guidance warning that emollients can soak into clothing and bedding, making them more likely to catch fire. Keep away from naked flames, cigarettes, and open fires, and wash clothing and bedding regularly to reduce this risk.

Can I use Dermol 500 Lotion as a soap substitute?

Yes, Dermol 500 Lotion is specifically designed to be used as a soap substitute, which is particularly beneficial for people whose skin is aggravated by conventional soaps and shower gels. Apply it to wet skin, lather gently, and rinse off thoroughly. This helps cleanse the skin without stripping its natural oils.

How long can you use Dermol 500 Lotion for?

Dermol 500 Lotion can be used long-term as part of a daily skincare routine for chronic dry skin conditions such as eczema or psoriasis. There is no set maximum duration of use, as emollients are generally recommended for ongoing maintenance. If your skin condition does not improve or worsens despite regular use, consult your GP for further assessment.

What are the alternatives to Dermol 500 Lotion?

Common alternatives include Diprobase Cream, Cetraben Lotion, Doublebase Gel, and Aveeno Dermexa — all of which are emollients used for dry skin and eczema, though most do not contain antimicrobial agents. You can browse a range of options in our skin care collection. Your pharmacist can help you choose the most appropriate product based on your skin type and condition.

Does Dermol 500 Lotion contain steroids?

No, Dermol 500 Lotion does not contain any corticosteroids. It is a pure emollient and antimicrobial product, making it suitable for long-term daily use without the risks associated with topical steroid use. If you require a steroid-containing product for a flare-up, speak to your GP or pharmacist for appropriate advice.

What are the latest findings on antimicrobial emollients for eczema?

Research continues to support the role of antimicrobial emollients in managing atopic eczema, particularly given the well-established link between Staphylococcus aureus colonisation and eczema flare-ups. Clinical guidelines from NICE and the NHS recommend emollients as the foundation of eczema management, with antimicrobial formulations considered where bacterial colonisation is a contributing factor. Always discuss treatment choices with your GP or dermatologist for personalised advice.

What should I do if I miss applying Dermol 500 Lotion?

If you forget to apply Dermol 500 Lotion at your usual time, simply apply it as soon as you remember and continue with your normal routine. There is no risk of "overdose" from applying an emollient, but try not to skip applications regularly as consistent use is what maintains the skin barrier over time. If your skin feels particularly dry or irritated after missing a dose, apply a slightly more generous amount to help restore moisture levels.

How Should You Use Dermol 500 Lotion?

Dermol 500 Lotion can be used in two ways — as a leave-on moisturiser applied directly to the skin, or as a soap substitute used during washing. Using it correctly makes a significant difference to how well it manages your dry skin condition. Follow these steps for best results:

Avoid contact with the eyes. If the lotion gets into your eyes, rinse immediately with plenty of clean water.

What Is the Correct Dose of Dermol 500 Lotion?

There is no fixed single dose for an emollient — the key is to apply it generously and regularly. The NHS advises that emollients should be used liberally, and that using too little is one of the most common reasons they don't work as well as expected. The table below gives a general guide:

When Is the Best Time to Use Dermol 500 Lotion?

The best times to apply Dermol 500 Lotion are immediately after bathing or washing, when the skin is still slightly damp — this helps lock in moisture more effectively. Applying before bed is also beneficial, as the skin has time to absorb the lotion overnight without being washed off. During the day, reapply whenever your skin feels dry, tight, or itchy, particularly after handwashing.

How Long Can You Use Dermol 500 Lotion For?

Dermol 500 Lotion is suitable for long-term, ongoing use as part of a daily skincare routine. Emollients are not a short-term fix — they work best when used consistently over time to maintain the skin barrier and reduce the frequency and severity of flare-ups. If your symptoms do not improve after several weeks of regular use, or if your skin condition worsens, speak to your GP or dermatologist for further assessment and advice.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Dermol 500 Lotion?

Dermol 500 Lotion is generally well tolerated, and most people use it without experiencing any side effects. However, as with any topical product, some individuals may notice mild reactions, particularly when first starting treatment or if the skin is already broken or sensitive.

  • Mild stinging or tingling sensation on first application, especially on broken or inflamed skin
  • Temporary greasiness or residue on the skin surface immediately after application
  • A feeling of warmth at the application site

What Are the Less Common Side Effects of Dermol 500 Lotion?

Less common reactions are possible, particularly in people with sensitive skin or a history of contact allergies. If you notice any of the following, stop using the product and consult your pharmacist or GP.

  • Skin redness or increased irritation at the application site
  • Folliculitis — inflammation of the hair follicles, more likely if the lotion is applied against the direction of hair growth
  • Allergic contact dermatitis — a reaction to one of the active or inactive ingredients in the formulation
  • Dry or flaky skin that worsens rather than improves with use

What Are the Serious Side Effects of Dermol 500 Lotion?

Serious side effects are rare but require prompt medical attention. A severe allergic reaction (anaphylaxis) is uncommon but possible with any topical product containing antiseptic agents such as chlorhexidine or benzalkonium chloride. Seek emergency medical help immediately if you experience any of the following after applying Dermol 500 Lotion:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • A widespread skin rash, hives, or blistering
  • Dizziness, rapid heartbeat, or feeling faint

What Should You Do If You Experience Side Effects?

If you notice mild irritation or redness, try reducing the frequency of application and see if symptoms settle. For persistent or worsening reactions, stop using the product and speak to your pharmacist or GP. They may recommend an alternative emollient without antimicrobial agents if sensitivity to those ingredients is suspected. Never ignore a reaction that is spreading or getting worse — always seek professional advice promptly.

Can Dermol 500 Lotion Interact With Other Medicines?

No significant drug interactions are currently known for Dermol 500 Lotion when used topically. However, if you are using other topical medicines — such as corticosteroid creams or topical antibiotics — apply Dermol 500 Lotion first and allow it to absorb before applying the other product, unless your prescriber advises otherwise. This helps ensure each product works as intended without diluting the other. Always inform your pharmacist of all medicines you are using, including over-the-counter products.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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