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Ametop Gel 4% - 1.5g

Ametop Gel 4% - 1.5g

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  • ✔️ Numbs skin within 30–45 minutes before needle procedures
  • ✔️ Contains tetracaine 4% for effective localised anaesthesia
  • ✔️ Suitable for adults and children aged one month and over
  • ✔️ Anaesthetic effect lasts up to six hours after gel removal
  • ✔️ Single-use 1.5g tube — convenient for planned procedures

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What Is Ametop Gel and How Does It Numb Skin?

 

Ametop gel is a topical local anaesthetic gel containing tetracaine hydrochloride 4%. It is applied directly to intact skin to numb the area before needle-based procedures — things like blood tests, cannulation, or vaccinations. If you or your child finds injections particularly distressing, this small 1.5g tube can make a real difference. It is available over the counter without a prescription, making it easy to pick up ahead of a planned procedure.

Tetracaine has been used in clinical settings for decades and is well established as an effective surface anaesthetic. Each tube contains 1.5g of gel — enough for a single application site. You can find it alongside other first aid products at Cured Pharmacy, priced at just £1.99.

 

How Does Ametop Gel Work on the Skin?

 

Tetracaine works by blocking voltage-gated sodium channels in the peripheral nerve endings just beneath the skin surface. When sodium cannot flow into the nerve cell, the nerve cannot fire — and pain signals simply do not reach the brain. It is a well-understood mechanism used across many local anaesthetic medicines.

  • Tetracaine penetrates intact skin within 30 to 45 minutes of application.
  • It produces localised numbness without affecting deeper tissues.
  • The anaesthetic effect persists for approximately 4 to 6 hours after the gel is removed.
  • It does not require injection — the gel sits on the skin surface under an occlusive dressing.

 

Who Is Ametop Gel Suitable For?

 

Ametop gel is suitable for adults and children aged 1 month and over. It is particularly useful for people who experience needle anxiety, children undergoing routine blood tests or vaccinations, and patients requiring repeated cannulation. It is also used in clinical settings by nurses and healthcare professionals before venepuncture.

  • Adults and children aged 1 month and over
  • People with needle phobia or significant procedure anxiety
  • Children having blood tests, vaccinations, or IV cannulation
  • Patients with chronic conditions requiring frequent venous access

It is not suitable for use on broken or inflamed skin, mucous membranes, or near the eyes. It should not be used in neonates under 1 month of age.

 

How Does Ametop Gel Compare to EMLA Cream?

 

Feature Ametop Gel 4% EMLA Cream
Active ingredient Tetracaine hydrochloride 4% Lidocaine 2.5% + Prilocaine 2.5%
Onset of action 30–45 minutes 60 minutes
Duration of effect 4–6 hours post-removal 1–2 hours post-removal
Minimum age 1 month Varies by formulation

 

How Should You Store Ametop Gel and Is It Clinically Suitable for You?

 

Store Ametop gel below 25°C and do not freeze it. Keep it in its original packaging and out of reach of children. Once the tube is opened, use it immediately — do not save leftover gel for later use, as the tube is designed for single application. If you are unsure whether this product is right for you, particularly if you have a known allergy to ester-type local anaesthetics, speak to your pharmacist before use. You can also browse our skin care range for related topical products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Ametop Gel 4% - 1.5g specifications
Treatment category Topical local anaesthesia
Mechanism of action Sodium channel blockade in peripheral nerve endings
Effective 30–45 minutes after application
Suitable for Adults and children aged 1 month and over
Active ingredient Tetracaine hydrochloride 4%
Pack size 1.5g tube
Strength 4% w/w
UK classification Pharmacy (P) medicine
Drug class Ester-type local anaesthetic
Preparation Gel
Route of administration Topical (intact skin only)

Specifications of Ametop Gel 4% - 1.5g

 

What Is Ametop Gel and What Is It Used For?

 

Ametop Gel 4% contains the active ingredient tetracaine hydrochloride, an ester-type local anaesthetic. It is used to numb a small area of intact skin before needle procedures such as venepuncture (blood tests), intravenous cannulation, and vaccinations. The gel is applied topically — meaning directly onto the skin surface — and works without any injection being needed beforehand.

It is particularly valued in paediatric care, where reducing the pain and distress of needle procedures is a clinical priority. Adults with needle anxiety also benefit from its use. Ametop gel is a Pharmacy (P) medicine in the UK, meaning it can be purchased without a prescription but should be used according to the instructions provided.

 

What Do You Need to Know Before Using Ametop Gel?

 

Before applying Ametop Gel, read the following carefully. There are situations where this product should not be used or should be used with caution.

Do not use Ametop Gel if you:

  • Are allergic to tetracaine, any other ester-type local anaesthetic, or any ingredient in the gel
  • Need to apply it to broken, inflamed, or infected skin
  • Need to apply it to mucous membranes (e.g. inside the mouth or nose)
  • Are treating a neonate under 1 month of age
  • Need to apply it near the eyes

Drug interactions to be aware of:

  • No clinically significant interactions are known at topical doses
  • Inform your pharmacist if you are taking any medicines that affect the heart rhythm (antiarrhythmics), as a precaution
  • If you are using other topical medicines on the same area, seek pharmacist advice before combining

 

How Should You Use Ametop Gel?

 

Always use Ametop Gel exactly as directed. Do not apply more than instructed, and do not leave it on for longer than recommended. If you are using this for a child, an adult should apply and supervise the gel at all times.

  1. Identify the area of intact skin where the needle procedure will take place.
  2. Squeeze approximately half the tube (around 1g) onto the skin in a small mound — do not rub it in.
  3. Cover the gel with the occlusive dressing provided or a suitable waterproof dressing.
  4. Leave in place for 30 to 45 minutes before the procedure.
  5. Remove the dressing and wipe away the gel immediately before the needle is inserted.
  6. Do not apply to more than one site at a time unless directed by a healthcare professional.
Indication Age Group Dose Application Time
Venepuncture / cannulation Adults Approx. 1g (half tube) 30–45 minutes
Venepuncture / cannulation Children (1 month+) Approx. 1g (half tube) 30–45 minutes
Vaccination Adults and children Approx. 1g (half tube) 30–45 minutes

If you are looking for additional products to support your child's health and comfort, explore our baby and toddler range at Cured Pharmacy.

 

What Are the Possible Side Effects of Ametop Gel?

 

Like all medicines, Ametop Gel can cause side effects, although not everyone experiences them. Most side effects are localised to the application site and resolve once the gel is removed.

Common side effects:

  • Redness (erythema) at the application site
  • Mild swelling (oedema) of the skin
  • Itching or a mild burning sensation
  • Blanching (temporary paleness) of the skin

Less common side effects:

  • Localised allergic skin reaction (contact dermatitis)
  • Prolonged skin discolouration
  • In rare cases, systemic absorption may cause dizziness or light-headedness — seek medical advice immediately if this occurs

Stop using the gel and seek medical advice if you notice signs of a serious allergic reaction, including facial swelling, difficulty breathing, or a widespread rash. For broader pain management options, you may also wish to browse our pain relief collection.

 

How Should You Store Ametop Gel?

 

  • Store below 25°C in a cool, dry place
  • Do not freeze
  • Keep in the original packaging to protect from light
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the tube
  • Use the entire tube contents in a single application — do not store opened tubes for later use
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Ametop Gel online in the UK?

You can buy Ametop Gel 4% 1.5g directly from Cured Pharmacy online for just £1.99, with no prescription required. It is a Pharmacy (P) medicine available over the counter. Simply add it to your basket and it will be dispatched to your door.

How does Ametop Gel work in the body?

Ametop Gel contains tetracaine hydrochloride, which blocks sodium channels in the nerve endings just beneath the skin surface. This prevents pain signals from travelling to the brain, producing localised numbness. The effect is confined to the application site and does not affect deeper tissues or the rest of the body.

How do I apply Ametop Gel step by step?

Squeeze approximately 1g of gel (roughly half the tube) onto the intact skin area where the needle will be inserted. Cover it with an occlusive dressing and leave for 30 to 45 minutes. Remove the dressing and wipe away the gel just before the procedure begins — do not rub the gel into the skin.

How long does Ametop Gel take to work?

Ametop Gel typically takes 30 to 45 minutes to produce adequate skin numbing after application. The anaesthetic effect can last for approximately 4 to 6 hours after the gel is removed. Do not leave the gel on for longer than 60 minutes without clinical guidance.

What are the side effects of Ametop Gel and how do I manage them?

The most common side effects are localised redness, mild swelling, and itching at the application site — these usually resolve quickly once the gel is removed. Less commonly, a contact allergic reaction may occur. If you notice widespread rash, facial swelling, or difficulty breathing, remove the gel immediately and seek urgent medical attention.

Who is eligible to use Ametop Gel?

Ametop Gel is suitable for adults and children aged 1 month and over. It is not recommended for neonates under 1 month of age. People with a known allergy to ester-type local anaesthetics should not use this product and should speak to their pharmacist about alternatives.

Can children use Ametop Gel safely?

Yes — Ametop Gel is suitable for children aged 1 month and over and is widely used in paediatric clinical settings before blood tests and cannulation. An adult should always apply and supervise the gel when used on a child. You can find other child-friendly health products in our baby and toddler collection.

What happens if I leave Ametop Gel on for too long?

Leaving Ametop Gel on for longer than recommended (beyond 60 minutes) may increase the risk of skin irritation or, in rare cases, greater systemic absorption of tetracaine. Always follow the 30 to 45 minute application guideline and remove the gel promptly before the procedure. If you are unsure, speak to your pharmacist.

Is Ametop Gel the same as EMLA cream?

No — they are different products with different active ingredients. Ametop Gel contains tetracaine hydrochloride 4%, while EMLA cream contains a combination of lidocaine and prilocaine. Ametop generally has a faster onset (30–45 minutes versus 60 minutes for EMLA) and a longer duration of effect after removal, though it may cause more localised redness.

Can I use Ametop Gel if I am pregnant or breastfeeding?

There is limited clinical data on the use of tetracaine during pregnancy or breastfeeding. Because the gel is applied topically and systemic absorption is minimal, the risk is considered low — but you should always speak to your doctor or pharmacist before using any medicine during pregnancy or whilst breastfeeding.

Can I use Ametop Gel on my face or near my eyes?

No — Ametop Gel must not be applied near the eyes, to mucous membranes, or to broken or inflamed skin. It is intended for use on intact skin only, typically on the inner arm or back of the hand before venepuncture. If you need eye-related topical treatments, visit our eye care collection for appropriate products.

How many tubes of Ametop Gel do I need for one procedure?

One 1.5g tube is designed for a single application site — you will use approximately half the tube (1g) per site. If you need to numb more than one site, you would require an additional tube. Do not reuse or store an opened tube for a later procedure.

What are the alternatives to Ametop Gel for numbing skin?

The main alternative topical anaesthetic available in the UK is EMLA cream (lidocaine/prilocaine). Some clinics also use lidocaine spray or patches for surface anaesthesia. For general pain management options, you can browse our pain relief range at Cured Pharmacy.

How long can you keep using Ametop Gel?

Ametop Gel is intended for single-use application — each tube should be used in full for one procedure and then discarded. There is no long-term daily use regimen for this product. If you require numbing gel regularly for repeated procedures, speak to your GP or nurse about the most appropriate approach for your situation.

What does the latest research say about tetracaine gel for needle pain?

Clinical evidence consistently supports tetracaine gel as an effective topical anaesthetic for reducing needle-related pain in both adults and children. Studies published in paediatric and anaesthesia literature confirm its faster onset compared to lidocaine-prilocaine combinations. It remains a recommended option in UK clinical guidelines for procedural pain management in children.

How Should You Use Ametop Gel?

Ametop Gel is applied topically to intact skin only — never rub it in or apply it to broken, inflamed, or infected areas. Always wash your hands before and after handling the gel, and keep it away from your eyes and mouth.

If you are applying the gel to a child, an adult must supervise the entire process. Do not apply to more than one site at a time unless directed by a healthcare professional.

What Is the Correct Dose of Ametop Gel?

The standard dose for a single application site is approximately 1g of gel, which is roughly half of the 1.5g tube. This applies to both adults and children aged 1 month and over. Do not apply more than this amount to a single site, as it will not increase the numbing effect and may increase the risk of skin irritation.

When Is the Best Time to Use Ametop Gel?

Apply Ametop Gel 30 to 45 minutes before your scheduled needle procedure. This gives the tetracaine enough time to penetrate the skin and produce adequate numbness at the site. If you apply it too early — more than 60 minutes before the procedure — the gel may cause increased skin irritation without additional benefit.

Plan ahead. If your appointment is at 10:00am, apply the gel at around 9:15am. Remove it promptly when you arrive for your procedure so the healthcare professional can access the site immediately.

How Long Can You Use Ametop Gel For?

Ametop Gel is intended for single-use, short-term application only. Each 1.5g tube is designed for one procedure at one site. Once opened, the tube should be used immediately and any remaining gel discarded — do not store an opened tube for future use.

There is no long-term daily use regimen for this product. If you require skin numbing regularly for repeated procedures, speak to your GP, nurse, or pharmacist about the most appropriate ongoing approach for your individual needs.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Ametop Gel?

Most people who use Ametop Gel experience only mild, localised reactions at the application site. These are generally short-lived and resolve once the gel is removed. They are not a sign that the gel is not working — in fact, some redness is a normal response to tetracaine.

  • Redness (erythema) at the application site
  • Mild swelling or puffiness of the skin
  • Itching or a tingling sensation
  • Temporary blanching (paleness) of the skin
  • Mild burning sensation during application

What Are the Less Common Side Effects of Ametop Gel?

Less commonly, some people may experience a more pronounced skin reaction. These are not dangerous in most cases but should be monitored. If any of the following persist or worsen after removing the gel, seek pharmacist advice.

  • Contact dermatitis (localised allergic skin reaction with rash or blistering)
  • Prolonged skin discolouration at the application site
  • Excessive swelling beyond the application area
  • Skin peeling or crusting after repeated use

What Are the Serious Side Effects of Ametop Gel?

Serious side effects from Ametop Gel are rare when the product is used correctly on intact skin. However, if the gel is applied to broken skin or mucous membranes, systemic absorption of tetracaine may increase, raising the risk of more significant effects. Signs of systemic toxicity include dizziness, light-headedness, confusion, or an irregular heartbeat — remove the gel immediately and seek urgent medical attention if any of these occur.

A severe allergic reaction (anaphylaxis) is very rare but possible. Symptoms include facial swelling, difficulty breathing, a widespread rash, or a sudden drop in blood pressure. Call 999 immediately if you suspect anaphylaxis.

What Should You Do If You Experience Side Effects?

For mild side effects such as redness or itching, simply remove the gel and dressing and allow the skin to settle. Most reactions resolve within a few hours. Do not reapply the gel to the same area if a reaction has occurred.

If you experience a more significant reaction — or if you are unsure whether what you are experiencing is normal — contact your pharmacist or GP for advice. Keep the product packaging with you so the healthcare professional can review the ingredients.

Can Ametop Gel Interact With Other Medicines?

No clinically significant drug interactions are known at the topical doses used with Ametop Gel. However, if you are taking medicines that affect heart rhythm (antiarrhythmics such as amiodarone or flecainide), inform your pharmacist before use as a precaution. Similarly, if you are applying other topical medicines to the same area of skin, seek pharmacist advice before combining them to avoid unexpected skin reactions.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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