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Lyclear Dermal Cream Permethrin 5% - 30g (BRAND MAY VARY)

Lyclear Dermal Cream Permethrin 5% - 30g (BRAND MAY VARY)

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  • ✔️ Kills scabies mites and eggs with a single application
  • ✔️ NHS-recommended first-line permethrin 5% scabies treatment
  • ✔️ Effective for adults and children aged 2 months and over
  • ✔️ Clinically proven to clear scabies infestations within two applications
  • ✔️ Convenient 30g tube — enough for one full-body adult treatment

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What Is Permethrin Cream for Scabies and How Does It Help?

 

Scabies is an intensely itchy skin condition caused by tiny mites called Sarcoptes scabiei that burrow into the outer layers of your skin. It spreads easily through close physical contact, and it can affect anyone — regardless of age or hygiene. If you've been diagnosed with scabies, or you suspect you might have it, permethrin cream for scabies is the first-line treatment recommended by the NHS. Lyclear Dermal Cream contains permethrin 5% and is available to buy online from Cured Pharmacy without a prescription, making it a convenient and clinically recognised option for treating this uncomfortable infestation.

Each 30g tube contains enough cream for a full-body application for one adult. You'll find this product listed under our Head Lice collection, alongside other treatments for parasitic skin conditions. Please note that the brand of cream supplied may vary, but the active ingredient — permethrin 5% — remains the same.

 

How Does Lyclear Dermal Cream Work Against Scabies Mites?

 

Permethrin belongs to a class of medicines called pyrethroids. It works by targeting the nervous system of the scabies mite, disrupting sodium channel function in nerve cell membranes. This leads to paralysis and death of the mite — and crucially, it also affects mite eggs, helping to prevent reinfestation from newly hatched larvae.

  • Permethrin penetrates the mite's cuticle and interferes with nerve signal transmission.
  • Sodium channels in the mite's neurons are held open, causing continuous nerve firing.
  • This results in paralysis and death of both adult mites and larvae.
  • The cream remains active on the skin surface for the duration of the treatment period (8–12 hours).

 

Who Should Use Lyclear Dermal Cream?

 

This cream is suitable for most adults and children aged 2 months and over who have been diagnosed with scabies. It's worth noting that everyone in the same household — and any close physical contacts — should be treated at the same time, even if they don't yet have symptoms. This is essential to prevent re-infection.

  • Adults and teenagers with confirmed or suspected scabies
  • Children aged 2 months and over (under medical supervision for infants)
  • Household contacts of an infected person, whether symptomatic or not
  • People who have not responded to malathion-based treatments

 

How Does Permethrin Cream Compare to Other Scabies Treatments?

 

Feature Permethrin 5% Cream (This Product) Malathion 0.5% Liquid
Active ingredient Permethrin 5% Malathion 0.5%
NHS first-line recommendation Yes Second-line option
Application time 8–12 hours 24 hours
Suitable for children From 2 months From 6 months (check product)

 

Is Permethrin Cream Suitable for Sensitive Skin or Specific Groups?

 

If you have sensitive skin, eczema, or broken skin, you should speak to your pharmacist before using this cream, as it may cause additional irritation. Permethrin cream for scabies is generally well tolerated, but it should be used with caution in people with known hypersensitivity to pyrethroids or chrysanthemums. Pregnant or breastfeeding women should seek medical advice before use. You can also browse our Skin Care collection for complementary products to help soothe irritated skin during and after treatment.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Lyclear Dermal Cream Permethrin 5% 30g specifications
Treatment category Scabies / Parasitic skin infestation
Active ingredient Permethrin 5%
Mechanism of action Pyrethroid — disrupts mite nerve cell sodium channels causing paralysis
Effective against Sarcoptes scabiei (scabies mites) and eggs
Suitable for Adults and children aged 2 months and over
Pack size 30g tube
Strength 5% w/w permethrin
UK classification Pharmacy (P) medicine
Drug class Pyrethroid antiparasitic
Preparation Cream
Route of administration Topical (applied to skin)

Specifications of Lyclear Dermal Cream Permethrin 5% 30g

 

What Is Lyclear Dermal Cream and What Is It Used For?

 

Lyclear Dermal Cream contains permethrin 5% as its active ingredient. It is used to treat scabies — a contagious skin condition caused by the microscopic mite Sarcoptes scabiei. The mites burrow into the skin and lay eggs, causing an intensely itchy rash, particularly at night. The NHS identifies permethrin cream as the recommended first-line treatment for scabies in the UK. It is applied to the skin and works by killing both the mites and their eggs, helping to clear the infestation with a single application in most cases.

 

What Do You Need to Know Before Using Lyclear Dermal Cream?

 

Before applying this cream, read the following carefully. There are certain situations where you should not use it, or where you should seek advice first.

Do not use this cream if you:

  • Are allergic to permethrin, any pyrethroid, pyrethrin, or any other ingredient in the cream
  • Have a known allergy to chrysanthemums or related plants
  • Are treating an infant under 2 months of age without medical supervision

Speak to your pharmacist or GP before use if you:

  • Are pregnant or breastfeeding
  • Have severe or broken skin, eczema, or psoriasis
  • Are applying to a child under 2 years of age
  • Have previously had an allergic reaction to any topical antiparasitic treatment

Drug interactions:

  • No clinically significant drug interactions with permethrin cream have been identified when used topically as directed.
  • Avoid using other topical products on the same area at the same time unless advised by a healthcare professional.

 

How Should You Use Lyclear Dermal Cream?

 

Always use this cream exactly as directed. If you are unsure, ask your pharmacist. For best results, apply to cool, dry skin — ideally after a bath or shower. Do not apply immediately after a hot bath, as this increases absorption and may reduce effectiveness.

  1. Wash and dry your skin thoroughly before applying.
  2. Apply the cream from the neck downwards, covering the entire body surface including between fingers and toes, under nails, the groin, and all skin folds.
  3. For children under 2, elderly patients, and immunocompromised individuals, also apply to the scalp, face, and neck — avoiding the eyes and mouth.
  4. Leave the cream on for 8 to 12 hours (overnight application is ideal).
  5. Wash the cream off thoroughly after the treatment period.
  6. If hands are washed during the treatment period, reapply cream to the hands.
  7. A second application one week later is often recommended to catch any newly hatched mites.
  8. All close contacts and household members should be treated simultaneously.
Indication Age Group Dose Frequency
Scabies Adults and children ≥2 months Apply to whole body (neck down); scalp/face for young children Once; repeat after 7 days if needed
Crusted (Norwegian) scabies Adults (under medical supervision) Multiple applications as directed by a doctor As prescribed

If you are managing other skin conditions alongside scabies, you may find our Creams and Ointments collection helpful for soothing post-treatment skin irritation.

 

What Are the Possible Side Effects of Lyclear Dermal Cream?

 

Like all medicines, permethrin cream can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the skin.

Common side effects:

  • Mild burning or stinging sensation on application
  • Itching at the application site (note: itching may persist for up to 4 weeks after treatment — this is normal)
  • Temporary skin redness or rash
  • Tingling or numbness of the skin

Less common side effects:

  • Worsening of existing eczema or dermatitis
  • Oedema (swelling) at the application site
  • Allergic skin reactions, including contact dermatitis

Stop using the cream and seek medical advice if you develop signs of a serious allergic reaction, such as swelling of the face, lips, or throat, difficulty breathing, or a severe skin reaction. These reactions are rare but require prompt attention.

 

How Should You Store Lyclear Dermal Cream?

 

Correct storage helps maintain the cream's effectiveness and safety. Follow these guidelines:

  • Store below 25°C in a cool, dry place.
  • Do not refrigerate or freeze.
  • Keep the tube tightly closed when not in use.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the tube or carton.
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy.

For other treatments related to skin and parasitic conditions, you might also want to explore our First Aid collection for wound care and skin protection products.

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Frequently Asked Questions

Where can I buy permethrin cream for scabies online in the UK?

You can buy Lyclear Dermal Cream Permethrin 5% directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available without a prescription for adults and children aged 2 months and over. Simply add it to your basket and it will be dispatched discreetly to your door.

How does permethrin 5% cream work to treat scabies?

Permethrin is a pyrethroid that disrupts the nerve cell sodium channels of the scabies mite, causing paralysis and death. It is effective against both adult mites and their eggs, which is why it is the NHS's first-line recommended treatment. A single overnight application to the whole body is usually sufficient to clear the infestation.

How do I apply Lyclear Dermal Cream step by step?

Wash and dry your skin, then apply the cream from the neck downwards, covering all skin folds, between fingers and toes, and under nails. Leave it on for 8 to 12 hours — overnight is ideal — then wash it off thoroughly. If you wash your hands during this period, reapply cream to them immediately.

How many times do I need to apply permethrin cream for scabies?

One application is usually enough, but the NHS recommends a second application seven days after the first to ensure any newly hatched mites are also eliminated. All household members and close contacts should be treated at the same time, even if they have no symptoms. This prevents re-infection passing back and forth.

What is the best time to apply permethrin cream?

The best time to apply permethrin cream is in the evening, so it can remain on the skin overnight for the full 8 to 12 hours. Apply to cool, dry skin — not immediately after a hot bath or shower, as heat increases skin absorption and may reduce the cream's effectiveness. Wash it off the following morning.

What are the common side effects of Lyclear Dermal Cream?

The most common side effects are mild and temporary, including burning, stinging, itching, or redness at the application site. Itching can persist for up to four weeks after treatment — this is a normal immune response to dead mites under the skin and does not mean the treatment has failed. If you develop a severe skin reaction or signs of allergy, stop use and seek medical advice.

How do I manage itching after using permethrin cream?

Post-treatment itching is very common and can last up to four weeks even after successful treatment. You can use a mild, unperfumed moisturiser or a soothing emollient to help calm the skin. If itching is severe, your pharmacist may recommend an antihistamine or a mild hydrocortisone cream — browse our Skin Care collection for suitable options.

Who is eligible to use Lyclear Dermal Cream?

Lyclear Dermal Cream is suitable for adults and children aged 2 months and over. It should be used with caution in pregnant or breastfeeding women, who should seek advice from a doctor or pharmacist first. People with known allergies to pyrethroids or chrysanthemums should not use this product.

Can children use permethrin cream for scabies?

Yes, permethrin cream is suitable for children aged 2 months and over. For infants and young children, the cream should also be applied to the scalp, face, and neck — carefully avoiding the eyes and mouth — under the guidance of a healthcare professional. Always follow the dosage instructions and consult your pharmacist if you are unsure.

Is permethrin cream safe to use during pregnancy or breastfeeding?

The NHS advises that pregnant or breastfeeding women should seek medical advice before using permethrin cream. While it is applied topically and systemic absorption is low, it is important to discuss the risks and benefits with your GP or pharmacist before proceeding. Do not self-treat without professional guidance during pregnancy.

What happens if scabies does not clear after using permethrin cream?

If symptoms persist beyond four weeks after completing two applications, you should see your GP, as this may indicate treatment failure, reinfestation from an untreated contact, or a different skin condition. Your doctor may consider an alternative treatment such as malathion or oral ivermectin in certain cases. Make sure all household contacts were treated simultaneously to rule out re-infection.

What are the alternatives to permethrin cream for scabies?

The main alternative to permethrin cream is malathion 0.5% aqueous liquid, which is used as a second-line treatment when permethrin is not suitable or has not worked. In severe or crusted (Norwegian) scabies, oral ivermectin may be prescribed by a doctor. You can explore related treatments in our Head Lice and Scabies collection.

How long does it take for scabies to clear after treatment?

The mites are killed within hours of applying permethrin cream, but itching and rash can persist for up to four weeks as your immune system reacts to the dead mites and their waste products still present in the skin. This is entirely normal and does not mean the treatment has not worked. If new burrows or rash appear after four weeks, consult your GP.

Do I need to wash bedding and clothing after using permethrin cream?

Yes — the NHS recommends washing all clothing, bedding, and towels used in the 72 hours before treatment on a hot wash (at least 50°C) to kill any mites. Items that cannot be washed should be sealed in a plastic bag for at least 72 hours. This step is essential to prevent re-infection after treatment.

What does the latest research say about permethrin cream for scabies?

Permethrin 5% cream remains the most widely studied and clinically supported topical treatment for scabies, with consistent evidence of high efficacy when applied correctly. Published clinical literature continues to support its use as a first-line agent, with cure rates typically reported above 90% following two applications. The NHS and BNF both continue to recommend it as the treatment of choice for scabies in the UK.

How Should You Use Lyclear Dermal Cream?

Before applying the cream, have a bath or shower and allow your skin to cool and dry completely. Applying to warm or damp skin can increase absorption and reduce the treatment's effectiveness. Use the following steps to ensure full coverage:

What Is the Correct Dose of Lyclear Dermal Cream?

The amount of cream needed depends on the patient's age and body size. One 30g tube is typically sufficient for a single full-body application in one adult. Always use enough cream to cover the entire body surface as described above — do not apply sparingly, as incomplete coverage may result in treatment failure.

When Is the Best Time to Use Lyclear Dermal Cream?

Evening application is strongly recommended so the cream can remain on the skin overnight, fulfilling the required 8 to 12 hour contact time. Avoid applying immediately after a hot bath, as this dilates blood vessels and may increase systemic absorption. Allow your skin to cool for at least 30 minutes before applying.

All members of the household and close physical contacts should apply the cream on the same evening, even if they have no symptoms. This coordinated approach is essential to prevent re-infection.

How Long Can You Use Lyclear Dermal Cream For?

Lyclear Dermal Cream is intended for short-term use only. In most cases, one or two applications — seven days apart — are all that is needed to clear a scabies infestation. You should not use this cream repeatedly or for prolonged periods without medical advice.

If symptoms persist beyond four weeks after completing treatment, or if you notice new burrows or a spreading rash, consult your GP. Continued itching alone after treatment is normal and does not require further applications of the cream.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Lyclear Dermal Cream?

Most people who use Lyclear Dermal Cream experience only mild, localised side effects that resolve on their own. These are generally related to the skin's reaction to the active ingredient, permethrin, rather than a sign that anything is wrong.

  • Mild burning or stinging sensation on application
  • Itching at the application site (this is very common and may persist for up to four weeks after treatment)
  • Temporary skin redness or flushing
  • Tingling or numbness of the skin

It is important to understand that itching after treatment does not mean the cream has failed. Your immune system continues to react to dead mites and their waste products in the skin for several weeks, which is entirely normal.

What Are the Less Common Side Effects of Lyclear Dermal Cream?

A smaller number of people may experience more noticeable skin reactions. These are less common but worth being aware of before you start treatment.

  • Worsening of pre-existing eczema or dermatitis
  • Localised swelling (oedema) at the application site
  • Contact dermatitis — a red, itchy, or blistering rash caused by skin sensitivity to the cream
  • Dry or flaking skin following treatment

If you have a history of sensitive skin or eczema, speak to your pharmacist before using this cream. They may be able to recommend a suitable emollient to use alongside treatment.

What Are the Serious Side Effects of Lyclear Dermal Cream?

Serious side effects from topical permethrin are rare, but you should be aware of the signs of a severe allergic reaction (anaphylaxis). Stop using the cream immediately and seek emergency medical help if you experience any of the following:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Severe skin blistering or peeling
  • Rapid heartbeat or dizziness

These reactions are very uncommon, but they require prompt medical attention. Do not wait to see if symptoms improve on their own.

What Should You Do If You Experience Side Effects?

For mild side effects such as itching or redness, no specific treatment is usually needed — these will resolve on their own. You can apply a gentle, unperfumed moisturiser to soothe the skin. If itching is particularly troublesome, your pharmacist may suggest an antihistamine tablet or a mild topical corticosteroid cream to help manage discomfort.

If you experience a skin reaction that worsens or does not improve within a few days of completing treatment, contact your GP or pharmacist for advice. Always report any unexpected or severe reactions to the Medicines and Healthcare products Regulatory Agency (MHRA) via the Yellow Card scheme.

Can Lyclear Dermal Cream Interact With Other Medicines?

No clinically significant drug interactions have been identified for permethrin cream when used topically as directed. However, you should avoid applying other topical products — such as medicated creams, oils, or lotions — to the same area at the same time, as these may affect how the cream is absorbed or how well it works. Always inform your pharmacist of any other medicines or topical treatments you are currently using before starting treatment with this cream.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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