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Dermol 500 Lotion- 500ml

Dermol 500 Lotion- 500ml

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  • ✔️ Moisturises and soothes dry, itchy, eczema-prone skin daily
  • ✔️ Dual-action formula hydrates and fights skin bacteria
  • ✔️ Works as both a leave-on moisturiser and soap substitute
  • ✔️ Contains chlorhexidine to reduce eczema-triggering bacterial colonisation
  • ✔️ Suitable for adults and children with chronic dry skin conditions

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What Is Dermol 500 Lotion and How Does It Help Dry Skin?

 

If you live with dry, itchy, or eczema-prone skin, you'll know how relentless it can feel. Ordinary soaps and cleansers strip away the skin's natural oils, leaving it tight, sore, and more vulnerable to flare-ups. Dermol 500 lotion is an antimicrobial emollient that works as both a leave-on moisturiser and a soap substitute — giving your skin the hydration it needs while helping to reduce the bacteria that can make conditions like eczema worse. You can explore the full range of skin care products available at Cured Pharmacy if you're looking for a broader routine.

Each 500ml bottle contains four active ingredients: liquid paraffin 10%, isopropyl myristate 10%, benzalkonium chloride 0.1%, and chlorhexidine dihydrochloride 0.1%. The combination of emollient and antimicrobial action makes it particularly useful for people whose dry skin conditions are complicated by bacterial colonisation — something that's especially common in atopic eczema. At just £9.99, it's a cost-effective option for everyday skin management.

 

How Does Dermol 500 Lotion Work on the Skin?

 

The lotion works through two complementary mechanisms. The emollient components — liquid paraffin and isopropyl myristate — form a protective film over the skin surface, reducing water loss and softening the outer layers. The antimicrobial agents then target bacteria such as Staphylococcus aureus, which is known to colonise the skin in eczema and trigger inflammatory flare-ups.

  • Liquid paraffin and isopropyl myristate hydrate and soften the skin by reducing transepidermal water loss
  • Benzalkonium chloride disrupts bacterial cell membranes, reducing microbial load on the skin surface
  • Chlorhexidine dihydrochloride provides additional broad-spectrum antimicrobial activity
  • Used as a soap substitute, it cleanses without the harsh detergent effect of conventional soaps

 

Who Should Use Dermol 500 Lotion?

 

This lotion is suitable for adults and children with a range of dry skin conditions. It's particularly well-suited to people who need both moisturisation and antimicrobial protection as part of their daily skin management. If you're unsure whether it's right for you, a pharmacist can advise.

  • People with atopic eczema or dermatitis
  • Those with dry, flaky, or itchy skin requiring regular emollient therapy
  • Individuals who need a soap substitute to avoid irritation from conventional cleansers
  • Patients whose skin conditions are prone to bacterial colonisation or secondary infection

 

How Does Dermol 500 Lotion Compare to Other Emollients?

 

Feature Dermol 500 Lotion Plain Aqueous Cream
Antimicrobial action Yes (benzalkonium chloride + chlorhexidine) No
Soap substitute use Yes Limited — not recommended by NHS
Leave-on moisturiser Yes Yes
Suitable for eczema Yes Not recommended — may worsen eczema

 

Is Dermol 500 Lotion Safe to Store and Use Long-Term?

 

Dermol 500 lotion should be stored below 25°C, away from direct sunlight, and kept out of reach of children. Once opened, use within the period indicated on the packaging. It's worth noting that paraffin-based emollients — including this one — are flammable. Dressings, clothing, and bedding that have come into contact with the product can catch fire more easily, so keep away from naked flames and cigarettes. You can also browse our range of creams and ointments for complementary skin treatments.

Long-term use is generally well tolerated when used as directed. If your skin condition worsens or does not improve after regular use, speak to your GP or pharmacist for further assessment.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Dermol 500 Lotion 500ml specifications
Treatment category Emollient / Antimicrobial moisturiser
Mechanism of action Emollient film formation + antimicrobial activity against skin bacteria
Effective for Dry skin, eczema, dermatitis, pruritus
Suitable for Adults and children (consult pharmacist for infants)
Active ingredients Benzalkonium chloride 0.1%, Chlorhexidine dihydrochloride 0.1%, Isopropyl myristate 10%, Liquid paraffin 10%
Pack size 500ml
UK classification P (Pharmacy medicine)
Drug class Emollient with antimicrobial agents
Preparation Lotion
Route of administration Topical (skin)

Specifications of Dermol 500 Lotion 500ml

 

What Is Dermol 500 Lotion and What Is It Used For?

 

Dermol 500 lotion is a topical emollient containing two moisturising agents (liquid paraffin and isopropyl myristate) and two antimicrobial agents (benzalkonium chloride and chlorhexidine dihydrochloride). It is used to manage dry skin conditions including eczema, atopic dermatitis, ichthyosis, and pruritus. It can be applied directly to the skin as a leave-on moisturiser or used as a soap substitute during washing. The NHS recommends emollients as a first-line treatment for eczema and other dry skin conditions, and they should be used regularly — even when the skin appears to be clear.

 

What Do You Need to Know Before Using Dermol 500 Lotion?

 

Before using this lotion, read the following carefully. Some people should not use it, and there are important safety warnings to be aware of.

Do not use Dermol 500 Lotion if you:

  • Are allergic to benzalkonium chloride, chlorhexidine, liquid paraffin, isopropyl myristate, or any other ingredient in the formulation
  • Have a known sensitivity to any antimicrobial agent in this product

Warnings and precautions:

  • This product is flammable — keep away from fire, flames, and cigarettes during and after application
  • Fabric (clothing, bedding, dressings) soaked with paraffin-based emollients can ignite more easily — wash regularly and do not allow to dry near open flames
  • Avoid contact with the eyes
  • If your skin condition worsens or you develop signs of infection, stop use and consult your GP
  • Consult a healthcare professional before use in infants or very young children

Drug interactions:

  • No significant drug interactions are currently known for topical use of this product
  • If you are using other topical medicines (e.g. topical corticosteroids), apply Dermol 500 Lotion first and allow it to absorb before applying other treatments, or follow your prescriber's instructions

 

How Should You Use Dermol 500 Lotion?

 

Using an emollient correctly makes a real difference to how well it works. Apply generously and regularly — don't wait for your skin to feel dry before reaching for the bottle. If you're also managing a condition like eczema, you may find it helpful to browse our skin care collection for additional support products.

  1. Wash your hands before applying the lotion
  2. Apply a generous amount to the affected area using smooth, downward strokes in the direction of hair growth
  3. Do not rub vigorously — this can cause friction and worsen irritation
  4. As a soap substitute: apply to wet or dry skin, lather gently, then rinse off thoroughly
  5. As a leave-on moisturiser: apply directly to clean, dry skin and leave to absorb
  6. Wash hands after application unless the hands are the area being treated
Use Age Group Amount Frequency
Leave-on moisturiser Adults & children Apply liberally 2–4 times daily or as directed
Soap substitute (washing) Adults & children Apply to wet skin, rinse off Each time you wash
Infants Under 2 years As directed by GP/pharmacist As directed

 

What Are the Possible Side Effects of Dermol 500 Lotion?

 

Side effects with emollients are uncommon, but they can occur. If you experience any of the following, stop using the product and speak to your pharmacist or GP.

Common side effects:

  • Mild skin irritation or stinging at the application site
  • Temporary redness of the skin
  • A feeling of greasiness or heaviness on the skin

Less common side effects:

  • Allergic contact dermatitis (rash, itching, or swelling at the site of application)
  • Folliculitis (inflammation of hair follicles) — more likely if the product is applied against the direction of hair growth
  • Hypersensitivity reactions — rare but possible with chlorhexidine-containing products

If you notice any signs of a serious allergic reaction — such as swelling of the face, lips, or throat, difficulty breathing, or a widespread rash — seek emergency medical attention immediately.

 

How Should You Store Dermol 500 Lotion?

 

Correct storage helps maintain the product's effectiveness and safety. You can also find other baby and toddler skincare options at Cured Pharmacy if you're managing a child's skin condition alongside your own.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the bottle tightly closed when not in use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the bottle
  • Do not store near naked flames — this product is flammable
  • Do not dispose of via wastewater or household waste — return unused medicine to your pharmacist

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Dermol 500 Lotion online in the UK?

You can buy Dermol 500 Lotion 500ml online from Cured Pharmacy for just £9.99, without needing a prescription. It's a Pharmacy (P) medicine, so it's available over the counter. Simply add it to your basket and it will be dispatched directly to your door.

How does Dermol 500 Lotion work in the body?

Dermol 500 Lotion works topically — it doesn't enter the bloodstream. The emollient ingredients (liquid paraffin and isopropyl myristate) form a protective layer on the skin surface to lock in moisture and reduce water loss. The antimicrobial agents (benzalkonium chloride and chlorhexidine) reduce the bacterial load on the skin, which can help prevent flare-ups in conditions like eczema.

How do I use Dermol 500 Lotion step by step?

Using Dermol 500 Lotion correctly is straightforward. Follow these steps:

  1. Apply a generous amount to the affected skin using smooth, downward strokes
  2. Do not rub vigorously — gentle application reduces irritation
  3. As a soap substitute, apply to wet skin, lather gently, and rinse off
  4. As a leave-on moisturiser, apply to clean skin and allow to absorb

Repeat two to four times daily, or as directed by your GP or pharmacist.

How often should I apply Dermol 500 Lotion?

Apply Dermol 500 Lotion two to four times daily as a leave-on moisturiser, or every time you wash as a soap substitute. Consistency is key — regular use, even when your skin feels comfortable, helps maintain the skin barrier and reduces the frequency of flare-ups. Your GP or dermatologist may advise a different frequency depending on the severity of your condition.

What are the side effects of Dermol 500 Lotion?

Side effects are uncommon but can include mild skin irritation, temporary redness, or a stinging sensation at the application site. Rarely, an allergic reaction to chlorhexidine or benzalkonium chloride may occur, presenting as a rash or swelling. If you experience any worsening of your skin condition or signs of an allergic reaction, stop use and speak to your pharmacist or GP promptly.

How do I manage side effects of Dermol 500 Lotion?

If you experience mild irritation, try applying a smaller amount less frequently and see if your skin adjusts. Avoid applying to broken or infected skin unless directed by a healthcare professional. If irritation persists or worsens, discontinue use and consult your pharmacist — they may recommend an alternative emollient from our creams and ointments range.

Is Dermol 500 Lotion suitable for children and babies?

Dermol 500 Lotion can be used in children, but you should always consult a GP or pharmacist before using any medicated emollient on infants or very young children. The antimicrobial ingredients mean it's not a standard first-choice emollient for babies without professional guidance. For general baby skincare, you may also want to explore our baby and toddler range.

Who is eligible to use Dermol 500 Lotion?

Dermol 500 Lotion is suitable for adults and children with dry skin conditions such as eczema, dermatitis, ichthyosis, and pruritus. It is not suitable for people with a known allergy to any of its ingredients, including chlorhexidine or benzalkonium chloride. If you are pregnant, breastfeeding, or have a complex skin condition, speak to your GP before starting use.

Is Dermol 500 Lotion flammable — is it safe to use?

Yes, Dermol 500 Lotion is flammable due to its paraffin content. This is a known risk with paraffin-based emollients — the MHRA has issued guidance advising patients to keep away from fire, flames, and cigarettes during and after application. Clothing and bedding that have absorbed the product can catch fire more easily, so wash them regularly and never allow them to dry near open flames or heat sources.

What happens if I miss an application of Dermol 500 Lotion?

If you forget to apply Dermol 500 Lotion at your usual time, simply apply it as soon as you remember. Do not apply a double amount to make up for a missed application. Emollients work best when used consistently, so try to build application into your daily routine — for example, after bathing or washing.

What are the alternatives to Dermol 500 Lotion?

Alternatives include other antimicrobial emollients such as Dermol 200 Shower Emollient or Dermol 600 Bath Emollient, as well as non-antimicrobial emollients like Diprobase, Cetraben, or Hydromol. The right choice depends on your skin type, the severity of your condition, and whether antimicrobial action is needed. A pharmacist can help you choose the most appropriate option from our skin care collection.

Can I use Dermol 500 Lotion with topical steroids?

Yes, Dermol 500 Lotion can be used alongside topical corticosteroids. The general guidance is to apply the emollient first, allow it to absorb for around 30 minutes, and then apply the steroid cream or ointment. Always follow the specific instructions given by your GP or dermatologist, as the order of application can affect how well each product works.

How long can you use Dermol 500 Lotion for?

Dermol 500 Lotion can be used long-term as part of an ongoing dry skin management routine. Emollients are generally recommended for continuous use in conditions like eczema — stopping when the skin feels better often leads to a return of symptoms. If you have been using it for several weeks without improvement, speak to your GP for a review of your treatment plan.

What are the latest studies on antimicrobial emollients like Dermol 500 Lotion?

Research continues to explore the role of antimicrobial emollients in managing atopic eczema, particularly in relation to Staphylococcus aureus colonisation, which is strongly associated with eczema flare-ups. Current NHS guidance supports the use of emollients as a cornerstone of eczema management, though the specific benefit of antimicrobial additives over standard emollients is still being evaluated in clinical trials. Speak to your dermatologist for the most up-to-date personalised advice.

Can Dermol 500 Lotion be used on the face?

Dermol 500 Lotion can be applied to the face, but take care to avoid contact with the eyes. If you are using it on facial eczema or dry skin around the nose and mouth, apply carefully and wash hands thoroughly afterwards. If facial skin is particularly sensitive or the condition is severe, consult your GP or dermatologist before use.

How Should You Use Dermol 500 Lotion?

Dermol 500 Lotion is designed for two purposes: as a leave-on moisturiser and as a soap substitute. Using it correctly for both applications will give you the best results and help protect your skin barrier over time.

What Is the Correct Dose of Dermol 500 Lotion?

There is no fixed dose for emollients — the key is to apply liberally and regularly. The table below provides general guidance based on use and age group. Always follow the advice of your GP or pharmacist if they have given you specific instructions.

When Is the Best Time to Use Dermol 500 Lotion?

The best time to apply Dermol 500 Lotion as a leave-on moisturiser is immediately after bathing or washing, while the skin is still slightly damp — this helps seal in moisture more effectively. Applying before bed is also beneficial, as the skin has time to absorb the lotion overnight without being disturbed by clothing or activity. Building application into a consistent daily routine — morning and evening at minimum — tends to produce the most noticeable improvement in skin condition over time.

How Long Can You Use Dermol 500 Lotion For?

Dermol 500 Lotion is suitable for long-term, ongoing use as part of a dry skin management routine. Emollients work best when used continuously — stopping when the skin feels better often leads to a return of dryness and irritation. If you have been using the lotion consistently for four to six weeks without any noticeable improvement, or if your skin condition worsens at any point, speak to your GP or dermatologist for a review of your treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

Based on 5 reviews
60%
(3)
20%
(1)
20%
(1)
0%
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A
Anonymous

Fast delivery but bottles were broken inside the box

A
Anonymous

Only just started using it as a soap but already seeing improvements in skin.

A
Anonymous

Good value

J
Jan

This lotion is a first class product. I have dry skin on my arms and legs. I apply this lotion every night before bed. It's none greasy and quickly absorbed. After using it for a month, my skin is fine : soft, smooth and healthy. I consider it an effective and pleasant lotion to use. The price was excellent too. Will definitely re order when necessary.

B
Barbara

Useful being able to use this product for washing as well as moisturising intimate areas

What Are the Most Common Side Effects of Dermol 500 Lotion?

Most people use Dermol 500 Lotion without experiencing any side effects. When reactions do occur, they are usually mild and localised to the area of application. Common side effects include:

  • Mild stinging or burning sensation on application, particularly to broken or inflamed skin
  • Temporary redness or warmth at the application site
  • A feeling of greasiness or heaviness on the skin immediately after application

These effects often settle as your skin adjusts to the product. If they persist beyond the first few days of use, speak to your pharmacist.

What Are the Less Common Side Effects of Dermol 500 Lotion?

Less commonly, some people may experience reactions related to the antimicrobial ingredients in the formulation. These are more likely in individuals with sensitive skin or a history of contact allergies. Less common side effects include:

  • Allergic contact dermatitis — presenting as a rash, itching, or blistering at the site of application
  • Folliculitis (inflammation of hair follicles) — more likely if the product is applied against the direction of hair growth
  • Skin dryness or peeling in some individuals, particularly with frequent use as a soap substitute

What Are the Serious Side Effects of Dermol 500 Lotion?

Serious side effects are rare but can occur, particularly in people with a known sensitivity to chlorhexidine. Chlorhexidine hypersensitivity reactions have been reported and can range from localised skin reactions to, in very rare cases, anaphylaxis. Seek emergency medical attention immediately if you experience any of the following after applying this product:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • A widespread skin rash or hives
  • Dizziness, rapid heartbeat, or collapse

What Should You Do If You Experience Side Effects?

If you notice mild irritation, try reducing the frequency of application and see whether your skin improves. Avoid applying to broken, infected, or weeping skin unless specifically directed by a healthcare professional. For persistent or worsening reactions, stop using the product and consult your pharmacist or GP. They can assess whether the reaction is related to a specific ingredient and recommend an alternative emollient if needed.

Can Dermol 500 Lotion Interact With Other Medicines?

No significant drug interactions are currently known for Dermol 500 Lotion when used topically as directed. However, if you are using other topical treatments — such as corticosteroid creams, topical antibiotics, or antifungal preparations — it is good practice to apply Dermol 500 Lotion first, allow it to absorb for approximately 30 minutes, and then apply the other product. This prevents dilution of either treatment and ensures both work as intended. Always follow the specific guidance of your prescriber or pharmacist.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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