Sildenafil

Want to Buy Sildenafil Tablets Online?

Erectile dysfunction (ED) is more common than many men realise. In fact, the NHS estimates that around half of all men between 40 and 70 experience it to some degree. It can affect confidence, relationships, and overall wellbeing — but the good news is that effective, clinically proven treatment is available. If you want to buy sildenafil tablets online, Cured Pharmacy makes the process straightforward, discreet, and safe. Bristol Sildenafil is a licensed generic medicine containing sildenafil citrate, the same active ingredient found in Viagra, available from just £0.45 per tablet. You can explore our full range of men's health treatments at our men's health collection.

Sildenafil has been used to treat erectile dysfunction for over two decades. It is one of the most studied medicines in this therapeutic area, with a well-established safety and efficacy profile. As a PDE5 inhibitor, it works specifically to support the natural physiological process of achieving an erection — but only when sexual stimulation is present. It does not increase libido or cause erections spontaneously.

How Does Sildenafil Work in the Body?

Understanding the mechanism helps you use this medicine correctly. Erections rely on a complex interplay of nerve signals, blood flow, and smooth muscle relaxation. When ED occurs, this process is disrupted — often because an enzyme called phosphodiesterase type 5 (PDE5) breaks down a chemical called cyclic GMP too quickly, preventing adequate blood flow to the penis.

• Sexual stimulation triggers the release of nitric oxide in the penile tissue.
• Nitric oxide activates an enzyme that produces cyclic GMP (cGMP).
• cGMP relaxes smooth muscle and dilates blood vessels in the penis.
• Sildenafil inhibits PDE5, preventing cGMP from being broken down too rapidly.
• This sustains the relaxation of blood vessels, allowing an erection to develop and be maintained.

It is worth noting that sildenafil does not work without sexual stimulation. The nitric oxide pathway must be activated first — the medicine simply supports and prolongs the natural response.

Who Is Sildenafil Suitable For?

Sildenafil is licensed for adult men with erectile dysfunction. It is suitable for a wide range of patients, including those whose ED has a physical cause (such as diabetes or cardiovascular disease) and those where psychological factors play a role. That said, it is not appropriate for everyone, and a clinical assessment is always required before supply.

• Adult men aged 18 and over with diagnosed or self-reported erectile dysfunction.
• Men whose ED is linked to conditions such as type 2 diabetes or hypertension.
• Men who have not responded adequately to lifestyle changes alone.
• Men who have previously used sildenafil or Viagra without adverse effects.

It is not suitable for women or children, and it must not be used recreationally or in combination with nitrate medicines.

How Does Sildenafil Compare to Branded Viagra?

How Should You Store Sildenafil and Is It Clinically Suitable for You?

Store sildenafil tablets below 30°C in a dry place, away from direct sunlight and out of reach of children. Do not use after the expiry date printed on the packaging. If you are managing other health conditions alongside ED — for example, if you also need support with vitamins and supplements for general wellbeing — it is worth discussing your full medication list with a pharmacist before starting treatment.

Clinical suitability depends on your medical history, current medicines, and cardiovascular health. Men with a history of recent heart attack, stroke, or low blood pressure should seek GP advice before using sildenafil. The same applies to anyone taking alpha-blockers or HIV protease inhibitors such as ritonavir.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

What Is Sildenafil and What Is It Used For?

Sildenafil is a prescription-strength medicine reclassified in the UK as a Pharmacy (P) medicine for erectile dysfunction, meaning it can be supplied by a pharmacist following a clinical assessment — without a GP prescription. It belongs to a class of medicines called PDE5 inhibitors. Its primary use is to help adult men achieve and maintain an erection sufficient for satisfactory sexual activity. It does not cure erectile dysfunction, but it provides reliable, on-demand support when taken correctly.

Sildenafil is not used to treat premature ejaculation, low libido, or infertility. It is also not licensed for use in women or anyone under 18 years of age.

What Do You Need to Know Before Using Sildenafil?

Before taking sildenafil, it is essential to review the following contraindications and potential interactions carefully. This is not an exhaustive list — always read the patient information leaflet supplied with your medicine.

Do not take sildenafil if you:

• Are taking any form of nitrate medicine (e.g. glyceryl trinitrate, isosorbide mononitrate) for angina or heart problems — this combination can cause a life-threatening drop in blood pressure.
• Have been advised by a doctor to avoid sexual activity due to cardiovascular risk.
• Have had a recent heart attack or stroke (within the last 6 months).
• Have severe liver impairment or end-stage renal disease requiring dialysis.
• Have a rare inherited eye condition such as retinitis pigmentosa.
• Are allergic to sildenafil or any of the tablet's excipients.
• Are taking riociguat (used for pulmonary hypertension).

Known drug interactions — sildenafil may interact with:

• Nitrates (absolute contraindication).
• Alpha-blockers (e.g. tamsulosin, doxazosin) — may cause low blood pressure.
• HIV protease inhibitors such as ritonavir — increase sildenafil plasma levels significantly.
• Other PDE5 inhibitors — do not combine.
• Grapefruit juice — may increase sildenafil blood levels.
• Antifungals such as ketoconazole — may increase sildenafil exposure.

How Should You Take Sildenafil Correctly?

Taking sildenafil correctly gives you the best chance of it working well. Follow these steps each time you use it:

1. Take one tablet approximately 30 to 60 minutes before planned sexual activity.
2. Swallow the tablet whole with a glass of water.
3. Avoid taking it with or after a high-fat meal, as this can delay absorption and reduce effectiveness.
4. Ensure sexual stimulation is present — sildenafil will not cause an erection without it.
5. Do not take more than one tablet in any 24-hour period.

What Are the Possible Side Effects of Sildenafil?

Like all medicines, sildenafil can cause side effects, although not everyone experiences them. Most are mild and resolve on their own. If you are also managing other health concerns, you may find it helpful to browse our pain relief collection for headache management options.

Common side effects (may affect up to 1 in 10 people):

• Headache
• Facial flushing (redness and warmth)
• Indigestion or upset stomach
• Nasal congestion
• Dizziness
• Visual disturbances (e.g. blurred vision, altered colour perception)

Less common side effects (may affect up to 1 in 100 people):

• Palpitations or increased heart rate
• Nausea
• Skin rash
• Muscle pain
• Dry mouth

Seek immediate medical attention if you experience chest pain, a prolonged erection lasting more than four hours (priapism), sudden vision or hearing loss, or signs of a severe allergic reaction such as swelling of the face or throat.

How Should You Store Sildenafil Safely?

• Store below 30°C in a dry place, away from direct sunlight and moisture.
• Keep in the original packaging until use.
• Keep out of the sight and reach of children.
• Do not use after the expiry date printed on the pack.
• Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy for safe disposal.

If you are managing multiple health conditions and need support with sexual health more broadly, our condoms and sexual health collection offers a range of complementary products.