Mysimba Diet Pills UK - Cheapest Price From £125.95

Clinically Proven UK Registered Pharmacy

Cheapest Mysimba Diet Pills UK - From £125.95

Get Mysimba at the cheapest UK price from £125.95 with £20 off using code Weightlossnew.

UK-registered clinical team
Confidential and secure
No GP visit needed
Next-day delivery included — no hidden costs or surprise charges
Genuine Products
UK-licensed only
Fast Delivery
Next-day available
Expert Advice
UK pharmacists
Woman using Cured Pharmacy online consultation for weight loss treatment

Check your BMI

Height 175 cm
Weight 82 kg

Your BMI

26.8
Start Free Consultation

Free · BMI thresholds shown are illustrative. Final eligibility is confirmed by a UK prescriber during your free consultation.

LIVE PRICING

Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro Weight Loss Injections (Tirzepatide) KwikPen - UK-licensed prescription Treatment
Treatment

Mounjaro Weight Loss Injections (Tirzepatide) KwikPen

From £145.00

Future orders save 5%
Buy Now
Wegovy (Semaglutide) Weight Loss Injection - UK-licensed prescription Treatment
Treatment

Wegovy (Semaglutide) Weight Loss Injection

From £89.00

Future orders save 5%
Buy Now
Wegovy® Oral Tablets (Semaglutide Pill) - UK-licensed prescription Treatment
Treatment

Wegovy® Oral Tablets (Semaglutide Pill)

From £83.00

Future orders save 5%
Buy Now
Saxenda - UK-licensed prescription Treatment
Treatment

Saxenda

From £68.00

Future orders save 5%
Buy Now
Orlistat - UK-licensed prescription Treatment
Treatment

Orlistat

From £32.00

Future orders save 5%
Buy Now
Xenical Orlistat 120mg Capsules - UK-licensed prescription Treatment
Treatment

Xenical Orlistat 120mg Capsules

From £49.99

Future orders save 5%
Buy Now
Alli Weight Loss Capsules 60mg - UK-licensed prescription Treatment
Treatment

Alli Weight Loss Capsules 60mg

From £49.99

Future orders save 5%
Buy Now
Orlos (Orlistat) 60mg Weight Loss Aid - UK-licensed prescription Treatment
Treatment

Orlos (Orlistat) 60mg Weight Loss Aid

From £22.29

Future orders save 5%
Buy Now
Mysimba Tablets - UK-licensed prescription Treatment
Treatment

Mysimba Tablets

From £125.95

Future orders save 5%
Buy Now

What Are Mysimba Diet Pills and How Do They Work?

Published: 16 August 2026

Mysimba diet pills are a prescription-only weight loss medication combining naltrexone and bupropion to help adults with obesity or weight-related health conditions achieve sustainable weight reduction. Available from Cured Pharmacy at £125.95 with £20 off your first order using code Weightlossnew, Mysimba works by targeting appetite and reward pathways in the brain. Clinical trials demonstrate that when combined with a reduced-calorie diet and increased physical activity, Mysimba can support meaningful weight loss in patients with a BMI of 30 or above, or 27 with comorbidities [1].

How Mysimba Diet Pills Work in the Body

Mysimba diet pills contain two active ingredients: naltrexone hydrochloride (8mg) and bupropion hydrochloride (90mg) per tablet. This dual-action combination targets the hypothalamus and mesolimbic reward system, regions of the brain that regulate hunger, cravings, and food reward [1]. Naltrexone is an opioid receptor antagonist traditionally used to manage alcohol and opioid dependence, whilst bupropion is an antidepressant and smoking cessation aid that inhibits the reuptake of dopamine and noradrenaline.

When used together, these agents work synergistically to reduce appetite and diminish the pleasure associated with eating, making it easier for patients to adhere to a calorie-controlled diet. The medication is taken orally, with dosing gradually increased over four weeks to minimise side effects. Patients typically start with one tablet daily in the morning, building up to the maintenance dose of two tablets twice daily [2]. This titration schedule helps the body adjust and reduces the risk of nausea, headache, and other common initial side effects.

Clinical evidence from the COR trials—a series of four phase III studies involving over 4,500 participants—showed that patients taking Mysimba lost an average of 5-10% of their baseline body weight over 56 weeks, compared to 1-3% in the placebo group [1]. Importantly, around 50% of participants on Mysimba achieved at least 5% weight loss, and approximately 28% lost 10% or more, outcomes associated with significant improvements in cardiovascular risk factors and glycaemic control.

Who Can Use Mysimba Diet Pills in the UK?

Mysimba diet pills are licensed in the UK for adults aged 18 and over with a body mass index (BMI) of 30 kg/m² or greater, or a BMI of 27 kg/m² or greater in the presence of weight-related comorbidities such as type 2 diabetes, hypertension, or dyslipidaemia [2]. The medication is intended as an adjunct to a comprehensive weight management programme that includes dietary modification, increased physical activity, and behavioural support.

Before prescribing Mysimba, a UK-registered clinician will conduct a thorough assessment to ensure the treatment is appropriate and safe. Patients with uncontrolled hypertension, a history of seizures, eating disorders (such as bulimia or anorexia nervosa), or those taking monoamine oxidase inhibitors (MAOIs) are not suitable candidates [3]. Mysimba is also contraindicated in pregnancy and breastfeeding, and women of childbearing potential should use effective contraception during treatment.

At Cured Pharmacy, all patients complete a free online consultation reviewed by our UK-registered clinical team, led by superintendent pharmacist Tarun Kumar (GPhC 2233073). This ensures that Mysimba diet pills are prescribed safely, with consideration of your medical history, current medications, and weight loss goals. If approved, your medication is dispensed from our GPhC-registered pharmacy (9012511) and delivered discreetly to your door.

Contraindications and Cautions

Mysimba is not suitable for everyone. It should not be used by individuals with a current or prior diagnosis of seizure disorders, as bupropion lowers the seizure threshold [3]. Patients with severe hepatic or renal impairment, those undergoing abrupt discontinuation of alcohol or benzodiazepines, or anyone with a known hypersensitivity to naltrexone or bupropion must avoid this medication. Additionally, caution is advised in patients with a history of mania, bipolar disorder, or suicidal ideation, as bupropion can affect mood and behaviour.

Mysimba Diet Pills Dosage and Administration

The recommended dosing schedule for Mysimba diet pills follows a gradual titration to the target maintenance dose. During week one, patients take one tablet each morning. In week two, the dose increases to one tablet in the morning and one in the evening. Week three involves two tablets in the morning and one in the evening, and from week four onwards, the maintenance dose is two tablets twice daily (morning and evening) [2].

This step-wise approach minimises the risk of adverse effects such as nausea, constipation, headache, and dizziness, which are most common during the initial weeks of treatment. Tablets should be swallowed whole with water and can be taken with or without food, though taking them with meals may reduce gastrointestinal discomfort. It is important not to crush, chew, or split the tablets, as this can alter the release profile and increase side effects.

Patients should be monitored regularly, with weight and blood pressure assessed after 16 weeks of treatment. If a patient has not lost at least 5% of their baseline body weight by this point, discontinuation of Mysimba is recommended, as further weight loss is unlikely [2]. Conversely, those who respond well may continue treatment, with ongoing clinical review to ensure sustained benefit and tolerability.

Treatment Type Frequency Starting Price
Mysimba Tablets Oral tablet (naltrexone/bupropion) Twice daily £125.95
Orlistat Oral capsule (lipase inhibitor) Three times daily £32.00
Wegovy Injection (semaglutide) Once weekly £89.00
Saxenda Injection (liraglutide) Once daily £68.00
Mounjaro Injection (tirzepatide) Once weekly £145.00

Mysimba Diet Pills Side Effects and Safety

Like all prescription medications, Mysimba diet pills can cause side effects, though not everyone will experience them. The most commonly reported adverse effects include nausea (reported by up to 32% of patients), constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhoea [3]. These side effects are usually mild to moderate and tend to diminish as the body adjusts to the medication.

More serious but less common side effects include elevated blood pressure and heart rate, which necessitate regular monitoring, particularly in patients with pre-existing cardiovascular conditions. There have been reports of neuropsychiatric events, including mood changes, agitation, depression, and suicidal thoughts, particularly in patients with a history of psychiatric disorders [3]. Patients and caregivers should be vigilant for any changes in mood or behaviour and report these to a healthcare professional immediately.

Seizures are a rare but serious risk, occurring in approximately 0.1-0.4% of patients taking bupropion-containing products. The risk is dose-dependent and increased in individuals with predisposing factors such as a history of head trauma, metabolic disorders, or concurrent use of medications that lower the seizure threshold [3]. If a seizure occurs, Mysimba should be discontinued permanently. Allergic reactions, including rash, pruritus, and angioedema, have also been reported and require prompt medical attention.

Managing Common Side Effects

To minimise nausea and gastrointestinal upset, patients are advised to take Mysimba diet pills with food and stay well-hydrated. Constipation can often be managed with increased dietary fibre, fluid intake, and regular physical activity. If headaches persist, paracetamol or ibuprofen may be used, but patients should consult their pharmacist or prescriber if symptoms are severe or prolonged. Insomnia can be mitigated by taking the evening dose earlier, ensuring it is not taken too close to bedtime.

Mysimba Diet Pills vs Other Weight Loss Treatments

When considering Mysimba diet pills, patients often compare them to other prescription weight loss options available in the UK, such as Orlistat, Wegovy (semaglutide), Saxenda (liraglutide), and Mounjaro (tirzepatide). Each medication works through a different mechanism and is suited to different patient profiles and preferences.

Orlistat, available as Xenical or generic formulations, works by inhibiting pancreatic lipase, reducing dietary fat absorption by approximately 30% [4]. It is taken three times daily with meals and is most effective for patients who consume a moderate-fat diet. Common side effects include oily stools, flatulence, and faecal urgency, which can be socially inconvenient. In contrast, Mysimba targets central appetite regulation and does not cause gastrointestinal fat malabsorption, making it a more suitable option for patients who prefer to avoid these specific side effects.

GLP-1 receptor agonists such as Wegovy, Saxenda, and Mounjaro are injectable medications that enhance satiety, slow gastric emptying, and improve glycaemic control. Clinical trials have shown these agents can produce greater average weight loss than Mysimba—Wegovy and Mounjaro, in particular, have demonstrated average weight reductions of 15-20% in some studies [5]. However, they require subcutaneous injection (weekly for Wegovy and Mounjaro, daily for Saxenda), which some patients find inconvenient or uncomfortable. Mysimba diet pills, being oral tablets, offer a non-injectable alternative for those who prefer or require it, though with more modest average weight loss outcomes.

Cost Considerations

Mysimba is available at Cured Pharmacy from £125.95, with £20 off your first order using code Weightlossnew. While GLP-1 agonists can be more expensive, and Orlistat is generally less costly, the choice of treatment should be guided by clinical appropriateness, patient preference, tolerability, and the prescriber's assessment. Cured Pharmacy offers transparent upfront pricing and a free online consultation, ensuring you receive the most suitable and cost-effective treatment for your weight loss journey.

Buying Mysimba Diet Pills Safely Online in the UK

Purchasing Mysimba diet pills online offers convenience and discretion, but it is essential to use a legitimate, GPhC-registered pharmacy to ensure you receive genuine, licensed medication and appropriate clinical oversight. Cured Pharmacy is a UK-registered online pharmacy (GPhC 9012511) with a qualified clinical team led by superintendent pharmacist Tarun Kumar (GPhC 2233073).

All patients must complete a free online consultation, which typically takes under three minutes. This assessment is reviewed by a UK-registered prescriber who will determine whether Mysimba is safe and appropriate for you based on your medical history, current medications, BMI, and weight loss goals. If approved, your prescription is dispensed and dispatched in discreet, unbranded packaging with next-day delivery options available.

Beware of websites offering Mysimba diet pills without a prescription or at prices significantly below the UK market rate, as these may be selling counterfeit or unlicensed products that pose serious health risks. Always verify that the pharmacy is registered with the General Pharmaceutical Council and that a qualified prescriber reviews your consultation. At Cured Pharmacy, we guarantee 100% genuine UK-licensed medicines, transparent pricing, and the lowest prices in the UK, backed by our commitment to patient safety and regulatory compliance.

Scientific References

  1. Greenway, F. L., Fujioka, K., Plodkowski, R. A., Mudaliar, S., Guttadauria, M., Erickson, J., ... & COR-I Study Group. (2010). Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet, 376(9741), 595-605. [accessed 16 August 2026]
  2. Electronic Medicines Compendium. (2023). Mysimba 8 mg/90 mg prolonged-release tablets - Summary of Product Characteristics (SmPC). Retrieved from https://www.medicines.org.uk/emc/product/2687/smpc [accessed 16 August 2026]
  3. Medicines and Healthcare products Regulatory Agency. (2017). Naltrexone/bupropion (Mysimba): risk of severe hypertension and associated cardiovascular events. Drug Safety Update, 10(10), A1. [accessed 16 August 2026]
  4. Torgerson, J. S., Hauptman, J., Boldrin, M. N., & Sjöström, L. (2004). XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care, 27(1), 155-161. [accessed 16 August 2026]
  5. Wilding, J. P., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., ... & STEP 1 Study Group. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989-1002. [accessed 16 August 2026]

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication.

Trusted by thousands

Real people, real results

Jane L.

"Brilliant. Lost 4 stone on mounjaro no side effects at all. Cured pharmacy are excellent. Always helpful pens sent out quickly always comes with needles and sterile wipes. If you want to go on GLP-1 go to cured pharmacy. So professional. Thank you cured pharmacy you changed my health and well being."

Ann-Marie

"I absolutely love this product, I have been using 2.5mg as maintenance dose and have managed to control my weight without any side effects and can still eat well balanced meals. The pharmacy is very efficient friendly and helpful I would not purchase from anywhere else."

Sacha W.

"So far I'm really impressed by my results it's crazy cause I'm not snacking like how I used to do and I see my face slimming down already and it's only been 2 and a half weeks. Can't wait to give my feedback in 5 months time thank you cured pharmacy."

Kimberly G.

"Mounjaro has corrected my hormonal weight gain during menopause. I am using it now to maintain that balance. The results for me have been exceptional!"

Jennifer

"Great really helps cure those nasty habits can't wait for my next mounjaro pen."

How it Works?

Select from our recommended UK-licensed medications.

1

Choose your treatment

Step 1: Choose your treatment from Cured Pharmacy

Select safe UK treatments. Quick answers.

2

Answer quick questions

Step 2: Answer quick consultation questions

We will deliver direct to you as quickly as tomorrow.

3

Get it delivered fast

Step 3: Fast discreet delivery to your door

Start Your Assessment For Weight Loss

Start your journey to better health today.

  • Reviewed by UK-based prescribers
  • Takes under 3 minutes
  • Discreet Packaging

Start Your Journey To Better Health Today

Once you complete a short online assessment you will be able to choose your preferred treatment from safe medically approved options tailored to you.

Start My Assessment

Returning Customer?

Log in to Your Account

Faq

How long does it take for Mysimba diet pills to work?
Most patients begin to notice weight loss within the first 4-8 weeks of treatment, with maximum effects typically observed after 16-24 weeks when combined with diet and exercise. Your prescriber will review your progress at 16 weeks to assess ongoing suitability.
Can I buy Mysimba diet pills without a prescription in the UK?
No, Mysimba is a prescription-only medication in the UK and legally requires assessment and approval by a registered prescriber. Cured Pharmacy provides a free online consultation to ensure safe, legal access.
What is the success rate of Mysimba diet pills?
In clinical trials, approximately 50% of patients on Mysimba lost at least 5% of their body weight, and around 28% achieved 10% or more weight loss over 56 weeks. Individual results vary based on adherence to diet and lifestyle changes.
Are Mysimba diet pills safe for long-term use?
Mysimba can be used long-term under medical supervision, provided it remains effective and well-tolerated. Regular monitoring of weight, blood pressure, and overall health is essential.
Can I take Mysimba diet pills if I have type 2 diabetes?
Yes, Mysimba may be prescribed for patients with type 2 diabetes and a BMI of 27 or above, though blood glucose and medications should be monitored closely as weight loss can affect glycaemic control.
What happens if I miss a dose of Mysimba?
If you miss a dose, take it as soon as you remember unless it is close to your next scheduled dose. Do not take a double dose to make up for a missed one, and contact your pharmacist if you are unsure.
Will I regain weight after stopping Mysimba diet pills?
Weight regain is possible if healthy eating and physical activity habits are not maintained after stopping treatment. Mysimba is most effective as part of a sustained lifestyle change programme.
Can I drink alcohol while taking Mysimba?
Alcohol should be minimised or avoided, as it can increase the risk of seizures and neuropsychiatric side effects. Discuss your alcohol consumption with your prescriber during your consultation.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Last reviewed: 16 August 2026

Last updated on 16 August 2026.

Review History

Our experts continually monitor new findings in health and medicine, and we update our articles when new information becomes available.

Why this page was updated on 16 August 2026

Content checked and updated as part of our periodic review, to ensure accuracy and currentness.

Current version (16 August 2026)

Edited by: The Editorial Team

Medically reviewed by:

Tarun Kumar, GPhC No. 2233073, Prescribing Pharmacist


How we source info.

When we present you with stats, data, opinion or a consensus, we'll tell you where this came from.