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Wegovy (Semaglutide) Weight Loss Injection

Wegovy (Semaglutide) Weight Loss Injection

  • 1. Ozempic®️-equivalent therapy now available for weight management
  • 2. Average weight loss of 17%, with 1 in 3 patients achieving over 20%
  • 3. May help reduce osteoarthritis-related pain
  • 4. Wegovy®️ is not expected to impact the effectiveness of oral contraceptives
  • 5. Supports cardiovascular risk reduction
  • 6. Over 22 million patients treated with semaglutide-based therapies since 2018

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Is Wegovy the Right Semaglutide Weight Loss Injection for You?

 

Losing weight is rarely straightforward. If you have tried diet and exercise without achieving meaningful results, you are not alone — and you are not failing. Obesity is a complex, chronic condition influenced by hormones, genetics, and metabolism. That is exactly where semaglutide weight loss injection comes in. Wegovy (semaglutide 2.4 mg) is a once-weekly injectable medicine licensed in the UK for weight management in adults with obesity or overweight with at least one related health condition. It is available from Cured Pharmacy following a clinical consultation and valid prescription.

Wegovy is manufactured by Novo Nordisk and belongs to a class of medicines called GLP-1 receptor agonists. It was approved by the Medicines and Healthcare products Regulatory Agency (MHRA) for use in the UK and represents a significant step forward in medically supervised weight management. If you are exploring your options, our weight loss collection includes a range of clinically supported products to support your journey.

 

How Does Wegovy Work in the Body?

 

Wegovy works by mimicking a naturally occurring hormone called glucagon-like peptide-1 (GLP-1). This hormone is released after eating and plays a key role in regulating appetite and blood sugar. By activating GLP-1 receptors in the brain, semaglutide reduces hunger signals and increases feelings of fullness — so you naturally eat less without feeling deprived.

  • Activates GLP-1 receptors in the hypothalamus, reducing appetite
  • Slows gastric emptying, prolonging the sensation of fullness after meals
  • Reduces cravings and food-seeking behaviour
  • Helps regulate blood glucose levels, which can reduce energy dips that trigger snacking

It is worth noting that Wegovy works best alongside a reduced-calorie diet and increased physical activity. It is not a standalone solution — it is a tool that, used correctly, can make sustainable weight loss far more achievable.

 

Who Should Use Wegovy — and Who Is It Suitable For?

 

Wegovy is a prescription-only medicine, which means it is not suitable for everyone. Your prescriber will assess your medical history, current medications, and BMI before recommending it. Generally, Wegovy is indicated for:

  • Adults with a BMI of 30 kg/m² or above (classified as obese)
  • Adults with a BMI of 27 kg/m² or above who also have at least one weight-related condition, such as type 2 diabetes, high blood pressure, or dyslipidaemia
  • People who have not achieved adequate weight loss through diet and lifestyle changes alone
  • Those who are committed to a long-term, medically supervised weight management programme

It is not suitable for use during pregnancy, breastfeeding, or in people under 18 years of age. People with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) must not use Wegovy.

 

How Does Wegovy Compare to Other Weight Loss Injections?

 

Feature Wegovy (Semaglutide 2.4 mg) Ozempic (Semaglutide 1 mg/2 mg)
Licensed indication Weight management Type 2 diabetes
Maintenance dose 2.4 mg once weekly Up to 2 mg once weekly
Administration Subcutaneous injection (pre-filled pen) Subcutaneous injection (pre-filled pen)
Average weight loss (clinical trials) Approximately 15% body weight Not licensed for weight loss

 

How Should You Store Wegovy and Is It Clinically Suitable for You?

 

Before starting any semaglutide weight loss injection, your prescriber will review your full medical history. People with a history of pancreatitis, diabetic retinopathy, or severe gastrointestinal disease should discuss these conditions carefully before use. If you are managing related conditions such as blood sugar levels, you may also find our diabetes monitoring range helpful alongside your treatment plan.

Wegovy pens should be stored in a refrigerator between 2°C and 8°C before first use. After first use, the pen can be kept at room temperature (below 30°C) or in the refrigerator for up to six weeks. Never freeze Wegovy, and keep it away from direct sunlight and heat. Always check the expiry date before injecting.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Wegovy (Semaglutide) Weight Loss Injection specifications
Treatment category Weight management / Obesity
Active ingredient Semaglutide
Drug class GLP-1 receptor agonist
Mechanism of action Mimics GLP-1 hormone to reduce appetite and slow gastric emptying
Strengths 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4 mg (dose escalation)
Pack sizes 4 pre-filled pens (4-week supply per pack)
Route of administration Subcutaneous injection
Preparation Solution for injection in pre-filled pen
UK classification Prescription Only Medicine (POM)
Suitable for Adults aged 18 and over with BMI ≥30, or BMI ≥27 with weight-related comorbidity
Effective When used alongside a reduced-calorie diet and increased physical activity

Specifications of Wegovy (Semaglutide) Weight Loss Injection

 

What Is Wegovy and What Is It Used For?

 

Wegovy contains semaglutide, a GLP-1 receptor agonist that works by regulating appetite and energy intake. It is licensed in the UK as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management. It is indicated for adults with an initial BMI of 30 kg/m² or greater, or 27 kg/m² or greater in the presence of at least one weight-related comorbidity such as type 2 diabetes, hypertension, or obstructive sleep apnoea. Wegovy is given as a once-weekly subcutaneous injection and is available only on prescription following a clinical assessment.

 

What Do You Need to Know Before Using Wegovy?

 

Wegovy is not suitable for everyone. Before starting treatment, your prescriber must be aware of your full medical history. Do not use Wegovy if any of the following apply to you:

  • You have a personal or family history of medullary thyroid carcinoma (MTC)
  • You have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You are under 18 years of age
  • You have a known hypersensitivity to semaglutide or any excipient in the formulation
  • You have a history of severe gastrointestinal disease, including gastroparesis

Tell your prescriber if you have ever had pancreatitis, diabetic retinopathy, kidney problems, or depression. Use with caution in people with a history of suicidal ideation, as mood changes have been reported with GLP-1 receptor agonists.

Regarding drug interactions, semaglutide may delay gastric emptying and therefore affect the absorption of oral medicines taken at the same time. Inform your prescriber or pharmacist of all medicines you are taking, including:

  • Oral contraceptives (absorption may be reduced — additional contraception may be advised)
  • Insulin or other antidiabetic medicines (risk of hypoglycaemia may increase)
  • Warfarin or other anticoagulants (INR monitoring may be required)

 

How Should You Use Wegovy Correctly?

 

Wegovy is injected once weekly, on the same day each week, at any time of day — with or without food. Inject subcutaneously into the abdomen, thigh, or upper arm. Rotate injection sites each week to reduce the risk of skin reactions. Follow this step-by-step process:

  1. Wash your hands thoroughly with soap and water before handling the pen.
  2. Remove the pen cap and check the solution — it should be clear, colourless, or slightly yellow with no particles.
  3. Select a clean injection site (abdomen, thigh, or upper arm) and clean the skin with an alcohol swab.
  4. Press the pen firmly against the skin and press the injection button until you hear a click.
  5. Hold the pen in place for at least 6 seconds to ensure the full dose is delivered.
  6. Remove the pen, replace the cap, and dispose of it safely in a sharps bin.
Indication Age Group Dose Frequency
Weight management (initiation) Adults ≥18 0.25 mg Once weekly for 4 weeks
Weight management (escalation) Adults ≥18 0.5 mg → 1 mg → 1.7 mg Each dose for 4 weeks
Weight management (maintenance) Adults ≥18 2.4 mg Once weekly (ongoing)
Not licensed for use in children Under 18 Not applicable Not applicable

If you experience significant gastrointestinal side effects during dose escalation, your prescriber may delay moving to the next dose level. Never increase your dose faster than the schedule above without medical guidance. If you are also managing digestive discomfort, our indigestion range may offer some supportive relief for mild symptoms.

 

What Are the Possible Side Effects of Wegovy?

 

Like all medicines, Wegovy can cause side effects, though not everyone will experience them. Most side effects are gastrointestinal in nature and tend to be most noticeable during the dose escalation phase. They usually improve as your body adjusts.

Common side effects (affecting more than 1 in 10 people):

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Stomach pain or discomfort
  • Headache
  • Fatigue

Less common side effects (affecting up to 1 in 10 people):

  • Injection site reactions (redness, bruising, or itching)
  • Dizziness
  • Burping or flatulence
  • Gallstones or gallbladder problems
  • Increased heart rate
  • Hair loss (telogen effluvium — usually temporary)

Seek immediate medical attention if you experience severe abdominal pain that does not go away (possible sign of pancreatitis), changes in vision, or signs of an allergic reaction such as swelling of the face, lips, or throat. If you notice unexpected changes in your skin or hair, our skin care range may help manage minor skin-related concerns alongside your treatment.

 

How Should You Store Wegovy Safely?

 

  • Store unused pens in a refrigerator at 2°C–8°C; do not freeze.
  • After first use, the pen may be stored below 30°C or in the refrigerator for up to 6 weeks.
  • Keep away from direct sunlight and heat sources.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the label.
  • Dispose of used pens in an approved sharps container — do not place in household waste.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Wegovy online in the UK?

You can order Wegovy through a GPhC-registered online pharmacy such as Cured Pharmacy after completing a clinical consultation and receiving a valid UK prescription. Wegovy is a prescription-only medicine, so it cannot legally be dispensed without a prescriber assessment. Always ensure the pharmacy you use displays its GPhC registration number clearly on its website.

How does semaglutide work for weight loss in the body?

Semaglutide mimics the GLP-1 hormone, which acts on appetite-regulating centres in the brain to reduce hunger and increase feelings of fullness after eating. It also slows the rate at which food leaves the stomach, helping you feel satisfied for longer. Over time, this leads to a natural reduction in calorie intake and, when combined with lifestyle changes, meaningful weight loss.

How do I use the Wegovy injection pen step by step?

Wash your hands, remove the pen cap, and check the solution is clear before use. Press the pen firmly against a clean injection site — abdomen, thigh, or upper arm — and press the button until you hear a click, holding for at least 6 seconds. Rotate your injection site each week and dispose of the used pen in a sharps bin.

What is the correct starting dose of Wegovy?

The starting dose of Wegovy is 0.25 mg once weekly for the first four weeks, which helps your body adjust and minimises gastrointestinal side effects. The dose is then gradually increased every four weeks — through 0.5 mg, 1 mg, and 1.7 mg — until reaching the maintenance dose of 2.4 mg once weekly at week 17. Never skip the escalation schedule without guidance from your prescriber.

What is the best day and time to take Wegovy?

Wegovy can be taken on any day of the week, at any time of day, with or without food — the key is consistency. Choose a day that fits your routine and stick to it each week, as this helps maintain steady drug levels in your body. If you need to change your injection day, ensure at least two days have passed since your last dose.

Who is eligible for Wegovy in the UK?

Wegovy is licensed for adults aged 18 and over with a BMI of 30 kg/m² or above, or a BMI of 27 kg/m² or above alongside at least one weight-related health condition such as type 2 diabetes, high blood pressure, or high cholesterol. It is not suitable for use during pregnancy, breastfeeding, or in people with a personal or family history of medullary thyroid carcinoma or MEN 2. A prescriber will assess your full medical history before approving treatment.

What are the most common side effects of Wegovy?

The most commonly reported side effects of Wegovy are gastrointestinal, including nausea, vomiting, diarrhoea, constipation, and stomach discomfort. These are most noticeable during the dose escalation phase and typically improve as your body adjusts to the medication. Eating smaller meals, avoiding fatty or spicy foods, and staying well hydrated can help manage these effects.

How do I manage nausea caused by Wegovy?

Eating smaller, more frequent meals and avoiding rich, fatty, or heavily spiced foods can significantly reduce nausea when starting Wegovy. Staying hydrated and eating slowly also helps — try not to lie down immediately after eating. If nausea is severe or persistent, speak to your prescriber, as they may recommend delaying your dose escalation. You can also explore our sickness and nausea range for supportive remedies.

What happens if I miss a dose of Wegovy?

If you miss a dose and your next scheduled injection is more than five days away, take the missed dose as soon as you remember. If fewer than five days remain until your next dose, skip the missed dose entirely and resume your regular weekly schedule. Never take two doses within five days of each other, as this increases the risk of side effects.

How long do you stay on Wegovy?

Wegovy is designed for long-term use as part of a medically supervised weight management programme, and treatment duration is reviewed regularly by your prescriber. Clinical evidence suggests that weight regain is common if the medication is stopped, so many patients continue treatment indefinitely provided it remains effective and well tolerated. Your prescriber will assess your progress at regular intervals and advise on whether to continue.

How does Wegovy compare to Ozempic?

Both Wegovy and Ozempic contain semaglutide, but they are licensed for different indications — Wegovy is specifically approved for weight management at a maintenance dose of 2.4 mg weekly, while Ozempic is licensed for type 2 diabetes at doses up to 2 mg weekly. Using Ozempic off-label for weight loss is not recommended, as Wegovy's dose escalation schedule and clinical evidence base are specifically designed for obesity management. Always use the medicine that has been prescribed for your specific condition.

Can I use Wegovy if I have type 2 diabetes?

Yes, Wegovy can be used in people with type 2 diabetes, and it is one of the qualifying weight-related comorbidities that may make you eligible for treatment with a BMI of 27 or above. However, if you are already taking insulin or other antidiabetic medicines, your prescriber will need to adjust your diabetes treatment to reduce the risk of hypoglycaemia. Regular blood glucose monitoring is advisable — our diabetes monitoring range can support this.

Will I regain weight if I stop taking Wegovy?

Clinical studies have shown that stopping semaglutide typically leads to gradual weight regain, as the appetite-suppressing effects of the medication are no longer active. This is why Wegovy is considered a long-term treatment rather than a short-term fix, and why lifestyle changes — including diet and physical activity — are essential throughout treatment. Speak to your prescriber before stopping Wegovy to discuss a managed plan.

What are the latest clinical findings on semaglutide for weight loss?

The STEP (Semaglutide Treatment Effect in People with Obesity) clinical trial programme demonstrated that adults using semaglutide 2.4 mg weekly alongside lifestyle intervention lost an average of approximately 15% of their body weight over 68 weeks, compared to around 2.4% with placebo. NICE approved Wegovy for use in specialist weight management services in the UK in 2023 (TA875), recognising its clinical effectiveness. Ongoing research continues to explore its cardiovascular benefits, with the SELECT trial showing a significant reduction in major cardiovascular events in people with obesity.

Are there any alternatives to Wegovy for weight loss in the UK?

Other licensed weight management options in the UK include liraglutide (Saxenda), another GLP-1 receptor agonist given as a daily injection, and tirzepatide (Mounjaro), a dual GIP/GLP-1 receptor agonist approved by the MHRA for weight management. Orlistat is an oral option available on prescription or over the counter that works by reducing fat absorption. You can explore a range of supportive products in our weight loss collection, though prescription medicines require a clinical consultation.

How Should You Use Wegovy?

Wegovy is given as a once-weekly subcutaneous injection, meaning it is injected just under the skin rather than into a muscle or vein. It is important to follow the injection technique carefully each time to ensure the full dose is delivered and to minimise the risk of skin reactions at the injection site.

What Is the Correct Dose of Wegovy?

Wegovy follows a structured dose escalation schedule designed to minimise gastrointestinal side effects while your body adjusts to the medication. The maintenance dose of 2.4 mg once weekly is reached gradually over approximately 16 weeks. Do not attempt to accelerate this schedule without explicit guidance from your prescriber.

When Is the Best Time to Use Wegovy?

Wegovy can be injected at any time of day, with or without food — there is no requirement to take it at a specific time relative to meals. The most important thing is to choose a consistent day of the week and stick to it, as this maintains steady drug levels and makes it easier to remember your dose. Many people find it helpful to link their injection day to a regular weekly routine, such as a Monday morning or Sunday evening.

If you need to change your injection day, you may do so as long as at least two days (48 hours) have passed since your last dose. After that, continue on your new chosen day each week.

How Long Can You Use Wegovy For?

Wegovy is intended for long-term, ongoing use as part of a medically supervised weight management programme. Unlike short-term interventions, it is designed to support sustained weight loss over months and years, with regular clinical review to assess effectiveness and tolerability. Your prescriber will evaluate your progress at scheduled appointments and advise whether to continue, adjust, or stop treatment.

If you have not lost at least 5% of your initial body weight after 28 weeks at the maintenance dose of 2.4 mg, your prescriber will reassess whether Wegovy is the right treatment for you. Stopping treatment abruptly without medical guidance is not recommended, as weight regain is likely without a managed transition plan.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

Based on 79 reviews
58%
(46)
14%
(11)
13%
(10)
9%
(7)
6%
(5)
A
Anonymous

I've not found a lot of difference at the moment, my food noise is still the same, and im still eating the same, I will persevere.

M
Marie Beardmore

Received in reasonable time once it was approved but that took weeks. However, it has led me feeling nauseous and bloated.

S
Stuart Toop

Delivered very quickly, I was quite impressed with that. Product itself is to early to judge as it’s only been one week, but I’ve noticed small pockets of not feel hungry but only the once or twice in this first week.

D
Dennis Donaldson

Suppression has kicked in since going from .5 to 1.0

K
Kelly Houston-pullen

Amazing

Frequently Asked Question

The injectable weight loss drug Wegovy® (semaglutide) works effectively for people who have a BMI above 30. The medication is available for people with a BMI above 27 who also have weight-related health issues including high blood pressure, type 2 diabetes, heart disease and raised cholesterol.

Wegovy weight loss injection works by replicating a natural gut hormone which helps control hunger and increase feelings of fullness to support weight loss through diet restriction and exercise.

The Wegovy Weight Loss Injection comes in a pre-filled pen form. The medication needs to beadministered once weekly at the same time point every week. The pen features tiny needles which result in a comfortable injection experience. You can administer Wegovy through the abdomen or thigh or upper arm at any daily time with or without eating food. Your first order includes instructions while the Wegovy website provides additional information including a video tutorial about Wegovy usage.

The medication Wegovy is approved for use in adults who have a BMI of 30 or higher or a BMI of 27 and above with weight-related health issues including high blood pressure, diabetes, heart disease and elevated cholesterol. The medication cannot be used for weight loss in people with type 2 diabetes.

Your treatment begins with a small dose which gets higher every four weeks. The initial dose begins at 0.25 mg once per week for four weeks. The medication dose increases every four weeks until you reach the recommended maintenance dose of 2.4 mg. Your weight will be evaluated after six months of treatment to confirm effectiveness and you must lose about 5% of your starting weight to maintain your prescription.
Wegovy Weight Loss Injection stands as one of the most effective weight loss treatments because it helps more than 85% of users achieve their weight loss journey with ongoing support. The study shows that two-thirds of participants lose more than 10% of their body weight and one-third of participants lose more than 20%. The average weight loss for users exceeds 15 kg.
When you buy Wegovy Weight Loss Injection for the first time, you will receive the lowest dose pen, containing 4 doses for the initial 28-day treatment. It must be stored in a refrigerator between 2-8°C, but if necessary, it can also be kept at room temperature for short periods. Each box includes 4 needles, a sharps bin, an instruction leaflet, and extra tips for weight loss. Complete a consultation for an injectable weight loss pen and select the starter pack. With each new order, you’ll receive your next pen and 4 needles.
When you buy Wegovy Weight Loss Injection for the first time, you will receive the lowest dose pen, containing 4 doses for the initial 28-day treatment. It must be stored in a refrigerator between 2- 8°C, but if necessary, it can also be kept at room temperature for short periods. Each box includes 4 needles, a sharps bin, an instruction leaflet, and extra tips for weight loss. Complete a consultation for an injectable weight loss pen and select the starter pack. With each new order, you’ll receive your next pen and 4 needles.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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gid://shopify/MediaImage/56227513991491 Wegovy® FACTS What Is Wegovy® ?

The injectable weight loss drug Wegovy® (semaglutide) works effectively for people who have a BMI above 30. The medication is available for people with a BMI above 27 who also have weight-related health issues including high blood pressure, type 2 diabetes, heart disease and raised cholesterol.

How does Wegovy Weight Loss Injection work?

Wegovy weight loss injection works by replicating a natural gut hormone which helps control hunger and increase feelings of fullness to support weight loss through diet restriction and exercise.

How to use Wegovy® injection pen?

The Wegovy Weight Loss Injection comes in a pre-filled pen form. The medication needs to beadministered once weekly at the same time point every week. The pen features tiny needles which result in a comfortable injection experience. You can administer Wegovy through the abdomen or thigh or upper arm at any daily time with or without eating food. Your first order includes instructions while the Wegovy website provides additional information including a video tutorial about Wegovy usage.

Who is Wegovy® suitable for?

The medication Wegovy is approved for use in adults who have a BMI of 30 or higher or a BMI of 27 and above with weight-related health issues including high blood pressure, diabetes, heart disease and elevated cholesterol. The medication cannot be used for weight loss in people with type 2 diabetes.

Wegovy® Dosage? Your treatment begins with a small dose which gets higher every four weeks. The initial dose begins at 0.25 mg once per week for four weeks. The medication dose increases every four weeks until you reach the recommended maintenance dose of 2.4 mg. Your weight will be evaluated after six months of treatment to confirm effectiveness and you must lose about 5% of your starting weight to maintain your prescription. How effective is Wegovy Injection for weight loss? Wegovy Weight Loss Injection stands as one of the most effective weight loss treatments because it helps more than 85% of users achieve their weight loss journey with ongoing support. The study shows that two-thirds of participants lose more than 10% of their body weight and one-third of participants lose more than 20%. The average weight loss for users exceeds 15 kg. Buying Wegovy® for the first time? When you buy Wegovy Weight Loss Injection for the first time, you will receive the lowest dose pen, containing 4 doses for the initial 28-day treatment. It must be stored in a refrigerator between 2-8°C, but if necessary, it can also be kept at room temperature for short periods. Each box includes 4 needles, a sharps bin, an instruction leaflet, and extra tips for weight loss. Complete a consultation for an injectable weight loss pen and select the starter pack. With each new order, you’ll receive your next pen and 4 needles.