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Mysimba Tablets

Mysimba Tablets

  • Ozempic®️-equivalent therapy now available for weight management
  • Average weight loss of 17%, with 1 in 3 patients achieving over 20%
  • May help reduce osteoarthritis-related pain
  • Wegovy®️ is not expected to impact the effectiveness of oral contraceptives
  • Supports cardiovascular risk reduction
  • Over 22 million patients treated with semaglutide-based therapies since 2018

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What is Mysimba?

Mysimba is a prescription-only weight loss medication that comes as film-coated tablets. Each tablet contains 2 active ingredients, which are naltrexone hydrochloride and bupropion hydrochloride. Both ingredients act in the areas of the brain that are in control of controlling appetite and cravings, which in turn helps with reducing overeating and long-term weight management.

How to order Mysimba tablets

Getting your hands on Mysimba online is pretty simple. Here at Cured Pharmacy, you just need to follow these four easy steps:

1.      Fill out our quick medical consultation so one of our pharmacists can check if Mysimba is not only safe for you but the right option for you.

2.      Choose the pack size you want.

3.      Our UK-registered pharmacist will review your consultation. 

4.      Once approved, your order is dispensed at our pharmacy and shipped straight to your door with tracked and discreet delivery.

Who is Mysimba suitable for?

Mysimba is designed for people who have strong cravings for food and emotional eaters, rather than just people who eat large portions. If you are the type that always finds yourself eating a snack when you have already eaten and don’t need to, or you find yourself reaching for food when you’re stressed, bored, or tired, then Mysimba is the right option for you. Emotional eating has been recognised as a medical cause for gaining weight. Mysimba helps by working on the brain signals that control hunger and cravings so that you can feel more in control around food. In order to take Mysimba, you will have to fulfil a few medical conditions, such as

  • A body mass index of 30 or higher (which typically makes you clinically obese),
  • A BMI of 27 or greater, in addition to a weight-related condition 

Mysimba might also be an appropriate option if you’re open to medical support in losing weight but aren’t ready for weekly injections like Wegovy or Mounjaro. As it is a tablet, it is often considered a more direct and simple option. If you are uncertain about your BMI, you can use a special online calculator like this one designed by the NHS.

 

How does Mysimba work? 

Mysimba targets the brain’s “reward” and “hunger” centres basically. Each tablet contains two active ingredients: bupropion and naltrexone. They work together to reduce hunger anytime the brain signals that you need food and also reduce cravings, the brain signals that you must have a specific food, even when you are not hungry. 

This enables you to eat less, reduce snacking, and be consistent and strict with your diet and change to a healthier way of life. Both drugs have been safely used for decades in other treatments, including aiding people to quit smoking, so their effect on cravings is well established.

 

How long does Mysimba take to work?

Mysimba isn’t an overnight fix. You typically see weight loss after taking the medication for 4 and a half months if you are following a diet and nutritional plan and maintaining exercise. The first box, which has 112 tablets, lasts for about 38 days, because your daily dose gradually increases during the first 3 weeks. Then, after that, each box of Mysimba will last 4 weeks.


How effective is Mysimba?

Studies have shown that people taking Mysimba lost 2 to 4 times more weight when compared with people who just diet and exercise. That’s a huge difference when you think about how difficult it can be to see results by yourself.

In trials with over 2000 people, the most noticeable results happened around the 16-week mark, which is about 4 months into Mysimba medication.

Who should NOT use Mysimba?

·         Have uncontrolled high blood pressure

·         Have or have had seizures

·         You take other medications that contain bupropion

·         History of eating disorders (such as anorexia or bulimia)

·         Use opioids or are withdrawing from opioids

·         Drink heavily or are dependent on alcohol, sedative medicines, and benzodiazepines

·         Are allergic to bupropion, naltrexone, or any of the ingredients listed in the PIL

Can I get Mysimba from my GP?

It’s unlikely. The reason why the NHS stopped prescribing Mysimba in 2017 is because of the cost compared to other weight loss treatments. Here at Cured Pharmacy, we make it possible to access Mysimba safely. 

The point of taking Mysimba is to incrementally increase the dosage so your body has a chance to become accustomed. You don’t simply go up to the full amount right off the bat. Here’s how the doses schedule will look:

Week 1: 1 tablet in the morning

Week 2: 1 tablet in the morning + 1 tablet in the evening

Week 3: 2 tablets in the morning + 1 tablet in the evening

Week 4 onwards: 2 tablets in the morning + 2 tablets in
the evening (that’s the maximum dose)

 

The tablets should be taken whole with water; don’t crush or chew them, just swallow. And they should always go down with food, as that helps your body absorb the medicine better.

Even more importantly, follow the plan your pharmacist has put in place. Mysimba is most effective when taken exactly as directed, in combination with a healthy diet and some light exercise.

Possible Side Effects of Mysimba

Like any medicine, Mysimba can cause side effects, but not everyone gets them. Most are mild and go away as your body gets used to the tablets.

The most common side effects are:

Feeling sick (nausea)    
Headaches
Trouble sleeping (insomnia)
Dry mouth
Constipation
Dizziness

Less common side effects include:

  • Anxiety or feeling restless
  • Shaking (tremors)
  • Hot flushes or sweating more than usual
  • Changes in taste
  • Stomach pain

Serious Side Effects

Serious side effects with Mysimba are rare, but they can happen. If you notice any of these, call 999 right away or go straight to A&E.

  • Mental health changes
  • Fainting/loss of consciousness.
  • Muscle breakdown (Rhabdomyolysis)
  • Severe allergic reaction
  • Severe skin reactions
  • Liver damage
  • Manic episodes
  • Low blood sugar (hypoglycemia)
  • Notice your mood getting much worse, or have thoughts of harming yourself

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2088658
Muzammil Peerally

Authored by:

Muzammil Peerally

Superintendent Pharmacist

GPhC Number: 2232689
Tarun Kumar

Reviewed by:

Tarun Kumar

Clinical Leads

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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Comparison of Weight Loss Injectables

Features

Mounjaro®

Injectable Pen

Wegovy®

Injectable Pen

Saxenda®

Injectable Pen

Active Ingredient Tirzepatide Semaglutide Liraglutide
Mechanism of Action GLP-1 and GIP receptor agonist GLP-1 receptor agonist GLP-1 receptor agonist
Administration Weekly injection Weekly injection Daily injection
Dosage Varies by patient, typically starting low Varies, typically starting at 0.25 mg Varies, starting at 0.6 mg
Effect on Appetite Significantly reduces appetite and cravings Reduces appetite and increases satiety Reduces appetite and increases satiety
Average Weight Loss Up to 20% body weight reduction Up to 15% body weight reduction Significant weight reduction
Side Effects Nausea, vomiting, diarrhoea, constipation Nausea, vomiting, diarrhoea, constipation Nausea, diarrhoea, constipation, hypoglycemia
Approval FDA-approved for weight loss FDA-approved for weight loss FDA-approved for weight loss
Suitable For Adults with BMI ≥30 or ≥27 with comorbidities Adults with BMI ≥30 or ≥27 with comorbidities Adults with BMI ≥30 or ≥27 with comorbidities