Skip to product information
1 of 2

  • Images are for illustration purposes only
  • Gphc Registered
  • Join over 100k customers
  • Fixed prices and no subscriptions
  • Discreet next day delivery.
  • Free shipping on all orders over £50

Mysimba Tablets

Mysimba Tablets

  • 1. Ozempic®️-equivalent therapy now available for weight management
  • 2. Average weight loss of 17%, with 1 in 3 patients achieving over 20%
  • 3. May help reduce osteoarthritis-related pain
  • 4. Wegovy®️ is not expected to impact the effectiveness of oral contraceptives
  • 5. Supports cardiovascular risk reduction
  • 6. Over 22 million patients treated with semaglutide-based therapies since 2018

We’re proud to offer fast and discreet delivery for all our medicines & treatments.

Price Checker

Regular price £125.95
Sale price £125.95
Sale Sold out
  • Lowest price guarantee
  • Includes FREE private prescription
View full details

Mysimba Tablets

Product Description 

Mysimba is a prescription medication used for weight management in adults who are overweight or obese. It contains two active ingredients Naltrexone hydrochloride (8mg) and bupropion hydrochloride (90mg) which work together to regulate appetite and food cravings.

How It Works

  • Bupropion is an antidepressant that affects dopamine and norepinephrine levels which can help reduce appetite.
  • Naltrexone is an opioid antagonist that influences brain pathways involved in food craving and eating behavior.
  • Together these components help control hunger and reduce food intake supporting long term weight loss efforts.

How to Use

Mysimba should be taken exactly as prescribed by a healthcare professional. The dosing schedule is gradual starting with one tablet per day and increasing over four weeks to the recommended maintenance.

Warning & Precaution

  • Not suitable for pregnant or breastfeeding women.
  • Avoid if you have uncontrolled high blood pressure, seizure disorders or a history of eating disorders.
  • Do not take Mysimba if you are dependent on opioids or undergoing withdrawal.
  • May increase the risk of seizures particularly if taken with alcohol.
  • Side effects may include nausea dizziness dry mouth constipation insomnia and increased heart rate.

Storage Information

  • Store at home temperature (15-25°C or 59-77°F) in dry place away from moisture and heat.
  • Keep out of reach of children.
  • Do not use past the expiration date.

The point of taking Mysimba is to incrementally increase the dosage so your body has a chance to become accustomed. You don’t simply go up to the full amount right off the bat. Here’s how the doses schedule will look:

Week 1: 1 tablet in the morning

Week 2: 1 tablet in the morning + 1 tablet in the evening

Week 3: 2 tablets in the morning + 1 tablet in the evening

Week 4 onwards: 2 tablets in the morning + 2 tablets in
the evening (that’s the maximum dose)

 

The tablets should be taken whole with water; don’t crush or chew them, just swallow. And they should always go down with food, as that helps your body absorb the medicine better.

Even more importantly, follow the plan your pharmacist has put in place. Mysimba is most effective when taken exactly as directed, in combination with a healthy diet and some light exercise.

Possible Side Effects of Mysimba

Like any medicine, Mysimba can cause side effects, but not everyone gets them. Most are mild and go away as your body gets used to the tablets.

The most common side effects are:

Feeling sick (nausea)    
Headaches
Trouble sleeping (insomnia)
Dry mouth
Constipation
Dizziness

Less common side effects include:

  • Anxiety or feeling restless
  • Shaking (tremors)
  • Hot flushes or sweating more than usual
  • Changes in taste
  • Stomach pain

Serious Side Effects

Serious side effects with Mysimba are rare, but they can happen. If you notice any of these, call 999 right away or go straight to A&E.

  • Mental health changes
  • Fainting/loss of consciousness.
  • Muscle breakdown (Rhabdomyolysis)
  • Severe allergic reaction
  • Severe skin reactions
  • Liver damage
  • Manic episodes
  • Low blood sugar (hypoglycemia)
  • Notice your mood getting much worse, or have thoughts of harming yourself

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

We’re a safe and
regulated UK service

Registered Pharmacy Badge

Lowest Price Guarantee

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

100% discreet packaging

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

Agent

Need help?
Talk to our friendly experts now

How our service works

Service Setup

Service setup

Discreet Packaging

Discreet packaging

Express Delivery

Express delivery

Comparison of Weight Loss Injectables

Features

Mounjaro®

Injectable Pen

Wegovy®

Injectable Pen

Saxenda®

Injectable Pen

Active Ingredient Tirzepatide Semaglutide Liraglutide
Mechanism of Action GLP-1 and GIP receptor agonist GLP-1 receptor agonist GLP-1 receptor agonist
Administration Weekly injection Weekly injection Daily injection
Dosage Varies by patient, typically starting low Varies, typically starting at 0.25 mg Varies, starting at 0.6 mg
Effect on Appetite Significantly reduces appetite and cravings Reduces appetite and increases satiety Reduces appetite and increases satiety
Average Weight Loss Up to 20% body weight reduction Up to 15% body weight reduction Significant weight reduction
Side Effects Nausea, vomiting, diarrhoea, constipation Nausea, vomiting, diarrhoea, constipation Nausea, diarrhoea, constipation, hypoglycemia
Approval FDA-approved for weight loss FDA-approved for weight loss FDA-approved for weight loss
Suitable For Adults with BMI ≥30 or ≥27 with comorbidities Adults with BMI ≥30 or ≥27 with comorbidities Adults with BMI ≥30 or ≥27 with comorbidities