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Colgate Duraphat 2800 Toothpaste

Colgate Duraphat 2800 Toothpaste

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  • ✔️ Contains 2800ppm fluoride — nearly double standard toothpaste strength
  • ✔️ Remineralises weakened enamel to halt early decay progression
  • ✔️ Clinically indicated for dry mouth, gum recession, and orthodontic patients
  • ✔️ Reduces cariogenic bacterial activity with every brush
  • ✔️ Replaces regular toothpaste — no extra steps needed

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What Is Duraphat 2800 Toothpaste and How Does It Protect Your Teeth?

 

If your dentist has told you that you're at higher-than-average risk of tooth decay, you've probably heard about Duraphat 2800 toothpaste. This is a high-strength fluoride toothpaste containing 2800 parts per million (ppm) of sodium fluoride — nearly double the concentration found in standard over-the-counter toothpastes. It's designed for adults and young people aged 16 and over who need extra protection against dental caries. You can browse our full range of oral health products to find the right support for your dental care routine.

Tooth decay remains one of the most common preventable health conditions in the UK, according to the NHS. When the enamel on your teeth is repeatedly exposed to acids from bacteria and sugary foods, it begins to weaken and erode. Standard toothpastes help, but for people with specific risk factors — such as dry mouth, gum recession, or a history of frequent cavities — a higher fluoride concentration can make a meaningful difference to long-term dental health.

 

How Does Colgate Duraphat 2800 Work to Prevent Decay?

 

Fluoride works by integrating into the structure of tooth enamel, making it more resistant to acid attack. At 2800ppm, Duraphat 2800 toothpaste delivers a significantly higher dose of fluoride to the tooth surface than everyday toothpastes. Here's how the process works:

  • Sodium fluoride in the toothpaste binds to hydroxyapatite crystals in the enamel, forming fluorapatite — a harder, more acid-resistant compound.
  • It inhibits the activity of Streptococcus mutans and other cariogenic bacteria that produce the acids responsible for decay.
  • It promotes remineralisation of early-stage enamel lesions, potentially reversing the very earliest signs of decay before a cavity forms.
  • Regular use maintains a sustained fluoride reservoir in the saliva and on tooth surfaces, providing ongoing protection between brushing sessions.

The key difference from standard toothpaste is the concentration. Most over-the-counter toothpastes contain between 1000ppm and 1450ppm fluoride. Duraphat 2800 sits above that threshold, making it particularly effective for patients whose teeth need more intensive support.

 

Who Should Use Colgate Duraphat 2800 Toothpaste?

 

This toothpaste is not intended as a general-use product for everyone. It's specifically indicated for adults and young people aged 16 and over who face an elevated risk of dental caries. Your dentist or pharmacist may recommend it if you fall into one or more of the following categories:

  • You have a history of frequent or recurrent dental cavities.
  • You suffer from dry mouth (xerostomia), which reduces saliva's natural protective effect.
  • You have gum recession that exposes the softer root surfaces of your teeth to decay.
  • You wear orthodontic appliances such as fixed braces, which make thorough cleaning more difficult.
  • You have a medical condition or take medications that increase your caries risk.

It is not suitable for children under 16. If you're unsure whether this product is right for you, speak to your dentist or pharmacist before starting use.

 

How Does Duraphat 2800 Compare to Other Fluoride Toothpastes?

 

Feature Duraphat 2800 Standard Toothpaste (1450ppm) Duraphat 5000
Fluoride concentration 2800ppm sodium fluoride 1000–1450ppm sodium fluoride 5000ppm sodium fluoride
Suitable age 16 and over All ages (formulation dependent) 16 and over (typically prescription)
Intended use High caries risk adults General daily oral hygiene Very high caries risk adults
UK availability OTC / pharmacy Supermarket / pharmacy Prescription only

 

How Should You Store Duraphat 2800 Toothpaste and Is It Clinically Suitable for You?

 

Store Duraphat 2800 toothpaste below 25°C, away from direct sunlight and out of reach of children. Do not use after the expiry date printed on the tube. The product should be kept in its original packaging to protect it from moisture.

Clinically, Duraphat 2800 toothpaste is well-tolerated by most adults when used as directed. However, if you have any known hypersensitivity to fluoride or any of the excipients listed in the patient information leaflet, you should not use this product. If you're managing other aspects of your health alongside your dental care — for example, if you're taking medications that cause dry mouth as a side effect — it's worth exploring our dental products range for complementary support.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Colgate Duraphat 2800 Toothpaste specifications
Treatment category Dental caries prevention
Mechanism of action Remineralisation of enamel via sodium fluoride; inhibition of cariogenic bacteria
Effective for Prevention of dental decay in high-risk adults
Suitable for Adults and young people aged 16 and over
Active ingredient Sodium fluoride 2800ppm (0.619% w/w)
Pack size 75ml tube
Strength 2800ppm fluoride
UK classification General Sale / Pharmacy medicine
Drug class Fluoride-containing dental preparation
Preparation Toothpaste (topical gel/paste)
Route of administration Topical (oral)

Specifications of Colgate Duraphat 2800 Toothpaste

 

What Is Colgate Duraphat 2800 and What Is It Used For?

 

Colgate Duraphat 2800 is a fluoride toothpaste containing 2800ppm sodium fluoride. It is used to prevent dental caries (tooth decay) in adults and young people aged 16 and over who are considered to be at high risk. It works by strengthening tooth enamel and reducing the ability of bacteria to produce decay-causing acids. It is used in place of your regular toothpaste, not in addition to it.

Duraphat 2800 toothpaste is particularly recommended for people with conditions or circumstances that increase their susceptibility to cavities — including dry mouth, gum recession, orthodontic treatment, or a history of frequent decay. It is not a treatment for existing cavities; rather, it is a preventive measure to stop new ones from forming and to slow the progression of early enamel damage.

 

What Do You Need to Know Before Using Colgate Duraphat 2800?

 

Before using this toothpaste, make sure it is appropriate for you. There are some important contraindications and warnings to be aware of:

  • Do not use if you are under 16 years of age.
  • Do not use if you have a known hypersensitivity to sodium fluoride or any other ingredient in the formulation.
  • Do not swallow the toothpaste — always spit after brushing and do not rinse.
  • Do not use in addition to other high-fluoride products unless directed by a dentist or doctor.
  • Use with caution if you already consume fluoride supplements or live in an area with fluoridated water at high levels — discuss with your dentist.
  • Not recommended during pregnancy or breastfeeding unless specifically advised by a healthcare professional.

In terms of drug interactions, there are no clinically significant interactions known for topically applied fluoride toothpaste at this concentration. However:

  • Calcium-containing products (such as certain antacids or dairy consumed immediately before brushing) may reduce fluoride uptake — allow a gap where possible.
  • If you are taking any medication that causes dry mouth as a side effect, inform your dentist, as this may affect how you use fluoride products.

 

How Should You Use Colgate Duraphat 2800 Toothpaste?

 

Using this toothpaste correctly is essential to getting the most benefit from it. Follow these steps each time you brush:

  1. Apply a pea-sized amount (approximately 1–2cm) of toothpaste to a soft-bristled toothbrush.
  2. Brush all tooth surfaces — outer, inner, and chewing surfaces — for a full two minutes.
  3. Spit out the toothpaste thoroughly after brushing.
  4. Do not rinse your mouth with water afterwards — this washes away the fluoride before it can act on the enamel.
  5. Do not eat or drink for at least 30 minutes after brushing.
  6. Use twice daily, morning and evening, in place of your regular toothpaste.
Indication Age Group Dose Frequency
High caries risk prevention 16 years and over Pea-sized amount (1–2cm) Twice daily
Not applicable Under 16 years Do not use

If you are also managing other aspects of your health, such as taking vitamins to support bone and dental health, you may find our vitamins and supplements range a useful complement to your dental care routine.

 

What Are the Possible Side Effects of Colgate Duraphat 2800?

 

Side effects with Duraphat 2800 toothpaste are uncommon when used as directed. However, as with any medicine, some people may experience unwanted effects. If you notice anything that concerns you, stop use and speak to your pharmacist or dentist.

Common side effects:

  • Mild gum irritation or sensitivity, particularly when first starting use
  • Temporary changes in taste perception

Less common side effects:

  • Dental fluorosis (white spots or streaking on teeth) — this is more likely with prolonged excessive use or if additional fluoride sources are consumed simultaneously
  • Mouth ulcers or soft tissue irritation in sensitive individuals
  • Allergic reactions (rare) — symptoms may include swelling, rash, or difficulty breathing; seek immediate medical attention if this occurs

Swallowing large amounts of fluoride toothpaste can cause nausea, vomiting, or abdominal pain. This is why it is essential to spit thoroughly and keep the product out of reach of children.

 

How Should You Store Colgate Duraphat 2800 Toothpaste?

 

Proper storage helps maintain the effectiveness and safety of this product. Follow these guidelines:

  • Store below 25°C in a cool, dry place.
  • Keep away from direct sunlight and heat sources.
  • Keep the tube tightly closed when not in use.
  • Store in the original packaging to protect from moisture.
  • Keep out of the sight and reach of children at all times.
  • Do not use after the expiry date printed on the tube or carton.
  • Do not dispose of via wastewater or household waste — return unused medicines to your pharmacy for safe disposal.

If you have any concerns about storage or the condition of your toothpaste, speak to your pharmacist. You can also explore our wider range of dental products for additional oral health support.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Duraphat 2800 toothpaste online in the UK?

You can buy Duraphat 2800 toothpaste online from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £10.49 per tube. It is available without a prescription for adults aged 16 and over. Simply add it to your basket and it will be dispatched directly to your door.

How does Duraphat 2800 toothpaste work in the body?

Duraphat 2800 works by delivering 2800ppm sodium fluoride directly to the tooth surface during brushing. The fluoride integrates into the enamel structure, forming fluorapatite — a compound that is more resistant to acid attack than natural enamel. It also inhibits the bacteria that produce decay-causing acids, providing a dual protective effect.

How do I use Duraphat 2800 toothpaste step by step?

Follow these steps for correct use:

  1. Apply a pea-sized amount to a soft toothbrush.
  2. Brush all tooth surfaces for two minutes.
  3. Spit out thoroughly — do not rinse with water.
  4. Avoid eating or drinking for at least 30 minutes.

Use twice daily in place of your regular toothpaste, not alongside it.

What is the correct dose of Duraphat 2800 toothpaste for adults?

Adults and young people aged 16 and over should use a pea-sized amount — roughly 1–2cm of toothpaste — twice daily. Do not use more than this amount per session, and always spit rather than swallow. Using more than directed does not increase the benefit and may increase the risk of side effects.

What are the side effects of Duraphat 2800 toothpaste?

Side effects are uncommon but may include:

  • Mild gum irritation or sensitivity
  • Temporary changes in taste
  • Dental fluorosis (white spots) with prolonged excessive use

Serious allergic reactions are rare. If you experience swelling, rash, or difficulty breathing, seek immediate medical attention.

How do I manage side effects of Duraphat 2800 toothpaste?

Mild gum irritation often settles within the first week or two of use as your mouth adjusts to the higher fluoride concentration. If irritation persists, speak to your dentist or pharmacist — they may advise reducing frequency temporarily or switching to a different product. Never exceed the recommended dose in an attempt to speed up results.

Who is eligible to use Duraphat 2800 toothpaste?

Duraphat 2800 is suitable for adults and young people aged 16 and over who are at elevated risk of dental decay. This includes people with dry mouth, gum recession, orthodontic appliances, or a history of frequent cavities. It is not suitable for children under 16, and those who are pregnant or breastfeeding should seek advice from a healthcare professional before use.

What happens if I miss a use of Duraphat 2800 toothpaste?

If you forget to use it at your usual time, simply carry on with your next scheduled brushing session as normal. Do not apply a double amount to make up for a missed use — this will not improve results and may cause unnecessary irritation. Consistency over time is what delivers the protective benefit.

Can I use Duraphat 2800 toothpaste if I have dry mouth?

Yes — in fact, people with dry mouth (xerostomia) are among those most likely to benefit from Duraphat 2800 toothpaste. Saliva plays a key role in protecting teeth from decay, so reduced saliva flow significantly increases caries risk. High-strength fluoride toothpaste helps compensate for this reduced natural protection. You can also explore our oral health range for additional dry mouth products.

What are the alternatives to Duraphat 2800 toothpaste?

The main alternative is Duraphat 5000 toothpaste, which contains 5000ppm fluoride and is typically available on prescription for adults with very high caries risk. Standard fluoride toothpastes (1000–1450ppm) are suitable for people at lower risk. Your dentist is best placed to advise which concentration is appropriate for your individual situation.

How long can you use Duraphat 2800 toothpaste for?

Duraphat 2800 can be used as part of your long-term daily oral hygiene routine for as long as your dentist or pharmacist recommends. There is no set maximum duration, but your dental professional should review your caries risk periodically to determine whether continued use at this fluoride level remains appropriate. Regular dental check-ups are important alongside its use.

Is Duraphat 2800 toothpaste available on NHS prescription?

Duraphat 2800 can be prescribed on the NHS in certain circumstances, particularly for patients identified as high caries risk by their NHS dentist. However, it is also available to purchase over the counter from registered pharmacies like Cured Pharmacy without a prescription, for adults aged 16 and over. Buying it directly may be more convenient if you do not currently have an NHS dentist.

Can I use Duraphat 2800 toothpaste with braces or orthodontic appliances?

Yes — people wearing fixed orthodontic appliances are at increased risk of decay because braces make thorough cleaning more difficult, and plaque can accumulate around brackets. Duraphat 2800 toothpaste is often recommended in this context to provide additional enamel protection during treatment. Always follow the specific advice of your orthodontist or dentist. You can also find other relevant products in our dental products collection.

What are the latest studies on high fluoride toothpaste for cavity prevention?

Clinical evidence consistently supports the use of higher-concentration fluoride toothpastes in high-risk adult populations. NICE guidance and NHS recommendations acknowledge that toothpastes above 1500ppm fluoride provide greater caries-preventive benefit for adults at elevated risk compared to standard formulations. Research published in dental literature supports the use of 2800ppm and 5000ppm fluoride toothpastes as effective preventive interventions in this group.

Does Duraphat 2800 toothpaste help with sensitive teeth?

While Duraphat 2800 is primarily indicated for caries prevention rather than dentine hypersensitivity, the remineralisation of enamel it promotes may help reduce sensitivity over time in some users. If tooth sensitivity is your primary concern, speak to your dentist — they can advise whether Duraphat 2800 or a dedicated sensitivity toothpaste is more appropriate for your needs.

How Should You Use Colgate Duraphat 2800 Toothpaste?

Using Duraphat 2800 correctly is just as important as using it consistently. Unlike standard toothpaste, the way you finish brushing matters enormously — skipping the "don't rinse" step significantly reduces how much fluoride your enamel actually absorbs.

Follow these steps every time you brush:

What Is the Correct Dose of Colgate Duraphat 2800 Toothpaste?

The dose is the same for all eligible users — a pea-sized amount applied twice daily. Do not use more than this per session; a larger amount does not provide greater protection and increases the risk of swallowing fluoride accidentally.

When Is the Best Time to Use Colgate Duraphat 2800 Toothpaste?

The most effective times to use Duraphat 2800 are in the morning after breakfast and last thing at night before bed. The evening application is particularly important — brushing before sleep means the fluoride remains in contact with your enamel for longer, as saliva flow naturally decreases overnight. This extended contact time maximises the remineralisation benefit.

Try to make the evening brush your final oral activity of the day. Avoid snacking, drinking anything other than water, or using a standard mouthwash immediately after brushing, as this disrupts the fluoride's protective action.

How Long Can You Use Colgate Duraphat 2800 Toothpaste For?

There is no fixed maximum duration for using Duraphat 2800 toothpaste. It can be used as part of your ongoing daily oral hygiene routine for as long as your dentist or pharmacist considers it appropriate for your level of caries risk. Many people use it long-term, particularly if the underlying risk factors — such as dry mouth or gum recession — are ongoing.

Your dentist should review your dental health at regular check-ups to assess whether continued use at this fluoride concentration remains the right choice for you. If your risk level changes, they may recommend stepping down to a standard fluoride toothpaste.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Colgate Duraphat 2800 Toothpaste?

Most people who use Duraphat 2800 toothpaste as directed do not experience significant side effects. However, as with any medicine applied to sensitive oral tissues, some people notice mild effects when they first start using it. These typically settle within the first week or two.

  • Mild gum irritation or tenderness, particularly around the gum line
  • Temporary changes in taste or a slightly different sensation in the mouth after brushing
  • Increased tooth sensitivity in the first few days of use

What Are the Less Common Side Effects of Colgate Duraphat 2800 Toothpaste?

Less common side effects are generally associated with incorrect use — particularly using too much toothpaste, swallowing it, or using it alongside other high-fluoride products without dental supervision.

  • Dental fluorosis — white spots, streaking, or mottling on the tooth surface, caused by excessive fluoride intake over time
  • Mouth ulcers or soft tissue irritation in individuals with particularly sensitive oral mucosa
  • Nausea or stomach discomfort if significant amounts are accidentally swallowed

What Are the Serious Side Effects of Colgate Duraphat 2800 Toothpaste?

Serious side effects are rare but require prompt attention. Allergic reactions to sodium fluoride or any of the excipients in the formulation can occur, though this is uncommon. If you experience any of the following, stop using the product immediately and seek urgent medical advice:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Widespread skin rash or hives
  • Severe mouth or throat irritation

What Should You Do If You Experience Side Effects of Colgate Duraphat 2800?

For mild side effects such as gum irritation or taste changes, continue using the toothpaste as directed and allow a week or two for your mouth to adjust. If irritation persists or worsens, speak to your pharmacist or dentist — they may suggest a short break or a temporary reduction in frequency. Do not increase the dose in an attempt to speed up results, as this will not help and may worsen irritation.

If you accidentally swallow a large amount of toothpaste, contact NHS 111 or your nearest A&E department for advice. Keep the product packaging with you so healthcare professionals can assess the amount of fluoride involved.

Can Colgate Duraphat 2800 Toothpaste Interact With Other Medicines?

There are no clinically significant drug interactions known for topically applied fluoride toothpaste at this concentration. However, a few practical considerations are worth noting. Calcium-rich foods or drinks consumed immediately before brushing may slightly reduce fluoride uptake by the enamel — try to allow a gap between eating dairy products and brushing where possible. If you are taking fluoride supplements prescribed by your doctor or dentist, inform them that you are also using Duraphat 2800, as combined fluoride intake should be monitored. Medications that cause dry mouth as a side effect may actually increase your need for high-strength fluoride toothpaste — discuss this with your prescriber or pharmacist.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question


Colgate Duraphat 2800 is a high-fluoride toothpaste used to prevent dental cavities, especially in people at high risk of tooth decay. It strengthens tooth enamel and reduces sensitivity caused by weakened enamel.


It is recommended for adults and adolescents over 16 who have a higher chance of developing cavities. This includes individuals with orthodontic braces, dry mouth, gum recession, or a history of frequent dental decay.


No. You should not use it alongside regular fluoride toothpaste because it contains a much higher fluoride concentration. Use only Duraphat 2800 unless your dentist advises otherwise.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What is Colgate Duraphat 2800 Toothpaste used for?


Colgate Duraphat 2800 is a high-fluoride toothpaste used to prevent dental cavities, especially in people at high risk of tooth decay. It strengthens tooth enamel and reduces sensitivity caused by weakened enamel.

Who should use Duraphat 2800?


It is recommended for adults and adolescents over 16 who have a higher chance of developing cavities. This includes individuals with orthodontic braces, dry mouth, gum recession, or a history of frequent dental decay.

Can Duraphat 2800 be used with regular toothpaste?


No. You should not use it alongside regular fluoride toothpaste because it contains a much higher fluoride concentration. Use only Duraphat 2800 unless your dentist advises otherwise.