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Zeroderm Ointment 500g

Zeroderm Ointment 500g

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  • ✔️ Soothes and moisturises dry, itchy, eczema-prone skin
  • ✔️ Forms an occlusive barrier to lock in skin moisture
  • ✔️ Suitable for adults, children, and infants under guidance
  • ✔️ Fragrance-free and preservative-free paraffin formulation
  • ✔️ Can be used as a daily soap substitute in the bath

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What Is Zeroderm Ointment and How Does It Help Dry Skin?

 

If you live with dry, itchy, or flaky skin, you'll know how relentless it can feel — especially during colder months when central heating strips moisture from the air. Zeroderm ointment is a paraffin-based emollient designed to moisturise and protect skin affected by conditions such as eczema, psoriasis, ichthyosis, and other forms of dry skin disease. It contains white soft paraffin (98%) and liquid paraffin (2%), forming a rich, occlusive barrier that locks in moisture and helps restore the skin's natural protective function. You can browse our full range of creams and ointments if you're looking for additional emollient options.

Dry skin conditions are extremely common in the UK. The NHS estimates that eczema alone affects around one in five children and one in twelve adults. Emollients like this one are considered a cornerstone of treatment — not just for symptom relief, but for ongoing skin barrier maintenance. At just £7.99 for a 500g tub, Zeroderm ointment offers a cost-effective way to manage dry skin as part of a daily routine.

 

How Does Zeroderm Ointment Work on the Skin?

 

Emollients work differently from standard moisturisers. Rather than simply adding water to the skin, they create a physical barrier that slows transepidermal water loss (TEWL) — the process by which moisture evaporates from the skin surface. Here's how Zeroderm ointment achieves this:

  • Occlusion: White soft paraffin forms a semi-impermeable film over the skin, trapping existing moisture beneath the surface.
  • Softening: Liquid paraffin helps to soften and smooth rough, thickened, or scaly skin, making it more comfortable.
  • Barrier restoration: Regular use supports the skin's natural lipid barrier, reducing sensitivity and reactivity over time.
  • Itch reduction: By keeping the skin hydrated, the ointment helps reduce the itch-scratch cycle that worsens many skin conditions.

Because it is ointment-based rather than cream or lotion-based, it tends to be more effective for very dry or thickened skin — though it can feel greasier on application. Many patients find it works best applied at night, allowing the skin to absorb it fully while sleeping.

 

Who Should Use Zeroderm Ointment?

 

This emollient is suitable for a wide range of people. It's particularly useful for those with chronic dry skin conditions that require regular, ongoing moisturisation. It can be used by adults, children, and — under appropriate guidance — infants too.

  • Adults and children with eczema (atopic dermatitis)
  • People with psoriasis or ichthyosis
  • Those with contact dermatitis or irritant skin reactions
  • Anyone experiencing general dry, flaky, or itchy skin

It is available over the counter without a prescription, making it easy to access. If you're managing a skin condition alongside other health concerns, our skin care collection includes a variety of complementary products that may support your routine.

 

How Does Zeroderm Ointment Compare to Other Emollients?

 

Feature Zeroderm Ointment 500g Aqueous Cream
Base type Paraffin (occlusive ointment) Water-based cream
Moisture retention High — occlusive barrier Lower — evaporates faster
Suitable for very dry skin Yes Less effective
Flammability risk Yes — paraffin-based No
Price (500g) £7.99 Varies

 

Is Zeroderm Ointment Safe to Store and Use Long-Term?

 

Zeroderm ointment should be stored below 25°C, away from direct sunlight and out of reach of children. Once opened, check the product for any changes in smell or texture before each use. There is no known expiry concern with short-term use, but always check the label for the manufacturer's recommended use-by date.

One important safety point: all paraffin-based emollients carry a fire risk. The NHS advises that clothing, bedding, and dressings that have come into contact with paraffin-based products can catch fire much more easily than usual. Keep away from naked flames, cigarettes, and other ignition sources at all times. This is a serious risk and should not be overlooked.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Zeroderm Ointment 500g specifications
Treatment category Dry skin / Emollient therapy
Mechanism of action Occlusive emollient — forms a barrier to prevent transepidermal water loss
Effective for Eczema, psoriasis, ichthyosis, dry and itchy skin
Suitable for Adults, children, and infants (under guidance)
Active ingredient White soft paraffin 98%, liquid paraffin 2%
Pack size 500g
UK classification General Sale List (GSL)
Drug class Emollient
Preparation Ointment
Route of administration Topical (applied to the skin)

Specifications of Zeroderm Ointment 500g

 

What Is Zeroderm Ointment and What Is It Used For?

 

Zeroderm ointment is a topical emollient containing white soft paraffin (98%) and liquid paraffin (2%). It is used to moisturise, soothe, and protect dry, rough, or inflamed skin. It is indicated for use in conditions including eczema, psoriasis, ichthyosis, and other forms of dry skin disease. Emollients are recommended by the NHS as a first-line treatment for these conditions and should be used regularly — even when the skin appears to be improving — to maintain the skin barrier and prevent flare-ups.

 

What Do You Need to Know Before Using Zeroderm Ointment?

 

Before using this product, read the following carefully. Most people can use Zeroderm ointment safely, but there are some important warnings to be aware of.

Do not use Zeroderm Ointment if you:

  • Are allergic to white soft paraffin, liquid paraffin, or any other ingredient in the product
  • Have a known hypersensitivity to any paraffin-based product

Warnings and precautions:

  • Paraffin-based emollients are flammable — clothing, bedding, and dressings soaked with this product can catch fire easily; keep away from naked flames and cigarettes
  • Do not apply to broken, infected, or weeping skin without first consulting your GP or pharmacist
  • Applying in the direction of hair growth reduces the risk of folliculitis (blocked hair follicles)
  • If your skin condition worsens or does not improve after regular use, seek medical advice
  • Use in infants only under the guidance of a healthcare professional

Drug interactions:

  • No significant drug interactions are known for topical paraffin-based emollients
  • If you are using topical corticosteroids or other medicated creams, apply Zeroderm ointment at a different time to avoid diluting the active treatment

 

How Should You Use Zeroderm Ointment?

 

Using an emollient correctly makes a real difference to how well it works. Apply it generously and regularly — the NHS recommends using emollients at least twice daily, and more frequently during flare-ups. You can also use it as a soap substitute in the bath or shower to avoid stripping the skin of natural oils. If you're looking for complementary products for your little one, our baby and toddler range includes gentle skincare options suitable for sensitive skin.

  1. Wash and dry your hands before applying.
  2. Scoop out the required amount using a clean spatula or spoon — avoid dipping fingers directly into the tub to prevent contamination.
  3. Apply the ointment to the affected area in smooth, downward strokes in the direction of hair growth.
  4. Allow the ointment to absorb for a few minutes before dressing.
  5. Repeat as often as needed throughout the day, or as directed by your doctor or pharmacist.
Indication Age Group Dose Frequency
Dry skin / eczema Adults Apply liberally to affected area 2–4 times daily or as needed
Dry skin / eczema Children Apply liberally to affected area 2–4 times daily or as needed
Dry skin / eczema Infants Apply sparingly under medical guidance As directed by GP or pharmacist
Soap substitute All ages Apply before bathing, rinse off Each bath or shower

 

What Are the Possible Side Effects of Zeroderm Ointment?

 

Side effects from emollients are uncommon, but they can occur. Most people tolerate Zeroderm ointment well. If you do experience any of the following, stop using the product and speak to your pharmacist or GP.

Common side effects:

  • Temporary greasiness or heaviness on the skin surface
  • Mild skin irritation or stinging on first application

Less common side effects:

  • Folliculitis (inflammation or infection of hair follicles, particularly if applied against the direction of hair growth)
  • Contact dermatitis (allergic reaction to an ingredient — rare with paraffin-based products)
  • Skin redness or rash

 

How Should You Store Zeroderm Ointment?

 

Correct storage keeps the product safe and effective for the duration of use. Our skin care collection includes a range of emollients and moisturisers, all of which should be stored according to their individual product guidelines.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the lid tightly closed when not in use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the label
  • Do not store near naked flames or ignition sources — paraffin-based products are flammable

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Zeroderm Ointment online in the UK?

You can buy Zeroderm Ointment 500g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £7.99. No prescription is needed as it is available over the counter. Simply add it to your basket and select your preferred delivery option at checkout.

How does Zeroderm Ointment work on dry skin?

Zeroderm ointment works by forming an occlusive layer over the skin surface, which traps moisture and significantly reduces transepidermal water loss. The white soft paraffin base softens and soothes rough, dry, or inflamed skin, while the liquid paraffin component helps smooth the skin's texture. Used regularly, it helps restore the skin's natural barrier function and reduces the frequency of flare-ups.

How do I apply Zeroderm Ointment step by step?

Start by washing and drying your hands, then scoop out the required amount using a clean spatula to avoid contaminating the tub. Apply the ointment gently to the affected area in smooth strokes following the direction of hair growth, which helps prevent folliculitis. Allow it to absorb for a few minutes before putting on clothing or dressings.

How often should I use Zeroderm Ointment?

The NHS recommends using emollients at least twice daily, though during a flare-up you may need to apply more frequently — sometimes up to four or more times per day. Consistency is key; using it even when your skin looks clear helps maintain the barrier and prevent future flare-ups. Your GP or pharmacist can advise on the frequency that suits your specific condition.

Can I use Zeroderm Ointment on my face?

Yes, Zeroderm ointment can generally be applied to the face, including around the eyes, as long as you avoid direct contact with the eyes themselves. If you experience any stinging, redness, or irritation on the face, discontinue use and consult your pharmacist. For very sensitive facial skin, your GP may recommend an alternative formulation.

Is Zeroderm Ointment safe for babies and young children?

Zeroderm ointment is generally considered suitable for use in children and, under appropriate medical guidance, in infants too. Always consult your GP or pharmacist before applying any emollient to a very young baby, particularly if the skin is broken or infected. You can also explore our baby and toddler range for other gentle skincare options.

What are the side effects of Zeroderm Ointment?

Side effects are uncommon but can include temporary skin irritation, mild stinging on first application, or folliculitis if the ointment is applied against the direction of hair growth. Allergic reactions are rare with paraffin-based products but can occur — signs include redness, rash, or worsening of the skin condition. If you notice any of these, stop using the product and speak to your pharmacist or GP.

Is Zeroderm Ointment a fire hazard?

Yes — this is an important safety warning. Like all paraffin-based emollients, Zeroderm ointment is flammable, and clothing, bedding, or dressings that have absorbed the product can catch fire much more easily than usual. The NHS and MHRA both advise keeping paraffin-based emollients well away from naked flames, cigarettes, and other ignition sources. This risk applies even after the product has dried on fabric.

Who is eligible to use Zeroderm Ointment?

Zeroderm ointment is suitable for most adults and children with dry skin conditions such as eczema, psoriasis, ichthyosis, or general dry skin. It is available without a prescription, making it accessible to anyone who needs it. Those with known allergies to paraffin or any of the product's ingredients should avoid it and seek an alternative emollient.

What happens if I miss an application of Zeroderm Ointment?

If you forget to apply Zeroderm ointment at your usual time, simply apply it as soon as you remember and then continue with your normal routine. Do not apply a double amount to make up for a missed application. Consistency over time matters more than any single missed dose — try to build application into your daily routine, such as after bathing.

Can I use Zeroderm Ointment with topical steroids?

Yes, emollients and topical corticosteroids are often used together as part of an eczema management plan. However, you should apply them at different times — for example, apply the steroid cream first, wait 30 minutes, and then apply the emollient. This prevents the emollient from diluting the steroid and reduces the risk of spreading it to unaffected areas. Always follow your GP's or pharmacist's specific instructions.

What are the alternatives to Zeroderm Ointment?

There are several paraffin-based emollient ointments available in the UK, including Epaderm Ointment, Hydromol Ointment, and Diprobase Ointment. The best choice depends on your skin type, personal preference, and how your skin responds to treatment. You can explore our full range of creams and ointments to compare available options.

How long can I use Zeroderm Ointment for?

Zeroderm ointment can be used long-term as part of a daily skincare routine for chronic dry skin conditions such as eczema or psoriasis. There is no set maximum duration of use for emollients — they are designed for ongoing maintenance. If your skin condition does not improve or worsens despite regular use, consult your GP for a full assessment.

Can I use Zeroderm Ointment as a soap substitute?

Yes — the NHS recommends using emollients as soap substitutes to avoid stripping the skin of its natural oils during washing. Apply a small amount of Zeroderm ointment to wet skin in the bath or shower, then rinse off gently. This is particularly helpful for people with eczema or very sensitive skin who find conventional soaps irritating.

What are the latest recommendations on emollient use for eczema?

Current NHS and NICE guidance continues to recommend emollients as the foundation of eczema management, used regularly and in large quantities regardless of whether the skin is currently flaring. Research supports the idea that consistent emollient use from an early age may help strengthen the skin barrier and reduce the severity of atopic conditions over time. Speak to your GP or dermatologist for personalised advice based on your skin's needs.

How Should You Use Zeroderm Ointment?

Zeroderm ointment is applied directly to the skin and works best when used consistently as part of your daily routine. The more regularly you apply it, the better it maintains your skin's moisture barrier — so don't wait for a flare-up to start using it.

Follow these steps for correct application:

You can also use Zeroderm ointment as a soap substitute. Apply it to wet skin before bathing, then rinse off gently — this helps cleanse without stripping the skin's natural oils.

What Is the Correct Dose of Zeroderm Ointment?

There is no fixed dose for emollients — the key is to apply liberally and frequently. The NHS advises that adults with eczema may use up to 500g of emollient per week, so do not be afraid to apply generously. The table below provides a general guide based on age and indication.

When Is the Best Time to Use Zeroderm Ointment?

The best time to apply Zeroderm ointment is immediately after bathing or showering, while the skin is still slightly damp. This helps seal in moisture and maximises the emollient effect. Many people also find a second application at bedtime particularly helpful, as the ointment can work overnight without being rubbed off by clothing or daily activity.

If you are using topical corticosteroids alongside this product, apply the steroid first, wait at least 30 minutes, and then apply the emollient. This prevents the emollient from diluting or spreading the steroid to unintended areas.

How Long Can You Use Zeroderm Ointment For?

Zeroderm ointment is suitable for long-term, ongoing use. Unlike medicated treatments, emollients do not carry a risk of dependency or tolerance, and there is no recommended maximum duration. For chronic conditions such as eczema or psoriasis, it should be used continuously — even during periods when the skin appears clear — to maintain the barrier and prevent future flare-ups.

If your skin condition does not improve after several weeks of regular use, or if it worsens at any point, consult your GP or pharmacist for further assessment and advice.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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Bibi
Amazing product

Used to have it prescribed but now GP won't give. Works wonders on my skin

What Are the Most Common Side Effects of Zeroderm Ointment?

Most people tolerate Zeroderm ointment very well, and side effects are uncommon. Because it contains only paraffin-based ingredients with no added preservatives or fragrances, the risk of irritation is lower than with many other emollient formulations.

  • Temporary greasiness or heaviness on the skin surface immediately after application
  • Mild stinging or tingling on first application, particularly on broken or very dry skin
  • Slight discomfort if applied to sensitive areas

What Are the Less Common Side Effects of Zeroderm Ointment?

Less commonly, some people may experience the following. These are not dangerous in most cases, but you should stop using the product and seek advice if they persist or worsen.

  • Folliculitis — inflammation or infection of the hair follicles, usually caused by applying the ointment against the direction of hair growth
  • Skin redness or mild rash at the site of application
  • Contact dermatitis — an allergic reaction to one of the ingredients, though this is rare with paraffin-based products
  • Acne-like spots in areas where the ointment is applied heavily over a prolonged period

What Are the Serious Side Effects of Zeroderm Ointment?

Serious side effects from Zeroderm ointment are very rare. However, the most significant risk associated with paraffin-based emollients is not a skin reaction — it is fire. The NHS and MHRA have issued guidance warning that paraffin-based emollients can make clothing, bedding, and dressings highly flammable. This risk remains even after the product has dried on fabric. There have been reported cases of serious burns and fatalities linked to this hazard.

If you experience signs of a severe allergic reaction — such as swelling of the face, lips, or throat, difficulty breathing, or widespread hives — seek emergency medical attention immediately.

What Should You Do If You Experience Side Effects of Zeroderm Ointment?

If you notice any skin irritation, rash, or worsening of your condition after using Zeroderm ointment, stop applying it and consult your pharmacist or GP. In most cases, mild side effects resolve on their own once you stop using the product. Your pharmacist can help you identify whether the reaction is related to the ointment or to your underlying skin condition, and can recommend an alternative emollient if needed.

For the fire risk specifically: wash any clothing or bedding that has come into contact with the ointment before use near flames, and always keep away from cigarettes and naked flames after application.

Can Zeroderm Ointment Interact With Other Medicines?

No significant drug interactions are known for topical paraffin-based emollients. However, if you are using other topical treatments — such as corticosteroid creams, antifungal preparations, or medicated dressings — you should apply them at separate times to avoid diluting their effect. Always inform your GP or pharmacist about all products you are using on your skin, including over-the-counter emollients.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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