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Hydrocortisone

Hydrocortisone

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  • ✔️ Relieves eczema itching and redness within 24–48 hours
  • ✔️ Targets inflammation directly at the skin surface
  • ✔️ Suitable for adults and children aged 10 and over
  • ✔️ Effective for dermatitis, insect bites, and mild rashes
  • ✔️ Mild 1% strength — safe for short-term OTC use

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What Is Hydrocortisone Cream and How Does It Help?

 

Hydrocortisone cream is a mild topical corticosteroid used to relieve the itching, redness, and inflammation that come with a range of common skin conditions. Whether you're dealing with a flare-up of eczema, a patch of contact dermatitis, or the irritating aftermath of an insect bite, it offers targeted, short-term relief directly at the site of irritation. Available over the counter in a 1% strength, it's one of the most widely used topical treatments in the UK. You can browse our full range of creams and ointments to find the right formulation for your skin concern.

Hydrocortisone belongs to a class of medicines called corticosteroids. At the 1% concentration available without prescription, it's considered a mild steroid — suitable for short-term use on most areas of the body, excluding the face and broken skin. The NHS recognises it as an effective first-line treatment for mild inflammatory skin conditions in adults and children aged 10 and over.

 

How Does Hydrocortisone Work on Inflamed Skin?

 

When your skin becomes inflamed, your immune system releases a cascade of chemical signals — including prostaglandins and cytokines — that cause the redness, swelling, and itch you feel. Hydrocortisone works by binding to glucocorticoid receptors inside skin cells, which then suppresses the production of these inflammatory mediators. The result? Calmer, less reactive skin.

  • Reduces the release of inflammatory chemicals such as prostaglandins and histamine
  • Constricts small blood vessels in the skin, reducing redness and swelling
  • Decreases the activity of immune cells that drive the inflammatory response
  • Relieves itching by dampening the nerve signals triggered by inflammation

It doesn't treat the underlying cause of your skin condition — but it does give your skin the breathing space it needs to settle down, especially during a flare.

 

Who Is Hydrocortisone Cream Suitable For?

 

This treatment is appropriate for a wide range of people experiencing mild to moderate inflammatory skin reactions. It's particularly useful if you've been diagnosed with a condition that flares periodically and you need something reliable to manage those episodes quickly.

  • Adults and children aged 10 and over with mild eczema or atopic dermatitis
  • People experiencing contact dermatitis from soaps, cosmetics, or metals
  • Anyone with insect bite reactions causing localised redness and itching
  • Those with mild allergic skin reactions or heat rash

It is not suitable for use on infected skin, acne, rosacea, or around the eyes. If you're pregnant or breastfeeding, speak to your pharmacist or GP before using any topical steroid. If your skin condition is severe, widespread, or not improving after seven days, you should seek medical advice rather than continuing self-treatment.

 

How Does Hydrocortisone Cream Compare to Other Topical Treatments?

 

Feature Hydrocortisone Cream 1% Antihistamine Cream
Mechanism Suppresses inflammatory response via glucocorticoid receptors Blocks histamine H1 receptors locally
Best for Eczema, dermatitis, insect bites, mild allergic rashes Insect bites, nettle rash, mild urticaria
Speed of action Improvement within 24–48 hours Rapid itch relief, often within hours
Duration of use Up to 7 days OTC without medical advice Short-term use only

 

Is Hydrocortisone Cream Safe to Store at Home?

 

Yes — provided you follow a few straightforward guidelines. Store your hydrocortisone cream below 25°C, away from direct sunlight and out of reach of children. Don't use it after the expiry date printed on the packaging, and never share it with someone else, even if their symptoms look similar to yours. If you're managing a skin condition alongside other health concerns, our skin care collection includes a range of complementary products that may support your overall skin health.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Hydrocortisone Cream specifications
Treatment category Topical corticosteroid / anti-inflammatory
Mechanism of action Glucocorticoid receptor agonist; suppresses inflammatory mediators in skin
Effective for Eczema, contact dermatitis, insect bites, mild allergic skin reactions
Suitable for Adults and children aged 10 and over
Active ingredient Hydrocortisone 1%
Strengths 1% (OTC); higher strengths available on prescription only
UK classification Pharmacy (P) medicine
Drug class Mild topical corticosteroid
Preparation Cream / ointment / gel
Route of administration Topical (applied to skin)

Specifications of Hydrocortisone Cream

 

What Is Hydrocortisone and What Is It Used For?

 

Hydrocortisone 1% cream is a mild corticosteroid medicine applied directly to the skin to reduce inflammation, itching, and redness. It is used to treat a range of inflammatory skin conditions, including eczema (atopic dermatitis), contact dermatitis, seborrhoeic dermatitis, insect bite reactions, and mild allergic skin rashes. It works locally — meaning it acts at the site of application rather than throughout your whole body — which is why it's considered safe for short-term OTC use at this strength. The NHS recommends it as a first-line option for mild inflammatory skin conditions in adults and children aged 10 and over.

 

What Do You Need to Know Before Using Hydrocortisone?

 

Before applying this cream, it's important to check that it's appropriate for your situation. There are certain conditions and circumstances where you should not use it without speaking to a doctor or pharmacist first.

Do not use hydrocortisone cream if you:

  • Are allergic to hydrocortisone or any other ingredient in the product
  • Have a skin infection (bacterial, fungal, or viral) at the site of application
  • Have acne, rosacea, or perioral dermatitis
  • Are applying it around the eyes or on the eyelids
  • Are treating a child under 10 years old without a doctor's advice
  • Have broken, ulcerated, or severely damaged skin at the application site

Use with caution if you:

  • Are pregnant or breastfeeding — seek medical advice before use
  • Have diabetes, as topical steroids can occasionally affect blood glucose levels with prolonged use
  • Are using other topical medicines on the same area of skin
  • Have psoriasis — topical steroids can sometimes cause a rebound flare

Drug interactions:

  • No significant interactions are known for topical hydrocortisone at 1% OTC strength
  • Avoid using alongside other topical steroids on the same area without medical guidance
  • If you are using immunosuppressant medicines, speak to your GP before starting any topical steroid

 

How Should You Use Hydrocortisone Cream?

 

Using this cream correctly makes a real difference to how well it works — and helps you avoid unnecessary side effects. Always follow the instructions on the packaging or as directed by your pharmacist.

  1. Wash and dry your hands thoroughly before applying the cream
  2. Clean and gently pat dry the affected area of skin
  3. Apply a thin layer of cream to the affected area only — do not rub in aggressively
  4. Wash your hands again after application, unless you are treating your hands
  5. Do not cover the treated area with an airtight dressing unless advised by a doctor
  6. Use once or twice daily, as directed — do not apply more frequently than recommended
  7. Do not use for more than seven days without seeking medical advice
Indication Age Group Dose Frequency
Mild eczema / dermatitis Adults & children ≥10 years Thin layer to affected area Once or twice daily
Insect bite reaction Adults & children ≥10 years Thin layer to bite site Once or twice daily
Contact dermatitis Adults & children ≥10 years Thin layer to affected area Once or twice daily
Children under 10 Under 10 years Only under medical supervision — do not use OTC

If you're also managing an allergic reaction alongside your skin symptoms, you might find our allergy and hay fever range helpful for additional symptom relief.

 

What Are the Possible Side Effects of Hydrocortisone?

 

Like all medicines, hydrocortisone cream can cause side effects, although not everyone experiences them. Most side effects are mild and related to how the cream is used — particularly if it's applied too frequently or for too long.

Common side effects:

  • Mild burning, stinging, or itching at the application site
  • Skin dryness or peeling around the treated area
  • Temporary redness immediately after application

Less common side effects (usually associated with prolonged or excessive use):

  • Skin thinning (atrophy) — particularly with long-term use or use on delicate skin areas
  • Stretch marks (striae) if used under occlusive dressings or in skin folds
  • Changes in skin pigmentation
  • Increased hair growth at the application site
  • Worsening of skin infections if applied to infected skin

Systemic side effects (affecting the whole body) are very unlikely with OTC 1% hydrocortisone used correctly and for short periods. If you notice any unexpected changes to your skin or feel unwell, stop using the cream and speak to your pharmacist or GP.

 

How Should You Store Hydrocortisone Cream?

 

Correct storage keeps the cream effective and safe to use throughout its shelf life. If you're also keeping other medicines at home, our first aid collection has everything you need for a well-stocked home medicine cabinet.

  • Store below 25°C in a cool, dry place — avoid bathrooms where heat and humidity fluctuate
  • Keep away from direct sunlight
  • Keep the tube tightly closed when not in use
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via household waste — return unused product to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy hydrocortisone cream online in the UK?

You can buy hydrocortisone cream 1% directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £12.99. It is available without a prescription for adults and children aged 10 and over for short-term use on mild inflammatory skin conditions. Simply add it to your basket and complete a brief online consultation to confirm suitability.

How does hydrocortisone cream work in the body?

Hydrocortisone is a mild corticosteroid that binds to glucocorticoid receptors within skin cells, suppressing the release of inflammatory chemicals such as prostaglandins and cytokines. This reduces the redness, swelling, and itching that characterise conditions like eczema and contact dermatitis. It works locally at the site of application rather than throughout your whole body, which is why it's considered safe for short-term OTC use.

How do I apply hydrocortisone cream step by step?

Start by washing and drying your hands, then gently clean and pat dry the affected skin area. Apply a thin layer of cream to the affected area only — avoid rubbing it in aggressively — and wash your hands again afterwards unless you're treating your hands. Use once or twice daily for up to seven days, and do not cover the area with an airtight dressing unless a doctor has advised you to.

How long does hydrocortisone cream take to work?

Most people notice a reduction in itching and redness within 24 to 48 hours of starting treatment. Full improvement is typically seen within one week of consistent, correct use. If your symptoms haven't improved after seven days, stop using the cream and speak to your GP or pharmacist, as you may need a different treatment.

What is the correct dose of hydrocortisone cream for adults?

For adults, apply a thin layer of hydrocortisone cream 1% to the affected area once or twice daily. You should use the smallest amount needed to cover the affected skin — more is not more effective and increases the risk of side effects. Do not use for longer than seven days without medical advice.

Can I use hydrocortisone cream on my face?

You should not apply hydrocortisone cream to your face unless specifically directed by a doctor or dermatologist. Facial skin is thinner and more sensitive, making it more susceptible to side effects such as skin thinning, rosacea flares, and perioral dermatitis. If you have a facial skin condition, speak to your GP about a more appropriate treatment option.

Is hydrocortisone cream safe for children?

Hydrocortisone cream 1% can be used in children aged 10 and over without a prescription for short-term treatment of mild skin conditions. For children under 10, you must seek a doctor's advice before using any topical steroid, as their skin absorbs medicines more readily and the risk of side effects is higher. Always use the smallest effective amount for the shortest possible time in children.

What are the side effects of hydrocortisone cream?

Common side effects include mild burning, stinging, or itching at the application site, and occasional skin dryness. With prolonged or excessive use, more significant effects such as skin thinning, stretch marks, or changes in pigmentation can occur. Systemic side effects are very unlikely when using the 1% OTC strength correctly and for short periods.

How do I manage side effects of hydrocortisone cream?

To minimise side effects, always apply the thinnest layer needed to cover the affected area and avoid using the cream for longer than seven days without medical advice. If you experience persistent burning, worsening redness, or signs of a skin infection such as increased warmth or pus, stop using the cream and contact your pharmacist or GP. Never apply to broken or infected skin.

Who is eligible to use hydrocortisone cream without a prescription?

Adults and children aged 10 and over can use hydrocortisone cream 1% without a prescription for short-term treatment of mild eczema, contact dermatitis, insect bite reactions, and mild allergic skin rashes. It is not suitable for people with skin infections, acne, rosacea, or those who are pregnant or breastfeeding without first seeking medical advice. If you're unsure whether it's right for you, our pharmacists are available to help — you can also explore our skin care collection for additional options.

What happens if I miss a dose of hydrocortisone cream?

If you forget to apply the cream at your usual time, apply it as soon as you remember — unless it's nearly time for your next application, in which case simply skip the missed dose. Do not apply a double amount to make up for a missed application. Consistency matters, but doubling up won't speed up your recovery and may increase the risk of side effects.

Can I use hydrocortisone cream for insect bites?

Yes — hydrocortisone cream is commonly used to relieve the itching, redness, and swelling caused by insect bites and stings. Apply a thin layer to the affected area once or twice daily until symptoms settle, which is usually within a few days. If the bite site shows signs of infection — such as spreading redness, warmth, or discharge — do not use hydrocortisone and seek medical advice instead.

What are the alternatives to hydrocortisone cream?

Alternatives depend on your specific skin condition. For mild eczema, regular use of emollients and moisturisers can help manage symptoms between flares. Antihistamine creams may help with insect bite itching, and for more severe or widespread skin conditions, your GP may prescribe a stronger corticosteroid. You can also explore our allergy and hay fever range if your skin symptoms are linked to an allergic reaction.

How long can you use hydrocortisone cream for?

Without medical supervision, you should not use hydrocortisone cream for more than seven consecutive days on any area of skin. Prolonged use increases the risk of skin thinning and other local side effects. If your condition requires longer treatment, speak to your GP, who may recommend a different approach or monitor your use of a topical steroid more closely.

What are the latest studies on hydrocortisone cream for eczema?

Topical corticosteroids including hydrocortisone remain the most widely studied and recommended first-line treatment for mild to moderate eczema flares, as supported by NICE guidelines and NHS clinical guidance. Research continues to confirm that short-term, correctly applied topical steroids are safe and effective when used as directed. Ongoing studies are exploring optimal treatment intervals and the role of proactive (maintenance) therapy in reducing flare frequency.

How Should You Use Hydrocortisone Cream?

Using hydrocortisone cream correctly is essential for getting the best results while keeping side effects to a minimum. Always apply it to clean, dry skin and use the smallest amount needed to cover the affected area — a thin layer is all that's required.

Follow these steps each time you apply the cream:

What Is the Correct Dose of Hydrocortisone Cream?

The dose depends on the area being treated and the age of the person using it. Always use the lowest effective amount for the shortest time necessary. Applying more than recommended does not improve results and increases the risk of side effects.

When Is the Best Time to Use Hydrocortisone Cream?

There is no single "best" time of day to apply hydrocortisone cream, but consistency matters. Many people find it easiest to apply after their morning shower and again in the evening before bed, which fits naturally into a skincare routine. If you're using an emollient or moisturiser alongside the cream, apply the emollient first and wait at least 30 minutes before applying hydrocortisone — this prevents the emollient from diluting the active ingredient.

Avoid applying the cream immediately before swimming or bathing, as water will wash it away before it has had time to absorb properly.

How Long Can You Use Hydrocortisone Cream For?

For OTC use without medical supervision, hydrocortisone cream should not be applied for more than seven consecutive days to any area of skin. This limit exists because prolonged use — particularly on thin or sensitive skin — can lead to skin thinning, changes in pigmentation, and other local side effects. If your symptoms haven't resolved within a week, or if they worsen at any point, stop using the cream and consult your GP or pharmacist.

If your doctor has prescribed hydrocortisone or advised a longer course, follow their specific instructions carefully. They may recommend a different application schedule or a step-down approach to avoid rebound flares.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Hydrocortisone Cream?

Most people who use hydrocortisone cream 1% for short periods experience few or no side effects. When they do occur, they are usually mild and localised to the area of application. Common side effects include:

  • Mild burning or stinging sensation immediately after application
  • Itching at the application site
  • Temporary redness or skin irritation
  • Dryness or flaking of the treated skin

These effects are generally short-lived and tend to settle as your skin adjusts to the treatment. If they persist or feel severe, stop using the cream and speak to your pharmacist.

What Are the Less Common Side Effects of Hydrocortisone Cream?

Less common side effects are more likely to occur when the cream is used for longer than recommended, applied too frequently, or used under occlusive dressings. They include:

  • Skin thinning (atrophy) — particularly with prolonged use or use on delicate areas such as the face or skin folds
  • Stretch marks (striae) at the application site
  • Changes in skin colour (hypopigmentation or hyperpigmentation)
  • Increased hair growth (hypertrichosis) at the treated area
  • Worsening of a pre-existing skin infection if applied to infected skin
  • Contact allergy to one of the cream's ingredients (rare)

These effects are largely avoidable by following the recommended dosage and duration of use. Never apply the cream to infected, broken, or ulcerated skin.

What Are the Serious Side Effects of Hydrocortisone Cream?

Serious systemic side effects are very unlikely when using hydrocortisone cream 1% correctly for short periods. However, if large areas of skin are treated, or if the cream is used under occlusive dressings for extended periods, a small amount of hydrocortisone may be absorbed into the bloodstream. In rare cases, this can affect the adrenal glands — a condition known as adrenal suppression. Signs to watch for include unusual fatigue, dizziness, or feeling unwell. Seek medical attention promptly if you experience these symptoms.

Allergic reactions to hydrocortisone itself are rare but possible. Signs of a serious allergic reaction include swelling of the face, lips, or throat, difficulty breathing, or a widespread rash. If this happens, stop using the cream immediately and call 999 or go to your nearest A&E.

What Should You Do If You Experience Side Effects?

For mild side effects such as temporary stinging or dryness, you can usually continue using the cream as directed while monitoring your symptoms. If side effects are persistent, worsening, or causing you concern, stop applying the cream and contact your pharmacist or GP for advice. You should also stop using the cream if you notice signs of a skin infection developing at the treatment site — such as increased warmth, swelling, pus, or crusting — and seek medical advice promptly.

You can report suspected side effects of any medicine in the UK directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Hydrocortisone Cream Interact With Other Medicines?

No significant drug interactions are known for topical hydrocortisone 1% used at OTC strengths. However, you should avoid applying other topical medicines — including other corticosteroids — to the same area of skin at the same time without medical guidance, as this can increase the risk of side effects. If you are taking immunosuppressant medicines or have a condition that affects your immune system, speak to your GP before using any topical steroid.

Always tell your pharmacist about all medicines you are currently taking, including over-the-counter products and supplements, before starting a new treatment.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question


Hydrocortisone treats inflammation and itching caused by eczema, dermatitis, allergic skin reactions, insect bites, and mild rashes. It doesn't cure the cause of the problem, but it calms the flare-up so your skin can heal more comfortably.


You can, but only carefully. Facial skin is thinner and absorbs steroids more easily. Use a very small amount, for no longer than 3–5 days, and avoid the eye area completely. It’s best to confirm with a pharmacist before using it on your face.


No — it only reduces inflammation. If the skin is infected (ringworm, impetigo, athlete’s foot, etc.), hydrocortisone alone can actually make symptoms worse. In those cases, a doctor may prescribe a combination treatment with an antifungal or antibiotic.


Many people feel relief from itching within minutes, while redness and swelling usually start improving within 24–48 hours. Full improvement can take a few days depending on how irritated the skin was initially.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What skin problems does Hydrocortisone Cream treat?


Hydrocortisone treats inflammation and itching caused by eczema, dermatitis, allergic skin reactions, insect bites, and mild rashes. It doesn't cure the cause of the problem, but it calms the flare-up so your skin can heal more comfortably.

Can I use Hydrocortisone on my face?


You can, but only carefully. Facial skin is thinner and absorbs steroids more easily. Use a very small amount, for no longer than 3–5 days, and avoid the eye area completely. It’s best to confirm with a pharmacist before using it on your face.

Does Hydrocortisone treat fungal or bacterial infections?


No — it only reduces inflammation. If the skin is infected (ringworm, impetigo, athlete’s foot, etc.), hydrocortisone alone can actually make symptoms worse. In those cases, a doctor may prescribe a combination treatment with an antifungal or antibiotic.

How long does it take for Hydrocortisone Cream to work?


Many people feel relief from itching within minutes, while redness and swelling usually start improving within 24–48 hours. Full improvement can take a few days depending on how irritated the skin was initially.