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Xyzal Tablets (Levocetirizine)

Xyzal Tablets (Levocetirizine)

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Xyzal tablets for Long-Lasting Allergy Relief

 

You can rely on Xyzal tablets to provide effective relief from allergic rhinitis and chronic urticaria symptoms. Each tablet contains 5mg of levocetirizine dihydrochloride, a third-generation antihistamine that works by blocking histamine H1 receptors in your body. This action helps reduce the inflammatory response that causes your allergy symptoms.

Levocetirizine is the active R-enantiomer of cetirizine, which means it provides targeted antihistamine action with reduced sedative effects compared to older antihistamine medications. You can take this medication once daily to manage your seasonal or perennial allergic rhinitis symptoms effectively.

 

How Levocetirizine Works in Your Body

 

When you're exposed to allergens like pollen, dust mites, or pet dander, your immune system releases histamine as part of the allergic response. Levocetirizine works by selectively binding to peripheral H1 histamine receptors, preventing histamine from triggering the cascade of symptoms you experience during an allergic reaction.

The medication reaches peak plasma concentrations approximately 0.9 hours after oral administration, with effects lasting up to 24 hours. This pharmacokinetic profile allows for convenient once-daily dosing whilst maintaining consistent symptom control throughout the day and night.

 

Who Benefits from This Antihistamine Treatment

 

You may find levocetirizine particularly helpful if you suffer from seasonal allergic rhinitis (hay fever) or perennial allergic rhinitis caused by indoor allergens. The medication is also licensed for treating chronic idiopathic urticaria in adults and children over 6 years of age. Many people seeking allergy and hay fever treatments choose this medication for its reliable symptom control.

This antihistamine is suitable for you if you experience:

  • Sneezing and runny nose from seasonal or perennial allergies
  • Itchy, watery eyes during allergy season
  • Nasal congestion related to allergic rhinitis
  • Chronic hives or urticaria symptoms

 

Why Choose Non-Sedating Antihistamine Therapy

 

Unlike first-generation antihistamines, levocetirizine has minimal ability to cross the blood-brain barrier, which significantly reduces the likelihood of drowsiness and cognitive impairment. This characteristic makes it suitable for daytime use when you need to maintain normal activities, work, or drive.

Clinical studies have demonstrated that levocetirizine at therapeutic doses does not significantly impair psychomotor performance or cause sedation in most patients. You can therefore continue your daily routine whilst managing your allergy symptoms effectively.

 

Clinical Suitability and Storage Requirements

 

You should store these tablets in their original packaging at room temperature, below 30°C, and protect them from moisture. The medication has been studied in clinical trials involving thousands of patients with allergic rhinitis and chronic urticaria, demonstrating both efficacy and safety when used as directed.

If you have kidney impairment, your doctor may need to adjust your dose, as levocetirizine is primarily eliminated through renal excretion. The medication is not recommended if you have severe kidney disease or if you're allergic to levocetirizine, cetirizine, or any other ingredients in the tablets.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

 

Recommended Dosage for Adults and Adolescents

You should take one 5mg tablet once daily, preferably in the evening. Swallow the tablet whole with water, and you can take it with or without food according to your preference. The timing of administration does not significantly affect the medication's absorption or effectiveness.

If you forget to take a dose, take it as soon as you remember unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. You should not take a double dose to make up for a forgotten tablet.

Administration Guidelines and Treatment Duration

You can continue taking levocetirizine for as long as you're exposed to the allergen causing your symptoms. For seasonal allergic rhinitis, this might mean taking the medication throughout the pollen season. For perennial allergies or chronic urticaria, you may need longer-term treatment as advised by your healthcare provider.

If you have mild to moderate kidney problems, your doctor may recommend taking one tablet every other day instead of daily. You should always follow the dosage instructions provided by your healthcare professional, especially if you have any underlying medical conditions that might affect how your body processes the medication.

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Understanding Potential Side Effects

Like all medicines, Xyzal tablets can have side effects, although not everyone will experience them. Most people tolerate levocetirizine well, but you should be aware of possible reactions so you can seek appropriate eye care or medical attention if needed.

The most commonly reported side effects include drowsiness, fatigue, and dry mouth, though these occur less frequently than with older antihistamines. Some people may also experience headache or mild gastrointestinal symptoms during the first few days of treatment.

Known side effects that have been reported include:

  • Drowsiness or fatigue
  • Dry mouth
  • Headache
  • Nausea
  • Dizziness
  • Abdominal pain
  • Diarrhoea
  • Weakness or asthenia
  • Nasopharyngitis
  • Weight gain
  • Increased appetite
  • Sleep disturbances

If you experience these or any other side effects, speak to your doctor or pharmacist right away. For more information about reporting side effects please see the MHRA Yellow Card Scheme.

Frequently Asked Question

Xyzal Tablets contain Levocetirizine 5mg, a powerful, non-drowsy antihistamine designed to tackle allergy symptoms quickly and effectively. Whether you are struggling with hay fever, dust allergies, or pet allergies, Xyzal offers effective relief to help treat a variety of these symptoms, such as reducing sneezing, itchy or watery eyes, a runny nose, and irritating skin reactions. 


Most people feel relief within 1 hour, with full effects lasting 24 hours.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What is Xyzal used for?

Xyzal Tablets contain Levocetirizine 5mg, a powerful, non-drowsy antihistamine designed to tackle allergy symptoms quickly and effectively. Whether you are struggling with hay fever, dust allergies, or pet allergies, Xyzal offers effective relief to help treat a variety of these symptoms, such as reducing sneezing, itchy or watery eyes, a runny nose, and irritating skin reactions. 

How long does Xyzal take to work?


Most people feel relief within 1 hour, with full effects lasting 24 hours.