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Xyzal Tablets (Levocetirizine)

Xyzal Tablets (Levocetirizine)

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  • ✔️ Relieves hay fever, hives, and allergic rhinitis symptoms effectively
  • ✔️ Provides continuous 24-hour allergy relief with once-daily dosing
  • ✔️ Low-sedating formula suitable for adults and children aged 6 and over
  • ✔️ Targets histamine receptors selectively for fast-acting symptom control
  • ✔️ Clinically recognised treatment for chronic idiopathic urticaria (hives)

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What Are Levocetirizine Tablets UK Used For?

 

If you've ever spent a spring morning sneezing uncontrollably or woken up with itchy, streaming eyes, you'll know how disruptive allergies can be. Xyzal Tablets contain levocetirizine tablets UK — a third-generation antihistamine used to relieve the symptoms of allergic rhinitis (including hay fever) and chronic idiopathic urticaria (hives) in adults and children aged 6 years and over. Available from Cured Pharmacy for just £9.99, it offers a clinically recognised option for managing allergy symptoms that interfere with daily life. You can browse our full range of allergy and hay fever treatments if you're looking for additional support alongside this product.

Levocetirizine is the active R-enantiomer of cetirizine. Because it targets histamine receptors more selectively, it is used at a lower dose — 5mg — compared to cetirizine's standard 10mg. The NHS recognises antihistamines as a first-line treatment for allergic conditions, and levocetirizine sits firmly within that category.

 

How Do Xyzal Tablets Work in the Body?

 

Allergic reactions happen when your immune system overreacts to a harmless substance — pollen, pet dander, dust mites — and releases a chemical called histamine. Histamine then binds to H1 receptors throughout the body, triggering the familiar cascade of sneezing, itching, watery eyes, and nasal congestion. Levocetirizine works by selectively blocking those H1 receptors, preventing histamine from binding and stopping the reaction before it takes hold.

  • Selectively antagonises peripheral H1 histamine receptors
  • Reduces vascular permeability, limiting swelling and redness
  • Inhibits the release of inflammatory mediators from mast cells
  • Provides symptom relief within one hour of ingestion, with effects lasting up to 24 hours

 

Who Should Use Xyzal Tablets?

 

Xyzal is suitable for a broad range of people dealing with allergy-related symptoms. It is particularly useful if you need once-daily dosing that fits around a busy schedule, or if you've found older antihistamines like chlorphenamine too sedating. That said, it's not right for everyone — always read the label and speak to a pharmacist if you're unsure.

  • Adults and children aged 6 years and over with seasonal or perennial allergic rhinitis
  • People experiencing chronic idiopathic urticaria (persistent hives without a clear cause)
  • Those with dust mite, pet, or pollen allergies seeking 24-hour symptom control
  • Individuals who have not responded adequately to other antihistamines

 

How Does Xyzal Compare to Other Antihistamines?

 

Feature Xyzal (Levocetirizine 5mg) Cetirizine 10mg
Active ingredient Levocetirizine dihydrochloride Cetirizine hydrochloride
Generation Third-generation Second-generation
Sedation profile Low-sedating Low-sedating
Dosing frequency Once daily (5mg) Once daily (10mg)
Licensed age range 6 years and over 2 years and over (syrup)

 

Is Xyzal Suitable for Long-Term Use and How Should It Be Stored?

 

For people with perennial allergic rhinitis or chronic urticaria, levocetirizine tablets UK may be used on a longer-term basis under medical guidance. Clinical evidence supports its use for up to six months in adults with chronic urticaria, though you should review ongoing use with your GP or pharmacist regularly. If you also experience eye-related allergy symptoms such as itching or redness, our eye care collection includes additional products that may complement your treatment.

Store Xyzal tablets below 25°C in a dry place, away from direct sunlight. Keep the pack out of reach and sight of children. Do not use after the expiry date printed on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Xyzal Tablets (Levocetirizine) specifications
Treatment category Antihistamine / Allergy relief
Mechanism of action Selective H1 histamine receptor antagonist
Effective for Allergic rhinitis, chronic idiopathic urticaria
Suitable for Adults and children aged 6 years and over
Active ingredient Levocetirizine dihydrochloride 5mg
Strengths 5mg
UK classification P (Pharmacy medicine)
Drug class Third-generation antihistamine
Preparation Film-coated tablet
Route of administration Oral

Specifications of Xyzal Tablets (Levocetirizine)

 

What Is Xyzal and What Is It Used For?

 

Xyzal Tablets contain levocetirizine dihydrochloride 5mg, a selective antihistamine used to relieve symptoms caused by allergic conditions. It is indicated for the symptomatic treatment of allergic rhinitis (both seasonal and perennial) and chronic idiopathic urticaria in adults and children aged 6 years and over. Symptoms it helps to manage include sneezing, nasal congestion, runny nose, itchy and watery eyes, and skin itching or hives.

 

What Do You Need to Know Before Using Xyzal?

 

Before taking Xyzal, it is important to check whether it is appropriate for you. Do not take this medicine if any of the following apply:

  • You are allergic to levocetirizine, cetirizine, hydroxyzine, or any other ingredient in the tablet
  • You have severe kidney disease (end-stage renal impairment with creatinine clearance below 10 mL/min)
  • You have a rare inherited condition called galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption
  • You are under 6 years of age

Speak to your doctor or pharmacist before taking Xyzal if you have kidney problems, as your dose may need to be adjusted. The following medicines may interact with levocetirizine:

  • Alcohol and other central nervous system (CNS) depressants — may increase sedation
  • Ritonavir (used to treat HIV) — may increase levocetirizine levels in the blood
  • Theophylline — may slightly reduce the clearance of levocetirizine

 

How Should You Use Xyzal Tablets?

 

Always take Xyzal exactly as directed on the label or as advised by your pharmacist. The tablet should be swallowed whole with water and can be taken with or without food.

  1. Check the expiry date on the packaging before use
  2. Take one 5mg tablet once daily, preferably in the evening
  3. Swallow the tablet whole with a glass of water
  4. Do not crush or chew the tablet
  5. Continue taking for the duration recommended by your pharmacist or doctor
Indication Age Group Dose Frequency
Allergic rhinitis / Urticaria Adults and adolescents (12+) 5mg (1 tablet) Once daily
Allergic rhinitis / Urticaria Children aged 6–11 years 2.5mg (half tablet) Once daily in the evening
Renal impairment (mild) Adults 5mg Once daily (consult GP)

If you are also managing symptoms such as nasal congestion or throat irritation, you may find our ear, nose and throat collection helpful for complementary products.

 

What Are the Possible Side Effects of Xyzal?

 

Like all medicines, Xyzal can cause side effects, although not everyone gets them. Most side effects are mild and resolve on their own. If you experience anything severe or unexpected, stop taking the medicine and seek medical advice.

Common side effects (may affect up to 1 in 10 people):

  • Drowsiness or somnolence
  • Headache
  • Dry mouth
  • Fatigue or tiredness

Less common side effects (may affect up to 1 in 100 people):

  • Abdominal pain or nausea
  • Dizziness
  • Palpitations
  • Skin rash or itching (paradoxical reaction)
  • Difficulty passing urine (urinary retention)

Rarely, serious hypersensitivity reactions including angioedema (swelling of the face, lips, or throat) or anaphylaxis have been reported. Seek emergency medical help immediately if this occurs.

 

How Should You Store Xyzal Tablets?

 

Correct storage helps maintain the effectiveness and safety of your medicine. If you're managing multiple health products at home, it's worth keeping a dedicated, safe storage space for all your medicines.

  • Store below 25°C in a dry place
  • Keep away from direct sunlight and moisture
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the carton
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you're looking for additional support during allergy season, our allergy and hay fever range includes a variety of products to help manage your symptoms alongside Xyzal.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Xyzal tablets online in the UK?

You can buy Xyzal 5mg levocetirizine tablets online from Cured Pharmacy, a GPhC-registered online pharmacy. Simply add the product to your basket and complete a short health questionnaire before checkout. We dispatch orders quickly so you can start managing your allergy symptoms without delay.

How does levocetirizine work in the body?

Levocetirizine selectively blocks H1 histamine receptors, preventing histamine from triggering allergy symptoms such as sneezing, itching, and a runny nose. It is the active enantiomer of cetirizine, meaning it targets receptors with greater selectivity at a lower dose. The effect typically begins within one hour and lasts for up to 24 hours.

How do I take Xyzal tablets step by step?

Take one 5mg tablet once daily, preferably in the evening, swallowed whole with a glass of water. The tablet can be taken with or without food, so it fits easily into your routine. Do not crush or chew the tablet, and never take more than the recommended dose.

What is the best time of day to take Xyzal?

The recommended time to take Xyzal is in the evening, as this aligns with the 24-hour duration of action and may reduce the impact of any drowsiness during waking hours. Taking it at the same time each day also helps maintain consistent levels of the medicine in your system. If you find evening dosing inconvenient, speak to your pharmacist about the most suitable timing for you.

Can Xyzal cause drowsiness?

Xyzal is classed as a low-sedating antihistamine, but drowsiness is still listed as a common side effect that may affect up to 1 in 10 people. You should avoid driving or operating heavy machinery until you know how the medicine affects you personally. Alcohol can increase the sedative effect, so it is best avoided while taking Xyzal.

Is Xyzal suitable for children?

Xyzal 5mg tablets are licensed for children aged 6 years and over; children aged 6–11 should take half a tablet (2.5mg) once daily in the evening. Children under 6 years should not use this formulation — speak to your GP or pharmacist for age-appropriate alternatives. Always supervise children when taking any medicine.

What happens if I miss a dose of Xyzal?

If you miss a dose, take it as soon as you remember — unless it is nearly time for your next scheduled dose, in which case skip the missed one entirely. Never take a double dose to compensate for a missed tablet, as this increases the risk of side effects. Simply continue with your normal dosing schedule the following day.

How does Xyzal compare to cetirizine or loratadine?

Levocetirizine is the active enantiomer of cetirizine and is used at half the dose (5mg versus 10mg) to achieve a comparable antihistamine effect, with some evidence suggesting a slightly higher receptor binding affinity. Loratadine is another low-sedating antihistamine but works via a slightly different pharmacological profile and may suit people who experience side effects with levocetirizine. All three are recognised first-line options for allergic rhinitis by the NHS.

Who should not take Xyzal tablets?

Xyzal is not suitable for people with severe kidney disease (end-stage renal impairment), those allergic to levocetirizine or cetirizine, or children under 6 years of age. People with galactose intolerance or glucose-galactose malabsorption should also avoid this product due to its excipients. Always check with your pharmacist if you have an existing medical condition before starting any new medicine.

Can I take Xyzal if I am pregnant or breastfeeding?

The safety of levocetirizine during pregnancy and breastfeeding has not been fully established, and it is generally not recommended unless the potential benefit outweighs the risk as assessed by a doctor. Levocetirizine is known to pass into breast milk, so breastfeeding mothers should seek medical advice before use. Your GP or midwife can advise on the safest allergy management options during pregnancy.

How long can you take Xyzal for?

Xyzal can be used short-term for seasonal hay fever or longer-term for perennial allergic rhinitis and chronic idiopathic urticaria, under medical guidance. Clinical studies have supported its use for up to six months in adults with chronic urticaria. If your symptoms have not improved after four weeks of use, consult your GP to review your treatment plan.

What are the alternatives to Xyzal for hay fever?

Common alternatives include cetirizine, loratadine, and fexofenadine — all of which are low-sedating antihistamines available over the counter in the UK. Nasal corticosteroid sprays such as beclometasone are also recommended for moderate-to-severe hay fever symptoms. You can explore a range of options in our allergy and hay fever collection.

Can Xyzal interact with other medicines I am taking?

Xyzal may interact with CNS depressants (including sedatives and sleeping tablets), alcohol, ritonavir, and theophylline — all of which can alter the medicine's effect or increase side effects. Always inform your pharmacist of all medicines, supplements, and herbal remedies you are currently taking before starting Xyzal. If you take multiple medicines regularly, a medicines use review with your pharmacist is a good idea.

What are the latest studies on levocetirizine for allergy treatment?

Published clinical literature supports levocetirizine as an effective and well-tolerated antihistamine for both allergic rhinitis and chronic urticaria, with studies demonstrating significant symptom reduction compared to placebo. Research has also explored its use in combination with montelukast for more complex allergic presentations, though this is typically a prescription-only approach. Speak to your GP if your symptoms are not adequately controlled with standard antihistamine therapy alone.

Does Xyzal help with itchy eyes caused by allergies?

Yes — levocetirizine can help relieve itchy, watery eyes associated with allergic rhinitis by blocking the histamine response that causes ocular symptoms. For more targeted eye allergy relief, antihistamine eye drops may be used alongside an oral antihistamine. Browse our eye care collection for additional options to complement your treatment.

How Should You Use Xyzal Tablets?

Xyzal tablets are straightforward to use, but following the correct steps ensures you get the most from your treatment. Always read the patient information leaflet supplied with your pack before starting, and speak to your pharmacist if you have any questions about how to take this medicine.

Follow these steps each time you take Xyzal:

What Is the Correct Dose of Xyzal?

The dose of Xyzal varies depending on your age and the condition being treated. Always follow the dosage instructions on the label or as directed by your pharmacist or GP. Do not exceed the recommended dose.

When Is the Best Time to Use Xyzal?

The evening is generally the recommended time to take Xyzal, as this maximises the 24-hour coverage of the medicine while minimising any daytime drowsiness. Taking it at a consistent time each day — whether morning or evening — helps maintain steady levels of levocetirizine in your bloodstream and ensures continuous symptom relief. If you find that drowsiness is not an issue for you, morning dosing is also acceptable.

Try to link your dose to a daily habit, such as brushing your teeth or having your evening meal, so you are less likely to forget it.

How Long Can You Use Xyzal For?

For seasonal allergic rhinitis such as hay fever, Xyzal is typically used for the duration of the pollen season — usually a few weeks to a few months. For perennial allergic rhinitis or chronic idiopathic urticaria, longer-term use may be appropriate under medical supervision, with clinical evidence supporting use for up to six months in adults. If your symptoms persist or worsen after four weeks of treatment, you should consult your GP to reassess your management plan.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Xyzal?

Most people tolerate Xyzal well, but like all medicines, it can cause side effects in some individuals. Common side effects are generally mild and tend to resolve without any specific treatment. If they persist or become bothersome, speak to your pharmacist.

  • Drowsiness or somnolence
  • Headache
  • Dry mouth
  • Fatigue or tiredness
  • Nasopharyngitis (inflammation of the nose and throat)

What Are the Less Common Side Effects of Xyzal?

Less common side effects occur in fewer people but are still worth being aware of. If you notice any of the following, mention them to your pharmacist or GP at your next opportunity.

  • Nausea or abdominal pain
  • Dizziness or vertigo
  • Palpitations (awareness of your heartbeat)
  • Skin rash or itching (paradoxical reaction)
  • Difficulty passing urine (urinary retention)
  • Weight gain with prolonged use
  • Aggression or agitation (particularly in children)

What Are the Serious Side Effects of Xyzal?

Serious side effects are rare but require immediate medical attention. Hypersensitivity reactions, including anaphylaxis and angioedema (swelling of the face, lips, tongue, or throat), have been reported in very rare cases. If you experience sudden swelling, difficulty breathing, or a severe skin reaction after taking Xyzal, call 999 or go to your nearest A&E immediately. Do not take another dose.

Seizures have also been reported very rarely. If you or someone in your care experiences a seizure after taking levocetirizine, seek emergency medical help straight away.

What Should You Do If You Experience Side Effects?

For mild side effects such as drowsiness or a dry mouth, simple measures — staying hydrated, taking the tablet in the evening, and avoiding alcohol — can help reduce discomfort. If side effects are affecting your quality of life or do not improve within a few days, speak to your pharmacist, who may suggest an alternative antihistamine. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Never stop taking a prescribed medicine without speaking to your doctor first, even if you experience side effects.

Can Xyzal Interact With Other Medicines?

Xyzal can interact with certain medicines, which may increase the risk of side effects or alter how the medicine works. The most clinically significant interactions include CNS depressants (such as sedatives, sleeping tablets, and anxiolytics), which can enhance drowsiness when taken alongside levocetirizine. Ritonavir (used in HIV treatment) may increase levocetirizine plasma concentrations, and theophylline has been shown to slightly reduce levocetirizine clearance. Always tell your pharmacist about all medicines, supplements, and herbal remedies you are taking before starting Xyzal.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question

Xyzal Tablets contain Levocetirizine 5mg, a powerful, non-drowsy antihistamine designed to tackle allergy symptoms quickly and effectively. Whether you are struggling with hay fever, dust allergies, or pet allergies, Xyzal offers effective relief to help treat a variety of these symptoms, such as reducing sneezing, itchy or watery eyes, a runny nose, and irritating skin reactions. 


Most people feel relief within 1 hour, with full effects lasting 24 hours.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What is Xyzal used for?

Xyzal Tablets contain Levocetirizine 5mg, a powerful, non-drowsy antihistamine designed to tackle allergy symptoms quickly and effectively. Whether you are struggling with hay fever, dust allergies, or pet allergies, Xyzal offers effective relief to help treat a variety of these symptoms, such as reducing sneezing, itchy or watery eyes, a runny nose, and irritating skin reactions. 

How long does Xyzal take to work?


Most people feel relief within 1 hour, with full effects lasting 24 hours.