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Nasonex (Mometasone) Nasal Spray 50mcg (140 Dose)

Nasonex (Mometasone) Nasal Spray 50mcg (140 Dose)

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What Is Mometasone Nasal Spray and How Does It Help?

 

If you've ever struggled through hay fever season with a constantly blocked nose, relentless sneezing, and that all-too-familiar itchy feeling, you'll know how much it can disrupt daily life. Nasonex Mometasone Nasal Spray 50mcg (140 Dose) is a corticosteroid nasal spray designed to tackle exactly that. It contains mometasone furoate, an anti-inflammatory medicine that works directly inside the nasal passages to reduce swelling, congestion, and irritation caused by allergic rhinitis. You can explore a full range of allergy and hay fever treatments at Cured Pharmacy if you're looking for additional support alongside your nasal spray.

Nasonex is one of the most widely recognised nasal sprays for allergic rhinitis in the UK. Each actuation delivers exactly 50mcg of mometasone furoate, and the 140-dose bottle provides a generous supply — enough for a full treatment course for most adults. It is available over the counter for adults aged 18 and over, making it straightforward to access without needing a GP appointment every time.

 

How Does Nasonex Mometasone Nasal Spray Work in the Body?

 

Mometasone furoate belongs to the corticosteroid class of medicines. When sprayed into the nose, it acts locally on the nasal mucosa — the lining of your nasal passages — rather than being absorbed significantly into the bloodstream. This local action is what makes it both effective and well-tolerated for most people.

  • It inhibits the release of inflammatory mediators including histamine, prostaglandins, and leukotrienes.
  • It reduces swelling of the nasal lining, which directly relieves congestion.
  • It decreases mucus production, helping with a runny nose and post-nasal drip.
  • It suppresses the immune response in the nasal tissue that triggers sneezing and itching.

Because it works at the site of inflammation rather than systemically, the risk of the side effects associated with oral steroids is considerably lower. Full symptom relief may take a few days of consistent use, so it's worth starting treatment before your allergy season begins if possible.

 

Who Is Nasonex Nasal Spray Suitable For?

 

Nasonex is suitable for adults aged 18 and over who experience nasal symptoms related to allergic conditions. It is used for both seasonal allergic rhinitis — commonly triggered by pollen — and perennial allergic rhinitis, which occurs year-round and is often caused by dust mites, pet dander, or mould. It is also used under medical supervision for the treatment of nasal polyps.

  • Adults aged 18 and over with seasonal hay fever symptoms
  • Adults with perennial (year-round) allergic rhinitis
  • People who have not found adequate relief from antihistamines alone
  • Those seeking a non-drowsy alternative to oral allergy medicines

 

How Does Nasonex Compare to Other Nasal Sprays?

 

Feature Nasonex (Mometasone 50mcg) Beconase (Beclometasone 50mcg)
Active ingredient Mometasone furoate Beclometasone dipropionate
Doses per bottle 140 doses 200 doses
Suitable for nasal polyps Yes (under medical supervision) No (not licensed for polyps OTC)
Systemic bioavailability Less than 1% Approximately 44%

 

Is Nasonex Safe to Store and Use Long-Term?

 

Mometasone nasal spray has a well-established safety profile when used as directed. Store the bottle below 25°C, away from direct sunlight, and keep it out of reach of children. Do not freeze it. Once opened, use within the period stated on the packaging. If you're managing multiple allergy-related symptoms — for example, itchy or watery eyes alongside nasal congestion — you might also find it helpful to browse eye care products at Cured Pharmacy for complementary relief.

For long-term use beyond three months, it's advisable to check in with your GP or pharmacist. Prolonged use of any corticosteroid nasal spray warrants periodic review to ensure it remains appropriate for your needs.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nasonex (Mometasone) Nasal Spray 50mcg (140 Dose) specifications
Treatment category Allergic rhinitis, nasal polyps
Mechanism of action Corticosteroid — reduces nasal inflammation by inhibiting inflammatory mediator release
Effective for Seasonal and perennial allergic rhinitis; nasal polyps (under medical supervision)
Suitable for Adults aged 18 and over
Active ingredient Mometasone furoate 50mcg per actuation
Pack size 140 doses
Strength 50mcg per spray
UK classification Pharmacy (P) medicine
Drug class Corticosteroid (intranasal)
Preparation Aqueous nasal suspension
Route of administration Intranasal

Specifications of Nasonex (Mometasone) Nasal Spray 50mcg (140 Dose)

 

What Is Nasonex Mometasone Nasal Spray and What Is It Used For?

 

Nasonex Mometasone Nasal Spray 50mcg is a corticosteroid nasal spray used to relieve the symptoms of allergic rhinitis in adults aged 18 and over. Allergic rhinitis is an inflammatory condition of the nasal passages triggered by allergens such as pollen, house dust mites, animal dander, or mould spores. Symptoms typically include nasal congestion, sneezing, a runny nose, and nasal itching. The NHS recognises intranasal corticosteroids as a first-line treatment for moderate-to-severe allergic rhinitis because they address the underlying inflammation rather than simply masking symptoms.

Each spray delivers 50mcg of mometasone furoate directly to the nasal mucosa. The 140-dose bottle provides a substantial supply for ongoing treatment. It is also used under medical supervision for the management of nasal polyps — benign growths inside the nasal passages that can cause significant obstruction and loss of smell.

 

What Do You Need to Know Before Using Nasonex Nasal Spray?

 

Before using this spray, it's important to check whether it is appropriate for you. Do not use Nasonex if any of the following apply:

  • You are allergic to mometasone furoate or any other ingredient in the spray
  • You have an active nasal or sinus infection that has not been treated
  • You have had recent nasal surgery or a nasal injury — wait until healing is complete
  • You are under 18 years of age (OTC use is not recommended)
  • You are pregnant or breastfeeding — seek medical advice first
  • You have tuberculosis (active or latent) or any other untreated systemic infection

The following medicines may interact with mometasone furoate and should be discussed with your pharmacist or GP:

  • Ketoconazole and other strong CYP3A4 inhibitors (e.g. ritonavir, itraconazole) — may increase mometasone levels in the blood
  • Other corticosteroids (oral, inhaled, or topical) — combined use increases the risk of systemic steroid effects

 

How Should You Use Nasonex Mometasone Nasal Spray Correctly?

 

Using your nasal spray correctly makes a real difference to how well it works. Follow these steps each time:

  1. Shake the bottle gently before use.
  2. Blow your nose gently to clear the nasal passages.
  3. Remove the dust cap and prime the pump if using for the first time (press down 10 times until a fine mist appears).
  4. Tilt your head slightly forward — do not tilt it back.
  5. Close one nostril with a finger and insert the nozzle into the other nostril, angling it slightly away from the nasal septum.
  6. Press the pump down firmly once while breathing in gently through your nose.
  7. Breathe out through your mouth.
  8. Repeat in the other nostril.
  9. Wipe the nozzle clean and replace the dust cap.
Indication Age Group Dose Frequency
Seasonal allergic rhinitis Adults 18+ 2 sprays per nostril (200mcg total) Once daily
Perennial allergic rhinitis Adults 18+ 2 sprays per nostril (200mcg total) Once daily; reduce to 1 spray per nostril when controlled
Nasal polyps Adults 18+ (medical supervision) 2 sprays per nostril (200mcg total) Once or twice daily as directed by a doctor

 

What Are the Possible Side Effects of Nasonex Nasal Spray?

 

Like all medicines, Nasonex can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the nose and throat. If you're also managing other allergy-related conditions, you may find it useful to browse our ear, nose and throat range for additional support.

Common side effects (may affect up to 1 in 10 people):

  • Nosebleeds (epistaxis)
  • Nasal irritation or burning sensation
  • Headache
  • Pharyngitis (sore throat)

Less common side effects (may affect up to 1 in 100 people):

  • Nasal ulceration
  • Nasal septal perforation (rare, with prolonged use)
  • Disturbance of taste or smell
  • Increased intraocular pressure (eye pressure) — relevant if you have glaucoma
  • Hypersensitivity reactions including rash, urticaria, or angioedema

Stop using the spray and seek medical advice promptly if you develop a severe allergic reaction, experience significant nosebleeds, or notice any changes to your vision.

 

How Should You Store Nasonex Mometasone Nasal Spray?

 

Correct storage helps maintain the quality and effectiveness of your nasal spray throughout its shelf life. If you're looking for other medicines that need careful storage, our cold and flu range also includes products with specific storage requirements.

  • Store below 25°C in a cool, dry place
  • Do not freeze the bottle
  • Keep away from direct sunlight and heat sources
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the label
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nasonex nasal spray online in the UK?

You can buy Nasonex Mometasone Nasal Spray 50mcg (140 Dose) directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available as a Pharmacy (P) medicine for adults aged 18 and over without a prescription. Simply add it to your basket and complete a short online consultation to confirm suitability. You can also browse our full allergy and hay fever range for complementary products.

How does mometasone nasal spray work in the body?

Mometasone furoate is a corticosteroid that acts locally on the nasal mucosa to reduce inflammation. It works by inhibiting the release of inflammatory chemicals — including histamine, prostaglandins, and leukotrienes — that cause nasal swelling, congestion, and irritation. Because it acts locally rather than being absorbed significantly into the bloodstream, it has a low risk of systemic side effects compared to oral steroids. Most people notice a meaningful improvement in symptoms within two to three days of starting treatment.

How do I use Nasonex nasal spray step by step?

Shake the bottle gently, blow your nose, and tilt your head slightly forward. Insert the nozzle into one nostril while closing the other, then press the pump once while breathing in gently through your nose. Repeat in the other nostril, then wipe the nozzle and replace the cap. Avoid blowing your nose immediately after use, and try not to angle the nozzle towards the nasal septum (the central dividing wall) to reduce the risk of irritation or nosebleeds.

What is the correct dose of Nasonex 50mcg for adults?

The standard adult dose for allergic rhinitis is two sprays into each nostril once daily, giving a total daily dose of 200mcg of mometasone furoate. Once your symptoms are well controlled, your pharmacist or GP may advise reducing to one spray per nostril once daily as a maintenance dose. Do not exceed two sprays per nostril per day unless specifically directed by a doctor.

When is the best time to use Nasonex nasal spray each day?

There is no strict requirement to use Nasonex at a specific time of day, but using it at the same time each day helps you build a consistent routine and maintain steady levels of the medicine in your nasal tissue. Many people find it easiest to use it in the morning as part of their daily routine. If you suffer from hay fever, starting treatment a couple of weeks before your typical pollen season begins can help prevent symptoms from taking hold.

What are the common side effects of Nasonex mometasone nasal spray?

The most commonly reported side effects include nosebleeds, nasal irritation or a burning sensation, headache, and a sore throat. These are generally mild and often improve after the first week or two of use. If nosebleeds are frequent or heavy, stop using the spray and speak to your pharmacist or GP. Serious side effects such as nasal septal perforation are rare but have been reported with prolonged use of intranasal corticosteroids.

How do I manage side effects of Nasonex nasal spray?

To reduce the risk of nosebleeds and nasal irritation, make sure you are directing the spray away from the nasal septum and not sniffing forcefully after each dose. Keeping the nasal passages moisturised with a saline rinse before use can also help. If you experience persistent irritation, a short break from the spray and a review with your pharmacist is advisable. Never exceed the recommended dose, as this increases the risk of side effects without improving efficacy.

Who should not use Nasonex mometasone nasal spray?

Nasonex is not suitable for people with an active nasal or sinus infection, those who have recently had nasal surgery or a nasal injury, or anyone with a known allergy to mometasone furoate. It should not be used by children under 18 years without medical supervision. If you are pregnant, breastfeeding, or have a history of glaucoma, cataracts, or tuberculosis, speak to your GP before using this spray.

What happens if I miss a dose of Nasonex?

If you forget to use your spray, take the missed dose as soon as you remember — unless it is nearly time for your next scheduled dose, in which case simply skip the missed one and carry on as normal. Never use a double dose to compensate for a missed one. Consistency is important with corticosteroid nasal sprays, as they work best when used regularly rather than on an as-needed basis.

How long can you use Nasonex nasal spray for?

For seasonal allergic rhinitis, Nasonex is typically used throughout the allergy season — which for pollen sufferers in the UK usually runs from late March to September. For perennial rhinitis, longer-term use may be appropriate, but it is advisable to review your treatment with a GP or pharmacist every three months. Prolonged use without review is not recommended, as it allows your clinician to check for any signs of nasal mucosal changes or systemic effects.

Is Nasonex nasal spray non-drowsy?

Yes. Because mometasone furoate acts locally in the nasal passages and has very low systemic absorption (less than 1%), it does not cause the drowsiness associated with older antihistamine tablets such as chlorphenamine. This makes it a particularly useful option for people who need to drive, operate machinery, or remain fully alert during the day. It can also be used alongside non-drowsy antihistamines for additional symptom control during peak allergy season.

Can I use Nasonex nasal spray during pregnancy?

If you are pregnant or planning to become pregnant, you should speak to your GP or midwife before using Nasonex. While the systemic absorption of mometasone from a nasal spray is very low, the use of corticosteroids during pregnancy should always be discussed with a healthcare professional to weigh up the benefits and any potential risks. Do not self-medicate with this product during pregnancy without medical advice.

What are the alternatives to Nasonex for hay fever?

Other intranasal corticosteroid sprays available in the UK include beclometasone (Beconase), fluticasone (Flixonase), and budesonide (Rhinocort). Non-steroidal options include sodium cromoglicate nasal spray and antihistamine nasal sprays such as azelastine. Oral antihistamines — both drowsy and non-drowsy — are also widely used. The right choice depends on your symptom pattern, medical history, and personal preference; your pharmacist can help you decide. You can also explore our ear, nose and throat range for further options.

Does Nasonex nasal spray help with nasal polyps?

Yes, mometasone nasal spray is licensed for the treatment of nasal polyps in adults, but this indication requires medical supervision rather than self-treatment. Nasal polyps are benign growths in the nasal passages that can cause significant congestion, loss of smell, and breathing difficulties. If you suspect you have nasal polyps, see your GP for a proper diagnosis before starting treatment, as the dose and duration used for polyps differs from that used for allergic rhinitis.

What are the latest studies on mometasone nasal spray for allergic rhinitis?

Mometasone furoate nasal spray has been extensively studied and is consistently recommended as a first-line treatment for moderate-to-severe allergic rhinitis in clinical guidelines, including those from NICE and the British Society for Allergy and Clinical Immunology. Research continues to confirm its efficacy in reducing nasal symptoms with a favourable safety profile due to its low systemic bioavailability. It remains one of the most studied intranasal corticosteroids available in the UK, with decades of real-world evidence supporting its use.

How Should You Use Nasonex Mometasone Nasal Spray?

Using your nasal spray correctly is essential for getting the most out of your treatment. Before your first use, prime the pump by pressing it down 10 times until a fine mist appears — this ensures each subsequent dose is accurately delivered. If you haven't used the spray for more than 14 days, re-prime it with two presses before use.

Follow these steps each time you use Nasonex:

What Is the Correct Dose of Nasonex Mometasone Nasal Spray?

The dose you need depends on the condition being treated and how well your symptoms are controlled. Always follow the instructions provided with the product or as directed by your pharmacist or GP. The table below summarises the recommended doses for adults.

When Is the Best Time to Use Nasonex Nasal Spray?

Nasonex can be used at any time of day, but using it at the same time each day helps you maintain a consistent routine and ensures the medicine is working continuously in your nasal tissue. Many people find the morning most convenient — particularly hay fever sufferers, as pollen counts tend to rise during the day.

If you know your allergy season is approaching, starting treatment two weeks before your symptoms typically begin can help prevent inflammation from building up in the first place. This proactive approach is often more effective than waiting until symptoms are already severe.

How Long Can You Use Nasonex Mometasone Nasal Spray For?

For seasonal allergic rhinitis, use Nasonex throughout your allergy season — typically from late March to September for pollen-related hay fever in the UK. For perennial rhinitis triggered by year-round allergens such as dust mites or pet dander, longer-term use may be appropriate under medical guidance.

It is advisable to review your treatment with a GP or pharmacist every three months if you are using the spray continuously. This allows your clinician to check the nasal passages for any signs of mucosal changes and confirm that the treatment remains the right choice for you.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Nasonex Nasal Spray?

Most people tolerate Nasonex well, but like all medicines it can cause side effects in some users. The most frequently reported side effects are localised to the nose and throat and are generally mild in nature. They often improve after the first week or two of treatment as your nasal passages adjust to the spray.

  • Nosebleeds (epistaxis) — the most commonly reported side effect
  • Nasal irritation, burning, or stinging sensation
  • Headache
  • Pharyngitis (sore or irritated throat)
  • Nasal dryness

What Are the Less Common Side Effects of Nasonex Mometasone Spray?

Less common side effects occur in fewer than 1 in 100 users. If you notice any of the following, speak to your pharmacist or GP, particularly if they persist or worsen over time.

  • Nasal ulceration
  • Disturbance of taste or smell
  • Nasal septal perforation (a hole in the nasal septum) — rare, associated with prolonged use
  • Increased intraocular pressure — relevant if you have a history of glaucoma or cataracts
  • Skin reactions such as rash or urticaria
  • Wheezing or shortness of breath

What Are the Serious Side Effects of Nasonex Nasal Spray?

Serious side effects are rare but require prompt medical attention. Anaphylaxis (a severe allergic reaction) has been reported very rarely with mometasone nasal spray. Signs include sudden swelling of the face, lips, tongue, or throat, difficulty breathing, and a rapid drop in blood pressure. If you experience any of these symptoms, stop using the spray immediately and call 999 or go to your nearest A&E.

Prolonged use of any intranasal corticosteroid carries a small risk of systemic effects, including adrenal suppression, particularly if used alongside other corticosteroid medicines. This is why regular review with a healthcare professional is important for long-term users.

What Should You Do If You Experience Side Effects of Nasonex?

For mild side effects such as nasal irritation or occasional nosebleeds, try adjusting your technique — ensure you are directing the spray away from the nasal septum and not inhaling too forcefully. Using a saline nasal rinse before your dose can help keep the nasal passages moist and reduce irritation. If nosebleeds are frequent or heavy, stop using the spray and seek advice from your pharmacist or GP before continuing.

You can report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve the safety monitoring of medicines for everyone.

Can Nasonex Nasal Spray Interact With Other Medicines?

Mometasone furoate has a low potential for drug interactions due to its minimal systemic absorption. However, strong inhibitors of the CYP3A4 enzyme — such as ketoconazole, ritonavir, and itraconazole — can increase the amount of mometasone that enters the bloodstream, potentially raising the risk of systemic corticosteroid effects. If you are taking any of these medicines, speak to your pharmacist before using Nasonex. Concurrent use of other corticosteroids (oral, inhaled, or topical) should also be discussed with a healthcare professional, as combined use increases the overall steroid burden on the body.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question


Nasonex is used to treat allergic rhinitis (hay fever), non-allergic rhinitis, and nasal polyps. It helps reduce inflammation, congestion, sneezing, and runny nose.


Some people feel relief within 12–24 hours, but full effectiveness may take a few days of consistent use.


Yes. It is designed for daily use as prescribed. Continuous use helps maintain symptom control.


When used at the recommended dose, Nasonex is generally safe long-term. However, regular medical reviews are advised if used for extended periods.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What is Nasonex Nasal Spray used for?


Nasonex is used to treat allergic rhinitis (hay fever), non-allergic rhinitis, and nasal polyps. It helps reduce inflammation, congestion, sneezing, and runny nose.

How long does Nasonex take to work?


Some people feel relief within 12–24 hours, but full effectiveness may take a few days of consistent use.

Can I use Nasonex every day?


Yes. It is designed for daily use as prescribed. Continuous use helps maintain symptom control.

Is Nasonex safe for long-term use?


When used at the recommended dose, Nasonex is generally safe long-term. However, regular medical reviews are advised if used for extended periods.