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Fexofenadine 180mg & 120mg Tablets

Fexofenadine 180mg & 120mg Tablets

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  • ✔️ Relieves hay fever sneezing, itching and runny nose effectively
  • ✔️ Non-drowsy formula suitable for daytime use
  • ✔️ Available in 120mg for rhinitis and 180mg for hives
  • ✔️ Starts working within 1–3 hours of taking a tablet
  • ✔️ Suitable for adults and children aged 12 and over

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What Are Fexofenadine Tablets and How Do They Help?

 

Fexofenadine tablets are a second-generation, non-sedating antihistamine used to relieve the symptoms of seasonal allergic rhinitis — commonly known as hay fever — and chronic idiopathic urticaria (hives). Available in two strengths, 120mg and 180mg, they offer targeted allergy relief without the heavy drowsiness associated with older antihistamines like chlorphenamine. If you've ever tried a first-generation antihistamine and found yourself struggling to stay awake at your desk, you'll understand why that matters. You can explore the full range of allergy and hay fever treatments available at Cured Pharmacy.

Fexofenadine hydrochloride is the active ingredient. It's been widely used across the UK and Europe for decades, with a well-established safety profile backed by clinical evidence. Each tablet is taken orally, once daily, making it a straightforward option for people managing seasonal or year-round allergy symptoms.

 

How Do Fexofenadine Tablets Work in the Body?

 

Histamine is the chemical your immune system releases when it encounters an allergen — pollen, dust mites, pet dander, and so on. It's histamine that causes the sneezing, itching, watery eyes, and runny nose you associate with allergies. Fexofenadine works by selectively blocking peripheral H1 histamine receptors, preventing histamine from binding and triggering those symptoms.

  • Selectively targets H1 receptors in peripheral tissues
  • Does not significantly cross the blood-brain barrier, reducing sedation risk
  • Reaches peak plasma concentration within 1–3 hours of ingestion
  • Provides symptom relief lasting up to 24 hours with a single dose

Because it doesn't readily enter the central nervous system, fexofenadine is classified as a non-sedating antihistamine — a meaningful distinction if you drive, operate machinery, or simply need to stay sharp throughout the day.

 

Who Should Use Fexofenadine Tablets?

 

Fexofenadine is suitable for adults and children aged 12 and over. It's particularly well-suited to people who need reliable, all-day allergy relief without sedation. That said, it isn't appropriate for everyone, so it's worth checking the full list of contraindications before you start.

  • Adults and adolescents (12+) with seasonal allergic rhinitis
  • Adults with chronic idiopathic urticaria (persistent hives)
  • People who need to remain alert at work or while driving
  • Those who have experienced excessive drowsiness with older antihistamines

It is not recommended for children under 12, and caution is advised in people with severe kidney impairment. Always read the patient information leaflet before use.

 

How Do Fexofenadine Tablets Compare to Other Antihistamines?

 

Feature Fexofenadine Tablets Cetirizine 10mg
Generation Second-generation (non-sedating) Second-generation (low sedation)
Dosing frequency Once daily Once daily
Sedation risk Very low Low (slightly higher than fexofenadine)
Available strengths 120mg, 180mg 10mg
Suitable for urticaria Yes (180mg) Yes

 

How Should You Store Fexofenadine Tablets?

 

Store your fexofenadine tablets below 25°C in a dry place, away from direct sunlight. Keep them out of reach and sight of children. Do not use after the expiry date printed on the pack. If you're also managing skin-related allergy symptoms, you might find our skin care range a useful complement to your antihistamine treatment.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Fexofenadine Tablets 180mg & 120mg specifications
Treatment category Allergic rhinitis, chronic idiopathic urticaria
Mechanism of action Selective peripheral H1 histamine receptor antagonist
Effective for Hay fever symptoms, hives, itching, sneezing, runny nose
Suitable for Adults and children aged 12 and over
Active ingredient Fexofenadine hydrochloride
Strengths 120mg, 180mg
UK classification P (Pharmacy medicine)
Drug class Second-generation antihistamine
Preparation Film-coated tablet
Route of administration Oral

Specifications of Fexofenadine Tablets 180mg & 120mg

 

What Is Fexofenadine and What Is It Used For?

 

Fexofenadine hydrochloride belongs to a class of medicines called antihistamines. It is used to relieve the symptoms of seasonal allergic rhinitis — including sneezing, itchy and watery eyes, runny or blocked nose, and itchy throat — in adults and children aged 12 and over. The 180mg strength is also indicated for the relief of symptoms associated with chronic idiopathic urticaria, a condition characterised by persistent, itchy hives on the skin.

Unlike first-generation antihistamines, fexofenadine does not cause significant sedation in most people, making it a practical choice for daily use. It is available over the counter in the UK as a Pharmacy (P) medicine.

 

What Do You Need to Know Before Using Fexofenadine?

 

Before taking fexofenadine, it's important to check whether it is appropriate for you. Do not take fexofenadine if any of the following apply:

  • You are allergic to fexofenadine hydrochloride or any other ingredient in the tablet
  • You are under 12 years of age
  • You are pregnant or breastfeeding (seek medical advice first)
  • You have severe kidney (renal) impairment — dose adjustment may be needed

The following medicines may interact with fexofenadine. Always tell your pharmacist or doctor what you are taking:

  • Antacids containing aluminium or magnesium hydroxide — take fexofenadine at least 2 hours before or after these
  • Erythromycin or ketoconazole — may increase fexofenadine plasma levels
  • Rifampicin — may reduce the effectiveness of fexofenadine

Avoid drinking large quantities of grapefruit, orange, or apple juice around the time of taking your tablet, as these can reduce how much fexofenadine your body absorbs.

 

How Should You Use Fexofenadine Tablets?

 

Always take fexofenadine exactly as described in the patient information leaflet or as directed by your pharmacist. Swallow the tablet whole with water — not fruit juice. The following steps outline correct use:

  1. Check the correct strength for your condition (120mg for hay fever; 180mg for urticaria)
  2. Take one tablet once daily, at approximately the same time each day
  3. Swallow with a full glass of water
  4. Do not take with grapefruit, orange, or apple juice
  5. If you take antacids, leave at least 2 hours between the antacid and fexofenadine
Indication Age Group Dose Frequency
Seasonal allergic rhinitis Adults & children 12+ 120mg Once daily
Chronic idiopathic urticaria Adults & children 12+ 180mg Once daily
Renal impairment (mild–moderate) Adults 120mg Once daily (seek advice)

If you're also experiencing nasal congestion or eye symptoms alongside your allergy, you may find it helpful to browse our ear, nose and throat treatments for additional support.

 

What Are the Possible Side Effects of Fexofenadine?

 

Like all medicines, fexofenadine can cause side effects, although not everyone gets them. Most side effects are mild and resolve on their own.

Common side effects (may affect up to 1 in 10 people):

  • Headache
  • Dizziness
  • Nausea
  • Drowsiness (less common than with older antihistamines)
  • Fatigue

Less common side effects (may affect up to 1 in 100 people):

  • Dry mouth
  • Insomnia
  • Nervousness
  • Palpitations or rapid heartbeat
  • Skin rash or itching (paradoxical reaction)

Stop taking fexofenadine and seek immediate medical attention if you experience signs of a serious allergic reaction, such as swelling of the face, lips, tongue or throat, difficulty breathing, or a severe skin rash. These reactions are rare but require urgent care.

 

How Should You Store Fexofenadine Tablets?

 

Correct storage helps maintain the quality and effectiveness of your tablets. Follow these guidelines:

  • Store below 25°C
  • Keep in a dry place, away from direct sunlight and moisture
  • Keep the tablets in their original packaging
  • Store out of reach and sight of children
  • Do not use after the expiry date printed on the carton
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you're managing multiple allergy-related conditions, our eye care collection includes drops and treatments for allergic conjunctivitis that can be used alongside fexofenadine.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy fexofenadine tablets online in the UK?

You can buy fexofenadine tablets online in the UK from Cured Pharmacy, a GPhC-registered online pharmacy. Both 120mg and 180mg strengths are available without a prescription for adults and children aged 12 and over. Simply browse our allergy and hay fever collection and add your preferred strength to your basket.

How do fexofenadine tablets work in the body?

Fexofenadine selectively blocks peripheral H1 histamine receptors, stopping histamine from triggering allergy symptoms such as sneezing, itching, and a runny nose. Because it doesn't readily cross the blood-brain barrier, it causes far less drowsiness than older antihistamines. It typically reaches peak effect within 1–3 hours of taking a tablet.

What is the correct dose of fexofenadine for hay fever?

For seasonal allergic rhinitis (hay fever), the recommended dose is one 120mg tablet taken once daily with water. For chronic idiopathic urticaria, the dose is one 180mg tablet once daily. Do not exceed the stated dose without speaking to a pharmacist or GP first.

What is the best time of day to take fexofenadine?

There is no strict requirement to take fexofenadine at a specific time of day, but taking it at the same time each day helps maintain consistent blood levels. Many people find taking it in the morning works well, particularly during hay fever season when pollen counts tend to peak later in the day. Consistency is more important than the exact hour.

Can I take fexofenadine every day long-term?

Yes, fexofenadine can be taken daily throughout the allergy season or for longer periods if you have a chronic condition such as urticaria. For ongoing use beyond a few weeks, it's a good idea to check in with your GP or pharmacist to review whether it remains the right treatment for you. Long-term use is generally well tolerated in adults.

What are the side effects of fexofenadine tablets?

Common side effects include headache, dizziness, nausea, and fatigue. Less commonly, some people experience dry mouth, insomnia, or palpitations. Serious allergic reactions are rare but require immediate medical attention — stop taking the tablets and call 999 if you develop swelling of the face, lips, or throat, or have difficulty breathing.

How do I manage side effects of fexofenadine?

Most side effects are mild and tend to settle as your body adjusts. If you experience headaches, staying well hydrated can help. Taking the tablet with food may reduce nausea in some people, though it should still be taken with water rather than fruit juice. If side effects persist or feel severe, speak to your pharmacist or GP.

Can I take fexofenadine with other medicines?

Fexofenadine can interact with certain medicines, including antacids containing aluminium or magnesium hydroxide, erythromycin, and ketoconazole. Always tell your pharmacist about any other medicines, supplements, or herbal remedies you are taking before starting fexofenadine. This includes over-the-counter products as well as prescription medicines.

Is fexofenadine safe to take during pregnancy?

Fexofenadine is not recommended during pregnancy unless a doctor has specifically advised it, as safety data in pregnant women is limited. If you are pregnant, planning to become pregnant, or breastfeeding, speak to your GP or midwife before taking any antihistamine. They can advise on the safest option for your situation.

Who is eligible to take fexofenadine tablets?

Fexofenadine is suitable for adults and children aged 12 and over who have seasonal allergic rhinitis or chronic idiopathic urticaria. It is not suitable for children under 12, people with severe kidney impairment (without medical supervision), or those with a known allergy to fexofenadine hydrochloride. If you are unsure whether it is right for you, ask your pharmacist.

What happens if I miss a dose of fexofenadine?

If you miss a dose, take it as soon as you remember — unless it is nearly time for your next dose, in which case skip the missed dose entirely. Never take a double dose to make up for a forgotten one. Missing an occasional dose is unlikely to cause any harm, but try to take it at the same time each day to keep your symptoms under control.

How does fexofenadine compare to cetirizine for hay fever?

Both are second-generation antihistamines taken once daily, but fexofenadine is generally considered to have a lower risk of drowsiness than cetirizine. Cetirizine is available at 10mg, while fexofenadine comes in 120mg and 180mg strengths. The best choice depends on your individual response — some people find one works better for them than the other.

What are the alternatives to fexofenadine for allergies?

Other non-sedating antihistamines available in the UK include cetirizine, loratadine, and bilastine. Nasal corticosteroid sprays such as fluticasone are also recommended for moderate-to-severe hay fever. You can explore a range of options in our allergy and hay fever collection to find what suits you best.

Can fexofenadine be used for hives (urticaria)?

Yes — the 180mg strength of fexofenadine is specifically licensed for the relief of symptoms associated with chronic idiopathic urticaria in adults and children aged 12 and over. It helps reduce itching, redness, and the appearance of hives. If your hives are severe, persistent, or accompanied by swelling, seek medical advice promptly.

What are the latest findings on fexofenadine for allergic rhinitis?

Fexofenadine remains one of the most widely studied non-sedating antihistamines, with a consistent body of clinical evidence supporting its efficacy and tolerability for allergic rhinitis and urticaria. Current NHS and NICE guidance continues to recommend second-generation antihistamines like fexofenadine as a first-line treatment for hay fever. No significant new safety concerns have emerged in recent years.

How Should You Use Fexofenadine Tablets?

Fexofenadine tablets are taken orally, once a day. Always swallow the tablet whole with a full glass of water — never take it with grapefruit, orange, or apple juice, as these can significantly reduce how much of the medicine your body absorbs.

Follow these steps each time you take your tablet:

What Is the Correct Dose of Fexofenadine?

The dose you take depends on the condition you are treating and your age. Always follow the dosage instructions on the pack or as directed by your pharmacist or GP. Do not take more than the recommended daily dose.

When Is the Best Time to Use Fexofenadine?

Fexofenadine can be taken at any time of day, but consistency matters. Taking it at the same time each morning helps maintain steady levels in your bloodstream, which means more reliable symptom control throughout the day. During hay fever season, morning dosing is particularly practical as pollen counts often peak in the afternoon and evening.

If you forget to take your tablet in the morning, take it as soon as you remember — unless your next dose is due soon, in which case skip the missed dose and carry on as normal. Never double up.

How Long Can You Use Fexofenadine For?

For seasonal allergic rhinitis, fexofenadine is typically used throughout the allergy season — which in the UK can run from late March through to September depending on which pollens affect you. For chronic idiopathic urticaria, longer-term daily use may be appropriate, and this should be reviewed periodically with your GP or pharmacist.

If your symptoms do not improve after a few days of treatment, or if they worsen, seek advice from a healthcare professional. Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Fexofenadine?

Most people tolerate fexofenadine well, and side effects are generally mild. Because it is a non-sedating antihistamine, drowsiness is much less likely than with older medicines like chlorphenamine — but it can still occur in some individuals.

  • Headache
  • Dizziness
  • Nausea
  • Fatigue or tiredness
  • Drowsiness (less frequent than with first-generation antihistamines)

What Are the Less Common Side Effects of Fexofenadine?

Less common side effects affect fewer people but are still worth being aware of. If any of the following persist or feel troublesome, speak to your pharmacist or GP.

  • Dry mouth
  • Insomnia or difficulty sleeping
  • Nervousness or restlessness
  • Palpitations or a faster-than-normal heartbeat
  • Skin rash or itching (paradoxical reaction)
  • Abdominal discomfort

What Are the Serious Side Effects of Fexofenadine?

Serious side effects are rare, but you should stop taking fexofenadine immediately and seek urgent medical help if you experience any of the following signs of a severe allergic reaction (anaphylaxis):

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Severe skin rash, blistering, or peeling
  • Sudden drop in blood pressure causing dizziness or collapse

Call 999 immediately if you suspect anaphylaxis. Do not wait to see if symptoms improve on their own.

What Should You Do If You Experience Side Effects?

For mild side effects such as headache or nausea, these often settle within a few days as your body adjusts. Staying well hydrated and taking the tablet with food (but still with water, not juice) may help reduce nausea. If you experience drowsiness, avoid driving or operating machinery until you know how fexofenadine affects you.

You can report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety for everyone.

Can Fexofenadine Interact With Other Medicines?

Yes. Fexofenadine is known to interact with certain medicines, which can affect how well it works or increase the risk of side effects. The most clinically significant interactions include antacids containing aluminium or magnesium hydroxide (which reduce absorption), erythromycin and ketoconazole (which may increase fexofenadine levels in the blood), and rifampicin (which may reduce its effectiveness). Avoid taking fexofenadine with large quantities of grapefruit, orange, or apple juice for the same reason.

Always tell your pharmacist or doctor about every medicine, supplement, or herbal remedy you are taking before starting fexofenadine. If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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