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Betamethasone & Neomycin Cream

Betamethasone & Neomycin Cream

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  • ✔️ Targets both inflammation and bacterial infection simultaneously
  • ✔️ Reduces redness, swelling, and itching in infected eczema
  • ✔️ Contains moderately potent betamethasone for effective anti-inflammatory action
  • ✔️ Neomycin component kills bacteria causing secondary skin infections
  • ✔️ Suitable for adults and children aged two years and over

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What Is Betamethasone and Neomycin Cream?

 

If you're dealing with a skin flare-up that's both inflamed and showing signs of infection, a single-ingredient cream often isn't enough. Betamethasone and neomycin cream combines two active ingredients — a corticosteroid and an antibiotic — to tackle both problems at once. It's designed for inflammatory skin conditions where a secondary bacterial infection is present or suspected, such as infected eczema or infected contact dermatitis. You can explore the full range of skin care treatments available at Cured Pharmacy if you're unsure which product suits your needs.

This cream contains betamethasone valerate 0.1% and neomycin sulfate 0.5%. Betamethasone is a moderately potent corticosteroid, while neomycin is an aminoglycoside antibiotic with activity against a broad range of gram-positive and gram-negative bacteria. Together, they address the itch, redness, and swelling of inflamed skin alongside the bacterial component that can make flare-ups significantly worse.

 

How Does Betamethasone and Neomycin Cream Work?

 

The two active ingredients work through distinct but complementary mechanisms. Understanding how each one functions can help you use the cream more confidently and safely.

  • Betamethasone valerate binds to glucocorticoid receptors in skin cells, reducing the production of inflammatory mediators such as prostaglandins and cytokines. This leads to a reduction in redness, swelling, and itching.
  • Neomycin sulfate works by binding to the 30S ribosomal subunit of bacterial cells, inhibiting protein synthesis and ultimately killing susceptible bacteria. It targets organisms commonly found in infected skin, including Staphylococcus aureus.
  • Together, the two ingredients reduce the inflammatory response while simultaneously clearing the bacterial infection — addressing both the cause and the symptoms of infected skin conditions.
  • Because the cream is applied topically, systemic absorption is generally low when used correctly, though it can increase if applied to large areas or under occlusive dressings.

 

Who Should Use Betamethasone and Neomycin Cream?

 

This cream is intended for adults and children over two years of age who have an inflammatory skin condition complicated by, or at risk of, bacterial infection. It is not a first-line treatment for uncomplicated eczema — it's specifically indicated when infection is part of the picture. Always confirm suitability with a pharmacist or GP before starting treatment.

  • Adults with infected eczema or atopic dermatitis showing signs of bacterial infection (weeping, crusting, or worsening despite standard emollient use)
  • Patients with infected contact dermatitis or allergic dermatitis where a bacterial component is present
  • Individuals with localised infected skin rashes that have not responded to emollients alone
  • Those who have been assessed by a clinician and confirmed to have a condition appropriate for a combination steroid-antibiotic preparation

 

How Does Betamethasone and Neomycin Cream Compare to Other Treatments?

 

Feature Betamethasone & Neomycin Cream Hydrocortisone 1% Cream (OTC)
Steroid strength Moderately potent (betamethasone 0.1%) Mild (hydrocortisone 1%)
Antibiotic component Yes — neomycin sulfate 0.5% No
Suitable for infected skin Yes No — not indicated for infected skin
Suitable for children under 2 No Not recommended without medical advice

 

How Should You Store Betamethasone and Neomycin Cream?

 

Store the cream below 25°C in a cool, dry place away from direct sunlight. Keep the tube tightly closed when not in use, and always keep it out of the reach and sight of children. Do not use the cream after the expiry date printed on the packaging. If you're looking for other creams and ointments for skin conditions, Cured Pharmacy stocks a wide range of clinically appropriate topical treatments.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Betamethasone & Neomycin Cream specifications
Treatment category Infected inflammatory skin conditions
Mechanism of action Corticosteroid anti-inflammatory + aminoglycoside antibacterial
Effective for Infected eczema, infected contact dermatitis, infected allergic dermatitis
Suitable for Adults and children over 2 years
Active ingredients Betamethasone valerate 0.1%, Neomycin sulfate 0.5%
Strengths Betamethasone 0.1% / Neomycin 0.5%
UK classification Prescription-only medicine (POM)
Drug class Topical corticosteroid + aminoglycoside antibiotic combination
Preparation Cream
Route of administration Topical (cutaneous)

Specifications of Betamethasone & Neomycin Cream

 

What Is Betamethasone and Neomycin Cream and What Is It Used For?

 

Betamethasone and neomycin cream is a combination topical medicine used to treat inflammatory skin conditions where bacterial infection is also present. It contains two active ingredients: betamethasone valerate, a moderately potent corticosteroid, and neomycin sulfate, a broad-spectrum aminoglycoside antibiotic. The cream is indicated for conditions such as infected eczema (atopic dermatitis), infected contact dermatitis, and other inflammatory dermatoses complicated by bacterial infection. It is not suitable for treating fungal or viral skin infections.

 

What Do You Need to Know Before Using Betamethasone and Neomycin Cream?

 

Before applying this cream, it's important to be aware of the following contraindications and warnings. Do not use this cream if any of the following apply to you:

  • You are allergic to betamethasone, neomycin, other aminoglycoside antibiotics, or any other ingredient in the cream
  • You have a skin infection caused by a fungus (e.g. ringworm, athlete's foot) or a virus (e.g. cold sores, chickenpox)
  • You have acne, rosacea, or perioral dermatitis
  • You have an open wound or broken skin in the area to be treated
  • You are applying to the skin around the eyes (risk of glaucoma and cataracts with prolonged use near the eye)
  • The patient is a child under 2 years of age
  • You are pregnant or breastfeeding, unless specifically advised by your doctor

The following medicines or product types may interact with this cream, particularly if used over large areas or under occlusion:

  • Other topical corticosteroids used simultaneously on the same area
  • Systemic corticosteroids — combined use may increase the risk of adrenal suppression
  • Ritonavir and itraconazole — these can increase plasma concentrations of corticosteroids through CYP3A4 inhibition, even with topical preparations used over large areas

 

How Should You Use Betamethasone and Neomycin Cream?

 

Always use this cream exactly as directed by your prescriber or pharmacist. Do not apply more than instructed, and do not use it for longer than recommended. If you're unsure about any aspect of your treatment, speak to a healthcare professional before continuing.

  1. Wash your hands thoroughly before and after applying the cream.
  2. Clean and gently dry the affected area of skin.
  3. Apply a thin layer of cream to the affected area only — do not spread onto surrounding healthy skin.
  4. Gently rub in until absorbed. Do not cover with an airtight dressing unless specifically instructed by your doctor.
  5. Apply once or twice daily, as directed. Do not apply more frequently than prescribed.
  6. Avoid contact with eyes, mouth, or mucous membranes. If accidental contact occurs, rinse thoroughly with water.
Indication Age Group Dose Frequency
Infected eczema / dermatitis Adults Thin layer to affected area Once or twice daily
Infected eczema / dermatitis Children (2 years and over) Thin layer to affected area Once daily — use for shortest duration possible
Not indicated Children under 2 years Do not use

 

What Are the Possible Side Effects of Betamethasone and Neomycin Cream?

 

Like all medicines, this cream can cause side effects, although not everyone will experience them. If you notice any unexpected skin changes or feel unwell, stop using the cream and speak to your pharmacist or GP. You can also browse our allergy and hay fever range if you suspect your skin reaction may be allergy-related rather than infection-related.

Common side effects (may affect up to 1 in 10 people):

  • Mild burning, stinging, or itching at the application site
  • Skin dryness or peeling
  • Temporary worsening of redness immediately after application

Less common side effects (may affect up to 1 in 100 people):

  • Skin thinning (atrophy) with prolonged use
  • Stretch marks (striae), particularly in skin folds
  • Contact sensitisation to neomycin — this can cause a new allergic reaction to develop
  • Hypopigmentation (lightening of the skin) at the application site
  • Adrenal suppression with extensive or prolonged use, particularly in children
  • Increased hair growth at the application site (hypertrichosis)

 

How Should You Store Betamethasone and Neomycin Cream?

 

Correct storage helps maintain the effectiveness and safety of this cream. Follow these instructions carefully. If you're managing multiple skin treatments, our athletes foot and fungal infections range may also be relevant if a fungal element is suspected alongside your inflammatory condition.

  • Store below 25°C in a cool, dry place
  • Do not refrigerate or freeze
  • Keep the tube tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tube or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy betamethasone and neomycin cream online in the UK?

You can order betamethasone and neomycin cream through Cured Pharmacy, a GPhC-registered UK online pharmacy. You'll complete a short clinical questionnaire so our pharmacist team can confirm the treatment is appropriate for you before it's dispensed. This ensures you receive the right product safely and legally.

How does betamethasone and neomycin cream work in the body?

Betamethasone is a moderately potent corticosteroid that reduces inflammation by suppressing the local immune response, decreasing redness, swelling, and itching. Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis, killing the bacteria responsible for secondary skin infections. Together, they address both the inflammatory and infectious components of conditions like infected eczema.

How do I apply betamethasone and neomycin cream step by step?

Wash your hands, then clean and gently dry the affected area. Apply a thin layer of cream directly to the affected skin only, rubbing in gently until absorbed. Wash your hands again afterwards, and avoid touching your eyes or mouth after application.

How often should I apply betamethasone and neomycin cream?

The usual recommended frequency is once or twice daily, as directed by your prescriber or pharmacist. You should not apply it more frequently than instructed, as overuse increases the risk of side effects such as skin thinning. Always follow the specific guidance given to you at the time of prescribing.

How long does betamethasone and neomycin cream take to work?

Many patients notice a reduction in redness, itching, and swelling within two to three days of starting treatment. The antibacterial effect of neomycin typically begins working within the first few days as well. However, you should complete the full recommended course even if your skin appears to improve sooner.

What are the side effects of betamethasone and neomycin cream?

Common side effects include mild burning, stinging, or itching at the application site, and temporary skin dryness. With prolonged use, more serious effects such as skin thinning, stretch marks, or contact sensitisation to neomycin can occur. If you notice any unexpected skin changes, stop using the cream and speak to your pharmacist or GP.

Can I use betamethasone and neomycin cream on my face?

Facial use is generally not recommended unless specifically directed by a doctor, because the skin on the face is thinner and more prone to side effects such as skin atrophy and perioral dermatitis. Prolonged use near the eyes also carries a risk of raised intraocular pressure. Always seek medical advice before applying any corticosteroid cream to your face.

Is betamethasone and neomycin cream safe to use during pregnancy?

Topical corticosteroids should be used with caution during pregnancy, and this cream is not recommended unless your GP has specifically advised it. There is a theoretical risk of foetal growth restriction with extensive or prolonged use of potent topical steroids. Always consult your GP or midwife before using any prescription skin treatment during pregnancy.

Who is eligible to use betamethasone and neomycin cream?

This cream is suitable for adults and children aged two years and over who have an inflammatory skin condition complicated by bacterial infection, such as infected eczema or infected contact dermatitis. It is not suitable for children under two, or for people with known hypersensitivity to neomycin or other aminoglycosides. A clinical assessment is required before use.

What happens if I miss an application of betamethasone and neomycin cream?

If you forget to apply the cream at your usual time, apply it as soon as you remember — unless it is nearly time for your next application, in which case skip the missed dose. Do not apply a double amount to make up for a missed application. Consistent use at regular intervals gives the best results.

How long can I use betamethasone and neomycin cream for?

This cream should generally be used for the shortest effective period, typically no longer than one to two weeks without reassessment by a clinician. Prolonged use increases the risk of skin thinning, adrenal suppression, and neomycin sensitisation. If your condition has not improved after one week, contact your GP or pharmacist for further advice.

What are the alternatives to betamethasone and neomycin cream?

Alternatives include other combination steroid-antibiotic preparations such as hydrocortisone with fusidic acid (e.g. Fucidin H), or separate topical antibiotic and steroid treatments prescribed by a doctor. For uncomplicated eczema without infection, a plain emollient or mild steroid cream may be more appropriate. You can explore our broader skin care range for other options.

Can betamethasone and neomycin cream be used for infected eczema?

Yes — infected eczema is one of the primary indications for this cream. Signs of infected eczema include weeping, crusting, increased redness, and skin that is warm to the touch. If you suspect your eczema is infected, it's important to seek clinical advice promptly, as untreated skin infections can spread.

Can children use betamethasone and neomycin cream?

Children aged two years and over may use this cream under medical supervision, but it should be applied for the shortest possible duration and to the smallest area necessary. Children are more susceptible to systemic absorption of topical corticosteroids, which can affect growth and adrenal function with prolonged use. It must not be used in children under two years of age. You may also find our creams and ointments collection helpful for age-appropriate alternatives.

What are the latest clinical findings on combination steroid-antibiotic creams?

Current clinical guidance, including NHS and NICE recommendations, supports the short-term use of combination steroid-antibiotic preparations for infected inflammatory skin conditions where both components are clinically indicated. There is ongoing discussion in dermatology about the risk of neomycin sensitisation with repeated use, which is why treatment duration should be kept to a minimum. Your prescriber will weigh the benefits against the risks based on your individual clinical picture.

How Should You Use Betamethasone and Neomycin Cream?

Always apply this cream exactly as directed by your prescriber or pharmacist. Using it correctly ensures you get the most benefit while minimising the risk of side effects. Never apply to healthy skin surrounding the affected area, and avoid using under airtight dressings unless specifically instructed by a doctor.

Follow these steps each time you apply the cream:

What Is the Correct Dose of Betamethasone and Neomycin Cream?

The correct dose depends on the size of the affected area, the severity of the condition, and the age of the patient. A thin layer applied to the affected skin is sufficient — more cream does not mean faster or better results. Always follow the specific dosage instructions provided by your prescriber.

When Is the Best Time to Use Betamethasone and Neomycin Cream?

There is no single fixed time of day that is clinically superior for applying this cream, but consistency matters. Applying at the same time each day — for example, after your morning shower or before bed — helps you maintain a regular routine and reduces the chance of missing an application. If you are applying twice daily, space the applications evenly throughout the day, such as morning and evening.

Avoid applying immediately before swimming or bathing, as water will wash the cream away before it has had time to absorb properly. If you use emollients as part of your skin care routine, apply the emollient first and wait at least 30 minutes before applying this cream.

How Long Can You Use Betamethasone and Neomycin Cream For?

This cream is intended for short-term use only. In most cases, treatment should not exceed one to two weeks without a clinical review. Prolonged use of topical corticosteroids — particularly on sensitive areas such as the face, groin, or skin folds — increases the risk of skin thinning, stretch marks, and adrenal suppression, especially in children.

If your skin condition has not improved after seven days of treatment, or if it worsens at any point, stop using the cream and contact your GP or pharmacist. Do not restart treatment without further clinical assessment. Long-term or repeated courses should only be undertaken under medical supervision.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Betamethasone and Neomycin Cream?

Always apply this cream exactly as directed by your prescriber or pharmacist. Using it correctly ensures you get the most benefit while minimising the risk of side effects. Never apply to healthy skin surrounding the affected area, and avoid using under airtight dressings unless specifically instructed by a doctor.

Follow these steps each time you apply the cream:

What Is the Correct Dose of Betamethasone and Neomycin Cream?

The correct dose depends on the size of the affected area, the severity of the condition, and the age of the patient. A thin layer applied to the affected skin is sufficient — more cream does not mean faster or better results. Always follow the specific dosage instructions provided by your prescriber.

When Is the Best Time to Use Betamethasone and Neomycin Cream?

There is no single fixed time of day that is clinically superior for applying this cream, but consistency matters. Applying at the same time each day — for example, after your morning shower or before bed — helps you maintain a regular routine and reduces the chance of missing an application. If you are applying twice daily, space the applications evenly throughout the day, such as morning and evening.

Avoid applying immediately before swimming or bathing, as water will wash the cream away before it has had time to absorb properly. If you use emollients as part of your skin care routine, apply the emollient first and wait at least 30 minutes before applying this cream.

How Long Can You Use Betamethasone and Neomycin Cream For?

This cream is intended for short-term use only. In most cases, treatment should not exceed one to two weeks without a clinical review. Prolonged use of topical corticosteroids — particularly on sensitive areas such as the face, groin, or skin folds — increases the risk of skin thinning, stretch marks, and adrenal suppression, especially in children.

If your skin condition has not improved after seven days of treatment, or if it worsens at any point, stop using the cream and contact your GP or pharmacist. Do not restart treatment without further clinical assessment. Long-term or repeated courses should only be undertaken under medical supervision.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Betamethasone and Neomycin Cream?

Most people tolerate this cream well when used correctly and for the recommended duration. However, as with all topical medicines, some side effects can occur at the application site. These are usually mild and resolve once treatment is stopped.

  • Mild burning or stinging sensation immediately after application
  • Itching at the treated area
  • Skin dryness or flaking
  • Temporary redness or irritation

What Are the Less Common Side Effects of Betamethasone and Neomycin Cream?

Less common side effects are more likely to occur with prolonged use, application to large areas of skin, or use under occlusive dressings. Children are particularly susceptible to systemic effects due to their higher skin surface area to body weight ratio.

  • Skin thinning (atrophy) at the application site
  • Stretch marks (striae), particularly in skin folds such as the groin or armpits
  • Hypopigmentation — lightening of the skin at the treated area
  • Increased hair growth (hypertrichosis) at the application site
  • Contact sensitisation to neomycin — this can cause a new allergic skin reaction to develop, which may be mistaken for a worsening of the original condition
  • Miliaria (heat rash) if the area is covered or occluded

What Are the Serious Side Effects of Betamethasone and Neomycin Cream?

Serious side effects are uncommon with short-term, correctly applied topical use, but they can occur if the cream is misused or used for extended periods. Adrenal suppression — where the body's natural production of cortisol is reduced — is a risk with prolonged or widespread application of moderately potent corticosteroids. Symptoms may include fatigue, dizziness, and weight loss. In rare cases, raised intraocular pressure or cataracts can develop if the cream is applied near the eyes over a prolonged period. If you experience any of these symptoms, stop using the cream immediately and seek medical advice.

What Should You Do If You Experience Side Effects of Betamethasone and Neomycin Cream?

If you notice any side effects that concern you, stop applying the cream and contact your pharmacist or GP as soon as possible. For mild local reactions such as stinging or dryness, your pharmacist may advise you to reduce the frequency of application or switch to a different formulation. In the event of a serious allergic reaction — including widespread rash, swelling of the face or throat, or difficulty breathing — seek emergency medical attention immediately by calling 999 or going to your nearest A&E department.

Can Betamethasone and Neomycin Cream Interact With Other Medicines?

Significant drug interactions with topical betamethasone and neomycin cream are uncommon when the cream is used correctly on small areas of skin. However, if you are using other topical corticosteroids simultaneously, or if you are taking systemic corticosteroids, the combined effect may increase the risk of adrenal suppression. Medicines that inhibit the CYP3A4 enzyme — such as ritonavir or itraconazole — can increase systemic exposure to betamethasone, even from topical preparations used over large areas. Always inform your prescriber or pharmacist of all medicines you are currently taking, including over-the-counter products and supplements.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question


It’s used for skin conditions that are inflamed and at risk of infection — such as eczema, dermatitis, and allergic reactions — especially when bacteria may be present due to scratching.


Not unless a pharmacist specifically instructs you. Facial skin absorbs steroids more easily, increasing the risk of side effects.


If you’re using moisturisers, apply them after Betamethasone & Neomycin, leaving at least 15 minutes between products. Avoid using other steroid creams at the same time unless advised.


No. It only works for bacterial infections and inflammation. Using it on fungal or viral infections can make things worse.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What is Betamethasone & Neomycin Cream used for?


It’s used for skin conditions that are inflamed and at risk of infection — such as eczema, dermatitis, and allergic reactions — especially when bacteria may be present due to scratching.

Can I use it on my face?


Not unless a pharmacist specifically instructs you. Facial skin absorbs steroids more easily, increasing the risk of side effects.

Can I use other creams at the same time?


If you’re using moisturisers, apply them after Betamethasone & Neomycin, leaving at least 15 minutes between products. Avoid using other steroid creams at the same time unless advised.

Does this cream treat fungal infections?


No. It only works for bacterial infections and inflammation. Using it on fungal or viral infections can make things worse.