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HC45 Hydrocortisone Acetate Cream - 15g

HC45 Hydrocortisone Acetate Cream - 15g

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  • ✔️ Relieves itching and redness from eczema and dermatitis
  • ✔️ Soothes insect bites and mild allergic skin reactions
  • ✔️ Contains 1% hydrocortisone acetate for targeted inflammation relief
  • ✔️ Compact 15g tube ideal for travel and on-the-go use
  • ✔️ Suitable for adults and children aged 10 and over

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What Is HC45 Hydrocortisone Cream and What Does It Treat?

 

If you're dealing with itchy, inflamed, or irritated skin, hydrocortisone cream is one of the most widely used over-the-counter treatments available in the UK. HC45 Hydrocortisone Acetate Cream contains 1% hydrocortisone acetate as its active ingredient — a mild topical corticosteroid that helps calm the skin's inflammatory response. It's suitable for a range of everyday skin complaints, from eczema flare-ups to insect bites, and it's available without a prescription for adults and children aged 10 and over. You can browse our full range of creams and ointments if you're looking for additional topical treatments alongside this product.

At just £5.99 for a 15g tube, HC45 is an accessible, clinically recognised option for short-term relief of mild to moderate skin irritation. It's been a trusted name in UK pharmacies for many years, and it's particularly handy to keep in your medicine cabinet — or your travel kit — for those unexpected flare-ups.

 

How Does HC45 Hydrocortisone Acetate Cream Work?

 

Hydrocortisone is a corticosteroid that mimics the action of cortisol, a hormone naturally produced by your adrenal glands. When applied to the skin, it works by reducing the activity of the immune cells responsible for inflammation. Here's a simplified breakdown of the mechanism:

  • It binds to glucocorticoid receptors inside skin cells.
  • This reduces the production of pro-inflammatory chemicals such as prostaglandins and cytokines.
  • Blood vessels in the affected area constrict slightly, reducing redness and swelling.
  • The overall result is a reduction in itching, redness, and discomfort at the site of application.

Because HC45 contains only 1% hydrocortisone, it's classified as a mild corticosteroid — making it appropriate for short-term OTC use without a prescription, in line with NHS guidance.

 

Who Is HC45 Hydrocortisone Cream Suitable For?

 

HC45 is designed for people who need short-term relief from inflammatory skin conditions. It's particularly useful if you experience occasional flare-ups rather than chronic, severe skin disease. The following groups may find it beneficial:

  • Adults and children aged 10 and over with mild eczema or contact dermatitis.
  • People experiencing itching or irritation from insect bites or stings.
  • Those with mild allergic skin reactions, such as reactions to plants or cosmetics.
  • Travellers who want a compact, effective treatment for skin irritation on the go.

It is not suitable for use on infected skin, broken skin, or around the eyes without specific medical advice. If you're unsure whether this product is right for you, speak to a pharmacist before purchasing.

 

How Does HC45 Compare to Other Hydrocortisone Creams?

 

Feature HC45 Hydrocortisone Cream 15g Dermacort Hydrocortisone Cream 15g
Active ingredient Hydrocortisone acetate 1% Hydrocortisone 1%
Pack size 15g 15g
OTC availability Yes Yes
Suitable for children 10 years and over 10 years and over

 

Is HC45 Hydrocortisone Cream Safe to Store and Travel With?

 

HC45 is straightforward to store — keep it below 25°C, away from direct sunlight, and out of reach of children. The compact 15g tube makes it ideal for travel, and it fits easily into a toiletry bag or first aid kit. If you're heading abroad and want to be prepared for skin irritation from sun, insects, or unfamiliar plants, it's worth including alongside other essentials from our travel health range.

Do check the expiry date before travelling, and avoid storing the cream in very hot conditions such as a car glove compartment in summer. Once opened, use within the period indicated on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

HC45 Hydrocortisone Acetate Cream 15g specifications
Treatment category Topical corticosteroid / Skin inflammation
Active ingredient Hydrocortisone acetate 1%
Mechanism of action Reduces skin inflammation by suppressing inflammatory mediators
Suitable for Adults and children aged 10 and over
Pack size 15g
Strengths 1% hydrocortisone acetate
UK classification Pharmacy (P) medicine
Drug class Mild topical corticosteroid
Preparation Cream
Route of administration Topical (applied to skin)
Effective for Eczema, dermatitis, insect bites, mild allergic skin reactions

Specifications of HC45 Hydrocortisone Acetate Cream 15g

 

What Is HC45 Hydrocortisone Acetate Cream and What Is It Used For?

 

HC45 Hydrocortisone Acetate Cream is a mild topical corticosteroid containing 1% hydrocortisone acetate. It is used for the short-term relief of mild inflammatory skin conditions in adults and children aged 10 and over. The NHS recognises hydrocortisone cream as an effective treatment for a number of common skin complaints, including eczema, contact dermatitis, and reactions to insect bites. It works by reducing redness, swelling, and itching at the site of application.

Conditions it is commonly used to treat include:

  • Mild to moderate eczema
  • Contact dermatitis (e.g. from plants, metals, or cosmetics)
  • Insect bites and stings
  • Mild allergic skin reactions
  • Irritant dermatitis

 

What Do You Need to Know Before Using HC45 Hydrocortisone Cream?

 

Before applying HC45, it's important to check whether it's appropriate for your situation. Do not use this cream if any of the following apply:

  • You are allergic to hydrocortisone or any other ingredient in the cream.
  • The skin is infected — hydrocortisone can worsen bacterial, fungal, or viral skin infections.
  • You have acne, rosacea, or perioral dermatitis.
  • The affected area is broken or ulcerated skin.
  • You are applying it to a child under 10 years of age without a doctor's advice.
  • You wish to use it around the eyes without specific medical guidance.

Use with caution if you are pregnant or breastfeeding — speak to your GP or pharmacist before use. Prolonged or widespread application may increase systemic absorption, particularly in children or when used under occlusive dressings.

Known drug interactions to be aware of:

  • Ritonavir and itraconazole may increase plasma concentrations of corticosteroids — seek medical advice if you take these medicines.
  • Other topical corticosteroids should not be used on the same area simultaneously.

 

How Should You Use HC45 Hydrocortisone Cream?

 

Always use HC45 exactly as directed on the packaging or as advised by your pharmacist. Do not apply more than instructed, and do not use it for longer than recommended without seeking medical advice. If you're also managing a skin condition alongside other issues, our skin care collection includes complementary products that may help support your skin health.

  1. Wash and dry your hands thoroughly before applying the cream.
  2. Clean and gently dry the affected area of skin.
  3. Apply a thin layer of HC45 cream directly to the affected area.
  4. Gently rub the cream in until it is absorbed.
  5. Wash your hands again after application, unless your hands are the area being treated.
  6. Do not cover the treated area with an airtight dressing unless advised by a doctor.
Indication Age Group Dose Frequency
Eczema / dermatitis Adults & children 10+ Thin layer to affected area Once or twice daily
Insect bites / mild allergic reaction Adults & children 10+ Thin layer to affected area Once or twice daily
Facial use Adults only (with caution) Thin layer Once daily, max 7 days

 

What Are the Possible Side Effects of HC45 Hydrocortisone Cream?

 

Like all medicines, HC45 can cause side effects, although not everyone experiences them. Most side effects are related to prolonged or excessive use rather than short-term application as directed.

Common side effects:

  • Mild burning or stinging at the application site
  • Skin dryness or peeling
  • Temporary itching after application

Less common side effects (usually associated with prolonged use):

  • Skin thinning (atrophy)
  • Stretch marks (striae)
  • Changes in skin pigmentation
  • Increased hair growth at the application site
  • Worsening of skin infections if applied to infected skin

Stop using the cream and contact your GP if you notice any signs of a skin infection developing, or if your condition worsens rather than improves after a few days of use.

 

How Should You Store HC45 Hydrocortisone Cream?

 

Correct storage helps maintain the cream's effectiveness and safety. If you're building a home first aid kit, you might also find useful products in our allergy and hay fever range for managing related skin and respiratory reactions.

  • Store below 25°C in a cool, dry place.
  • Keep away from direct sunlight and heat sources.
  • Do not freeze.
  • Keep the tube tightly closed when not in use.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the packaging.
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy HC45 hydrocortisone cream online in the UK?

You can buy HC45 Hydrocortisone Acetate Cream 15g directly from Cured Pharmacy, a GPhC-registered online pharmacy, for just £5.99. It's available without a prescription as an over-the-counter medicine for adults and children aged 10 and over. Simply add it to your basket and it will be dispatched promptly to your door.

How does hydrocortisone cream work on inflamed skin?

Hydrocortisone is a mild corticosteroid that works by binding to receptors inside skin cells, reducing the production of inflammatory chemicals such as prostaglandins and cytokines. This suppresses the immune response in the skin, which in turn reduces redness, swelling, and itching. It does not treat the underlying cause of a skin condition — it relieves the symptoms while your skin recovers.

How do I apply HC45 hydrocortisone cream step by step?

Start by washing and drying your hands, then clean and gently dry the affected skin area. Apply a thin layer of the cream and rub it in gently until absorbed, then wash your hands again unless your hands are the treated area. Avoid covering the area with an airtight dressing unless a doctor has specifically advised this.

How quickly does HC45 hydrocortisone cream start to work?

Most people notice a reduction in itching and redness within 24 to 48 hours of starting treatment. Full improvement in the appearance of the skin may take several days of consistent, twice-daily application. If there is no improvement after 7 days, stop using the cream and consult your GP or pharmacist.

Can I use HC45 cream on my face?

HC45 can be applied to the face, but only for a maximum of 7 days and ideally under the guidance of a pharmacist or doctor. The skin on the face is thinner and more sensitive, making it more susceptible to side effects such as skin thinning with prolonged use. Avoid applying near the eyes or on areas affected by acne or rosacea.

Is HC45 hydrocortisone cream safe for children?

HC45 is not recommended for children under 10 years of age without a doctor's advice. For children aged 10 and over, it can be used under adult supervision following the same dosage instructions as for adults. Always use the smallest amount needed for the shortest time possible in younger patients.

What are the side effects of HC45 hydrocortisone cream?

Common side effects include mild burning, stinging, or temporary itching at the application site, which usually settles quickly. With prolonged or excessive use, more significant effects such as skin thinning, stretch marks, or changes in pigmentation can occur. Sticking to the recommended duration and amount of use greatly reduces the risk of these effects.

What happens if I use too much HC45 cream or use it for too long?

Using more than the recommended amount or applying it for longer than 7 days without medical advice can increase the risk of skin thinning, stretch marks, and in rare cases, systemic absorption of the steroid. If you accidentally apply too much on one occasion, this is unlikely to cause harm — but do not make a habit of it. Speak to your pharmacist if you're unsure how long to continue treatment.

Who should not use HC45 hydrocortisone cream?

You should not use HC45 if you have an infected skin condition, as hydrocortisone can mask or worsen infections. It is also not suitable for people with acne, rosacea, or perioral dermatitis, or for use on broken or ulcerated skin. If you are pregnant, breastfeeding, or taking medicines such as ritonavir or itraconazole, speak to your doctor or pharmacist before use. You can also explore our skin care collection for alternative options.

What are the alternatives to HC45 hydrocortisone cream?

Other 1% hydrocortisone creams available OTC in the UK include Dermacort and various pharmacy own-brand versions — all containing the same active ingredient at the same strength. For more severe or widespread eczema, a GP may prescribe a stronger corticosteroid. Emollients and moisturisers can also be used alongside hydrocortisone cream to help manage eczema symptoms.

Can I use HC45 cream for insect bites?

Yes — HC45 is specifically indicated for the relief of itching and inflammation caused by insect bites and stings. Apply a thin layer to the affected area once or twice daily until the irritation settles. It's a handy product to pack in your travel kit, and you'll find other useful travel health essentials in our travel range.

Can I use HC45 cream if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should speak to your GP or pharmacist before using HC45 cream. While topical hydrocortisone at 1% is considered low risk when used sparingly and for short periods, it is always best to seek professional advice during pregnancy and breastfeeding. Avoid applying to large areas of skin or under occlusive dressings during this time.

How long can I use HC45 hydrocortisone cream for?

HC45 should be used for no longer than 7 days without seeking medical advice, particularly on the face. For other body areas, short courses of up to 7 days are generally recommended for OTC use. If your symptoms persist beyond this period, consult your GP, as you may need a different treatment or a prescription-strength product.

What is the difference between hydrocortisone cream and hydrocortisone ointment?

Hydrocortisone cream has a lighter, water-based formulation that is absorbed more quickly and is generally preferred for weeping or moist skin conditions. Ointment is greasier and more occlusive, making it better suited to dry, thickened, or scaly skin. HC45 comes in cream form, which most people find easier to apply and less messy for everyday use.

What are the latest findings on topical hydrocortisone for eczema?

Current NHS and NICE guidance continues to support the use of mild topical corticosteroids like 1% hydrocortisone as a first-line treatment for mild eczema flare-ups. Research consistently shows that short-term use is safe and effective when applied correctly. The focus in recent guidance has been on using the lowest effective strength for the shortest necessary duration to minimise side effects.

How Should You Use HC45 Hydrocortisone Acetate Cream?

Using HC45 correctly makes a real difference to how well it works — and helps you avoid unnecessary side effects. Always read the patient information leaflet supplied with the product before use, and follow the steps below for safe, effective application.

What Is the Correct Dose of HC45 Hydrocortisone Acetate Cream?

The correct dose depends on the area being treated and the age of the patient. Always use the smallest amount that provides effective relief. Applying more cream than necessary does not improve results and increases the risk of side effects.

When Is the Best Time to Use HC45 Hydrocortisone Acetate Cream?

There is no single "best" time of day to apply HC45, but consistency matters. Applying it at the same times each day — for example, morning and evening after washing — helps maintain a steady effect on the skin. Many people find it easiest to apply after bathing, when the skin is clean and slightly warm, as this may aid absorption slightly.

If you are using an emollient or moisturiser alongside HC45, apply the emollient first and wait at least 30 minutes before applying the hydrocortisone cream. This prevents the emollient from diluting the active ingredient or affecting its absorption.

How Long Can You Use HC45 Hydrocortisone Acetate Cream For?

HC45 is intended for short-term use only. For most conditions, a course of up to 7 days is appropriate for OTC use without medical supervision. On the face, use should be limited to a maximum of 7 days regardless of the condition being treated, due to the increased sensitivity of facial skin.

If your symptoms have not improved after 7 days, or if they worsen at any point, stop using the cream and speak to your GP. Long-term or repeated use without medical oversight can lead to skin thinning and other unwanted effects. Your doctor can advise on whether a longer course or a different treatment is appropriate for your needs.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of HC45 Hydrocortisone Cream?

Most people who use HC45 as directed for short periods do not experience significant side effects. However, some mild reactions at the application site are possible, particularly when you first start using the cream.

  • Mild burning or stinging sensation immediately after application
  • Temporary itching at the treated area
  • Skin dryness or slight peeling
  • Mild redness around the application site

These effects are usually short-lived and tend to settle as your skin adjusts. If they persist or feel uncomfortable, speak to your pharmacist.

What Are the Less Common Side Effects of HC45 Hydrocortisone Cream?

Less common side effects are more likely to occur with prolonged use, application to large areas of skin, or use under occlusive dressings. They are not typical with short-term, correctly dosed use.

  • Skin thinning (atrophy) — particularly with extended use on delicate areas
  • Stretch marks (striae) at the application site
  • Changes in skin pigmentation (lightening or darkening)
  • Increased hair growth (hypertrichosis) at the treated area
  • Perioral dermatitis — a rash around the mouth if used on the face inappropriately
  • Allergic contact dermatitis to one of the cream's ingredients

If you notice any of these effects, stop using the cream and seek advice from your GP or pharmacist promptly.

What Are the Serious Side Effects of HC45 Hydrocortisone Cream?

Serious side effects from 1% hydrocortisone cream used as directed are rare. However, if the cream is applied to very large areas of skin, used under tight dressings, or used for prolonged periods — especially in children — there is a small risk of systemic absorption. This means a tiny amount of the steroid enters the bloodstream, which in rare cases can affect the adrenal glands.

Signs that may suggest systemic absorption include unusual weight gain, increased thirst, or changes in mood. These are very unlikely with OTC use but should be reported to a doctor immediately if they occur. Do not use HC45 on infected skin — doing so can cause the infection to spread or worsen significantly.

What Should You Do If You Experience Side Effects of HC45 Cream?

If you experience a mild reaction such as stinging or temporary redness, you can usually continue using the cream and monitor whether the reaction settles. However, if you develop signs of a skin infection — such as increased warmth, pus, or spreading redness — stop using HC45 immediately and contact your GP.

For any allergic reaction, including swelling of the face, lips, or throat, difficulty breathing, or a widespread rash, seek emergency medical attention straight away. This type of reaction is rare but requires urgent care.

Can HC45 Hydrocortisone Cream Interact With Other Medicines?

Topical hydrocortisone at 1% has very few clinically significant interactions when used as directed on small areas of skin. However, certain medicines can increase the concentration of corticosteroids in the body if systemic absorption occurs. These include ritonavir (used in HIV treatment) and itraconazole (an antifungal medicine). If you take either of these, speak to your doctor or pharmacist before using HC45.

Avoid using other topical corticosteroids on the same area of skin at the same time, as this increases the total steroid dose applied and raises the risk of side effects. Always inform your pharmacist of all medicines you are currently taking, including over-the-counter products.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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