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Fucidin Cream

Fucidin Cream

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  • ✔️ Treats impetigo, infected eczema, and bacterial skin infections
  • ✔️ Targets Staphylococcus aureus including some resistant strains
  • ✔️ Visible improvement typically seen within 2 to 3 days
  • ✔️ Suitable for adults, children, and infants under supervision
  • ✔️ Available in cream and ointment form for different skin types

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What Is Fusidic Acid Cream and How Does It Treat Skin Infections?

 

Fucidin Cream is a topical antibiotic containing fusidic acid cream at a 2% concentration. It is used to treat a range of bacterial skin infections, from impetigo to secondary infections in conditions like eczema. Bacterial skin infections are surprisingly common — and when they take hold, they can spread quickly, cause discomfort, and worsen underlying skin conditions. Having access to an effective, clinically proven treatment matters. You can explore our full range of creams and ointments if you are looking for additional topical treatments alongside this one.

Fucidin is a well-established brand in the UK, and fusidic acid has been used clinically for decades. It targets specific bacteria — most notably Staphylococcus aureus, including some strains that are resistant to other antibiotics. That makes it particularly useful for skin infections where staph bacteria are the likely culprit.

 

How Does Fucidin Cream Work Against Bacteria?

 

Fusidic acid works by interfering with bacterial protein synthesis. More specifically, it blocks a protein called elongation factor G (EF-G), which bacteria need to replicate and grow. Without this, the bacteria cannot multiply — and your immune system can clear the infection more effectively.

  • Inhibits bacterial protein synthesis at the ribosomal level
  • Blocks elongation factor G (EF-G), halting bacterial replication
  • Active against Staphylococcus aureus, including some penicillin-resistant strains
  • Works locally on the skin with minimal systemic absorption when used correctly

Because it acts locally rather than systemically, the risk of widespread side effects is low when used as directed. This is one reason it is a commonly recommended first-line option for mild to moderate skin infections.

 

Who Should Use Fucidin Cream and Is It Right for You?

 

Fucidin Cream is suitable for adults and children (including infants) who have a confirmed or suspected bacterial skin infection. It is particularly well-suited to people dealing with impetigo, infected cuts or grazes, or secondary bacterial infections on top of existing skin conditions. That said, it is not appropriate for everyone — and it is important to use it only when a bacterial infection is genuinely present, not for viral or fungal skin conditions.

  • Adults and children with impetigo
  • People with infected eczema or dermatitis
  • Those with minor infected wounds, cuts, or abrasions
  • Patients with folliculitis or other localised staph skin infections

 

How Does Fucidin Cream Compare to Other Topical Antibiotics?

 

Feature Fucidin Cream (Fusidic Acid 2%) Mupirocin (Bactroban) 2%
Active ingredient Fusidic acid Mupirocin
Primary use Impetigo, infected eczema, skin infections Impetigo, nasal decolonisation of MRSA
Suitable for children Yes, including infants Yes, over 2 years (cream form)
Formulation options Cream and ointment Cream and ointment

 

Is Fucidin Cream Safe to Store and Use Long-Term?

 

Fucidin Cream should be stored below 25°C, away from direct heat and sunlight, and kept out of reach of children. It is not intended for long-term continuous use — courses are typically limited to 7 days to reduce the risk of antibiotic resistance developing. If your skin infection has not improved after a week of treatment, you should speak to your GP rather than continuing to apply the cream independently.

If you are managing a skin condition that keeps becoming infected, it is worth exploring our skin care range for supportive products that may help reduce the frequency of flare-ups. Fusidic acid cream is a targeted treatment — not a long-term maintenance solution.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Fucidin Cream specifications
Treatment category Topical antibiotic / Bacterial skin infection
Active ingredient Fusidic acid 2%
Mechanism of action Inhibits bacterial protein synthesis by blocking elongation factor G
Effective against Staphylococcus aureus, Streptococcus spp., and other susceptible organisms
Suitable for Adults and children (including infants)
Pack sizes 15g
Strengths 2% w/w fusidic acid
UK classification Prescription-only medicine (POM)
Drug class Topical antibiotic (fusidane class)
Preparation Cream
Route of administration Topical (cutaneous)

Specifications of Fucidin Cream

 

What Is Fucidin Cream and What Is It Used For?

 

Fucidin Cream contains fusidic acid 2% w/w as its active ingredient. It belongs to a class of antibiotics called fusidanes and works specifically against bacteria on the surface of the skin. It is used to treat primary and secondary bacterial skin infections caused by susceptible organisms, most commonly Staphylococcus aureus.

Conditions it is commonly used to treat include:

  • Impetigo (a highly contagious bacterial skin infection common in children)
  • Infected eczema or atopic dermatitis
  • Infected cuts, wounds, or abrasions
  • Folliculitis (infected hair follicles)
  • Secondary infections in other inflammatory skin conditions

 

What Do You Need to Know Before Using Fucidin Cream?

 

Before applying Fucidin Cream, it is important to check whether it is appropriate for your situation. There are certain conditions and circumstances where it should be avoided or used with caution.

Do not use Fucidin Cream if you:

  • Are allergic to fusidic acid or any other ingredient in the cream
  • Have a fungal or viral skin infection — this cream will not treat those
  • Are applying it near the eyes without specific medical advice
  • Have extensive areas of broken or damaged skin (seek GP advice first)

Use with caution if you:

  • Are pregnant or breastfeeding — speak to your pharmacist or GP before use
  • Are using it on a child under 1 year old without medical supervision
  • Have previously experienced antibiotic resistance to fusidic acid

Known drug interactions:

  • Topical fusidic acid has minimal systemic absorption, so significant drug interactions are uncommon
  • If you are using other topical preparations on the same area, apply them at different times and seek pharmacist advice

 

How Should You Use Fucidin Cream Correctly?

 

Always follow the instructions provided with your prescription or as directed by your pharmacist. The general guidance for applying Fucidin Cream is as follows:

  1. Wash your hands thoroughly before and after application (unless treating your hands)
  2. Clean the affected area gently with mild soap and water, then pat dry
  3. Apply a thin layer of cream directly to the infected skin
  4. Gently rub in until absorbed — do not cover with an airtight dressing unless advised
  5. Apply three to four times daily, or as directed by your prescriber
  6. Complete the full course, even if the skin looks better before it ends
Indication Age Group Dose Frequency
Impetigo / skin infection Adults Small amount to affected area 3–4 times daily for up to 7 days
Impetigo / skin infection Children (all ages) Small amount to affected area 3–4 times daily for up to 7 days
Infected eczema Adults and children Small amount to affected area 3 times daily — review after 7 days

If you are also managing a fungal skin condition alongside a bacterial infection, you may find our athletes foot and fungal infections range helpful for separate treatment of any fungal element.

 

What Are the Possible Side Effects of Fucidin Cream?

 

Like all medicines, Fucidin Cream can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the area of application.

Common side effects:

  • Mild skin irritation or burning sensation at the application site
  • Redness or itching around the treated area
  • Dry or flaking skin

Less common side effects:

  • Contact dermatitis (an allergic skin reaction)
  • Eczematous skin changes with prolonged use
  • Hypersensitivity reactions — stop use immediately and seek advice if this occurs

If you notice any worsening of your skin condition, spreading redness, or signs of an allergic reaction (such as swelling or hives), stop using the cream and contact your GP or pharmacist promptly.

 

How Should You Store Fucidin Cream?

 

Correct storage helps maintain the effectiveness of the cream throughout its shelf life. For minor wound care products and first aid essentials, you might also want to browse our first aid collection.

  • Store below 25°C in a cool, dry place
  • Do not refrigerate or freeze
  • Keep the tube tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tube or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Fucidin Cream online in the UK?

You can buy Fucidin Cream from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. After a short online consultation to confirm suitability, your order is dispensed and dispatched discreetly. As a prescription-only medicine, it cannot be purchased over the counter without a valid prescription or online consultation.

How does fusidic acid cream work on bacterial skin infections?

Fusidic acid cream works by blocking a protein called elongation factor G (EF-G), which bacteria need to synthesise proteins and replicate. Without this process, the bacteria cannot grow or spread, allowing your immune system to clear the infection. It is particularly effective against Staphylococcus aureus, the most common cause of skin infections like impetigo.

How do I apply Fucidin Cream step by step?

Start by washing your hands and gently cleaning the affected area with mild soap and water. Apply a thin layer of cream directly to the infected skin and rub in gently. Repeat three to four times daily for up to 7 days, and always wash your hands after application unless your hands are the area being treated.

How long does Fucidin Cream take to work?

Many people notice an improvement in their skin infection within 2 to 3 days of starting treatment. However, it is important to complete the full 7-day course even if the skin looks better sooner. Stopping early can allow bacteria to survive and potentially become resistant to the antibiotic.

Can children use Fucidin Cream for impetigo?

Yes, Fucidin Cream is suitable for children of all ages, including infants, and is one of the most commonly used treatments for impetigo in children in the UK. It should be applied under adult supervision and used exactly as directed by a pharmacist or GP. If your child's infection does not improve within a few days, seek medical advice promptly.

What are the side effects of Fucidin Cream and how do I manage them?

The most common side effects are mild and include skin irritation, redness, or itching at the application site. These usually settle on their own as your skin adjusts. If you develop a more significant reaction such as contact dermatitis, swelling, or worsening symptoms, stop using the cream and speak to your pharmacist or GP.

Can I use Fucidin Cream on infected eczema?

Yes, Fucidin Cream is frequently used to treat secondary bacterial infections that develop on eczema-affected skin. It should only be used for short courses of up to 7 days to avoid antibiotic resistance. For ongoing eczema management, speak to your GP about a longer-term skin care plan — you can also browse our skin care range for supportive products.

What is the difference between Fucidin Cream and Fucidin Ointment?

Fucidin Cream has a lighter, water-based formulation that is better suited to moist, weeping, or inflamed skin. Fucidin Ointment is greasier and more occlusive, making it more appropriate for dry, scaly, or thickened skin. Both contain fusidic acid 2% as the active ingredient and work in the same way — the choice between them depends on the nature of your skin condition.

Who is eligible to use Fucidin Cream?

Fucidin Cream is suitable for adults and children with a bacterial skin infection caused by susceptible organisms. It is not appropriate for people who are allergic to fusidic acid, or for treating fungal or viral skin conditions. Pregnant or breastfeeding women should consult a pharmacist or GP before use.

What happens if I miss a dose of Fucidin Cream?

If you forget to apply Fucidin Cream at your usual time, apply it as soon as you remember. If it is nearly time for your next application, skip the missed dose and carry on with your regular schedule. Do not apply a double amount to make up for a missed application.

How long can you use Fucidin Cream for?

Fucidin Cream is typically used for a course of up to 7 days. Prolonged or repeated use is not recommended because it can contribute to antibiotic resistance, making the treatment less effective over time. If your infection has not cleared after 7 days, consult your GP rather than continuing to apply the cream independently.

What are the alternatives to Fucidin Cream?

The main alternative topical antibiotic used in the UK for similar indications is mupirocin (Bactroban), which is also effective against Staphylococcus aureus. For more widespread or severe infections, oral antibiotics such as flucloxacillin may be prescribed by a GP. If you are also dealing with a fungal skin condition, our athletes foot and fungal infections range covers separate antifungal treatments.

Is Fucidin Cream safe to use during pregnancy?

There is limited data on the use of topical fusidic acid during pregnancy, and systemic absorption from topical application is generally low. However, you should always consult your GP or midwife before using any prescription medicine during pregnancy or while breastfeeding. They can advise on whether the benefits outweigh any potential risks in your specific situation.

Can Fucidin Cream cause antibiotic resistance?

Yes, like all antibiotics, fusidic acid can contribute to resistance if used incorrectly — particularly if courses are not completed or if it is used repeatedly without medical supervision. This is why it is important to use it only when genuinely needed, for the shortest effective duration, and always to complete the prescribed course. Resistance to fusidic acid in Staphylococcus aureus has been documented in clinical settings.

What are the latest clinical findings on fusidic acid cream for impetigo?

Clinical guidelines from NICE and NHS England continue to support topical fusidic acid as a first-line treatment for localised non-bullous impetigo in both adults and children. Emerging concerns around resistance have led to guidance recommending short courses and limiting repeat prescriptions. Your GP or pharmacist can advise on the most current treatment pathway for your specific situation.

How Should You Use Fucidin Cream?

Fucidin Cream is applied directly to the affected area of skin. Always wash your hands before and after application, and make sure the skin is clean and dry before you begin.

What Is the Correct Dose of Fucidin Cream?

The dose of Fucidin Cream depends on the condition being treated and the age of the patient. Always follow the instructions given by your prescriber or pharmacist, and do not apply more than directed.

When Is the Best Time to Use Fucidin Cream?

There is no single fixed time of day that is clinically required for applying Fucidin Cream. However, spacing your applications evenly throughout the day — for example morning, midday, and evening — helps maintain a consistent level of the antibiotic on the skin. Applying it after washing the affected area is a practical approach that also helps keep the skin clean during treatment.

How Long Can You Use Fucidin Cream For?

Fucidin Cream is intended for short-term use only. The standard treatment course is up to 7 days. Using it for longer than recommended increases the risk of antibiotic resistance developing, which can make the treatment less effective in the future. If your infection has not improved after 7 days of treatment, do not continue applying the cream — contact your GP for further assessment and advice.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Fucidin Cream?

Most people tolerate Fucidin Cream well, and side effects are generally mild and localised to the area of application. They tend to settle on their own as your skin adjusts to the treatment.

  • Mild burning or stinging sensation at the application site
  • Skin redness or irritation
  • Itching around the treated area
  • Dry or flaking skin

What Are the Less Common Side Effects of Fucidin Cream?

Less frequently, some people may experience more noticeable skin reactions. These are not typical but are worth being aware of before you start treatment.

  • Contact dermatitis — an allergic skin reaction causing a rash, blistering, or swelling
  • Eczematous changes to the skin with prolonged or repeated use
  • Skin sensitisation — where the skin becomes increasingly reactive to the cream over time

What Are the Serious Side Effects of Fucidin Cream?

Serious side effects from topical fusidic acid are rare, particularly because systemic absorption through the skin is minimal when used correctly. However, hypersensitivity reactions can occasionally occur. Signs of a serious allergic reaction include significant swelling, hives, difficulty breathing, or a widespread skin rash. If you experience any of these, stop using the cream immediately and seek urgent medical attention.

What Should You Do If You Experience Side Effects?

If you notice mild irritation or redness, you can usually continue using the cream and monitor whether the reaction settles. If the side effect is more severe, persistent, or spreading, stop applying the cream and contact your pharmacist or GP. Do not try to treat an allergic reaction yourself — always seek professional advice. Keep a note of when the reaction started and what it looks like, as this will help your healthcare provider assess the situation.

Can Fucidin Cream Interact With Other Medicines?

Because Fucidin Cream is applied topically and has very low systemic absorption, significant interactions with other medicines are uncommon. However, if you are using other topical preparations on the same area of skin — such as emollients, steroid creams, or other antibiotics — you should apply them at different times and seek pharmacist advice to avoid reducing the effectiveness of either product. Always inform your pharmacist of all medicines you are currently using, including over-the-counter products.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question


Mainly bacterial skin infections — impetigo, infected eczema, infected dermatitis, and cuts or scrapes that got infected.


Most people see improvement in 2–3 days, but you should keep using it for the full course.


Yes, but use very lightly and only if a pharmacist said it’s fine — facial skin is way more sensitive.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What exactly does Fucidin Cream treat?


Mainly bacterial skin infections — impetigo, infected eczema, infected dermatitis, and cuts or scrapes that got infected.

How fast does it work?


Most people see improvement in 2–3 days, but you should keep using it for the full course.

Is it okay to use on my face?


Yes, but use very lightly and only if a pharmacist said it’s fine — facial skin is way more sensitive.