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E45 Moisturiser Cream Moisturiser Pump - 500g

E45 Moisturiser Cream Moisturiser Pump - 500g

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  • ✔️ Clinically proven emollient for eczema, dermatitis, and dry skin
  • ✔️ Restores the skin's natural moisture barrier with regular use
  • ✔️ Fragrance-free formula suitable for sensitive and reactive skin
  • ✔️ 500g pump dispenser for hygienic, easy whole-body application
  • ✔️ Suitable for adults, children, and everyday dry skin relief

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What Is E45 Moisturiser Cream and Who Is It For?

 

If you live with dry, itchy, or sensitive skin, you'll know how relentless it can feel — especially through the colder months. E45 moisturiser cream is one of the UK's most widely recommended emollients, trusted by dermatologists and GPs alike for decades. Available here in a convenient 500g pump dispenser, it's designed for everyday use on the face and body, offering lasting hydration without the faff of unscrewing a lid every time. You can browse the full range of emollients and topical treatments in our creams and ointments collection.

Dry skin is incredibly common in the UK. The NHS recognises emollients as a cornerstone treatment for conditions such as eczema, psoriasis, and ichthyosis — and E45 cream sits firmly within that category. It's available over the counter without a prescription, making it accessible for most people who need regular skin support.

 

How Does E45 Moisturiser Cream Work?

 

E45 cream works through a combination of three active ingredients that each play a distinct role in restoring and maintaining the skin's natural moisture barrier. Here's how they work together:

  • Light liquid paraffin (12.6%): Acts as an emollient, softening the outer layers of skin and reducing water loss through the skin surface.
  • White soft paraffin (14.5%): Creates an occlusive layer on the skin, physically sealing in moisture and protecting against environmental irritants.
  • Anhydrous lanolin — hypoallergenic (1%): Derived from wool wax, this ingredient helps the cream penetrate the skin more effectively, improving hydration at a deeper level.

Together, these ingredients work to replenish the lipid barrier that dry or compromised skin struggles to maintain on its own. The result is skin that feels softer, less tight, and less prone to cracking or flaking.

 

Who Should Use E45 Moisturiser Cream?

 

E45 cream is suitable for a wide range of people and skin types. It's particularly well-suited to those with chronic dry skin conditions, but it works just as well as a daily moisturiser for anyone whose skin needs a little extra care. That said, it's worth knowing who benefits most.

  • Adults and children with eczema or atopic dermatitis
  • People with psoriasis or ichthyosis seeking daily emollient support
  • Individuals with dry, flaky, or itchy skin caused by cold weather or frequent handwashing
  • Those with sensitive skin who need a fragrance-free, clinically tested moisturiser

It is not recommended for use on actively infected skin without medical advice. If you're unsure whether E45 cream is right for your skin condition, speak to your pharmacist or GP before starting use.

 

How Does E45 Cream Compare to Similar Emollients?

 

Feature E45 Moisturiser Cream 500g Pump Diprobase Cream
Active ingredients Light liquid paraffin, white soft paraffin, lanolin Cetomacrogol, liquid paraffin, white soft paraffin
Suitable for eczema Yes Yes
Fragrance-free Yes Yes
Lanolin-free No (contains hypoallergenic lanolin) Yes

 

Is E45 Cream Safe to Use Long-Term?

 

Yes — E45 moisturiser cream is considered safe for long-term daily use. Emollients like this one are routinely recommended by the NHS as part of ongoing management for chronic dry skin conditions, and there is no evidence of harm from prolonged use in most patients. The hypoallergenic lanolin used in the formula is processed to reduce the risk of sensitisation, though people with a known lanolin allergy should avoid it and consider a lanolin-free alternative.

If you're managing a skin condition alongside other health concerns, it's worth exploring our broader skin care collection for complementary products. Always store the cream below 25°C, keep it away from children, and avoid using it near open flames — paraffin-based products can be a fire hazard if they soak into fabric.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

E45 Moisturiser Cream Pump 500g specifications
Treatment category Emollient / Moisturiser
Mechanism of action Occlusive and emollient barrier; reduces transepidermal water loss
Effective for Dry skin, eczema, dermatitis, ichthyosis, psoriasis
Suitable for Adults, children, and babies (seek advice for under 12 months)
Active ingredients Light liquid paraffin 12.6%, white soft paraffin 14.5%, anhydrous lanolin (hypoallergenic) 1%
Pack size 500g
UK classification General Sale List (GSL)
Drug class Emollient
Preparation Cream
Route of administration Topical (skin)

Specifications of E45 Moisturiser Cream Pump 500g

 

What Is E45 Moisturiser Cream and What Is It Used For?

 

E45 Moisturiser Cream is a topical emollient used to treat and manage dry, itchy, and sensitive skin. It is clinically indicated for conditions including eczema, dermatitis, ichthyosis, and psoriasis, as well as everyday dry skin caused by environmental factors such as cold weather, central heating, or frequent handwashing. The NHS recommends emollients as a first-line treatment for dry skin conditions, and E45 cream is one of the most widely used products in this category across the UK.

The 500g pump format makes it particularly practical for regular, whole-body application — no need to dig into a tub with your fingers, which can introduce bacteria into the product. It's a small detail, but it matters when you're using a moisturiser multiple times a day.

 

What Do You Need to Know Before Using E45 Moisturiser Cream?

 

Before using E45 cream, check the following contraindications and warnings carefully:

  • Do not use if you have a known allergy to lanolin, light liquid paraffin, white soft paraffin, or any other listed ingredient
  • Do not apply to infected, broken, or weeping skin without first seeking medical advice
  • Avoid contact with the eyes
  • Paraffin-based emollients can soak into clothing and bedding — keep away from naked flames and do not smoke while applying
  • If your skin condition worsens or does not improve after regular use, consult your GP or pharmacist
  • Seek medical advice before using on babies under 12 months

Regarding drug interactions, E45 cream is a topical product and is not known to interact with oral or systemic medicines. However:

  • Do not apply at the same time as topical corticosteroids without spacing application times — your pharmacist can advise on the correct order and timing
  • Avoid using alongside other topical products on the same area without professional guidance

 

How Should You Use E45 Moisturiser Cream?

 

Using E45 cream correctly makes a real difference to how well it works. Follow these steps for best results:

  1. Wash and gently pat the affected area dry before applying
  2. Press the pump dispenser to release a sufficient amount of cream
  3. Apply to the skin using smooth, downward strokes in the direction of hair growth — this reduces the risk of folliculitis
  4. Massage gently until the cream is absorbed
  5. Reapply as often as needed throughout the day, or as directed by your doctor
  6. Wash hands after application unless the hands themselves are being treated
Indication Age Group Dose Frequency
Dry / sensitive skin Adults and children Apply liberally to affected area As often as required
Eczema / dermatitis Adults and children Apply liberally to affected area Multiple times daily, or as directed by GP
Ichthyosis / psoriasis Adults Apply liberally to affected area As directed by GP or dermatologist

 

What Are the Possible Side Effects of E45 Moisturiser Cream?

 

E45 cream is generally very well tolerated. Side effects are uncommon, but it's important to know what to look out for. If you're also managing other skin concerns, our skin care collection includes a range of products that may complement your routine.

Common side effects (may affect a small number of users):

  • Mild stinging or tingling immediately after application, particularly on broken or very dry skin
  • Temporary greasiness or heaviness on the skin surface

Less common side effects (rare but possible):

  • Skin rash or redness at the site of application
  • Allergic contact dermatitis — most commonly associated with the lanolin component
  • Folliculitis (inflammation of hair follicles) if cream is applied against the direction of hair growth

If you notice any signs of a serious allergic reaction — such as swelling of the face, lips, or throat, difficulty breathing, or severe skin irritation — stop using immediately and seek urgent medical attention.

 

How Should You Store E45 Moisturiser Cream?

 

Correct storage keeps the product safe and effective for its full shelf life. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep out of direct sunlight
  • Keep the pump cap closed when not in use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not store near naked flames or heat sources — paraffin-based products are flammable

If you're looking for additional support for skin conditions in children, our baby and toddler collection includes products specifically formulated for younger, more delicate skin.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy E45 Moisturiser Cream 500g pump online in the UK?

You can buy E45 Moisturiser Cream 500g pump directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £11.24 with convenient home delivery. It is also available in most high street pharmacies and supermarkets without a prescription. Buying online is often more cost-effective, particularly for a larger 500g size you'll use regularly.

How does E45 cream work on dry and sensitive skin?

E45 cream works by combining three active ingredients — light liquid paraffin, white soft paraffin, and hypoallergenic lanolin — to form a protective barrier on the skin surface. This barrier reduces transepidermal water loss, keeping moisture locked in and preventing the skin from drying out further. Over time, regular use helps restore the skin's natural lipid barrier, reducing itching, flaking, and tightness.

How do I use E45 Moisturiser Cream step by step?

Start by washing and gently patting the affected area dry, then press the pump to dispense the cream and apply it using smooth, downward strokes in the direction of hair growth. Massage gently until absorbed and reapply as often as needed throughout the day. Washing your hands after application is recommended unless you are treating the hands themselves.

Can I use E45 cream on my face?

Yes, E45 cream is suitable for use on the face for dry or sensitive skin, provided you avoid direct contact with the eyes. It is fragrance-free and clinically tested, making it a good option for facial skin that is prone to dryness or irritation. If you experience any redness or worsening of your skin after applying it to your face, stop use and consult a pharmacist.

Is E45 Moisturiser Cream suitable for babies and children?

E45 cream is suitable for use in children and adults, and can be used on babies, though it is advisable to seek GP or pharmacist advice before applying any emollient to a baby under 12 months. For younger children with eczema or dry skin, you can explore our baby and toddler collection for age-appropriate options. Always patch-test on a small area of skin first when using any new product on a child.

What are the side effects of E45 cream?

Side effects from E45 cream are uncommon, but some people may experience mild stinging or tingling on application, particularly on very dry or broken skin. Rarely, an allergic reaction to the lanolin component can occur, presenting as redness, rash, or worsening irritation at the application site. If you notice any signs of a serious allergic reaction such as swelling or difficulty breathing, stop use immediately and seek urgent medical attention.

Who is eligible to use E45 Moisturiser Cream?

E45 cream is suitable for most adults and children with dry, sensitive, or eczema-prone skin, and is available without a prescription as a General Sale List (GSL) medicine. It is not suitable for people with a known allergy to lanolin, light liquid paraffin, or white soft paraffin. Those with infected or weeping skin should seek medical advice before using any emollient.

What is the difference between E45 cream and E45 lotion?

E45 cream has a thicker, more occlusive consistency that makes it particularly effective for very dry, cracked, or eczema-prone skin where a stronger moisture barrier is needed. E45 lotion is lighter and spreads more easily, making it more comfortable for use over larger body areas or in warmer weather. Your choice between the two will depend on the severity of your dryness and personal preference.

How long can you use E45 cream for?

E45 cream can be used long-term as part of a daily skincare routine for chronic dry skin conditions such as eczema or psoriasis — there is no recommended maximum duration of use. The NHS advises that emollients should be used regularly and consistently, even when the skin appears to have improved, to prevent flare-ups. If your condition does not improve or worsens over time, speak to your GP or dermatologist.

What is the best time to apply E45 Moisturiser Cream?

E45 cream can be applied at any time of day, but applying it immediately after bathing or showering — while the skin is still slightly damp — helps to lock in moisture more effectively. Many people find that applying it before bed allows the cream to work overnight when the skin is at rest and not exposed to environmental irritants. For eczema management, your GP may recommend a specific application schedule as part of your treatment plan.

Can E45 cream be used alongside steroid creams?

Yes, E45 cream is commonly used alongside topical corticosteroids as part of an eczema management plan, but you should not apply both products to the same area at exactly the same time. The general guidance is to apply the emollient first, allow it to absorb for around 30 minutes, and then apply the steroid cream — though your pharmacist or GP may advise differently. Always follow the specific instructions given by your healthcare provider.

Is E45 cream safe to use during pregnancy?

E45 cream is generally considered safe to use during pregnancy for the management of dry or itchy skin, as it is a topical product with minimal systemic absorption. However, as with any product used during pregnancy, it is always sensible to check with your midwife, GP, or pharmacist before starting use. They can confirm it is appropriate for your individual circumstances and skin condition.

What are the alternatives to E45 Moisturiser Cream?

Common alternatives to E45 cream include Diprobase Cream, Aveeno Cream, Cetraben Cream, and Doublebase Gel — all of which are emollients used for similar dry skin conditions. If you have a lanolin allergy, a lanolin-free option such as Diprobase may be more suitable. You can explore a range of emollient options in our creams and ointments collection.

Is the E45 cream pump dispenser more hygienic than a tub?

Yes — the pump dispenser format is generally considered more hygienic than a tub because you don't need to insert fingers into the product each time, which can introduce bacteria and contaminate the cream over time. This is particularly relevant for people with broken or inflamed skin, where infection risk is higher. The 500g pump size also makes it practical and economical for regular, whole-body use.

What are the latest recommendations on emollient use for eczema?

Current NHS guidance recommends that emollients should be applied liberally and frequently — at least twice daily — as a core part of eczema management, even during periods when the skin appears clear. Research continues to support early and consistent emollient use as a way to strengthen the skin barrier and reduce the frequency of eczema flare-ups. Your GP or dermatologist can advise on the most appropriate emollient regimen for your specific skin type and condition severity.

How Should You Use E45 Moisturiser Cream?

Using E45 cream correctly helps you get the most out of every application. The pump dispenser makes it easy to dispense the right amount without contaminating the product, which is particularly important if you're applying it to broken or sensitive skin.

What Is the Correct Dose of E45 Moisturiser Cream?

There is no fixed dose for E45 cream in the traditional sense — the amount you use will depend on the size of the area being treated and the severity of your dryness. As a general rule, apply liberally and frequently rather than sparingly. The NHS advises that emollients should be used generously and regularly for best results in managing dry skin conditions.

When Is the Best Time to Use E45 Moisturiser Cream?

The most effective time to apply E45 cream is immediately after bathing or showering, while the skin is still slightly damp. This helps to seal in the residual moisture from washing, maximising the hydrating effect of the emollient. Applying before bed is also beneficial, as the skin can absorb the cream overnight without the interference of clothing friction or environmental exposure.

If you are using E45 cream alongside a topical corticosteroid, apply the emollient first and wait approximately 30 minutes before applying the steroid cream. This prevents the emollient from diluting the steroid and ensures both products work as intended.

How Long Can You Use E45 Moisturiser Cream For?

E45 cream is safe for long-term, continuous use. For chronic conditions such as eczema or psoriasis, the NHS recommends ongoing emollient use as a cornerstone of daily skin management — not just during flare-ups, but consistently to maintain the skin barrier. There is no evidence of harm from prolonged use in most patients.

If you notice no improvement after several weeks of regular use, or if your skin condition worsens, speak to your GP or pharmacist. They may recommend a different formulation or additional treatment alongside your emollient routine.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of E45 Moisturiser Cream?

E45 cream is well tolerated by the vast majority of people who use it. Common side effects are generally mild and tend to resolve quickly without any need to stop treatment. They are most likely to occur when you first start using the cream or when applying it to particularly dry or broken skin.

  • Mild stinging or tingling sensation immediately after application
  • Temporary greasiness or heaviness on the skin surface
  • A feeling of warmth at the application site

What Are the Less Common Side Effects of E45 Moisturiser Cream?

Less common side effects are rare but worth being aware of, particularly if you have a history of skin sensitivities or allergies. If any of the following occur, consider stopping use and speaking to a pharmacist before continuing.

  • Skin rash or redness at the site of application
  • Allergic contact dermatitis — most commonly linked to the hypoallergenic lanolin component
  • Folliculitis (inflammation of hair follicles), which can occur if the cream is applied against the direction of hair growth
  • Increased skin sensitivity or irritation in people with a pre-existing lanolin allergy

What Are the Serious Side Effects of E45 Moisturiser Cream?

Serious side effects from E45 cream are very rare. However, a small number of people may experience a significant allergic reaction, particularly those with an undiagnosed sensitivity to lanolin or paraffin-based ingredients. Signs of a serious allergic reaction include swelling of the face, lips, tongue, or throat, difficulty breathing, severe skin blistering, or a widespread rash. If you experience any of these symptoms, stop using the cream immediately and seek urgent medical attention or call 999.

What Should You Do If You Experience Side Effects of E45 Moisturiser Cream?

For mild side effects such as stinging or temporary greasiness, no action is usually needed — these typically settle within a few minutes of application. If you develop a rash or notice your skin condition worsening rather than improving, stop use and consult your pharmacist or GP. They can help identify whether the reaction is related to a specific ingredient and recommend a suitable alternative emollient if needed. You can also report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can E45 Moisturiser Cream Interact With Other Medicines?

As a topical product, E45 cream has no known interactions with oral or systemic medicines. However, applying it at the same time as a topical corticosteroid or other medicated cream to the same area may affect how well those products are absorbed. The standard advice is to apply your emollient first, allow it to absorb for around 30 minutes, and then apply any medicated topical treatment. Always follow the specific guidance given by your GP or pharmacist regarding the order and timing of topical products.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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