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E45 Itch Relief Cream

E45 Itch Relief Cream

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  • ✔️ Relieves itchy skin caused by eczema and dermatitis
  • ✔️ Contains urea to deeply hydrate dry, flaky skin
  • ✔️ Lauromacrogols reduce itch signals in skin nerve endings
  • ✔️ Suitable for adults and children over two years
  • ✔️ Can be used up to three times daily for ongoing relief

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What Is E45 Itch Relief Cream and How Does It Help Itchy Skin?

 

If you have ever dealt with persistently itchy, dry skin, you will know how disruptive it can be. Scratching brings only temporary relief and often makes things worse. E45 itch relief cream is a topical antipruritic medicine designed to tackle that itch directly, while also working to restore moisture to skin that has become dry, flaky, or irritated. It is available over the counter without a prescription, making it an accessible option for many people managing chronic skin conditions at home. You can find it alongside other creams and ointments at Cured Pharmacy.

The cream contains two active ingredients: urea 5% w/w and lauromacrogols 3% w/w. Together, these work on both the symptom of itch and the underlying dryness that so often triggers it. It is commonly used for conditions such as eczema, contact dermatitis, and other forms of dry, pruritic skin.

 

How Does E45 Itch Relief Cream Work on Itchy Skin?

 

The mechanism behind this cream is straightforward but clinically meaningful. Rather than simply masking the itch, it addresses it through two distinct pathways:

  • Lauromacrogols (3% w/w): These act as a local anaesthetic on the nerve endings in the skin, reducing the transmission of itch signals. This provides relatively rapid relief from the urge to scratch.
  • Urea (5% w/w): Urea is a naturally occurring humectant — it draws water into the outer layers of the skin (the stratum corneum), improving hydration and softening rough, flaky patches. It also has mild keratolytic properties, helping to break down thickened or scaly skin over time.
  • Combined effect: By addressing both the neurological itch signal and the skin barrier dysfunction that drives chronic dryness, the cream works on two fronts simultaneously.

This dual action makes it particularly useful for conditions where itch and dryness coexist — which, frankly, is most of them.

 

Who Is E45 Itch Relief Cream Suitable For?

 

This cream is suitable for a wide range of people, but it is worth knowing who benefits most. It is generally recommended for adults and children over 2 years of age. If you are managing a skin condition and looking for targeted itch relief alongside moisturisation, this could be a practical option. You might also want to explore our broader skin care range for complementary products.

  • Adults with eczema or atopic dermatitis experiencing persistent itch
  • People with contact dermatitis caused by irritants or allergens
  • Those with dry, flaky skin conditions including ichthyosis
  • Children over 2 years with itchy skin conditions (under medical guidance)

It is not suitable for use on broken, weeping, or infected skin without medical advice. Pregnant or breastfeeding women should consult their GP or pharmacist before use.

 

How Does E45 Itch Relief Cream Compare to Regular E45 Cream?

 

Feature E45 Itch Relief Cream Regular E45 Cream
Primary action Antipruritic + emollient Emollient only
Active ingredients Urea 5%, Lauromacrogols 3% Light liquid paraffin, white soft paraffin, hypoxyethylcellulose
Targets itch directly Yes No
Suitable for dry skin Yes Yes

 

Is E45 Itch Relief Cream Safe to Store and Use Long Term?

 

Store the cream below 25°C, away from direct sunlight and out of reach of children. Do not use after the expiry date printed on the packaging. Once opened, check the product's period-after-opening symbol (the open jar icon) for guidance on how long it remains usable — typically 12 months.

For long-term skin conditions, it is sensible to review your treatment plan with a GP or pharmacist periodically. E45 itch relief cream is intended for symptomatic relief; if your skin condition is worsening or not responding after four weeks of consistent use, seek professional advice rather than continuing indefinitely without review.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

E45 Itch Relief Cream specifications
Treatment category Antipruritic / Emollient
Mechanism of action Local anaesthetic effect (lauromacrogols) + humectant/keratolytic (urea)
Effective for Itchy, dry skin; eczema; contact dermatitis; ichthyosis
Suitable for Adults and children over 2 years
Active ingredients Urea 5% w/w, Lauromacrogols 3% w/w
Pack sizes 100g, 500g
UK classification P (Pharmacy medicine)
Drug class Antipruritic / Emollient
Preparation Cream
Route of administration Topical (cutaneous)

Specifications of E45 Itch Relief Cream

 

What Is E45 Itch Relief Cream and What Is It Used For?

 

E45 Itch Relief Cream is a topical medicine used to relieve itching and moisturise dry, flaky skin. It contains two active ingredients — urea 5% w/w and lauromacrogols 3% w/w — which work together to reduce the sensation of itch and improve skin hydration. It is used for conditions including eczema, contact dermatitis, and other pruritic (itchy) dry skin conditions. The NHS recognises emollients and topical antipruritics as key components of managing these conditions at home.

 

What Do You Need to Know Before Using E45 Itch Relief Cream?

 

Before applying this cream, there are some important safety points to be aware of. Do not use it if any of the following apply to you:

  • You are allergic to urea, lauromacrogols, or any other ingredient in the formulation
  • The skin is broken, weeping, or shows signs of infection (such as crusting, oozing, or increased warmth)
  • You have a known sensitivity to any component of the cream
  • You are applying it to a child under 2 years without first consulting a GP

Use with caution if you are pregnant or breastfeeding — speak to your pharmacist or GP before use. Avoid contact with the eyes, mouth, and mucous membranes. If accidental contact occurs, rinse thoroughly with water.

Regarding drug interactions, no significant interactions with other medicines have been identified for topical use of this product. However:

  • Avoid using alongside other topical products on the same area at the same time without pharmacist guidance
  • If you are using topical corticosteroids for eczema, apply them separately and allow each product to absorb before applying the next

 

How Should You Use E45 Itch Relief Cream Correctly?

 

Using this cream correctly will help you get the most benefit from it. Follow these steps each time you apply it:

  1. Wash and gently dry the affected area before application
  2. Take a small amount of cream and apply it directly to the itchy or dry skin
  3. Massage gently in a downward direction (following the direction of hair growth) until absorbed
  4. Wash your hands after application unless your hands are the area being treated
  5. Repeat up to three times daily, or as directed by your pharmacist or GP
Indication Age Group Dose Frequency
Itchy, dry skin / eczema Adults Apply a thin layer to affected area Up to 3 times daily
Itchy, dry skin / eczema Children over 2 years Apply a thin layer to affected area Up to 3 times daily
Contact dermatitis Adults Apply a thin layer to affected area Up to 3 times daily

If you are also managing eczema with other treatments, our skin care collection includes a range of complementary emollients and topical products.

 

What Are the Possible Side Effects of E45 Itch Relief Cream?

 

Like all medicines, E45 Itch Relief Cream can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the area of application.

Common side effects:

  • Mild stinging or burning sensation immediately after application
  • Temporary redness at the application site
  • Mild skin irritation

Less common side effects:

  • Allergic contact dermatitis (worsening rash or new redness)
  • Skin sensitivity or increased itching after application

If you notice any signs of a serious allergic reaction — such as swelling of the face, lips, or throat, difficulty breathing, or a widespread rash — stop using the cream immediately and seek urgent medical attention. The NHS advises contacting 999 or going to A&E for severe allergic reactions.

 

How Should You Store E45 Itch Relief Cream Safely?

 

Correct storage helps maintain the cream's effectiveness and safety. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the lid tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

If you are looking for additional support managing dry or itchy skin conditions, you may also find useful products in our baby and toddler range for younger family members with sensitive skin.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy E45 Itch Relief Cream online in the UK?

You can buy E45 Itch Relief Cream online from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available without a prescription as an over-the-counter medicine. Browse our full range of creams and ointments for related products.

How does E45 Itch Relief Cream work in the body?

E45 Itch Relief Cream works through two active ingredients applied directly to the skin. Lauromacrogols act on the nerve endings in the skin to reduce the sensation of itch, while urea draws moisture into the outer skin layers and softens dry, flaky patches. Together, they address both the itch signal and the underlying skin barrier dryness that often triggers it.

How do I apply E45 Itch Relief Cream step by step?

Clean and gently dry the affected area, then apply a small amount of cream and massage it in gently following the direction of hair growth. Use up to three times daily, and wash your hands after application unless your hands are the area being treated. Avoid applying to broken, weeping, or infected skin without first speaking to a pharmacist.

What is the correct dose of E45 Itch Relief Cream for adults?

For adults, apply a thin layer of E45 Itch Relief Cream to the affected area up to three times daily. There is no fixed quantity per application — use enough to cover the area without leaving a thick residue. If symptoms do not improve within four weeks, consult your GP or pharmacist.

What are the side effects of E45 Itch Relief Cream?

Most people tolerate E45 Itch Relief Cream well, but some may experience mild stinging, temporary redness, or skin irritation at the application site. Less commonly, allergic contact dermatitis or increased itching may occur. If you notice swelling, difficulty breathing, or a widespread rash, stop use immediately and seek urgent medical attention.

Is E45 Itch Relief Cream suitable for children?

E45 Itch Relief Cream is generally suitable for adults and children over 2 years of age. For children under 2, always consult a GP or pharmacist before use. You can also explore our baby and toddler range for products specifically formulated for younger, more sensitive skin.

Who is eligible to use E45 Itch Relief Cream?

Most adults and children over 2 years with itchy, dry skin conditions such as eczema, contact dermatitis, or ichthyosis are eligible to use this cream. It is not suitable for use on broken, infected, or weeping skin without medical advice. Pregnant or breastfeeding women should speak to their GP or pharmacist before use.

What happens if I accidentally apply too much E45 Itch Relief Cream?

Applying too much cream topically is unlikely to cause serious harm, but it may leave a greasy residue and could potentially increase the risk of mild local irritation. Simply wipe away any excess with a clean tissue. If the cream is accidentally ingested, contact NHS 111 or your nearest A&E for advice.

What is the difference between E45 Itch Relief Cream and regular E45 Cream?

Regular E45 Cream is primarily an emollient that moisturises and protects dry skin, but it does not contain ingredients specifically targeting the itch sensation. E45 Itch Relief Cream additionally contains lauromacrogols and urea, which directly reduce itch signals in the skin as well as providing moisturisation. If itch is your main concern, the itch relief formulation is the more targeted choice.

Can I use E45 Itch Relief Cream on my face?

Yes, E45 Itch Relief Cream can be applied to the face, but you should avoid contact with the eyes, mouth, and mucous membranes. If accidental contact occurs, rinse thoroughly with water. If you have sensitive facial skin or a specific facial skin condition, check with your pharmacist before use.

How long can you use E45 Itch Relief Cream for?

You can use E45 Itch Relief Cream for as long as symptoms persist, but if your condition has not improved after four weeks of regular use, you should consult your GP. Long-term use for chronic conditions such as eczema is common, but it is good practice to have your treatment plan reviewed periodically by a healthcare professional.

Can I use E45 Itch Relief Cream during pregnancy?

There is limited specific safety data on the use of E45 Itch Relief Cream during pregnancy. As a precaution, pregnant or breastfeeding women should consult their GP or pharmacist before using this product. Your healthcare provider can advise on the most appropriate treatment for itchy skin during pregnancy.

Are there any alternatives to E45 Itch Relief Cream?

Alternatives for itchy, dry skin include other emollient creams, urea-based moisturisers, and antihistamine creams for itch relief. For eczema, your GP may also recommend topical corticosteroids for short-term use. Browse our skin care collection to explore other options available without a prescription.

What are the latest studies on urea-based creams for eczema?

Research consistently supports the use of urea-containing emollients in the management of dry skin conditions including eczema, with studies showing improvements in skin hydration and barrier function. Urea is well established in dermatology as both a humectant and mild keratolytic agent. The NHS and NICE both recognise emollient therapy as a cornerstone of eczema management.

Can E45 Itch Relief Cream be used alongside other eczema treatments?

Yes, E45 Itch Relief Cream can generally be used alongside other eczema treatments such as topical corticosteroids, but you should apply each product separately and allow time for absorption between applications. Always follow the guidance of your GP or pharmacist when combining treatments. Avoid applying multiple topical products to the same area at the same time without professional advice.

How Should You Use E45 Itch Relief Cream?

E45 Itch Relief Cream is applied directly to the affected area of skin. Always read the label before use and follow the instructions below to ensure you are applying it safely and effectively.

Avoid applying to broken, weeping, or infected skin without first seeking medical advice. Keep the cream away from your eyes, mouth, and mucous membranes.

What Is the Correct Dose of E45 Itch Relief Cream?

There is no fixed quantity per application — use enough to cover the affected area with a thin layer. The table below summarises dosing guidance by indication and age group.

Do not apply more frequently than three times daily unless specifically advised by a healthcare professional.

When Is the Best Time to Use E45 Itch Relief Cream?

There is no single "best" time — consistency matters more than timing. Many people find it helpful to apply the cream after bathing or showering, when the skin is clean and slightly damp, as this can help lock in moisture more effectively. Applying a dose before bed can also be beneficial, as it allows the cream to work overnight without being rubbed off by clothing or daily activity.

If you are using other topical treatments such as corticosteroid creams, apply them at a different time to E45 Itch Relief Cream and allow each product to absorb fully before applying the next.

How Long Can You Use E45 Itch Relief Cream For?

You can use E45 Itch Relief Cream for as long as your symptoms require it. For chronic conditions such as eczema, ongoing use as part of a daily skincare routine is common and generally well tolerated. However, if your symptoms have not improved after four weeks of regular use, or if your condition worsens at any point, you should consult your GP or pharmacist rather than continuing without review.

For children, it is particularly important to have treatment reviewed regularly by a healthcare professional to ensure the approach remains appropriate as the child grows.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of E45 Itch Relief Cream?

Most people use E45 Itch Relief Cream without experiencing any significant side effects. When side effects do occur, they are usually mild and localised to the area of application. They often settle on their own as your skin adjusts to the product.

  • Mild stinging or burning sensation immediately after application
  • Temporary redness at the application site
  • Mild skin irritation or discomfort

What Are the Less Common Side Effects of E45 Itch Relief Cream?

Less commonly, some people may experience a more pronounced skin reaction. If you notice any of the following, stop using the cream and speak to your pharmacist or GP:

  • Worsening of itching or redness after application
  • Allergic contact dermatitis — a new or spreading rash at the application site
  • Increased skin sensitivity or peeling

These reactions may indicate a sensitivity to one of the ingredients in the formulation. Your pharmacist can help identify a suitable alternative if needed.

What Are the Serious Side Effects of E45 Itch Relief Cream?

Serious side effects are rare with topical use of this product. However, a severe allergic reaction (anaphylaxis) is possible with any medicine, even when applied to the skin. Seek emergency medical attention immediately if you experience any of the following:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • A widespread or rapidly spreading rash
  • Dizziness, feeling faint, or loss of consciousness

Call 999 or go to your nearest A&E if you suspect a severe allergic reaction.

What Should You Do If You Experience Side Effects of E45 Itch Relief Cream?

For mild side effects such as temporary stinging or redness, you can usually continue using the cream and monitor whether the reaction settles. If irritation persists beyond a few days or worsens, stop use and consult your pharmacist. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk — this helps improve medicine safety for everyone.

Never ignore a side effect that concerns you. Your pharmacist is a good first point of contact for advice on whether to continue, switch products, or seek further medical review.

Can E45 Itch Relief Cream Interact With Other Medicines?

No significant drug interactions have been identified for topical use of E45 Itch Relief Cream. However, if you are using other topical medicines on the same area — such as corticosteroid creams, antibiotic ointments, or other emollients — you should apply them at separate times and allow each to absorb fully before applying the next. Using multiple topical products simultaneously on the same area may reduce the effectiveness of each and increase the risk of skin irritation. Always inform your pharmacist of all medicines you are currently using, including over-the-counter products.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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