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E45 Itch Relief Cream

E45 Itch Relief Cream

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E45 Itch Relief Cream for Immediate Skin Comfort

 

E45 Itch Relief Cream provides targeted relief for itchy, irritated skin caused by various conditions including eczema, dermatitis, and general skin dryness. This topical treatment contains urea and lauromacrogols, which work together to moisturise the skin whilst reducing the sensation of itching. You can apply this cream directly to affected areas when discomfort occurs.

The cream is suitable for adults and children over 3 years of age, making it a versatile option for family use. Its non-greasy formula absorbs quickly into the skin, allowing you to continue with daily activities without residue or staining on clothing.

 

How E45 Itch Relief Cream Works on Your Skin

 

The active ingredients in this formulation target itching through two distinct mechanisms. Urea acts as a humectant, drawing moisture into the skin layers and helping to restore the skin's natural barrier function. This moisturising action helps reduce the dryness that often contributes to itching sensations.

Lauromacrogols provide a local anaesthetic effect, temporarily numbing the nerve endings in the skin that transmit itch signals. This dual approach addresses both the underlying dryness and the immediate discomfort, providing you with comprehensive itch relief cream benefits that work within minutes of application.

 

Who Can Benefit from This Dry Skin Treatment

 

This cream is particularly beneficial for people experiencing chronic skin conditions that cause persistent itching. You may find it helpful if you suffer from mild to moderate eczema, contact dermatitis, or age-related skin dryness. The formulation is gentle enough for sensitive skin whilst being effective for stubborn itch symptoms.

The treatment is suitable for various skin types and conditions:

  • Dry, flaky skin that feels tight and uncomfortable
  • Eczema-prone areas that become inflamed and itchy
  • Skin irritation from environmental factors or allergens
  • Age-related skin changes that cause increased sensitivity

You can use this cream alongside other skin care products in your routine, though you should allow time between applications of different treatments to avoid potential interactions.

 

Why Choose a Clinically Tested Formula

 

E45 Itch Relief Cream has undergone dermatological testing to ensure its safety and efficacy for treating itchy skin conditions. The formulation excludes common irritants such as fragrances and colourants, reducing the risk of additional skin reactions in people with sensitive skin.

The cream's pH-balanced formula works in harmony with your skin's natural acidity levels, helping to maintain the protective acid mantle that keeps harmful bacteria at bay. This consideration is particularly important when treating compromised skin that may be more vulnerable to infection.

 

Storage and Shelf Life Considerations

 

You should store this cream at room temperature, away from direct sunlight and heat sources. Keep the tube tightly closed when not in use to prevent contamination and maintain the product's effectiveness. The cream remains stable for the duration indicated on the packaging when stored correctly.

Check the expiry date before each use, and dispose of any remaining product after this date has passed. Once opened, use the cream within the timeframe specified on the packaging to ensure optimal therapeutic benefits.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

 

How to Apply E45 Itch Relief Cream Correctly

Clean and dry the affected area thoroughly before application. Apply a thin layer of cream to the itchy skin and gently massage until fully absorbed. You can use this treatment up to four times daily as needed, though most people find relief with fewer applications.

Wash your hands immediately after application unless you are treating your hands specifically. Avoid contact with eyes, mouth, and other mucous membranes during application. If accidental contact occurs, rinse thoroughly with clean water.

Dosage Guidelines for Different Age Groups

Adults and children over 12 years can apply the cream as needed throughout the day, with a maximum of four applications in any 24-hour period. For children aged 3-12 years, supervise application and use sparingly, applying only to the specific areas requiring treatment.

Do not use this product on children under 3 years of age unless specifically advised by a healthcare professional. If symptoms persist beyond one week of regular use, or if the condition worsens, discontinue use and consult your pharmacist or doctor for further guidance.

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Understanding Potential Side Effects

Like all medicines, E45 Itch Relief Cream can have side effects, although not everyone will experience them. Most people tolerate this treatment well, but you should be aware of possible reactions, particularly if you have sensitive skin or known allergies to topical treatments. If you experience any concerning symptoms, you can find additional support through our creams and ointments collection guidance.

The most commonly reported side effects involve local skin reactions at the application site. These typically occur within the first few days of use and often resolve as your skin adjusts to the treatment.

Possible side effects may include:

  • Mild skin irritation or redness at the application site
  • Temporary stinging or burning sensation upon application
  • Increased skin sensitivity in treated areas
  • Dry or flaky skin around the application site
  • Contact dermatitis in people with ingredient sensitivities
  • Localised swelling or inflammation
  • Skin discolouration that resolves after discontinuation
  • Allergic reactions including rash or hives
  • Worsening of existing skin conditions
  • Photosensitivity in treated areas when exposed to sunlight

If you experience these or any other side effects, speak to your doctor or pharmacist right away. For more information about reporting side effects please see the MHRA Yellow Card Scheme.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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