Skip to product information
1 of 1

  • Images are for illustration purposes only

E45 Dermatological Cream

E45 Dermatological Cream

  • 1. Ozempic®️-equivalent therapy now available for weight management
  • 2. Average weight loss of 17%, with 1 in 3 patients achieving over 20%
  • 3. May help reduce osteoarthritis-related pain
  • 4. Wegovy®️ is not expected to impact the effectiveness of oral contraceptives
  • 5. Supports cardiovascular risk reduction
  • 6. Over 22 million patients treated with semaglutide-based therapies since 2018

  • ✔️ Soothes and relieves dry, itchy, eczema-prone skin effectively
  • ✔️ Restores the skin barrier with three complementary emollient ingredients
  • ✔️ Fragrance-free and dermatologically tested for sensitive skin
  • ✔️ Suitable for adults, children, and infants under supervision
  • ✔️ Clinically recognised emollient recommended by NHS for dry skin

Price Checker

Regular price £4.49
Sale price £4.49
Sale Sold out
  • Lowest price guarantee
  • Includes FREE private prescription

Purchase Options

View full details

 

Is E45 Cream for Dry Skin Right for You?

 

If you have ever dealt with persistently dry, tight, or flaky skin, you will know how uncomfortable it can be — especially when it flares up in cold weather or after bathing. E45 cream for dry skin is one of the most widely recognised emollients available in the UK, trusted by patients and healthcare professionals alike for decades. It is available over the counter without a prescription, making it easy to access as part of your everyday skincare routine. You can browse the full range of skin care products at Cured Pharmacy to find the right option for your needs.

E45 Dermatological Cream contains a combination of light liquid paraffin (12.6%), white soft paraffin (14.5%), and hypoallergenic anhydrous lanolin (1%). These ingredients work together to moisturise and protect the skin barrier, helping to relieve dryness, itching, and flaking associated with a range of skin conditions. It is fragrance-free and has been dermatologically tested, making it a practical choice for people with sensitive skin.

 

How Does E45 Dermatological Cream Work?

 

E45 cream works primarily as an emollient — a substance that softens and soothes the skin by reducing water loss from the skin's surface. When your skin barrier is compromised, moisture escapes more easily, leading to dryness, irritation, and cracking. E45 helps restore that barrier function. Here is how it works:

  • Light liquid paraffin forms a thin film over the skin, reducing transepidermal water loss (TEWL) and keeping the skin hydrated.
  • White soft paraffin acts as an occlusive agent, sealing moisture into the upper layers of the skin and softening rough, thickened areas.
  • Hypoallergenic anhydrous lanolin helps to replenish the skin's natural lipid content, improving suppleness and reducing the sensation of tightness.
  • Together, these ingredients help to calm the itch-scratch cycle that is common in conditions like eczema and psoriasis.

The cream does not contain any active pharmaceutical ingredients in the traditional sense — it works mechanically rather than pharmacologically, which is why it is generally well tolerated even by those with sensitive or reactive skin.

 

Who Should Use E45 Dermatological Cream?

 

E45 cream is suitable for a wide range of people, from infants to older adults. It is particularly useful for anyone whose skin struggles to retain moisture naturally. The NHS recommends emollients as a first-line treatment for dry skin conditions, and E45 is one of the most commonly suggested options.

  • People with eczema (atopic dermatitis) who need regular moisturisation to manage flare-ups
  • Those with psoriasis looking to reduce scaling and discomfort between treatments
  • Individuals with ichthyosis or other chronic dry skin conditions
  • Anyone experiencing dry, chapped, or irritated skin due to environmental factors such as cold weather or frequent handwashing

It is also suitable for use during pregnancy, though it is always sensible to check with your midwife or GP if you have any concerns. Babies and young children can use E45 cream under adult supervision.

 

How Does E45 Cream Compare to Other Emollients?

 

Feature E45 Dermatological Cream Diprobase Cream
Active ingredients Light liquid paraffin, white soft paraffin, lanolin Liquid paraffin, white soft paraffin
Fragrance-free Yes Yes
Suitable for sensitive skin Yes (hypoallergenic lanolin) Yes
Available OTC Yes Yes

 

Is E45 Cream Safe to Store and Use Long-Term?

 

E45 Dermatological Cream should be stored below 25°C, away from direct sunlight and out of reach of children. Once opened, check the packaging for the period-after-opening (PAO) symbol — typically 12 months — and do not use the product beyond this date. Always use a clean spatula or wash your hands before applying to avoid contaminating the pot.

Long-term use of E45 cream for dry skin is generally considered safe when used as directed. However, if you notice any worsening of your skin condition, signs of infection (such as weeping, crusting, or increased redness), or an unexpected reaction, stop using the cream and speak to your pharmacist or GP. You may also find it helpful to explore our range of creams and ointments if you are looking for alternative formulations.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

E45 Dermatological Cream specifications
Treatment category Emollient / Dry skin treatment
Mechanism of action Occlusive and emollient — reduces transepidermal water loss and softens skin
Effective for Dry skin, eczema, psoriasis, ichthyosis, chapped skin
Suitable for Adults, children, and infants (under supervision)
Active ingredients Light liquid paraffin 12.6%, white soft paraffin 14.5%, anhydrous lanolin (hypoallergenic) 1%
Pack sizes 50g, 125g, 350g, 500g
UK classification General Sale List (GSL)
Drug class Emollient
Preparation Cream
Route of administration Topical (applied to skin)

Specifications of E45 Dermatological Cream

 

What Is E45 Dermatological Cream and What Is It Used For?

 

E45 Dermatological Cream is a topical emollient used to treat and manage dry, itchy, and flaking skin. It is suitable for a range of skin conditions including eczema, psoriasis, ichthyosis, and general dry skin caused by environmental factors. The NHS recommends emollients as a cornerstone of dry skin management, and E45 is one of the most frequently used options in both primary care and self-care settings. It works by moisturising the skin and helping to restore the skin's natural protective barrier, reducing discomfort and the urge to scratch.

 

What Do You Need to Know Before Using E45 Dermatological Cream?

 

Before using E45 cream, it is important to check whether it is appropriate for your situation. While it is generally well tolerated, there are some circumstances where caution is needed.

Do not use E45 Dermatological Cream if you:

  • Are allergic to any of the ingredients, including lanolin (wool fat) or any paraffin-based ingredient
  • Have a known sensitivity to lanolin — this is the most common cause of reactions to E45
  • Have an active skin infection — emollients should not be applied to infected skin without medical advice, as they may spread bacteria or fungi
  • Have acne-prone skin — occlusive ingredients may worsen blocked pores in some individuals

Drug interactions:

  • No clinically significant drug interactions are known for topical emollients like E45 cream
  • If you are using other topical treatments (such as topical corticosteroids), apply E45 cream first and allow it to absorb before applying the other product, or follow your prescriber's instructions
  • Paraffin-based emollients can be a fire hazard — dressings, clothing, and bedding that have been in contact with the cream can ignite more easily. Keep away from open flames and do not smoke while using the product

 

How Should You Use E45 Dermatological Cream?

 

Using E45 cream correctly makes a real difference to how effective it is. Apply it regularly — not just when your skin feels uncomfortable — to maintain the skin barrier and prevent flare-ups. If you are managing a condition like eczema, your GP or pharmacist may recommend using it several times a day.

  1. Wash and dry your hands before applying the cream.
  2. Apply a generous amount of cream to the affected area.
  3. Smooth gently into the skin in the direction of hair growth — do not rub vigorously.
  4. Allow the cream to absorb before dressing or applying other topical products.
  5. Reapply as often as needed throughout the day, particularly after washing or bathing.
  6. For best results, apply immediately after bathing while the skin is still slightly damp.
Indication Age Group Dose Frequency
Dry skin / eczema Adults Apply liberally to affected area 2–3 times daily or as needed
Dry skin / eczema Children Apply liberally to affected area 2–3 times daily or as needed
Dry skin / eczema Infants (under supervision) Apply sparingly to affected area As directed by GP or pharmacist
Psoriasis / ichthyosis Adults and children Apply liberally to affected area As often as required

If you are using E45 cream alongside other skin treatments, you may find it helpful to look at our wider range of skin care products for complementary options.

 

What Are the Possible Side Effects of E45 Dermatological Cream?

 

Side effects from E45 cream are uncommon, but they can occur. Most people use it without any problems at all. If you do notice a reaction, it is usually mild and resolves quickly once you stop using the product.

Common side effects:

  • Mild stinging or burning sensation immediately after application, particularly on broken or very dry skin
  • Temporary redness at the application site
  • A feeling of greasiness or heaviness on the skin

Less common side effects:

  • Contact dermatitis — an allergic skin reaction, most often linked to the lanolin component
  • Folliculitis (inflammation of hair follicles) if the cream is applied against the direction of hair growth or used excessively under occlusive dressings
  • Worsening of acne in acne-prone individuals

If you experience a severe allergic reaction — including significant swelling, difficulty breathing, or widespread rash — seek emergency medical attention immediately. For those managing eczema in children, our baby and toddler section includes additional products that may be suitable.

 

How Should You Store E45 Dermatological Cream?

 

  • Store below 25°C in a cool, dry place away from direct sunlight and heat sources
  • Keep the lid tightly closed when not in use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Check the period-after-opening (PAO) symbol on the pack — typically 12 months after first opening
  • Do not store near open flames — paraffin-based products are flammable
  • Do not freeze

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy E45 Dermatological Cream online in the UK?

You can buy E45 Dermatological Cream online from Cured Pharmacy, a GPhC-registered UK online pharmacy, without a prescription. It is classified as a General Sale List (GSL) medicine, meaning it is available over the counter. Simply add it to your basket and it will be dispatched directly to your door.

How does E45 cream work on dry skin?

E45 cream works by forming a protective film over the skin surface that reduces transepidermal water loss — the process by which moisture escapes from the skin. Its combination of light liquid paraffin, white soft paraffin, and hypoallergenic lanolin softens and soothes the skin barrier. This helps to relieve dryness, itching, and flaking associated with conditions like eczema and psoriasis.

How do I use E45 Dermatological Cream step by step?

Wash your hands, then apply a generous amount of E45 cream to the affected area and smooth it gently into the skin in the direction of hair growth. Use it regularly — ideally after bathing while the skin is still slightly damp — to lock in moisture effectively. Reapply throughout the day as needed, particularly after washing your hands or face.

Can I use E45 cream on my face?

Yes, E45 cream can be applied to the face for dry or sensitive skin, including around the nose and cheeks where dryness is common. Avoid direct contact with the eyes and do not apply to broken, infected, or acne-prone skin without speaking to a pharmacist or GP first. If you have very oily or acne-prone skin, a lighter formulation may be more suitable.

Is E45 cream suitable for babies and children?

E45 Dermatological Cream is suitable for use in babies and children, including those with eczema, under adult supervision. Always consult a pharmacist or GP before using any emollient on very young infants, particularly newborns. You can also explore our baby and toddler range for additional skincare options suitable for little ones.

What are the side effects of E45 cream?

Side effects are uncommon but may include mild stinging, temporary redness, or a feeling of greasiness at the application site. In rare cases, some people — particularly those sensitive to lanolin — may develop contact dermatitis. If you notice a worsening rash, significant swelling, or any sign of an allergic reaction, stop using the cream and seek medical advice promptly.

What is the best time to apply E45 cream?

The best time to apply E45 cream is immediately after bathing or showering, while your skin is still slightly damp — this helps to seal in moisture more effectively. Applying it before bed is also beneficial, as the skin has time to absorb the cream overnight without being washed off. For very dry or eczema-prone skin, applying two to three times daily is generally recommended.

How long can you use E45 cream for?

E45 cream can be used long-term as part of a daily skincare routine for chronic dry skin conditions — there is no set maximum duration of use. The NHS recommends that emollients be used continuously, even when the skin appears to have improved, to prevent flare-ups. If your skin condition does not improve after a few weeks of regular use, speak to your GP for further assessment.

What is the difference between E45 cream and E45 lotion?

E45 cream has a thicker, more occlusive consistency, making it better suited to very dry, cracked, or eczema-prone skin that needs intensive moisturisation. E45 lotion is lighter and easier to spread over larger body areas, making it more practical for everyday use on mildly dry skin. The choice between them depends on the severity of your dryness and personal preference.

Who is eligible to use E45 Dermatological Cream?

E45 cream is suitable for most people, including adults, children, and infants, who have dry, itchy, or flaky skin. It is not recommended for people with a known allergy to lanolin or any of the other ingredients. Those with infected skin should seek medical advice before using any emollient, as applying cream to an active infection can sometimes worsen the condition.

Can I use E45 cream during pregnancy?

E45 cream is generally considered safe to use during pregnancy for managing dry or itchy skin, as it is applied topically and is not absorbed systemically in significant amounts. However, it is always a good idea to check with your midwife or GP before starting any new skincare product during pregnancy. If you experience unusual skin changes during pregnancy, a healthcare professional can help identify the most appropriate treatment.

What happens if I miss an application of E45 cream?

Unlike oral medicines, missing a single application of E45 cream is unlikely to cause any significant problem — simply apply it as soon as you remember and continue with your usual routine. Do not apply a double amount to compensate for a missed application. Consistency over time is what matters most with emollients, so try to build regular application into your daily habits.

What are the alternatives to E45 Dermatological Cream?

Common alternatives to E45 cream include Diprobase Cream, Cetraben Cream, Doublebase Gel, and Aveeno Cream — all of which are emollients used for similar dry skin conditions. The right choice depends on your skin type, the severity of your condition, and any ingredient sensitivities you may have. You can explore a range of options in our creams and ointments collection.

Is E45 cream safe to use near an open flame?

No — paraffin-based emollients like E45 cream are flammable, and clothing, bedding, or dressings that have been in contact with the cream can catch fire more easily than usual. The MHRA has issued guidance advising patients not to smoke or go near open flames while using paraffin-based emollients. Always allow the cream to absorb fully and wash clothing and bedding regularly to reduce the risk.

What does the latest research say about emollients like E45 cream?

Current clinical evidence supports the regular use of emollients as a first-line treatment for dry skin conditions including eczema, with the NHS and NICE both recommending them as a cornerstone of management. Research continues to explore whether early emollient use in infants may help reduce the risk of developing eczema, though findings are still evolving. Emollients remain one of the most evidence-based, widely recommended interventions for maintaining skin barrier function.

How Should You Use E45 Dermatological Cream?

Using E45 cream correctly is straightforward, but a few simple steps make a real difference to how well it works. Always apply to clean skin, and try to build it into your daily routine rather than using it only when your skin feels uncomfortable.

What Is the Correct Dose of E45 Dermatological Cream?

There is no fixed dose for E45 cream in the way there is for oral medicines — the amount you use depends on the size of the area being treated and the severity of your dryness. As a general rule, apply liberally and reapply as often as your skin needs it throughout the day.

When Is the Best Time to Use E45 Dermatological Cream?

The most effective time to apply E45 cream is immediately after bathing or showering, while your skin is still slightly damp. This helps to trap moisture in the upper layers of the skin and maximises the emollient effect. Applying before bed is also a good habit, as the cream has time to work overnight without being washed off or rubbed away by clothing.

For people with eczema or psoriasis, applying the cream at consistent times each day — morning and evening as a minimum — helps to maintain the skin barrier and reduce the frequency of flare-ups. Do not wait until your skin feels very dry or itchy before applying; prevention is far easier than recovery.

How Long Can You Use E45 Dermatological Cream For?

E45 cream can be used indefinitely as part of a long-term skincare routine. Unlike some topical treatments, there is no risk of the skin becoming dependent on it or of it losing effectiveness over time. The NHS recommends that emollients be used continuously for chronic dry skin conditions, even during periods when the skin appears to have settled.

If you have been using E45 cream regularly for several weeks and your skin condition has not improved — or if it has worsened — speak to your GP or pharmacist. They can assess whether a different formulation or an additional treatment is needed.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

Be the first to write a review
0%
(0)
0%
(0)
0%
(0)
0%
(0)
0%
(0)

What Are the Most Common Side Effects of E45 Dermatological Cream?

Most people use E45 cream without experiencing any side effects at all. When reactions do occur, they are usually mild and short-lived. The most common issues tend to happen when the cream is first used or applied to particularly sensitive or broken skin.

  • Mild stinging or burning sensation immediately after application
  • Temporary redness at the site of application
  • A feeling of greasiness or heaviness on the skin surface
  • Slight itching in the first few minutes after applying

What Are the Less Common Side Effects of E45 Dermatological Cream?

Less commonly, some people may experience reactions that require them to stop using the product. These are more likely in individuals with a known sensitivity to one of the ingredients, particularly lanolin.

  • Contact dermatitis — an allergic skin reaction causing redness, itching, and a rash, most often linked to the lanolin (wool fat) component
  • Folliculitis — inflammation of the hair follicles, which can occur if the cream is applied against the direction of hair growth or used under occlusive dressings for extended periods
  • Worsening of acne or blocked pores in individuals with oily or acne-prone skin

What Are the Serious Side Effects of E45 Dermatological Cream?

Serious side effects from E45 cream are rare but can occur. The most significant risk is a severe allergic reaction (anaphylaxis), though this is extremely uncommon with topical emollients. A less obvious but important safety concern relates to the flammability of paraffin-based products.

Clothing, bedding, and dressings that have been in contact with paraffin-based emollients can ignite more easily than usual. The MHRA has issued safety guidance on this risk. Always keep away from open flames, naked lights, and do not smoke while using or immediately after applying E45 cream. Wash clothing and bedding regularly to reduce paraffin build-up.

What Should You Do If You Experience Side Effects of E45 Cream?

If you notice mild irritation or stinging after applying E45 cream, this often settles within a few minutes. Try applying a smaller amount and see if this helps. If the irritation persists or worsens, stop using the cream and speak to your pharmacist — they can help identify whether you are reacting to a specific ingredient and suggest an alternative emollient.

If you develop signs of a severe allergic reaction — such as widespread hives, significant facial swelling, difficulty breathing, or a rapid heartbeat — stop using the product immediately and call 999 or go to your nearest A&E department. Do not wait to see if symptoms improve on their own.

Can E45 Cream Interact With Other Medicines?

No clinically significant drug interactions are known for E45 Dermatological Cream when used as directed. However, if you are using other topical treatments — such as topical corticosteroids, antifungal creams, or antibiotic ointments — it is important to apply them in the correct order. Generally, apply E45 cream first, allow it to absorb for around 30 minutes, and then apply the other topical product. Always follow the specific instructions given by your prescriber or pharmacist.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

We’re a safe and
regulated UK service

Registered Pharmacy Badge

Lowest Price Guarantee

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

100% discreet packaging

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

Agent

Need help?
Talk to our friendly experts now

How our service works

Service Setup

Service setup

Discreet Packaging

Discreet packaging

Express Delivery

Express delivery