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E45 Daily Moisturiser Cream 5 Pack

E45 Daily Moisturiser Cream 5 Pack

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  • ✔️ Soothes and relieves dry, itchy, and sensitive skin
  • ✔️ Restores the skin's natural moisture barrier daily
  • ✔️ Fragrance-free formula suitable for sensitive and reactive skin
  • ✔️ Dermatologically tested emollient for eczema and psoriasis
  • ✔️ 5 pack format ensures you never run out of daily moisturiser

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Is E45 Daily Moisturiser Cream Right for Your Skin?

 

If you live with dry, itchy, or sensitive skin, you'll know how much of a difference a reliable moisturiser can make. The E45 daily moisturiser cream is one of the UK's most widely used emollients, trusted by patients and recommended by healthcare professionals for decades. Buying it as a 5 pack from Cured Pharmacy's skin care range means you'll always have a supply to hand — whether you keep one at home, at work, or in your bag.

Dry skin is incredibly common. The NHS notes that conditions such as eczema, psoriasis, and contact dermatitis can all cause the skin to become dry, cracked, and uncomfortable. Emollients like E45 are a cornerstone of managing these conditions, helping to restore the skin's natural barrier and reduce the urge to scratch.

 

How Does E45 Daily Moisturiser Cream Work on Dry Skin?

 

E45 works as an emollient — a substance that softens and soothes the skin by reducing water loss from the skin's surface. It doesn't just sit on top; it actively helps to restore the skin's protective barrier. Here's how it does that:

  • Light liquid paraffin — forms a thin, occlusive film over the skin to lock in moisture.
  • White soft paraffin — softens the outer layer of skin (the stratum corneum), making it more supple and less prone to cracking.
  • Hypoallergenic anhydrous lanolin — helps the cream absorb into the skin and provides additional moisturising properties without common allergens.

Together, these ingredients work to hydrate the skin from the outside in, reducing tightness, flaking, and irritation. Regular use helps maintain the skin's moisture balance, which is particularly important during colder months when central heating and low humidity strip the skin of its natural oils.

 

Who Should Use E45 Daily Moisturiser Cream?

 

E45 is suitable for a wide range of people. It's particularly useful for anyone whose skin is prone to dryness, sensitivity, or irritation. That said, it's always worth checking with your pharmacist if you're unsure whether it's right for your specific skin condition.

  • Adults and older children with dry or sensitive skin
  • People managing eczema, psoriasis, or ichthyosis
  • Those with skin that becomes dry due to frequent handwashing or occupational exposure
  • Individuals looking for a fragrance-free, dermatologically tested daily moisturiser

 

How Does E45 Daily Moisturiser Cream Compare to Other Emollients?

 

Feature E45 Daily Moisturiser Cream Diprobase Cream
Active ingredients Light liquid paraffin, white soft paraffin, lanolin Liquid paraffin, white soft paraffin
Fragrance-free Yes Yes
Suitable for sensitive skin Yes Yes
Available OTC in UK Yes Yes

 

Is E45 Daily Moisturiser Cream Safe to Store and Use Long-Term?

 

Yes — the E45 daily moisturiser cream is designed for regular, ongoing use and is safe to keep as part of your daily routine. Store it below 25°C, away from direct sunlight and out of reach of children. The 5 pack format is ideal if you use emollients frequently, as recommended by the NHS for conditions like eczema, where moisturising several times a day is often advised. You can also explore our wider range of creams and ointments if you need additional topical treatments alongside your moisturiser.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

E45 Daily Moisturiser Cream 5 Pack specifications
Treatment category Emollient / Moisturiser
Mechanism of action Occlusive and humectant emollient — reduces transepidermal water loss and softens the stratum corneum
Effective for Dry skin, eczema, psoriasis, ichthyosis, contact dermatitis
Suitable for Adults and children (consult pharmacist for infants)
Active ingredients Light liquid paraffin, white soft paraffin, anhydrous lanolin (hypoallergenic)
Pack size 5 pack
UK classification General Sale Medicine (GSL)
Drug class Emollient
Preparation Cream
Route of administration Topical (applied to skin)

Specifications of E45 Daily Moisturiser Cream 5 Pack

 

What Is E45 Daily Moisturiser Cream and What Is It Used For?

 

E45 Daily Moisturiser Cream is an over-the-counter emollient used to relieve and manage dry, itchy, and sensitive skin. It is suitable for use on the face and body and can be applied as often as needed throughout the day. The NHS recommends emollients as a first-line treatment for conditions such as eczema and psoriasis, where maintaining skin hydration is essential to reducing flare-ups and discomfort.

The cream is fragrance-free and dermatologically tested, making it appropriate for people with reactive or easily irritated skin. It is not a steroid cream and does not contain any active pharmaceutical ingredients that require a prescription — it works purely through its moisturising and barrier-restoring properties.

 

What Do You Need to Know Before Using E45 Daily Moisturiser Cream?

 

Before using E45 Daily Moisturiser Cream, read the following carefully. Although it is generally well tolerated, there are some situations where caution is needed.

Do not use this product if you:

  • Are allergic to any of the ingredients, including lanolin or paraffin-based substances
  • Have an active skin infection — treat the infection first before applying emollients
  • Have been advised by your GP to avoid lanolin-containing products

Take care and speak to your pharmacist if you:

  • Are pregnant or breastfeeding (though emollients are generally considered safe)
  • Are using this on a baby or infant under 12 months — seek pharmacist advice first
  • Have a known sensitivity to wool alcohols or related compounds

Drug interactions:

  • No significant drug interactions are known for topical emollients
  • If you are using a topical steroid or other medicated cream, apply E45 first and allow it to absorb before applying the other product, or follow your GP's instructions

Fire hazard warning: Paraffin-based emollients can soak into fabric and create a fire risk. Keep away from naked flames and do not smoke while using this product. Wash clothing and bedding regularly.

 

How Should You Use E45 Daily Moisturiser Cream?

 

Using E45 correctly makes a real difference to how effective it is. The NHS advises applying emollients generously and frequently — not just when skin feels dry. Here's how to get the most from it:

  1. Wash and gently pat your skin dry before applying.
  2. Take a generous amount of cream and apply it in smooth, downward strokes in the direction of hair growth — this reduces the risk of blocking hair follicles.
  3. Apply to all affected areas, including the face if needed, avoiding the eye area.
  4. Allow the cream to absorb before dressing or applying other topical products.
  5. Reapply throughout the day as needed — for eczema, the NHS recommends applying emollients at least 2–3 times daily.
Indication Age Group Dose Frequency
Dry / sensitive skin Adults & children Apply liberally to affected area As often as needed
Eczema management Adults & children Apply generously At least 2–3 times daily
Psoriasis / ichthyosis Adults Apply to affected skin As directed by GP

 

What Are the Possible Side Effects of E45 Daily Moisturiser Cream?

 

Side effects from E45 Daily Moisturiser Cream are uncommon, but they can occur. If you notice any of the following, stop using the cream and speak to your pharmacist or GP.

Common side effects:

  • Mild stinging or burning sensation immediately after application (usually temporary)
  • Skin feeling greasy or heavy after use

Less common side effects:

  • Skin rash or redness at the application site
  • Contact dermatitis — particularly in those sensitive to lanolin
  • Folliculitis (inflammation of hair follicles) if cream is applied against the direction of hair growth

If you experience a severe allergic reaction — including swelling of the face, lips, or throat, or difficulty breathing — seek emergency medical attention immediately. This is rare but serious. You can find further guidance on managing skin conditions through our skin care collection.

 

How Should You Store E45 Daily Moisturiser Cream?

 

Proper storage keeps the cream effective and safe to use throughout its shelf life. The 5 pack format is great for stocking up, so it's worth knowing how to store unused tubes correctly.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep all tubes out of reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not freeze
  • Once opened, use within the period indicated by the open-lid symbol on the tube

If you're managing multiple skin conditions alongside dry skin, it may be worth exploring our creams and ointments range for complementary topical treatments recommended by pharmacists.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy E45 Daily Moisturiser Cream online in the UK?

You can buy the E45 Daily Moisturiser Cream 5 Pack directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. Buying in a 5 pack offers excellent value for money compared to purchasing individual tubes. It's a convenient option if you use emollients regularly for conditions like eczema or dry skin.

How does E45 Daily Moisturiser Cream work in the body?

E45 works as a topical emollient, forming a protective film over the skin's surface that reduces transepidermal water loss. The combination of light liquid paraffin, white soft paraffin, and hypoallergenic lanolin softens the outer skin layer and helps restore the skin's natural moisture barrier. It does not contain steroids or antibiotics — it works purely through moisturising and barrier-restoring action.

How do I use E45 Daily Moisturiser Cream step by step?

Start by washing and gently patting your skin dry. Apply a generous amount of cream using smooth, downward strokes in the direction of hair growth to avoid blocking follicles. Allow it to absorb fully before dressing or applying any other topical products, and reapply as often as needed throughout the day.

How often should I apply E45 Daily Moisturiser Cream?

For general dry skin, apply as often as needed — there is no maximum number of daily applications. If you are managing eczema, the NHS recommends applying emollients at least two to three times a day, even when your skin feels comfortable. Consistent use is key to maintaining the skin's moisture barrier and preventing flare-ups.

Can I use E45 Daily Moisturiser Cream on my face?

Yes, E45 Daily Moisturiser Cream can be applied to the face as well as the body. Avoid the eye area and do not apply to broken, infected, or inflamed skin without first seeking advice from your GP or pharmacist. It is fragrance-free and dermatologically tested, making it suitable for facial use in most people with sensitive skin.

Is E45 Daily Moisturiser Cream suitable for babies and children?

E45 Daily Moisturiser Cream is generally considered suitable for children, but you should consult your GP or pharmacist before using it on babies under 12 months. For older children with eczema or dry skin, it can be used as part of a regular moisturising routine. Always patch test on a small area first if your child has particularly sensitive skin.

What are the side effects of E45 Daily Moisturiser Cream?

Side effects are uncommon but may include mild stinging or a temporary burning sensation after application, skin redness, or a rash — particularly in people sensitive to lanolin. If you develop signs of an allergic reaction such as swelling, hives, or difficulty breathing, stop using the cream immediately and seek medical attention. Speak to your pharmacist if you experience any persistent skin irritation.

Can E45 Daily Moisturiser Cream be used during pregnancy?

Emollients like E45 are generally considered safe to use during pregnancy, as they are applied topically and are not absorbed into the bloodstream in significant amounts. However, it is always sensible to check with your midwife, GP, or pharmacist before starting any new product during pregnancy. If you have any concerns about skin changes during pregnancy, your healthcare team can advise on the most appropriate options.

Is there a fire risk associated with E45 Daily Moisturiser Cream?

Yes — paraffin-based emollients, including E45, can soak into fabrics such as clothing and bedding and create a fire hazard. The MHRA has issued guidance advising patients to keep away from naked flames and not to smoke while using paraffin-containing products. Wash clothing and bedding regularly to reduce the build-up of product in fabric.

How long can you use E45 Daily Moisturiser Cream for?

E45 Daily Moisturiser Cream is safe for long-term, ongoing use and is designed to be part of a daily skincare routine. There is no recommended maximum duration — many people with chronic dry skin conditions use emollients indefinitely as part of their management plan. If your skin condition changes or worsens despite regular use, speak to your GP or pharmacist for a review.

What are alternatives to E45 Daily Moisturiser Cream?

There are several other emollient creams available over the counter in the UK, including Diprobase, Cetraben, Doublebase, and Aveeno. You can browse a range of options in our creams and ointments collection. Your pharmacist can help you choose the most suitable emollient based on your skin type, condition, and personal preference.

Does E45 Daily Moisturiser Cream contain steroids?

No — E45 Daily Moisturiser Cream does not contain any corticosteroids. It is a plain emollient that works by moisturising and protecting the skin rather than reducing inflammation. If you need a steroid cream for a condition like eczema, your GP or pharmacist can advise on appropriate options alongside your emollient routine.

Is the E45 Daily Moisturiser Cream 5 Pack good value for money?

Buying E45 in a 5 pack from Cured Pharmacy at £5.99 is a cost-effective way to stock up, especially if you use emollients daily or have multiple family members who need them. Stocking up also means you're less likely to run out, which is important when consistent moisturising is part of managing a skin condition. It's a practical choice for anyone who relies on E45 as part of their regular routine.

Can I use E45 Daily Moisturiser Cream alongside other skin treatments?

Yes — E45 can be used alongside other topical treatments such as steroid creams or medicated ointments. If you are using more than one topical product, apply E45 first and allow it to absorb before applying the medicated product, or follow the specific instructions given by your GP. You can also explore our wider skin care range for complementary products.

What are the latest recommendations on emollient use for eczema?

The NHS and NICE both recommend emollients as the foundation of eczema management, advising frequent and generous application throughout the day. Current guidance emphasises using emollients even during periods when eczema is not flaring, to maintain the skin barrier and reduce the frequency of flare-ups. Speak to your GP or dermatologist if your current emollient is not providing adequate relief, as they may recommend a different formulation or additional treatments.

How Should You Use E45 Daily Moisturiser Cream?

E45 Daily Moisturiser Cream is designed for topical application to the skin and is straightforward to use. Applying it correctly helps maximise its moisturising effect and reduces the risk of side effects such as folliculitis. Follow these steps each time you apply:

What Is the Correct Dose of E45 Daily Moisturiser Cream?

There is no fixed dose for emollient creams — the key principle is to apply liberally and frequently. The NHS advises using enough cream to cover the affected area generously, rather than applying a thin layer. The table below provides a general guide based on indication and age group.

When Is the Best Time to Use E45 Daily Moisturiser Cream?

The most effective times to apply E45 are immediately after bathing or showering, when the skin is still slightly damp — this helps to lock in moisture before it evaporates. Applying before bed is also beneficial, as the skin has time to absorb the cream overnight without being disturbed by clothing or washing. For people managing eczema or psoriasis, applying at regular intervals throughout the day — even when the skin feels comfortable — is recommended by the NHS to maintain the skin barrier and prevent flare-ups.

How Long Can You Use E45 Daily Moisturiser Cream For?

E45 Daily Moisturiser Cream can be used indefinitely as part of a daily skincare routine. It is not a medicated treatment with a defined course length — it is a moisturiser intended for ongoing use. People with chronic skin conditions such as eczema, psoriasis, or ichthyosis often use emollients every day for years without any adverse effects. If your skin condition does not improve with regular use, or if it worsens, speak to your GP or pharmacist who can review your treatment plan and suggest alternatives if needed.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use E45 Daily Moisturiser Cream?

E45 Daily Moisturiser Cream is designed for topical application to the skin and is straightforward to use. Applying it correctly helps maximise its moisturising effect and reduces the risk of side effects such as folliculitis. Follow these steps each time you apply:

What Is the Correct Dose of E45 Daily Moisturiser Cream?

There is no fixed dose for emollient creams — the key principle is to apply liberally and frequently. The NHS advises using enough cream to cover the affected area generously, rather than applying a thin layer. The table below provides a general guide based on indication and age group.

When Is the Best Time to Use E45 Daily Moisturiser Cream?

The most effective times to apply E45 are immediately after bathing or showering, when the skin is still slightly damp — this helps to lock in moisture before it evaporates. Applying before bed is also beneficial, as the skin has time to absorb the cream overnight without being disturbed by clothing or washing. For people managing eczema or psoriasis, applying at regular intervals throughout the day — even when the skin feels comfortable — is recommended by the NHS to maintain the skin barrier and prevent flare-ups.

How Long Can You Use E45 Daily Moisturiser Cream For?

E45 Daily Moisturiser Cream can be used indefinitely as part of a daily skincare routine. It is not a medicated treatment with a defined course length — it is a moisturiser intended for ongoing use. People with chronic skin conditions such as eczema, psoriasis, or ichthyosis often use emollients every day for years without any adverse effects. If your skin condition does not improve with regular use, or if it worsens, speak to your GP or pharmacist who can review your treatment plan and suggest alternatives if needed.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of E45 Daily Moisturiser Cream?

E45 Daily Moisturiser Cream is well tolerated by most people, and serious side effects are rare. However, as with any topical product, some individuals may experience mild reactions, particularly when first starting to use it. Common side effects tend to be mild and often resolve on their own.

  • Mild stinging or burning sensation immediately after application
  • Temporary skin redness at the site of application
  • Skin feeling greasy or heavy, particularly after generous application

What Are the Less Common Side Effects of E45 Daily Moisturiser Cream?

Less commonly, some people may experience a more noticeable skin reaction. These are more likely in individuals with a known sensitivity to lanolin or wool alcohols, which are present in the cream's formulation. If you notice any of the following, stop using the cream and seek advice from your pharmacist.

  • Skin rash or hives (urticaria) at the application site
  • Contact dermatitis — redness, itching, and inflammation caused by a reaction to an ingredient
  • Folliculitis — inflammation of hair follicles, which can occur if the cream is applied against the direction of hair growth
  • Increased skin sensitivity or worsening of existing skin irritation

What Are the Serious Side Effects of E45 Daily Moisturiser Cream?

Serious side effects from E45 Daily Moisturiser Cream are very rare. However, a small number of people may experience a hypersensitivity or allergic reaction. This is more likely in those with a known allergy to lanolin or paraffin-based ingredients. Seek emergency medical attention if you experience any of the following after applying the cream:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Severe skin blistering or peeling
  • Widespread rash or hives across the body

What Should You Do If You Experience Side Effects?

If you experience mild side effects such as temporary stinging or greasiness, these usually settle within a few minutes and do not require you to stop using the cream. For more persistent reactions such as a rash or worsening skin irritation, stop applying the cream and speak to your pharmacist or GP as soon as possible. They can help identify whether the reaction is related to E45 or another factor, and recommend an alternative emollient if needed. Do not ignore a skin reaction that is spreading or becoming more severe.

Can E45 Daily Moisturiser Cream Interact With Other Medicines?

No significant drug interactions are known for E45 Daily Moisturiser Cream when used as directed. However, if you are using other topical treatments — such as corticosteroid creams, antifungal preparations, or medicated ointments — apply E45 first and allow it to absorb before applying the other product. This prevents the emollient from diluting or interfering with the medicated treatment. Always follow the specific instructions given by your GP or pharmacist if you are using multiple topical products at the same time.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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