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Dermol Cream 500g

Dermol Cream 500g

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  • ✔️ Moisturises and protects dry, eczema-prone skin daily
  • ✔️ Reduces bacterial colonisation linked to eczema flares
  • ✔️ Doubles as a gentle, soap-free skin cleanser
  • ✔️ Suitable for adults, children, and sensitive skin types
  • ✔️ Large 500g tub ideal for frequent, whole-body application

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What Is Dermol Cream and How Does It Help Dry Skin?

 

If you live with eczema, psoriasis, or persistently dry skin, you'll know how exhausting it can be to find something that actually works. Dermol cream is a clinically used antimicrobial emollient that does two things at once — it moisturises and it helps protect the skin from bacterial colonisation, which is a known driver of eczema flares. Available in a generous 500g tub, it's a practical choice for anyone managing a long-term skin condition. You can explore the full range of creams and ointments available at Cured Pharmacy if you're comparing options.

Dermol cream contains four active ingredients: liquid paraffin 10%, isopropyl myristate 10%, benzalkonium chloride 0.1%, and chlorhexidine dihydrochloride 0.1%. The combination of emollient and antimicrobial action sets it apart from standard moisturisers. It is suitable for use on the body and face, and can also be used as a soap substitute — making it genuinely versatile for daily skin care routines.

 

How Does Dermol Cream Work to Soothe and Protect Skin?

 

The mechanism behind Dermol cream is straightforward but effective. Dry skin conditions like eczema involve a compromised skin barrier — one that loses moisture too quickly and lets irritants in. Dermol addresses this in two ways:

  • Emollient action: Liquid paraffin and isopropyl myristate form a protective film over the skin surface, reducing transepidermal water loss and softening dry, flaky skin.
  • Antimicrobial action: Benzalkonium chloride and chlorhexidine dihydrochloride reduce the presence of bacteria — particularly Staphylococcus aureus — on the skin surface. Bacterial colonisation is strongly associated with eczema flare-ups.
  • Soap substitute function: When used as a wash, it cleanses without stripping the skin's natural oils, unlike conventional soaps which can worsen dryness.

The NHS recommends emollients as a first-line treatment for eczema, advising that they should be applied regularly — even when the skin appears clear — to maintain the skin barrier and reduce the frequency of flares.

 

Who Should Use Dermol Cream and Is It Right for You?

 

Dermol cream is suitable for a wide range of people dealing with dry or inflammatory skin conditions. It's used by adults, the elderly, and children alike, though you should always check with a pharmacist or GP before using it on very young children or babies. It's particularly well-suited to those who need both moisturisation and antimicrobial protection in a single product.

It may be appropriate for you if you have:

  • Eczema (atopic dermatitis) — especially where bacterial colonisation is a recurring issue
  • Psoriasis with dry, scaling skin
  • Ichthyosis or other chronic dry skin conditions
  • Sensitive skin that reacts to standard soaps and detergents

 

How Does Dermol Cream Compare to Other Emollients?

 

Feature Dermol Cream 500g Plain Emollient (e.g. Diprobase Cream)
Antimicrobial agents Yes (benzalkonium chloride + chlorhexidine) No
Soap substitute use Yes Some formulations only
Suitable for eczema Yes Yes
OTC availability Yes Yes

 

Is Dermol Cream Suitable for Long-Term Use and How Should It Be Stored?

 

Yes — dermol cream is designed for regular, ongoing use as part of a daily emollient regimen. The NHS advises that emollients should be applied frequently throughout the day, not just during flares. Consistency is key. If you're managing a chronic condition, browse our skin care collection for complementary products that may support your routine.

Store Dermol Cream below 25°C, away from direct sunlight and out of reach of children. Do not use after the expiry date printed on the packaging. Once opened, use within 12 months. Always use a clean spatula or wash your hands before dipping into the tub to avoid contaminating the product.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Dermol Cream 500g specifications
Treatment category Emollient / Antimicrobial skin preparation
Mechanism of action Emollient barrier restoration + antimicrobial reduction of skin bacteria
Effective for Eczema, psoriasis, ichthyosis, dry and sensitive skin
Suitable for Adults, elderly, children (seek advice for infants)
Active ingredients Benzalkonium chloride 0.1%, Chlorhexidine dihydrochloride 0.1%, Isopropyl myristate 10%, Liquid paraffin 10%
Pack size 500g
UK classification General Sale List (GSL)
Drug class Emollient / Antiseptic
Preparation Cream
Route of administration Topical (skin)

Specifications of Dermol Cream 500g

 

What Is Dermol Cream 500g and What Is It Used For?

 

Dermol cream is an antimicrobial emollient cream used to manage dry, itchy, and inflamed skin conditions. It is indicated for eczema (atopic dermatitis), psoriasis, ichthyosis, and other conditions where the skin barrier is compromised. It works both as a leave-on moisturiser and as a soap substitute during washing. The NHS recommends regular emollient use as a cornerstone of eczema management, noting that emollients help reduce the frequency and severity of flares when used consistently.

It is available over the counter without a prescription and is suitable for use by adults and children. The 500g tub makes it a cost-effective option for those who need to apply emollients frequently throughout the day.

 

What Do You Need to Know Before Using Dermol Cream?

 

Before using Dermol cream, it's important to be aware of the following contraindications and warnings:

  • Do not use if you are allergic to benzalkonium chloride, chlorhexidine, liquid paraffin, isopropyl myristate, or any other ingredient in the formulation.
  • Avoid contact with the eyes, mouth, and mucous membranes.
  • Emollients can make bath and shower surfaces slippery — take extra care to avoid falls, particularly in elderly patients and children.
  • Emollient-soaked dressings and clothing can be a fire hazard. Keep away from open flames and do not smoke while using this product.
  • If your skin condition worsens or does not improve after two to four weeks of use, consult your GP.
  • Speak to your pharmacist or GP before use if you are pregnant or breastfeeding.

Regarding drug interactions, no significant interactions with other medicines have been identified for topical use of Dermol cream. However:

  • Chlorhexidine may be inactivated by soaps and anionic detergents — rinse skin thoroughly before applying if you have used soap.
  • If you are using other topical treatments (such as topical corticosteroids), apply Dermol cream first and allow it to absorb before applying other products, or follow your prescriber's instructions.

 

How Should You Use Dermol Cream Correctly?

 

Using Dermol cream correctly makes a real difference to how well it works. Here's how to apply it as a leave-on moisturiser:

  1. Wash and dry your hands before use.
  2. Use a clean spatula or spoon to remove cream from the tub — avoid dipping fingers directly in to prevent contamination.
  3. Apply a generous amount to the affected area.
  4. Massage gently into the skin using smooth, downward strokes in the direction of hair growth.
  5. Allow the cream to absorb before dressing or applying other topical products.
  6. Repeat as often as needed — the NHS advises applying emollients at least twice daily, and more frequently during flares.

To use as a soap substitute, apply to wet or dry skin, lather gently, and rinse off thoroughly. This is particularly useful for those whose skin reacts badly to conventional soaps and shower gels. If you're looking for additional support for skin conditions, our skin care collection includes a range of complementary products.

Indication Age Group Dose Frequency
Dry/eczema-prone skin (leave-on) Adults & children Apply liberally to affected area 2–3 times daily or as needed
Soap substitute (wash-off) Adults & children Apply to wet skin, lather, rinse At each wash
Infants (under 2 years) Infants As directed by GP or pharmacist As directed

 

What Are the Possible Side Effects of Dermol Cream?

 

Side effects with Dermol cream are uncommon, but it's worth knowing what to look out for. Most people tolerate it well, particularly when used as directed.

Common side effects:

  • Mild stinging or tingling on first application, particularly on broken or very inflamed skin
  • Temporary greasiness or heaviness on the skin surface

Less common side effects:

  • Allergic contact dermatitis — redness, itching, or a rash that worsens after application
  • Skin sensitisation to chlorhexidine or benzalkonium chloride (rare)
  • Folliculitis (inflammation of hair follicles) if the cream is applied against the direction of hair growth

If you experience any signs of an allergic reaction — including swelling, severe redness, or difficulty breathing — stop use immediately and seek urgent medical attention. For general skin concerns, you may also find our baby and toddler section helpful if you're managing a child's skin condition alongside your own.

 

How Should You Store Dermol Cream 500g?

 

  • Store below 25°C in a cool, dry place.
  • Keep away from direct sunlight and heat sources.
  • Keep the lid tightly closed when not in use.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the tub.
  • Once opened, use within 12 months.
  • Do not store in the bathroom — humidity can affect the product's stability.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Dermol Cream 500g online in the UK?

You can buy Dermol Cream 500g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £10.50. It is available without a prescription and can be ordered for home delivery. Browse our full creams and ointments collection for more emollient options.

How does Dermol Cream work on eczema-prone skin?

Dermol Cream works by combining emollient ingredients — liquid paraffin and isopropyl myristate — with two antimicrobial agents, benzalkonium chloride and chlorhexidine dihydrochloride. The emollients restore the skin's moisture barrier and reduce water loss, while the antimicrobials help reduce bacterial colonisation on the skin surface. Staphylococcus aureus in particular is strongly linked to eczema flare-ups, so reducing it can help keep skin calmer for longer.

How do I use Dermol Cream step by step?

As a leave-on moisturiser, apply a generous amount to the affected area and massage gently into the skin in the direction of hair growth. As a soap substitute, apply to wet skin, lather gently, and rinse off thoroughly. Use as often as needed — the NHS recommends applying emollients at least twice daily, even when skin appears clear.

Can Dermol Cream be used on the face?

Yes, Dermol Cream can be applied to the face, but you should avoid getting it into your eyes, mouth, or nose. If you are using it on a child's face, it is worth checking with your pharmacist or GP first. Apply sparingly around delicate facial areas and rinse immediately if contact with the eyes occurs.

Is Dermol Cream safe for babies and young children?

Dermol Cream can be used in children, but for babies and infants under two years of age, you should always seek advice from a GP or pharmacist before starting treatment. The antimicrobial ingredients are generally well tolerated, but a healthcare professional can confirm the most appropriate emollient for very young skin. Our baby and toddler section also has products specifically formulated for younger skin.

What are the side effects of Dermol Cream?

Side effects are uncommon but can include mild stinging on first application, temporary skin greasiness, or — rarely — allergic contact dermatitis presenting as increased redness or itching. If you notice your skin worsening after use, stop applying and speak to your pharmacist or GP. Serious allergic reactions are rare but require immediate medical attention.

How do I manage side effects of Dermol Cream?

If you experience mild stinging, this often settles after the first few applications as the skin adjusts. For persistent irritation or a worsening rash, discontinue use and consult your pharmacist — they may recommend an alternative emollient without antimicrobial agents. Always patch test a new product on a small area of skin before applying widely, especially if you have a history of skin sensitivities.

Who is eligible to use Dermol Cream?

Dermol Cream is suitable for most adults and children with dry, itchy, or inflamed skin conditions including eczema, psoriasis, and ichthyosis. It is not suitable for anyone with a known allergy to any of its ingredients, including chlorhexidine or benzalkonium chloride. If you are pregnant, breastfeeding, or managing a complex skin condition, speak to your GP before starting use.

What happens if I forget to apply Dermol Cream?

Unlike oral medicines, missing a single application of Dermol Cream is not a clinical concern — simply apply it as soon as you remember and continue your usual routine. Do not apply a double amount to compensate. Consistency over time matters more than any single application, so try to build it into your daily routine morning and evening.

What are the alternatives to Dermol Cream?

Common alternatives include plain emollients such as Diprobase Cream, Cetraben, or Doublebase Gel, which moisturise without antimicrobial agents. For those who specifically need antimicrobial action, Dermol 500 Lotion offers the same active ingredients in a lighter, pump-dispenser format. Your GP or pharmacist can help you choose the most appropriate emollient for your skin type and condition.

How long can you use Dermol Cream for?

Dermol Cream is suitable for long-term use as part of an ongoing emollient regimen — there is no set maximum duration. The NHS advises that emollients should be used continuously, even during periods when the skin appears clear, to maintain the skin barrier and prevent flares. Regular review with your GP or dermatologist is recommended for chronic conditions.

Can Dermol Cream be used as a soap substitute?

Yes — this is one of the key advantages of Dermol Cream. Apply it to wet or dry skin in the shower or bath, lather gently, and rinse off. This replaces conventional soap, which can strip the skin's natural oils and worsen dryness. The NHS recommends soap substitutes as an important part of eczema management.

Is Dermol Cream available on prescription in the UK?

Yes, Dermol Cream can be prescribed by a GP on the NHS for conditions such as eczema and psoriasis. It is also available to buy over the counter without a prescription from registered pharmacies, including Cured Pharmacy. Buying it OTC can be a convenient option if you already know it suits your skin.

What is the difference between Dermol Cream and Dermol 500 Lotion?

Both products share the same four active ingredients, but the cream is thicker and more occlusive — better suited to very dry, thickened, or localised patches of skin. Dermol 500 Lotion is a lighter formulation that comes in a pump dispenser, making it easier to apply over larger body areas. Your choice will depend on your skin type and personal preference.

What does the latest research say about antimicrobial emollients for eczema?

Research consistently supports the role of emollients in managing atopic eczema, with the NHS and NICE both recommending them as first-line treatment. The antimicrobial components in products like Dermol Cream target Staphylococcus aureus, which colonises the skin of the majority of people with atopic eczema and is associated with increased inflammation. Speak to your dermatologist or GP for the most up-to-date guidance on your individual treatment plan.

How Should You Use Dermol Cream?

Dermol Cream can be used in two ways — as a leave-on moisturiser or as a soap substitute during washing. Getting the application technique right helps you get the most from the product and reduces the risk of skin irritation.

Follow these steps for leave-on use:

What Is the Correct Dose of Dermol Cream?

There is no fixed dose for Dermol Cream in the way there is for oral medicines — the amount you use depends on the size of the area being treated and how dry your skin is. The NHS advises applying emollients liberally and frequently. As a general guide, adults with widespread eczema may use 500g or more per week.

When Is the Best Time to Use Dermol Cream?

The best times to apply Dermol Cream are immediately after bathing or showering, while the skin is still slightly damp — this helps lock in moisture more effectively. Applying it before bed is also beneficial, as the skin repairs itself overnight and a good emollient layer supports that process.

During a flare, you may need to apply more frequently — every two to three hours in severe cases. The NHS advises not waiting until your skin feels tight or itchy before reapplying; regular, proactive use is far more effective than reactive application.

How Long Can You Use Dermol Cream For?

Dermol Cream is designed for long-term, continuous use. Unlike topical corticosteroids, there is no restriction on how long you can use an emollient — in fact, stopping when your skin clears is one of the most common mistakes people make. The NHS recommends maintaining emollient use even during symptom-free periods to keep the skin barrier intact and reduce the likelihood of future flares.

If your skin condition does not improve after two to four weeks of regular use, or if it worsens at any point, consult your GP or pharmacist for a review of your treatment plan.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Dermol Cream?

Most people use Dermol Cream without experiencing any side effects. It is generally very well tolerated, even with frequent application. That said, as with any topical product, some people may notice mild reactions — particularly when starting treatment or applying to broken skin.

  • Mild stinging or tingling on first application, especially on inflamed or broken skin
  • Temporary greasiness or heaviness on the skin surface immediately after application
  • A slight film or residue on the skin, which usually absorbs within a few minutes

What Are the Less Common Side Effects of Dermol Cream?

Less commonly, some individuals may develop a reaction to one or more of the ingredients in Dermol Cream. Chlorhexidine and benzalkonium chloride, while effective antimicrobials, can occasionally cause sensitisation in susceptible individuals.

  • Allergic contact dermatitis — presenting as increased redness, itching, or a spreading rash at the application site
  • Skin sensitisation to chlorhexidine dihydrochloride or benzalkonium chloride
  • Folliculitis — inflammation of hair follicles, which can occur if the cream is applied against the direction of hair growth
  • Dryness or peeling if the product is used as a wash-off and not rinsed thoroughly

What Are the Serious Side Effects of Dermol Cream?

Serious side effects are rare but can occur. Chlorhexidine in particular has been associated with hypersensitivity reactions in some individuals, ranging from localised urticaria (hives) to, in very rare cases, anaphylaxis. If you have a known allergy to chlorhexidine, do not use this product.

Signs of a serious allergic reaction include sudden swelling of the face, lips, or throat, difficulty breathing, a widespread rash, or dizziness. These symptoms require immediate emergency medical attention — call 999 or go to your nearest A&E department.

What Should You Do If You Experience Side Effects of Dermol Cream?

If you notice mild irritation that does not settle after a few days, stop using the cream and speak to your pharmacist. They can help you identify whether the reaction is related to a specific ingredient and suggest an alternative emollient if needed. Do not continue using a product that is clearly making your skin worse.

For any signs of a serious allergic reaction, stop use immediately and seek urgent medical help. It is always worth doing a small patch test on a discreet area of skin before applying a new product widely, particularly if you have a history of contact allergies.

Can Dermol Cream Interact With Other Medicines?

No significant drug interactions have been identified for Dermol Cream when used topically as directed. However, chlorhexidine can be inactivated by anionic surfactants found in soaps and some other skincare products — so rinse your skin thoroughly before applying if you have used soap. If you are using topical corticosteroids or other prescribed skin treatments alongside Dermol Cream, apply the emollient first and allow it to absorb before applying other products, unless your prescriber advises otherwise.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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