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Dermol Cream - 500g

Dermol Cream - 500g

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  • ✔️ Moisturises and protects dry, eczema-prone skin daily
  • ✔️ Dual antimicrobial action reduces skin-worsening bacteria
  • ✔️ Works as both a leave-on cream and soap substitute
  • ✔️ Suitable for adults, children, and sensitive skin types
  • ✔️ Large 500g tub provides long-lasting daily skin coverage

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Is Dermol Cream for Dry Skin Right for You?

 

Dry, itchy, and inflamed skin can be genuinely exhausting to manage — especially when over-the-counter moisturisers just don't seem to cut it. Dermol cream for dry skin is a clinically recognised antimicrobial emollient that does more than simply hydrate. It helps restore the skin's natural protective barrier while simultaneously reducing the bacterial load that can worsen conditions like eczema and dermatitis. Available in a generous 500g tub, it's a practical, cost-effective option for anyone dealing with persistent dry skin. You can explore the full range of creams and ointments available at Cured Pharmacy if you're comparing your options.

Dermol Cream is manufactured by Dermal Laboratories and is widely used across the UK, both in NHS settings and as an over-the-counter purchase. It's suitable for everyday use on the face, hands, and body, and can double up as a soap substitute — making it particularly useful for people whose skin reacts badly to conventional soaps and shower gels.

 

How Does Dermol Cream Work to Soothe Dry Skin?

 

Dermol Cream works through a dual-action approach. The emollient components soften and hydrate the skin, while the antimicrobial agents target bacteria that commonly colonise compromised skin. Here's how each ingredient contributes:

  • Liquid paraffin (10%): Forms a protective film over the skin surface, locking in moisture and reducing transepidermal water loss.
  • Isopropyl myristate (10%): Enhances skin softness and helps the cream spread easily without leaving a heavy, greasy residue.
  • Benzalkonium chloride (0.1%): A quaternary ammonium antimicrobial agent that reduces bacterial colonisation, particularly Staphylococcus aureus, which is frequently found on eczematous skin.
  • Chlorhexidine dihydrochloride (0.1%): A well-established antiseptic that works alongside benzalkonium chloride to provide broader antimicrobial coverage.

Together, these ingredients address both the dryness and the microbial factors that can trigger or prolong flare-ups. It's a straightforward formulation, but one that's backed by years of clinical use in the UK.

 

Who Should Use Dermol Cream — and Who Is It Suited To?

 

Dermol Cream is suitable for a wide range of people dealing with dry or compromised skin. It's particularly well-suited to those whose skin conditions are prone to bacterial involvement. The NHS recommends emollients as a first-line treatment for eczema, and Dermol Cream fits neatly into that guidance. It's also appropriate for people who need a soap substitute, as standard soaps can strip the skin of its natural oils.

  • Adults and children with eczema or atopic dermatitis
  • People with psoriasis who need regular moisturisation
  • Individuals with contact dermatitis or irritant skin reactions
  • Anyone with chronically dry skin who needs a daily emollient

 

How Does Dermol Cream Compare to Other Emollients?

 

Feature Dermol Cream 500g Diprobase Cream
Antimicrobial agents Yes (benzalkonium chloride + chlorhexidine) No
Emollient base Liquid paraffin + isopropyl myristate Liquid paraffin + white soft paraffin
Soap substitute use Yes Yes
OTC availability Yes Yes

 

Is Dermol Cream Suitable During Pregnancy and How Should It Be Stored?

 

There is no specific contraindication to using Dermol cream for dry skin during pregnancy, but as with any topical product, it's sensible to check with your GP or midwife before introducing new skincare during pregnancy or breastfeeding. The antimicrobial components are present in low concentrations and are applied topically, so systemic absorption is minimal — but professional guidance is always worthwhile. You can also browse our wider skin care collection for complementary products.

Store Dermol Cream below 25°C, away from direct sunlight and out of reach of children. Do not use after the expiry date printed on the tub. Once opened, use within 12 months.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Dermol Cream 500g specifications
Treatment category Emollient / Antimicrobial moisturiser
Mechanism of action Restores skin moisture barrier; reduces bacterial colonisation
Effective for Dry skin, eczema, dermatitis, psoriasis
Suitable for Adults and children (including infants with medical advice)
Active ingredients Benzalkonium chloride 0.1%, Chlorhexidine dihydrochloride 0.1%, Isopropyl myristate 10%, Liquid paraffin 10%
Pack size 500g
UK classification General Sale / OTC
Drug class Emollient with antimicrobial agents
Preparation Cream
Route of administration Topical (skin)

Specifications of Dermol Cream 500g

 

What Is Dermol Cream and What Is It Used For?

 

Dermol Cream is a topical antimicrobial emollient used to manage dry skin conditions including eczema, atopic dermatitis, contact dermatitis, and psoriasis. It works by moisturising the skin and reducing the bacteria that can worsen inflammatory skin conditions. The NHS recommends emollients as a cornerstone of eczema management, and Dermol Cream is one of several emollients available for this purpose. It can be used as a leave-on moisturiser or as a soap substitute when washing.

 

What Do You Need to Know Before Using Dermol Cream?

 

Before using Dermol Cream, it's important to be aware of the following contraindications and precautions:

  • Do not use if you are allergic to benzalkonium chloride, chlorhexidine, liquid paraffin, isopropyl myristate, or any other ingredient in the formulation.
  • Avoid contact with the eyes. If contact occurs, rinse thoroughly with water.
  • Do not apply to open wounds, severely broken skin, or actively infected areas without medical advice.
  • Emollient creams can make surfaces slippery — take care when using in the bath or shower.
  • Emollients can soak into fabric and, when dry, create a fire risk. Keep clothing and bedding away from flames or heat sources.
  • Consult your GP or pharmacist before use if you are pregnant, breastfeeding, or using this product on a young infant.

Regarding drug interactions, no significant interactions with other medicines have been identified for topically applied Dermol Cream. However:

  • If you are using other topical treatments (such as topical corticosteroids), apply Dermol Cream first and allow it to absorb before applying other products.
  • Chlorhexidine may be inactivated by certain soaps — avoid using conventional soap immediately before or after application.

 

How Should You Use Dermol Cream Correctly?

 

Using Dermol Cream correctly makes a real difference to how well it works. Whether you're applying it as a moisturiser or using it as a soap substitute, the method matters. You can find further guidance on managing skin conditions in our skin care collection.

  1. Wash your hands before applying the cream.
  2. Take a sufficient amount of cream and apply it directly to the affected area of skin.
  3. Massage gently into the skin using smooth, downward strokes in the direction of hair growth — this reduces the risk of folliculitis.
  4. If using as a soap substitute, apply to wet skin, lather gently, then rinse off thoroughly.
  5. Reapply as often as needed — there is no strict maximum frequency for emollient use.
  6. Do not share your tub of cream with others to avoid cross-contamination.
Indication Age Group Dose Frequency
Dry skin / eczema (leave-on) Adults & children Apply liberally to affected area 2–4 times daily or as needed
Soap substitute Adults & children Apply to wet skin, rinse off Each time you wash
Infants (with medical advice) Under 2 years Small amount to affected area As directed by GP

 

What Are the Possible Side Effects of Dermol Cream?

 

Side effects with Dermol Cream are uncommon, but it's worth knowing what to look out for. Most people tolerate it well, particularly with regular use.

Common side effects:

  • Mild stinging or tingling on first application, particularly on broken or very dry skin
  • Temporary redness at the application site

Less common side effects:

  • Allergic contact dermatitis — a worsening rash or increased itching that may indicate sensitivity to chlorhexidine or benzalkonium chloride
  • Folliculitis (inflammation of hair follicles) if the cream is applied against the direction of hair growth
  • Skin dryness or irritation if the product is not rinsed off thoroughly when used as a soap substitute

If you notice any signs of an allergic reaction — such as swelling, hives, or difficulty breathing — stop using the product immediately and seek urgent medical attention.

 

How Should You Store Dermol Cream Safely?

 

Proper storage keeps the cream effective and safe to use. Follow these guidelines:

  • Store below 25°C in a cool, dry place.
  • Keep away from direct sunlight and heat sources.
  • Keep the tub tightly closed when not in use.
  • Keep out of reach and sight of children.
  • Do not use after the expiry date printed on the tub.
  • Once opened, use within 12 months.
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacist.

If you're managing a broader skin condition alongside dry skin, it may also be worth exploring our creams and ointments range for complementary treatments recommended by pharmacists.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Dermol Cream 500g online in the UK?

You can buy Dermol Cream 500g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £9.99. No prescription is required, and it's available for delivery across the UK. It's also stocked in some high street pharmacies, though buying online is often more convenient and competitively priced.

How does Dermol Cream work on dry and eczema-prone skin?

Dermol Cream works through a dual mechanism — the emollient oils (liquid paraffin and isopropyl myristate) restore the skin's moisture barrier and reduce water loss, while the antimicrobial agents (benzalkonium chloride and chlorhexidine) reduce bacterial colonisation on the skin surface. This is particularly relevant for eczema, where Staphylococcus aureus bacteria are known to worsen flare-ups. The result is skin that is both better hydrated and less prone to infection-driven inflammation.

How do I use Dermol Cream step by step?

Apply a generous amount of Dermol Cream to the affected area and massage it gently into the skin using smooth, downward strokes in the direction of hair growth. If you're using it as a soap substitute, apply it to wet skin, lather gently, and rinse off thoroughly. You can use it as often as needed throughout the day — there's no strict upper limit for emollient application.

Can I use Dermol Cream on my face?

Yes, Dermol Cream can be applied to the face, but you should avoid getting it into your eyes. If contact with the eyes does occur, rinse thoroughly with clean water. If you have a facial skin condition such as perioral dermatitis or seborrhoeic dermatitis, it's worth speaking to your GP before starting a new emollient, as some conditions require specific treatments.

Is Dermol Cream safe for babies and young children?

Dermol Cream can be used in children, including infants, but you should always consult your GP or pharmacist before applying any medicated emollient to a baby's skin. Infant skin is more permeable than adult skin, so professional guidance ensures the right product and frequency are used. You can also browse our baby and toddler range for age-appropriate skincare options.

What are the side effects of Dermol Cream?

Side effects are uncommon but can include mild stinging or redness on first application, particularly if the skin is very dry or broken. In rare cases, an allergic reaction to chlorhexidine or benzalkonium chloride may occur, presenting as increased redness, itching, or a worsening rash. If you suspect an allergic reaction, stop using the cream and speak to your pharmacist or GP promptly.

What is the correct dose of Dermol Cream for eczema?

There is no fixed dose for emollients — the NHS guidance is to apply liberally and frequently, typically two to four times daily or whenever the skin feels dry. The key principle is that you cannot really over-apply an emollient, so use as much as your skin needs. Consistency matters more than quantity — regular daily use is more effective than occasional heavy application.

How long can you use Dermol Cream for?

Dermol Cream can be used long-term as part of a daily skincare routine for chronic conditions like eczema or psoriasis — there is no defined maximum duration of use. However, if your skin condition is not improving or is getting worse despite regular emollient use, you should review this with your GP. Ongoing skin conditions often benefit from periodic reassessment to ensure the treatment plan remains appropriate.

What is the difference between Dermol Cream and Dermol 500 Lotion?

Dermol Cream has a thicker, richer consistency and is better suited to very dry or localised patches of skin, particularly on the hands, elbows, or knees. Dermol 500 Lotion is a lighter, more fluid formulation designed for use over larger body areas or as a soap substitute in the bath or shower. Both contain the same active ingredients, so the choice largely comes down to personal preference and the area being treated.

Can Dermol Cream be used as a soap substitute?

Yes — this is one of Dermol Cream's most useful features. Apply it to wet skin in place of soap or shower gel, lather gently, and rinse off. This is particularly helpful for people whose skin reacts badly to conventional soaps, which can strip natural oils and worsen dryness. Using an emollient as a soap substitute is a standard recommendation in NHS eczema management guidance.

Does Dermol Cream contain steroids?

No, Dermol Cream does not contain any corticosteroids. It is a plain emollient with antimicrobial agents and contains no steroids whatsoever. If your skin condition requires a steroid treatment, your GP may prescribe a separate topical corticosteroid to use alongside your emollient — the two are often used together as part of an eczema management plan.

Is there a fire risk with Dermol Cream?

Yes — this is an important safety point. Emollient creams, including Dermol Cream, can soak into fabric such as clothing, bedding, and dressings. Once dry, this residue is flammable and can ignite if exposed to a naked flame or heat source. The MHRA and NHS both advise washing clothing and bedding regularly and keeping away from open flames, cigarettes, and candles when using any paraffin-based emollient.

What are the alternatives to Dermol Cream for dry skin?

There are several emollient alternatives available, including Diprobase Cream, Cetraben Cream, Doublebase Gel, and Epaderm Ointment — each with slightly different formulations suited to different skin types and preferences. Unlike Dermol Cream, most of these alternatives do not contain antimicrobial agents, so they may be more appropriate if antimicrobial activity is not required. Browse our full range of creams and ointments to compare options.

Can I use Dermol Cream during pregnancy?

There is no specific contraindication to using Dermol Cream during pregnancy, as the active ingredients are applied topically and systemic absorption is minimal. That said, it's always sensible to check with your GP or midwife before introducing any new skincare product during pregnancy or while breastfeeding. They can confirm whether Dermol Cream is the most appropriate emollient for your needs at that time.

What are the latest findings on antimicrobial emollients for eczema?

Research continues to support the role of antimicrobial emollients in reducing Staphylococcus aureus colonisation on eczematous skin, which is associated with triggering and worsening flare-ups. Current NHS and NICE guidance recommends emollients as the foundation of eczema treatment, with antimicrobial variants considered where bacterial involvement is suspected. Speak to your GP or dermatologist for the most up-to-date personalised advice on managing your skin condition.

How Should You Use Dermol Cream?

Dermol Cream is straightforward to use, but applying it correctly helps you get the most benefit. Whether you're using it as a leave-on moisturiser or a soap substitute, the technique makes a difference to how well it works and how comfortable it feels on your skin.

What Is the Correct Dose of Dermol Cream?

There is no fixed maximum dose for emollients — the principle is to apply liberally and frequently. The NHS advises that emollients should be used generously and regularly, as consistent use is more effective than occasional heavy application. The table below provides a general guide.

When Is the Best Time to Use Dermol Cream?

The best time to apply Dermol Cream is immediately after bathing or washing, while the skin is still slightly damp — this helps lock in moisture more effectively. Applying it before bed is also beneficial, as the skin has time to absorb the emollient overnight without being washed off. For very dry or eczema-prone skin, applying at least twice daily — morning and evening — is generally recommended by the NHS.

If you are also using a topical corticosteroid, apply your emollient first, allow it to absorb for around 30 minutes, and then apply the steroid cream. This ensures neither product dilutes the other.

How Long Can You Use Dermol Cream For?

Dermol Cream can be used indefinitely as part of a long-term skincare routine for chronic dry skin conditions. Unlike topical steroids, there is no restriction on duration of use for emollients. However, if your skin condition is not responding after several weeks of consistent use, or if it appears to be worsening, you should speak to your GP or pharmacist for a review.

Regular reassessment of your skincare routine is good practice — skin conditions can change over time, and what works well at one stage may need adjusting later. Your pharmacist can advise on whether Dermol Cream remains the most suitable emollient for your needs.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Dermol Cream?

Most people use Dermol Cream without experiencing any side effects. It is generally well tolerated, even with frequent daily use. That said, as with any topical product, some people may notice mild reactions, particularly when first starting treatment or if the skin is very dry or broken.

  • Mild stinging or tingling sensation on first application to broken or very dry skin
  • Temporary redness or warmth at the application site
  • A slightly greasy feeling on the skin immediately after application

These effects are usually short-lived and tend to settle as the skin adjusts to regular emollient use. If stinging persists beyond the first few applications, speak to your pharmacist.

What Are the Less Common Side Effects of Dermol Cream?

Less commonly, some people may experience reactions that require attention. These are not typical but are worth being aware of before you start using the product.

  • Folliculitis — inflammation of the hair follicles, which can occur if the cream is applied against the direction of hair growth
  • Skin dryness or tightness if the cream is not rinsed off thoroughly when used as a soap substitute
  • Increased itching or a new rash developing after use, which may suggest sensitivity to one of the ingredients

If you notice any of these effects, stop using the cream and consult your pharmacist or GP before continuing.

What Are the Serious Side Effects of Dermol Cream?

Serious side effects are rare but can occur. The most significant concern is an allergic reaction to one of the active antimicrobial ingredients — chlorhexidine dihydrochloride or benzalkonium chloride. Chlorhexidine allergy, in particular, is a recognised cause of contact dermatitis and, in very rare cases, anaphylaxis.

Signs of a serious allergic reaction include:

  • Sudden worsening of skin redness, swelling, or blistering
  • Hives (urticaria) or widespread rash
  • Swelling of the face, lips, or throat
  • Difficulty breathing or swallowing

If you experience any of these symptoms, stop using Dermol Cream immediately and seek urgent medical attention or call 999.

What Should You Do If You Experience Side Effects?

For mild side effects such as temporary stinging or redness, you can usually continue using the cream and monitor whether the reaction settles. Applying the cream to a small test area first is a sensible precaution if you have sensitive skin or a history of product reactions.

For any persistent, worsening, or unexpected reaction, stop use and speak to your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve safety monitoring for all medicines and medical devices in the UK.

Can Dermol Cream Interact With Other Medicines?

No significant drug interactions have been identified for Dermol Cream when used topically. However, there are a few practical points to be aware of. Chlorhexidine can be inactivated by anionic surfactants found in some soaps, so avoid using conventional soap immediately before or after applying Dermol Cream. If you are using other topical treatments — such as a corticosteroid cream — apply Dermol Cream first, allow it to absorb for around 30 minutes, and then apply the other product. This prevents dilution and ensures both treatments work as intended.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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