Skip to product information
1 of 1

  • Images are for illustration purposes only

Avene Very High Protection Cleanance SPF50+ Sun Cream for Blemish-prone Skin50ml

Avene Very High Protection Cleanance SPF50+ Sun Cream for Blemish-prone Skin50ml

  • 1. Ozempic®️-equivalent therapy now available for weight management
  • 2. Average weight loss of 17%, with 1 in 3 patients achieving over 20%
  • 3. May help reduce osteoarthritis-related pain
  • 4. Wegovy®️ is not expected to impact the effectiveness of oral contraceptives
  • 5. Supports cardiovascular risk reduction
  • 6. Over 22 million patients treated with semaglutide-based therapies since 2018

  • ✔️ Provides very high SPF50+ UVA and UVB broad-spectrum protection
  • ✔️ Non-comedogenic formula will not block pores or trigger breakouts
  • ✔️ Mattifying texture controls shine on oily and combination skin
  • ✔️ Contains Avene Thermal Spring Water to soothe sensitised skin
  • ✔️ Ideal daily base for skin on active acne treatments

Price Checker

Regular price £21.00
Sale price £21.00
Sale Sold out
  • Lowest price guarantee
  • Includes FREE private prescription
View full details

 

Is Avene Cleanance SPF50+ the Right SPF50 Sunscreen for Acne-Prone Skin?

 

Finding a sunscreen that actually works for oily or blemish-prone skin can feel like a losing battle. Most formulas leave a greasy residue, block pores, or make breakouts worse — which is exactly why so many people skip sun protection altogether. That is a real problem. The NHS advises that protecting your skin from UV radiation is one of the most important steps you can take to reduce the risk of skin damage and skin cancer. The SPF50 sunscreen for acne-prone skin from Avene's Cleanance range is designed to change that experience entirely. It offers very high protection against both UVA and UVB rays in a lightweight, mattifying formula that sits comfortably on oily or combination skin without clogging pores. You can browse a wider range of skin health products in our skin care collection at Cured Pharmacy.

Avene is a French dermatological brand with a long-standing reputation for formulating products around its Thermal Spring Water, which has documented soothing and anti-irritant properties. The Cleanance range is specifically targeted at skin that is prone to spots, excess sebum, and congestion. At £21.00 for 50ml, this sun cream sits firmly in the specialist skincare category — and for good reason.

 

How Does Avene Cleanance SPF50+ Work to Protect Your Skin?

 

The protection in this formula comes from a combination of UV filters that work together to absorb and reflect both UVA and UVB radiation before it can damage skin cells. Here is how the mechanism breaks down:

  • UVB filters protect against the rays responsible for sunburn and direct DNA damage to skin cells.
  • UVA filters guard against longer-wave radiation that penetrates deeper into the dermis, contributing to premature ageing and increasing skin cancer risk.
  • SPF50+ rating means the product filters out approximately 98% of UVB radiation when applied correctly and in sufficient quantity.
  • Non-comedogenic formulation ensures the texture does not block follicles or contribute to comedone formation — a key concern for anyone with acne-prone skin.
  • Mattifying agents help absorb excess sebum throughout the day, reducing shine without drying the skin out.
  • Avene Thermal Spring Water provides a calming base that helps minimise irritation, particularly relevant for skin that is already sensitised by acne treatments.

 

Who Should Use Avene Cleanance SPF50+ Sun Cream?

 

This product is not a one-size-fits-all sunscreen. It has been specifically developed for a defined skin type, and it performs best when used by the right person. So who is it actually for?

  • People with oily or combination skin who find standard sunscreens too heavy or pore-blocking.
  • Those with acne-prone or blemish-prone skin who need daily UV protection without aggravating breakouts.
  • Individuals using topical acne treatments such as retinoids or benzoyl peroxide, which can increase photosensitivity.
  • Anyone with sensitive skin who needs a dermatologically tested, fragrance-conscious formula.

It is suitable for adults and older teenagers. If you are using prescription acne treatments, it is worth speaking to your pharmacist or GP before introducing new skincare products, as some treatments can alter how your skin responds to UV exposure.

 

How Does Avene Cleanance SPF50+ Compare to Other Sun Creams for Oily Skin?

 

Feature Avene Cleanance SPF50+ Standard SPF50 Sun Cream
SPF Rating SPF50+ (very high) SPF50 (high)
Suitable for acne-prone skin Yes — non-comedogenic Not always — may block pores
Finish Mattifying, lightweight Often greasy or shiny
Contains soothing ingredient Yes — Avene Thermal Spring Water Rarely
Dermatologically tested Yes Varies by brand

 

Is Avene Cleanance SPF50+ Suitable If You Are Using Acne Treatments?

 

This is one of the most common questions people ask. If you are currently using topical retinoids, azelaic acid, or other prescription acne treatments, your skin is likely more sensitive to sunlight than usual. The NHS recommends applying sunscreen daily when using such treatments, as they can increase your skin's vulnerability to UV damage. This SPF50 sunscreen for acne-prone skin is formulated to complement — not interfere with — active acne treatment regimens. Its non-comedogenic, lightweight texture means it layers well over medicated creams without causing additional congestion. If you are managing a more complex skin condition alongside acne, our creams and ointments collection includes a range of topical products that may be relevant to your routine.

Store this product below 25°C, away from direct sunlight and out of reach of children. Do not apply to broken, inflamed, or infected skin without first seeking medical advice.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Avene Very High Protection Cleanance SPF50+ Sun Cream for Blemish-prone Skin 50ml specifications
Treatment category Sun protection / Skincare
Mechanism of action Broad-spectrum UVA and UVB UV filter system; non-comedogenic mattifying base
Effective against UVA and UVB radiation; excess sebum; skin photosensitivity
Suitable for Oily, blemish-prone, acne-prone, and sensitive skin; adults and older teenagers
Active ingredient Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Pack size 50ml
SPF strength SPF50+ (very high protection)
UK classification Cosmetic / OTC skincare
Preparation Cream
Route of administration Topical (cutaneous)

Specifications of Avene Very High Protection Cleanance SPF50+ Sun Cream for Blemish-prone Skin 50ml

 

What Is Avene Cleanance SPF50+ and What Is It Used For?

 

Avene Very High Protection Cleanance SPF50+ Sun Cream is a topical photoprotective product designed for daily use on oily, blemish-prone, and acne-prone skin. It provides very high protection against both UVA and UVB radiation, helping to prevent sunburn, UV-induced skin damage, and the worsening of post-inflammatory hyperpigmentation — the dark marks that often linger after spots heal. The NHS advises that everyone should use sunscreen with at least SPF30, and ideally SPF50, when spending time outdoors, particularly between April and September in the UK when UV levels are highest. This product meets and exceeds that recommendation.

Beyond basic sun protection, the Cleanance formula addresses the specific needs of oily skin. It mattifies the complexion, controls shine, and is formulated to be non-comedogenic — meaning it will not block pores or contribute to new breakouts. It is also suitable for use as a daily base layer under makeup.

 

What Do You Need to Know Before Using Avene Cleanance SPF50+?

 

Before applying this product, please read the following carefully. While it is generally well tolerated, there are some situations where caution is needed.

Do not use this product if:

  • You are allergic to any of the listed ingredients, including any UV filter components.
  • You have open wounds, broken skin, or active skin infections in the area of application.
  • You have a known photosensitivity disorder without first consulting your GP or dermatologist.

Use with caution if:

  • You are pregnant or breastfeeding — while topical sunscreens are generally considered safe, it is always sensible to check with your midwife or GP.
  • You are using prescription topical treatments such as retinoids, benzoyl peroxide, or antibiotics — these can alter skin sensitivity.
  • Your child is under 12 — consult a pharmacist before use in younger children.

Known interactions:

  • No significant drug interactions are known for topically applied sunscreen products.
  • If using alongside other topical skincare actives, apply sunscreen as the final step in your morning routine.

 

How Should You Apply Avene Cleanance SPF50+ Correctly?

 

Correct application is essential for this product to deliver its stated level of protection. Many people apply far too little, which significantly reduces the effective SPF. Follow these steps for best results:

  1. Cleanse and dry your face thoroughly before application.
  2. Apply any prescription topical treatments or serums first and allow them to absorb.
  3. Dispense a generous amount of cream — approximately half a teaspoon for the face alone.
  4. Apply evenly across all exposed areas, including the neck and ears if exposed.
  5. Allow the product to absorb for at least 15 to 30 minutes before sun exposure.
  6. Reapply every two hours during sun exposure, and immediately after swimming or heavy sweating.
Indication Age Group Amount Frequency
Daily UV protection (face) Adults and teenagers (12+) Approx. 0.5 teaspoon Every morning; reapply every 2 hours in sun
Use during acne treatment Adults (18+) Generous, even layer Daily, as final morning skincare step

If you are managing your skin as part of a broader health routine, you may also find it helpful to explore our skin care collection for complementary products.

 

What Are the Possible Side Effects of Avene Cleanance SPF50+?

 

This product is dermatologically tested and generally very well tolerated. However, as with any topical product, reactions can occasionally occur.

Common side effects (may affect a small number of users):

  • Mild stinging or tingling on first application, particularly on sensitised skin.
  • Temporary redness at the site of application.
  • A slight white cast immediately after application, which typically fades within a few minutes.

Less common side effects:

  • Contact dermatitis — an allergic skin reaction causing itching, swelling, or a rash.
  • Increased breakouts in the first few days of use as skin adjusts (this usually settles).
  • Eye irritation if the product migrates near the eye area — rinse thoroughly with water if this occurs.

If you experience a severe allergic reaction — including significant swelling, hives, or difficulty breathing — seek urgent medical attention. The NHS provides guidance on recognising and managing allergic reactions. For general skin concerns or if you are unsure whether a reaction is product-related, speaking to a pharmacist is always a sensible first step. You can also explore our allergy and hay fever collection for antihistamine options if you experience a mild skin reaction.

 

How Should You Store Avene Cleanance SPF50+?

 

  • Store below 25°C in a cool, dry place away from direct sunlight.
  • Do not freeze — freezing can alter the texture and reduce the effectiveness of UV filters.
  • Keep the cap tightly closed when not in use to prevent contamination and drying out.
  • Keep out of reach and sight of children.
  • Do not use after the expiry date printed on the packaging.
  • Once opened, use within 12 months (check the period-after-opening symbol on the tube).
  • Do not leave in a hot car or direct sunlight — high temperatures can degrade the formula.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Avene Cleanance SPF50+ online in the UK?

You can buy Avene Very High Protection Cleanance SPF50+ sun cream directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £21.00 per 50ml tube. Orders are dispatched quickly with tracked UK delivery. You can also browse our full skin care collection for complementary products.

How does Avene Cleanance SPF50+ protect blemish-prone skin from the sun?

The formula uses a combination of chemical UV filters that absorb UVA and UVB radiation before it can penetrate and damage skin cells. The SPF50+ rating means it filters approximately 98% of UVB rays when applied in the correct quantity. Its non-comedogenic base ensures this protection is delivered without blocking pores or worsening breakouts.

How do I apply Avene Cleanance SPF50+ step by step?

Cleanse your face first, then apply any serums or prescription treatments and allow them to absorb. Apply a generous, even layer of the sun cream — roughly half a teaspoon for the face — at least 15 to 30 minutes before going outdoors. Reapply every two hours during sun exposure and immediately after swimming or towel drying.

Can I use Avene Cleanance SPF50+ as my daily moisturiser?

Yes, its lightweight, mattifying texture makes it well suited to daily use as a standalone morning product or as a base layer under makeup. It is designed to control shine throughout the day, making it a practical choice for oily skin types who want to simplify their morning routine. However, if your skin is very dry, you may wish to apply a separate lightweight moisturiser underneath.

Is Avene Cleanance SPF50+ suitable for sensitive skin?

Yes, Avene formulates its products with Thermal Spring Water, which has documented soothing and anti-irritant properties, making the range appropriate for sensitive skin. The Cleanance SPF50+ is dermatologically tested and free from ingredients commonly associated with irritation in sensitive skin types. If you have a known allergy to any cosmetic ingredient, always perform a patch test on a small area of skin before full application.

What are the side effects of Avene Cleanance SPF50+?

Side effects are uncommon but can include mild stinging, temporary redness, or a slight white cast immediately after application. In rare cases, contact dermatitis — an allergic skin reaction — may occur, presenting as itching, swelling, or a rash. If you experience any persistent or severe skin reaction, stop using the product and consult your pharmacist or GP.

Can I use Avene Cleanance SPF50+ while on prescription acne treatment?

Yes, and in fact daily sun protection is strongly recommended if you are using topical retinoids, benzoyl peroxide, or oral isotretinoin, as these treatments increase your skin's sensitivity to UV radiation. This SPF50 sunscreen for acne-prone skin is specifically designed to complement active acne treatment regimens without causing additional congestion. Always check with your prescribing doctor or pharmacist if you are unsure about combining products.

Can I use Avene Cleanance SPF50+ under makeup?

Absolutely — the mattifying, non-greasy finish makes it an ideal primer-like base under foundation, tinted moisturiser, or BB cream. Allow the sun cream to absorb for one to two minutes before applying makeup on top to ensure even coverage and avoid pilling. Many users find it actually improves the longevity of their makeup by controlling excess oil.

How is Avene Cleanance SPF50+ different from regular sunscreens?

Unlike most standard sunscreens, Avene Cleanance SPF50+ is specifically engineered for oily and blemish-prone skin — it is non-comedogenic, mattifying, and contains Avene Thermal Spring Water to soothe sensitised skin. Standard sunscreens are often formulated for general use and can feel heavy, greasy, or pore-blocking on oily skin types. This targeted formulation makes it a more appropriate daily choice for anyone managing acne or excess sebum.

What is the difference between SPF50 and SPF50+?

SPF50 filters approximately 98% of UVB radiation, while SPF50+ indicates the product has been tested and confirmed to exceed that threshold — offering marginally higher protection. In practical terms, the difference in UV filtration is small, but SPF50+ products must meet stricter testing criteria to carry that designation. The NHS recommends using at least SPF30, so SPF50+ exceeds the minimum recommendation comfortably.

How much Avene Cleanance SPF50+ should I apply to get the full SPF protection?

Most people apply far too little sunscreen, which significantly reduces the effective SPF. For the face, you should use approximately half a teaspoon (around 1.5 to 2ml), applied as an even, unbroken layer across all exposed skin. The SPF rating on the label is only achieved when the product is applied at the tested quantity — skimping on application means skimping on protection.

Is Avene Cleanance SPF50+ safe to use during pregnancy?

Topical sunscreens are generally considered safe during pregnancy, and protecting your skin from UV radiation remains important throughout. However, if you have any concerns about specific ingredients during pregnancy or breastfeeding, it is always best to check with your midwife, GP, or pharmacist before use. Mineral-based sunscreens are sometimes preferred during pregnancy, so discuss your options with a healthcare professional if you are unsure.

How long can I use Avene Cleanance SPF50+ for?

This product is suitable for ongoing daily use throughout the year, not just during summer months — UV radiation is present year-round in the UK, even on overcast days. Once opened, use within 12 months as indicated by the period-after-opening symbol on the packaging. There is no clinical reason to stop using it long-term, provided your skin continues to tolerate it well.

What are the alternatives to Avene Cleanance SPF50+ for oily skin?

Other options for oily or blemish-prone skin include La Roche-Posay Anthelios Uvamune 400 Oil Control Fluid SPF50+ and Bioderma Photoderm AKN Mat SPF30, both of which are formulated for similar skin types. The right choice depends on your skin's specific sensitivities, your budget, and whether you prefer a fluid or cream texture. Browsing our skin care collection can help you compare available options.

What are the latest findings on sunscreen use and acne-prone skin?

Dermatological research increasingly supports the daily use of non-comedogenic sunscreens in acne management, particularly for patients using photosensitising treatments. Studies have shown that UV exposure can worsen post-inflammatory hyperpigmentation — the dark marks left after spots — making sun protection an important part of acne care rather than an optional extra. The British Association of Dermatologists recommends daily broad-spectrum SPF50 use for anyone on acne treatment.

How Should You Use Avene Cleanance SPF50+ Sun Cream?

Using this sun cream correctly makes a real difference to how well it protects your skin. It is not enough to simply apply a thin smear — the SPF rating is only achieved when you use the right amount and reapply at the right intervals. Follow these steps each morning for reliable protection.

What Is the Correct Dose of Avene Cleanance SPF50+ to Use?

The amount you apply directly affects the level of protection you receive. Clinical testing of SPF products is conducted at 2mg per cm² of skin — which translates to roughly half a teaspoon for the face alone. Using less than this reduces the effective SPF significantly, so do not be tempted to apply sparingly.

When Is the Best Time to Use Avene Cleanance SPF50+?

Apply this sun cream every morning as the final step in your skincare routine, before makeup if worn. For effective protection, it should be on your skin at least 15 to 30 minutes before you step outside. Do not wait until you are already in the sun — UV exposure begins the moment you go outdoors, even on cloudy days. The NHS notes that UV radiation is present year-round in the UK, so daily application is recommended regardless of the season.

How Long Can You Use Avene Cleanance SPF50+ For?

There is no clinical limit on how long you can use this product. Daily, year-round sun protection is actively encouraged by dermatologists and the NHS, particularly for those using acne treatments that increase photosensitivity. Once opened, use the product within 12 months — check the period-after-opening symbol (a small open jar icon) on the packaging for confirmation. Discard the product if it changes colour, texture, or smell, as this may indicate degradation of the UV filters.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

Be the first to write a review
0%
(0)
0%
(0)
0%
(0)
0%
(0)
0%
(0)

What Are the Most Common Side Effects of Avene Cleanance SPF50+?

Most people use this sun cream without experiencing any adverse effects. It is dermatologically tested and formulated with tolerability in mind. That said, as with any topical product, a small number of users may notice mild reactions, particularly when first introducing it into their routine.

  • Mild stinging or tingling on application, especially on sensitised or post-treatment skin.
  • Temporary redness at the site of application that usually fades within minutes.
  • A slight white cast immediately after application, which typically disappears as the product absorbs.
  • A feeling of tightness on very dry skin types.

What Are the Less Common Side Effects of Avene Cleanance SPF50+?

Less commonly, some users may experience reactions that require attention. These are not typical but are worth being aware of before you start using the product.

  • Contact dermatitis — an allergic skin reaction presenting as itching, swelling, or a localised rash.
  • A temporary increase in breakouts during the first few days of use as skin adjusts to a new product.
  • Eye irritation if the product migrates near the eye area — rinse thoroughly with clean water if this occurs.
  • Folliculitis (inflamed hair follicles) in rare cases, particularly if the product is applied too heavily.

What Are the Serious Side Effects of Avene Cleanance SPF50+?

Serious reactions to topical sunscreen products are rare but can occur in individuals with specific allergies to UV filter ingredients. Signs of a serious allergic reaction include significant facial swelling, widespread hives, difficulty breathing, or a sudden drop in blood pressure. These symptoms require immediate medical attention — call 999 or go to your nearest A&E department without delay. Do not attempt to manage a severe allergic reaction at home.

What Should You Do If You Experience Side Effects of Avene Cleanance SPF50+?

If you notice mild irritation or redness, stop using the product temporarily and allow your skin to settle. You can try reintroducing it after a few days, applying to a small test area first. If the reaction persists or worsens, discontinue use entirely and consult your pharmacist or GP. Keep the product packaging so that a healthcare professional can review the ingredient list if an allergy is suspected. Never ignore a skin reaction that is spreading, blistering, or accompanied by systemic symptoms.

Can Avene Cleanance SPF50+ Interact With Other Medicines or Skincare Products?

No significant drug interactions are known for topically applied sunscreen products. However, if you are using prescription topical treatments — such as retinoids, azelaic acid, or topical antibiotics — apply those first and allow them to absorb before applying the sun cream. Layering products incorrectly can reduce the efficacy of both. If you are using any oral photosensitising medications, such as certain antibiotics or diuretics, your skin may be more reactive to UV radiation, making consistent daily SPF use even more important. Always discuss your full skincare and medication routine with your pharmacist if you are unsure.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

We’re a safe and
regulated UK service

Registered Pharmacy Badge

Lowest Price Guarantee

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

100% discreet packaging

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

Agent

Need help?
Talk to our friendly experts now

How our service works

Service Setup

Service setup

Discreet Packaging

Discreet packaging

Express Delivery

Express delivery