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Acnecide 5% Gel Benzoyl Peroxide - 60g

Acnecide 5% Gel Benzoyl Peroxide - 60g

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  • ✔️ Targets acne-causing bacteria directly at the source
  • ✔️ Unblocks pores and reduces excess sebum production
  • ✔️ Suitable for facial, back, and chest acne
  • ✔️ No antibiotic resistance risk with long-term use
  • ✔️ Visible improvement in acne typically within 4–6 weeks

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Is Benzoyl Peroxide Gel for Acne Right for You?

 

Acnecide 5% Gel is a clinically established, over-the-counter topical treatment for acne vulgaris. Each 60g tube contains 5% benzoyl peroxide as its active ingredient — one of the most widely recommended first-line acne treatments available in the UK. Whether you're dealing with blackheads, whiteheads, or inflamed spots, this gel targets the root causes of acne rather than simply masking the symptoms. If you're exploring your options within our skin care range, Acnecide is a well-evidenced starting point.

Acne affects up to 95% of people aged 11 to 30 in the UK at some point, according to the NHS. It can have a real impact on confidence and wellbeing, so finding a treatment that actually works matters. Acnecide 5% Gel is suitable for use on the face, back, and chest — the areas most commonly affected.

 

How Does Acnecide 5% Gel Work on Acne?

 

Benzoyl peroxide is a keratolytic and antimicrobial agent. It works through several complementary mechanisms to reduce acne lesions:

  • Antibacterial action: It releases free-radical oxygen into the follicle, killing Cutibacterium acnes (formerly Propionibacterium acnes), the bacteria most associated with acne inflammation.
  • Keratolytic effect: It promotes the shedding of dead skin cells, helping to unblock pores and prevent new comedones from forming.
  • Sebum reduction: It mildly reduces the production of excess sebum, which contributes to blocked follicles.
  • Anti-inflammatory: By reducing bacterial load, it indirectly lowers the inflammatory response in the skin.

Importantly, unlike topical antibiotics, benzoyl peroxide does not contribute to antibiotic resistance — a significant clinical advantage recognised by dermatology guidelines.

 

Who Is Acnecide 5% Gel Suitable For?

 

Acnecide 5% Gel is appropriate for adults and adolescents aged 12 and over with mild to moderate acne vulgaris. It is particularly useful for those who have not responded to gentle cleansing alone and want a targeted, evidence-based treatment.

  • Teenagers and adults with facial, chest, or back acne
  • People with oily or combination skin prone to blocked pores
  • Those looking to avoid antibiotic-based treatments
  • Individuals seeking an OTC option before consulting a GP

It is not recommended for children under 12, and those with very sensitive or eczema-prone skin should seek pharmacist advice before starting treatment.

 

How Does Acnecide 5% Gel Compare to Other Acne Treatments?

 

Feature Acnecide 5% Gel (Benzoyl Peroxide) Topical Antibiotic (e.g. Clindamycin)
Active ingredient Benzoyl peroxide 5% Clindamycin 1%
Antibiotic resistance risk None Yes — possible with prolonged use
Available OTC Yes Prescription only
Suitable for long-term use Yes, with monitoring Limited — resistance concerns

 

How Should You Store Acnecide 5% Gel?

 

Store Acnecide 5% Gel below 25°C, away from direct heat and sunlight. Keep the tube tightly closed when not in use, and always store it out of the reach and sight of children. Do not use the gel after the expiry date printed on the tube or carton.

As with all topical treatments, benzoyl peroxide gel for acne should be kept away from the eyes, mouth, nostrils, and any broken or sunburned skin. It can bleach hair, towels, and clothing — so allow it to dry fully before contact with fabrics. If you're also managing other skin concerns, browse our creams and ointments collection for complementary products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Acnecide 5% Gel Benzoyl Peroxide 60g specifications
Treatment category Acne treatment
Mechanism of action Antimicrobial and keratolytic
Effective for Mild to moderate acne vulgaris
Suitable for Adults and adolescents aged 12 and over
Active ingredient Benzoyl peroxide 5%
Pack size 60g
Strength 5%
UK classification General Sale / Pharmacy (P) medicine
Drug class Keratolytic / antimicrobial
Preparation Topical gel
Route of administration Topical (skin)

Specifications of Acnecide 5% Gel Benzoyl Peroxide 60g

 

What Is Acnecide 5% Gel and What Is It Used For?

 

Acnecide 5% Gel is a topical medicine containing 5% benzoyl peroxide. It is used to treat acne vulgaris — the most common form of acne — affecting the face, back, and chest. Acne develops when hair follicles become blocked with sebum and dead skin cells, creating an environment where bacteria can thrive and cause inflammation. Acnecide works directly at the site of the problem, making it a practical and well-tolerated option for many people.

The NHS recommends benzoyl peroxide as one of the first treatments to try for mild to moderate acne. It is available without a prescription, making it accessible for those who want to begin treatment promptly without waiting for a GP appointment.

 

What Do You Need to Know Before Using Acnecide 5% Gel?

 

Before applying Acnecide 5% Gel, read the following carefully. There are certain situations where this product should not be used or should be used with caution.

Do not use Acnecide 5% Gel if you:

  • Are allergic to benzoyl peroxide or any other ingredient in the gel
  • Have a known hypersensitivity to any component of the formulation
  • Have eczema, seborrhoeic dermatitis, or rosacea on the area to be treated
  • Are applying it to broken, sunburned, or severely irritated skin

Use with caution and speak to a pharmacist if you:

  • Have very sensitive skin or a history of contact dermatitis
  • Are pregnant or breastfeeding — seek medical advice before use
  • Are under 12 years of age
  • Are using other topical acne products at the same time

Known interactions:

  • Avoid using simultaneously with topical retinoids (e.g. tretinoin) unless directed by a doctor, as this may increase skin irritation
  • Do not combine with other oxidising agents on the skin
  • Using alongside topical antibiotics may be appropriate in some cases — always seek professional guidance

 

How Should You Apply Acnecide 5% Gel Correctly?

 

Correct application is key to getting the best results and minimising irritation. Follow these steps each time you use the gel:

  1. Wash the affected area gently with a mild, non-comedogenic cleanser and pat dry.
  2. Squeeze a small, pea-sized amount of gel onto a clean fingertip.
  3. Apply a thin, even layer over the entire affected area — not just individual spots.
  4. Wash your hands thoroughly after application.
  5. Allow the gel to dry completely before applying moisturiser or makeup.
  6. Avoid contact with eyes, nostrils, mouth, and lips. If contact occurs, rinse immediately with water.
Indication Age Group Dose Frequency
Mild to moderate acne vulgaris 12 years and over Thin layer to affected area Once daily initially; increase to twice daily if tolerated
Sensitive skin / initial use 12 years and over Thin layer to affected area Once daily or every other day
Children under 12 Under 12 Not recommended — seek medical advice

 

What Are the Possible Side Effects of Acnecide 5% Gel?

 

Like all medicines, Acnecide 5% Gel can cause side effects, although not everyone experiences them. Many side effects are mild and tend to improve as your skin adjusts over the first few weeks of use. If you're also managing other skin conditions, our skin care collection includes a range of supportive products.

Common side effects (may affect more than 1 in 10 people):

  • Skin dryness and flaking
  • Redness and mild burning sensation at the application site
  • Peeling or tightness of the skin
  • Temporary worsening of acne during the first 1–2 weeks

Less common side effects:

  • Contact dermatitis (allergic skin reaction) — stop use immediately if this occurs
  • Oedema (swelling) of the treated area
  • Blistering or severe skin irritation

If you experience signs of a serious allergic reaction — such as swelling of the face, difficulty breathing, or widespread rash — stop using the product and seek urgent medical attention.

 

How Should You Store Acnecide 5% Gel Safely?

 

Proper storage helps maintain the effectiveness and safety of the product. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the tube tightly closed after each use
  • Store out of the reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

If you have any questions about storage or safe disposal, your local pharmacist will be happy to help. You might also find it useful to explore our creams and ointments section for further skincare support.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Acnecide 5% Gel online in the UK?

You can buy Acnecide 5% Gel directly from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. It is available without a prescription as an over-the-counter medicine, so no GP visit is required. Simply add it to your basket and it will be dispatched promptly to your door.

How does benzoyl peroxide gel for acne actually work?

Benzoyl peroxide releases oxygen into the skin follicle, creating an environment that kills Cutibacterium acnes — the bacteria most responsible for acne inflammation. It also loosens and removes dead skin cells that block pores, and mildly reduces sebum production. This combined action tackles acne from multiple angles at once.

How do I use Acnecide 5% Gel step by step?

Start by washing the affected area with a gentle cleanser and patting it dry. Apply a thin layer of Acnecide 5% Gel to the whole affected area — not just individual spots — once daily to begin with. Wash your hands after application and allow the gel to dry fully before applying any other products.

How long does Acnecide 5% Gel take to show results?

Most people notice an improvement in their acne within 4 to 6 weeks of consistent daily use. Full results, including a significant reduction in spots and inflammation, may take up to 3 months. It is important not to stop treatment early even if initial progress seems slow.

What are the most common side effects of Acnecide 5% Gel?

The most common side effects are skin dryness, redness, peeling, and a mild burning or stinging sensation at the application site. These effects are usually temporary and tend to settle within the first two to three weeks as your skin adjusts. Using a non-comedogenic moisturiser can help manage dryness.

How do I manage skin irritation caused by Acnecide 5% Gel?

If you experience irritation, reduce application to every other day or once daily rather than twice daily, and apply a gentle, fragrance-free moisturiser after the gel has dried. Avoid using other potentially irritating products — such as exfoliants or alcohol-based toners — at the same time. If irritation is severe or persistent, stop use and speak to your pharmacist.

Can I use Acnecide 5% Gel if I have sensitive skin?

Yes, but you should start cautiously — apply the gel every other day rather than daily, and monitor your skin closely for excessive redness or peeling. Sensitive skin types may take longer to build tolerance to benzoyl peroxide. If you are unsure whether this product is right for your skin type, speak to a pharmacist before starting.

Is Acnecide 5% Gel safe to use during pregnancy?

The safety of benzoyl peroxide during pregnancy has not been fully established, and the NHS advises seeking medical advice before using topical acne treatments if you are pregnant or breastfeeding. Speak to your GP or midwife before starting Acnecide if you are pregnant. They can advise on the safest options for managing acne during pregnancy.

What happens if I miss a dose of Acnecide 5% Gel?

If you forget to apply Acnecide, simply apply it as soon as you remember and then continue with your usual routine. Do not apply a double amount to compensate for a missed application, as this increases the risk of skin irritation. Consistency is important for results, so try to apply it at the same time each day.

Who is eligible to use Acnecide 5% Gel?

Acnecide 5% Gel is suitable for adults and adolescents aged 12 and over with mild to moderate acne vulgaris. It is not recommended for children under 12, and those with eczema, rosacea, or very sensitive skin should seek pharmacist advice first. It is available without a prescription for eligible users.

What are the alternatives to Acnecide 5% Gel?

Alternatives include topical retinoids such as adapalene (available OTC as Differin), azelaic acid preparations, and prescription-only topical antibiotics such as clindamycin. For more severe acne, a GP may consider oral treatments. You can explore a range of skin care products at Cured Pharmacy to find what suits you best.

Can Acnecide 5% Gel be used on the back and chest?

Yes, Acnecide 5% Gel can be applied to acne on the back and chest as well as the face. Apply a thin layer to the affected areas following the same instructions as for facial use. Be particularly careful to allow the gel to dry before contact with clothing, as benzoyl peroxide can bleach fabrics.

How long can you use Acnecide 5% Gel for?

Acnecide 5% Gel can be used for as long as needed to control acne, but it is advisable to review your treatment after 3 months. If your acne has not improved after this time, or if it worsens, consult your GP for further assessment. Long-term use is generally considered safe, but ongoing monitoring is recommended.

Will Acnecide 5% Gel bleach my skin or hair?

Acnecide 5% Gel will not bleach your skin, but it can bleach hair, towels, pillowcases, and clothing if it comes into contact with them before drying. Allow the gel to dry fully after application before touching fabrics. Using white or old pillowcases and towels while using this product is a practical precaution many people find helpful.

What does the latest research say about benzoyl peroxide for acne?

Benzoyl peroxide remains one of the most evidence-supported topical treatments for acne, consistently recommended in UK and international dermatology guidelines. A key advantage highlighted in recent literature is its lack of contribution to antibiotic resistance — a growing concern with prolonged antibiotic use in acne management. Current NHS guidance continues to recommend it as a first-line OTC option for mild to moderate acne. You can also browse our creams and ointments collection for related skincare products.

How Should You Use Acnecide 5% Gel?

Always use Acnecide 5% Gel exactly as described in the patient information leaflet or as directed by your pharmacist. Before applying, wash the affected area with a mild, non-comedogenic cleanser and pat the skin dry — applying to damp skin can increase irritation. Follow these steps each time:

Do not apply to areas not affected by acne, and do not use more than the recommended amount. Using excessive quantities will not improve results and is more likely to cause irritation.

What Is the Correct Dose of Acnecide 5% Gel?

The dose depends on your age and how well your skin tolerates the treatment. Always start with the lowest frequency and increase gradually if your skin is coping well. The table below summarises the recommended dosing:

If you experience significant dryness or irritation at twice-daily use, reduce back to once daily until your skin adjusts.

When Is the Best Time to Use Acnecide 5% Gel?

For once-daily use, applying Acnecide in the evening after cleansing is often recommended, as this allows the gel to work overnight without interference from sunscreen or makeup. If you are using it twice daily, apply once in the morning and once in the evening. Consistency matters — try to apply at the same time each day to build a routine and maximise results.

Always apply a broad-spectrum SPF 30 or higher sunscreen during the day when using benzoyl peroxide, as it can increase your skin's sensitivity to UV radiation.

How Long Can You Use Acnecide 5% Gel For?

Acnecide 5% Gel can be used for as long as necessary to keep acne under control. Most clinical guidance suggests reviewing your treatment after 3 months to assess progress. If your acne has improved significantly, you may be able to reduce the frequency of application to maintain clear skin. If there has been little or no improvement after 3 months of consistent use, speak to your GP, who may recommend an alternative or additional treatment.

Long-term use is generally considered safe, but it is good practice to check in with your pharmacist or GP periodically, particularly if you notice any new skin reactions or changes.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Acnecide 5% Gel?

Most people who use Acnecide 5% Gel experience some degree of skin adjustment during the first few weeks of treatment. These effects are generally mild and tend to improve as your skin builds tolerance to benzoyl peroxide. Common side effects include:

  • Skin dryness and flaking at the application site
  • Redness or flushing of the treated skin
  • Mild burning or stinging sensation after application
  • Peeling or tightness of the skin
  • Temporary worsening of acne during the first one to two weeks of use

Using a gentle, non-comedogenic moisturiser after the gel has dried can help manage dryness and peeling without blocking pores.

What Are the Less Common Side Effects of Acnecide 5% Gel?

Less common side effects occur in a smaller proportion of users and may require you to adjust how you use the product or stop treatment altogether. If any of the following occur, reduce the frequency of application and consult your pharmacist:

  • Contact dermatitis — an allergic skin reaction causing intense redness, itching, or a rash
  • Swelling or oedema of the treated area
  • Blistering or crusting of the skin
  • Increased photosensitivity — greater sensitivity to sunlight than usual

These reactions are uncommon but should not be ignored. Stop using the product immediately if you develop a widespread rash or signs of an allergic reaction.

What Are the Serious Side Effects of Acnecide 5% Gel?

Serious side effects from Acnecide 5% Gel are rare but can occur. A severe allergic reaction (anaphylaxis) is a medical emergency. Seek immediate medical attention if you experience any of the following after applying the gel:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Widespread hives or a rapidly spreading rash
  • Dizziness or feeling faint

Do not use Acnecide again if you have experienced a serious allergic reaction to it or any of its ingredients.

What Should You Do If You Experience Side Effects?

For mild side effects such as dryness or redness, try reducing the frequency of application to every other day and use a fragrance-free moisturiser to support the skin barrier. Avoid using other potentially irritating products — such as alcohol-based toners, exfoliating scrubs, or other acne treatments — at the same time. If side effects are moderate or do not improve within two to three weeks, speak to your pharmacist or GP.

You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve the safety monitoring of medicines available in the UK.

Can Acnecide 5% Gel Interact With Other Medicines?

Acnecide 5% Gel is a topical product, so systemic drug interactions are unlikely. However, there are some important considerations when using it alongside other skincare or acne treatments. Avoid applying benzoyl peroxide at the same time as topical retinoids (such as tretinoin or adapalene), as this combination can significantly increase skin irritation. Using it alongside other drying or exfoliating agents — including salicylic acid or alcohol-based products — may also worsen dryness and peeling. If you are using prescription topical antibiotics for acne, your GP or dermatologist may recommend combining them with benzoyl peroxide to reduce the risk of antibiotic resistance — but always follow professional guidance on this.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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