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Paracetamol 500mg

Paracetamol 500mg

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  • ✔️ Relieves mild to moderate pain including headaches and toothache
  • ✔️ Reduces fever associated with colds and flu
  • ✔️ Gentle on the stomach — suitable without food
  • ✔️ Works within 30–60 minutes of taking a dose
  • ✔️ Suitable for adults and young people aged 16 and over

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What Is Paracetamol 500mg and How Does It Help?

 

Paracetamol 500mg is one of the most widely used over-the-counter medicines in the UK. It relieves mild to moderate pain and reduces fever, making it a go-to option for everyday ailments — from tension headaches and toothache to the aches that come with a cold or flu. You can browse our full range of pain relief products if you need something more targeted for your symptoms.

Paracetamol has been used clinically for decades and has a well-established safety profile when taken correctly. It is suitable for most adults and children over 16 at the standard 500mg tablet strength, and it is available without a prescription from pharmacies across the UK.

 

How Does Paracetamol Work to Relieve Pain and Fever?

 

Paracetamol acts centrally in the brain and spinal cord. Unlike ibuprofen or aspirin, it does not work primarily by reducing inflammation at the site of injury. Instead, it targets the pain and temperature regulation pathways in the central nervous system. Here is how it works:

  • It inhibits the synthesis of prostaglandins — chemical messengers that sensitise nerve endings to pain and signal the hypothalamus to raise body temperature.
  • By reducing prostaglandin activity in the brain, it lowers the perception of pain signals travelling from the body.
  • It acts on the hypothalamus to bring down an elevated temperature, helping you feel more comfortable during a fever.
  • Because it does not significantly inhibit peripheral prostaglandins, it is much gentler on the stomach than non-steroidal anti-inflammatory drugs (NSAIDs).

 

Who Is Paracetamol 500mg Suitable For?

 

Paracetamol 500mg tablets are suitable for a wide range of people. They are often the first-line recommendation from GPs and pharmacists for pain and fever because of their tolerability across different patient groups. That said, certain individuals should seek advice before use — more on that below.

  • Adults and young people aged 16 and over
  • People who cannot tolerate NSAIDs such as ibuprofen due to stomach problems
  • Pregnant women (at the lowest effective dose, for the shortest time, on GP advice)
  • People managing headaches, dental pain, period pain, back pain, or fever associated with cold and flu

 

How Does Paracetamol Compare to Ibuprofen for Pain Relief?

 

Feature Paracetamol 500mg Ibuprofen 200mg/400mg
Mechanism Central analgesic and antipyretic NSAID — anti-inflammatory, analgesic, antipyretic
Stomach safety Generally well tolerated on empty stomach Should be taken with food; can irritate stomach lining
Suitable in pregnancy Generally first choice (on GP advice) Avoid in pregnancy, especially third trimester
Anti-inflammatory effect Minimal Yes — useful for inflammatory conditions

 

How Should You Store Paracetamol 500mg Tablets?

 

Store paracetamol tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep them in their original packaging so you can always check the expiry date and dosage instructions. Most importantly, keep all medicines out of the reach and sight of children — paracetamol overdose is a medical emergency. If you are managing multiple health conditions, you might also find our cold and flu range useful, as many combination cold remedies already contain paracetamol — always check labels to avoid accidental double-dosing.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Paracetamol 500mg specifications
Treatment category Analgesic / Antipyretic
Mechanism of action Central inhibition of prostaglandin synthesis; antipyretic action via hypothalamus
Effective for Mild to moderate pain, fever, headache, toothache, period pain, cold and flu symptoms
Suitable for Adults and young people aged 16 and over
Active ingredient Paracetamol 500mg
Pack sizes 16, 32 tablets (standard OTC pack sizes)
Strengths 500mg per tablet
UK classification General Sale List (GSL)
Drug class Non-opioid analgesic
Preparation Tablet
Route of administration Oral

Specifications of Paracetamol 500mg

 

What Is Paracetamol 500mg and What Is It Used For?

 

Paracetamol 500mg tablets are an analgesic (painkiller) and antipyretic (fever reducer) available over the counter in the UK. They are used to treat mild to moderate pain including headaches, migraines, toothache, back pain, period pain, and muscular aches. They are also used to reduce a high temperature (fever) associated with infections such as colds and flu.

Paracetamol is classified as a General Sale List (GSL) medicine in the UK, meaning it can be purchased without a prescription from pharmacies, supermarkets, and online retailers. It is one of the most commonly recommended medicines by NHS clinicians for everyday pain management.

 

What Do You Need to Know Before Using Paracetamol 500mg?

 

Before taking paracetamol, it is important to check whether it is appropriate for you. Do not take these tablets if any of the following apply:

  • You are allergic to paracetamol or any of the tablet's excipients
  • You have severe liver disease or active liver failure
  • You are already taking another medicine that contains paracetamol (check all cold, flu, and combination pain relief products carefully)
  • You have phenylketonuria (some formulations may contain aspartame)

Speak to your pharmacist or GP before taking paracetamol if you have liver or kidney problems, regularly drink alcohol, are underweight or malnourished, or are taking any of the following medicines:

  • Warfarin or other anticoagulants — regular paracetamol use may enhance anticoagulant effect
  • Carbamazepine, phenytoin, or other enzyme-inducing medicines — may reduce paracetamol's effectiveness and increase the risk of liver toxicity
  • Metoclopramide or domperidone — may speed up paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken at the same time

 

How Should You Use Paracetamol 500mg?

 

Always read the patient information leaflet supplied with your tablets. Take paracetamol exactly as directed and never exceed the stated dose. Here is a step-by-step guide:

  1. Check the packaging to confirm the tablets are within their expiry date.
  2. Take 1 or 2 tablets (500mg or 1g) with a full glass of water.
  3. Paracetamol can be taken with or without food.
  4. Leave at least 4 hours between doses.
  5. Do not take more than 4 doses (8 tablets of 500mg) in any 24-hour period.
  6. If symptoms persist beyond 3 days, consult your GP or pharmacist.
Age Group Dose Frequency Maximum in 24 hours
Adults and young people aged 16+ 1–2 tablets (500mg–1g) Every 4–6 hours as needed 8 tablets (4g)
Children under 16 Not suitable — use age-appropriate liquid or lower-strength formulation

If you are managing pain alongside other symptoms such as digestive discomfort, you may also want to explore our IBS and cramps range for additional support.

 

What Are the Possible Side Effects of Paracetamol 500mg?

 

Paracetamol is well tolerated by most people when taken at the recommended dose. Serious side effects are uncommon but can occur, particularly if the dose is exceeded.

Common side effects (may affect up to 1 in 10 people):

  • Nausea (feeling sick) — usually mild
  • General feeling of being unwell

Less common or rare side effects:

  • Skin rash or itching — stop taking and seek medical advice if this occurs
  • Low blood pressure (hypotension) — reported rarely with intravenous paracetamol; less relevant at oral doses
  • Blood disorders such as thrombocytopenia (low platelet count) — very rare
  • Liver damage — this is the most serious risk and occurs almost exclusively with overdose or prolonged excessive use

If you experience any unexpected symptoms after taking paracetamol, stop use and speak to a pharmacist or GP. For a suspected overdose, call 999 or go to A&E immediately — do not wait for symptoms to develop, as liver damage may not be apparent for 24–72 hours.

 

How Should You Store Paracetamol 500mg?

 

  • Store below 25°C in a dry place, away from direct heat and sunlight
  • Keep in the original packaging to protect from moisture
  • Do not store in a bathroom cabinet — humidity can degrade the tablets
  • Keep out of the reach and sight of children at all times
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you are looking to support your overall health alongside pain management, our vitamins and supplements range includes products that may help with general wellbeing.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy paracetamol 500mg online in the UK?

You can buy paracetamol 500mg tablets online from Cured Pharmacy, a GPhC-registered UK online pharmacy. Simply add the product to your basket and complete checkout for fast UK delivery. It is a General Sale List medicine, so no prescription is required.

How does paracetamol 500mg work in the body?

Paracetamol works by inhibiting the production of prostaglandins in the brain and spinal cord — chemicals that transmit pain signals and raise body temperature. This reduces both the sensation of pain and any associated fever. It does not have a significant anti-inflammatory effect at the site of injury, which is why it differs from ibuprofen.

How do I take paracetamol 500mg step by step?

Follow these steps for safe use:

  1. Check the expiry date on the packet before use.
  2. Take 1–2 tablets with a full glass of water.
  3. You can take it with or without food.
  4. Wait at least 4 hours before taking another dose.
  5. Do not take more than 8 tablets (4g) in 24 hours.
What is the correct dose of paracetamol 500mg for adults?

The standard adult dose is 1–2 tablets (500mg–1g) every 4–6 hours as needed. You must not exceed 4g (eight 500mg tablets) in any 24-hour period. If you have liver or kidney problems, your pharmacist may recommend a lower dose.

How long does paracetamol 500mg take to work?

Paracetamol typically begins to work within 30–60 minutes of taking a dose orally. Peak effect is usually reached within 1–2 hours. If you have not noticed any improvement after taking the recommended dose, speak to your pharmacist before taking more.

Can I take paracetamol 500mg on an empty stomach?

Yes, paracetamol can be taken with or without food. Unlike NSAIDs such as ibuprofen, it does not irritate the stomach lining, making it a suitable option for people with sensitive stomachs or those who cannot tolerate anti-inflammatory medicines. This is one reason it is often recommended as a first-line painkiller.

What are the side effects of paracetamol 500mg?

At recommended doses, paracetamol is generally very well tolerated and serious side effects are rare. Occasionally, mild nausea or a skin rash may occur. The most significant risk is liver damage, which can happen if you take more than the recommended dose — even a modest overdose can be dangerous, so always stick to the stated amount.

Who should not take paracetamol 500mg tablets?

You should not take paracetamol 500mg tablets if you are allergic to paracetamol, have severe liver disease, or are already taking another product that contains paracetamol. People with liver or kidney conditions, those who drink alcohol regularly, or those who are malnourished should speak to a pharmacist or GP before use.

Can I take paracetamol 500mg if I am pregnant?

Paracetamol is generally considered the first-choice painkiller during pregnancy when used at the lowest effective dose for the shortest possible time. However, you should always consult your GP or midwife before taking any medicine during pregnancy, as guidance in this area continues to evolve. Do not take it routinely without medical advice.

What happens if I accidentally take too much paracetamol?

Taking too much paracetamol is a medical emergency. Even if you feel well initially, an overdose can cause serious and potentially fatal liver damage that may not become apparent for 24–72 hours. If you think you or someone else has taken too much, go to A&E or call 999 immediately — do not wait for symptoms to appear.

Does paracetamol 500mg interact with other medicines?

Yes, paracetamol can interact with certain medicines. Regular use alongside warfarin may enhance its anticoagulant effect. Enzyme-inducing medicines such as carbamazepine and phenytoin can reduce paracetamol's effectiveness and increase the risk of liver toxicity. Always check with your pharmacist if you are taking other medicines. You can also explore our first aid range for complementary products.

What are the alternatives to paracetamol 500mg for pain relief?

Common alternatives include ibuprofen (an NSAID suitable for inflammatory pain), aspirin (not suitable for under-16s or during pregnancy), and codeine-containing combination products (available from a pharmacist). The right choice depends on the type of pain and your medical history — your pharmacist can advise. Browse our full pain relief collection for more options.

How long can I keep taking paracetamol 500mg?

Paracetamol is intended for short-term use to manage acute pain or fever. If you find you need to take it regularly for more than 3 consecutive days, or if your symptoms are not improving, you should speak to your GP or pharmacist. Long-term regular use without medical supervision is not recommended.

What is the latest research on paracetamol 500mg?

Recent research has prompted some discussion around the routine use of paracetamol in pregnancy, with some studies suggesting a possible association with neurodevelopmental outcomes in children — though causality has not been established. The NHS and MHRA continue to advise that paracetamol remains the first-choice painkiller in pregnancy when used at the lowest effective dose for the shortest time. Always follow current NHS guidance and speak to your GP if you have concerns.

Can I give paracetamol 500mg tablets to my child?

No — paracetamol 500mg tablets are not suitable for children under 16. Children require age-appropriate formulations such as paracetamol oral suspension (liquid), which provides a dose calculated by weight and age. Always use a product specifically licensed for your child's age group. You can find suitable products in our baby and toddler range.

How Should You Use Paracetamol 500mg?

Paracetamol 500mg tablets are taken orally with a full glass of water. They can be swallowed with or without food, which makes them convenient to take at any time of day. Follow these steps each time you take a dose:

What Is the Correct Dose of Paracetamol 500mg?

The dose you take will depend on your age and the condition being treated. Always follow the dosage instructions on the packaging or as directed by your pharmacist. Never exceed the maximum daily dose, as doing so significantly increases the risk of liver damage.

When Is the Best Time to Use Paracetamol 500mg?

There is no single "best" time to take paracetamol — it should be taken when you need it, as symptoms arise. Because it can be taken with or without food, you are not restricted to mealtimes. If you are managing a persistent fever or ongoing pain, taking doses at regular intervals (every 4–6 hours) throughout the day can help maintain more consistent relief rather than waiting until symptoms become severe again.

If you are taking paracetamol to manage pain before a known trigger — such as before a dental procedure or during a menstrual cycle — your pharmacist may advise starting a dose in advance. Always follow their specific guidance in those situations.

How Long Can You Use Paracetamol 500mg For?

Paracetamol 500mg is intended for short-term use only. For most acute conditions such as headaches, toothache, or fever, you should not need to take it for more than 3 consecutive days without reassessing your symptoms. If pain or fever persists beyond this point, or if symptoms worsen, you should consult your GP or pharmacist rather than continuing to self-medicate.

Long-term regular use of paracetamol without medical supervision is not recommended. Paradoxically, taking painkillers — including paracetamol — on more than 10–15 days per month can lead to medication overuse headache (also known as rebound headache), which can make headaches more frequent and harder to treat.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Paracetamol 500mg?

Paracetamol 500mg tablets are taken orally with a full glass of water. They can be swallowed with or without food, which makes them convenient to take at any time of day. Follow these steps each time you take a dose:

What Is the Correct Dose of Paracetamol 500mg?

The dose you take will depend on your age and the condition being treated. Always follow the dosage instructions on the packaging or as directed by your pharmacist. Never exceed the maximum daily dose, as doing so significantly increases the risk of liver damage.

When Is the Best Time to Use Paracetamol 500mg?

There is no single "best" time to take paracetamol — it should be taken when you need it, as symptoms arise. Because it can be taken with or without food, you are not restricted to mealtimes. If you are managing a persistent fever or ongoing pain, taking doses at regular intervals (every 4–6 hours) throughout the day can help maintain more consistent relief rather than waiting until symptoms become severe again.

If you are taking paracetamol to manage pain before a known trigger — such as before a dental procedure or during a menstrual cycle — your pharmacist may advise starting a dose in advance. Always follow their specific guidance in those situations.

How Long Can You Use Paracetamol 500mg For?

Paracetamol 500mg is intended for short-term use only. For most acute conditions such as headaches, toothache, or fever, you should not need to take it for more than 3 consecutive days without reassessing your symptoms. If pain or fever persists beyond this point, or if symptoms worsen, you should consult your GP or pharmacist rather than continuing to self-medicate.

Long-term regular use of paracetamol without medical supervision is not recommended. Paradoxically, taking painkillers — including paracetamol — on more than 10–15 days per month can lead to medication overuse headache (also known as rebound headache), which can make headaches more frequent and harder to treat.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Paracetamol 500mg?

Paracetamol 500mg is one of the most widely tolerated over-the-counter medicines available in the UK. When taken at the recommended dose, most people experience no side effects at all. However, as with any medicine, some people may notice mild reactions.

  • Nausea (feeling sick) — usually mild and transient
  • General feeling of being unwell

What Are the Less Common Side Effects of Paracetamol 500mg?

Less common side effects are rare at therapeutic doses but can occur in some individuals. If you notice any of the following, stop taking paracetamol and speak to your pharmacist or GP promptly.

  • Skin rash, itching, or hives (urticaria)
  • Flushing or redness of the skin
  • Swelling of the face, lips, or throat (angioedema) — seek urgent medical attention if this occurs
  • Low blood pressure (hypotension) — very rare with oral doses
  • Blood disorders such as thrombocytopenia (low platelet count) or agranulocytosis — extremely rare

What Are the Serious Side Effects of Paracetamol 500mg?

The most serious risk associated with paracetamol is liver damage (hepatotoxicity). This does not occur at recommended doses in healthy individuals, but it can develop rapidly if the maximum daily dose is exceeded — even by a relatively small amount. The danger is that liver damage may not produce obvious symptoms for 24–72 hours after an overdose, by which time significant harm may already have occurred.

Kidney damage (nephrotoxicity) is also a recognised risk in cases of overdose or prolonged excessive use. If you suspect an overdose — even if you feel well — go to A&E immediately or call 999. Do not wait for symptoms to appear.

What Should You Do If You Experience Side Effects of Paracetamol 500mg?

For mild side effects such as nausea, these will usually resolve on their own. Taking paracetamol with a small amount of food or a full glass of water may help. If you develop a skin rash, swelling, or difficulty breathing, stop taking the medicine immediately and seek urgent medical attention, as these may indicate an allergic reaction.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety information for everyone.

Can Paracetamol 500mg Interact With Other Medicines?

Yes. Paracetamol can interact with several medicines, and it is important to check before combining it with anything else. Regular use alongside warfarin may increase the anticoagulant effect and raise the risk of bleeding. Enzyme-inducing medicines such as carbamazepine, phenytoin, rifampicin, and St John's Wort can reduce paracetamol's effectiveness and increase the risk of liver toxicity by altering how it is metabolised. Metoclopramide and domperidone can speed up paracetamol absorption, while cholestyramine may reduce it if taken simultaneously.

Crucially, many combination cold, flu, and pain relief products already contain paracetamol. Taking these alongside paracetamol 500mg tablets can lead to accidental overdose. Always check the ingredients of every medicine you are taking and speak to your pharmacist if you are unsure.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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