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Paracetamol 500mg

Paracetamol 500mg

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  • ✔️ Relieves mild to moderate pain within 30–60 minutes
  • ✔️ Reduces fever by acting on the brain's temperature centre
  • ✔️ Gentle on the stomach — suitable for those who cannot take ibuprofen
  • ✔️ Suitable for adults and young people aged 16 and over
  • ✔️ Each pack contains 500mg paracetamol — the standard therapeutic dose

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What Is Paracetamol 500mg and How Does It Help?

 

Paracetamol 500mg is one of the most widely used over-the-counter medicines in the UK. It is an analgesic (painkiller) and antipyretic (fever reducer) that has been trusted by patients and healthcare professionals for decades. Crescent Paracetamol 500mg tablets offer a straightforward, affordable option for managing everyday pain and high temperature — available from Cured Pharmacy for just £0.99. If you regularly deal with headaches, muscle aches, or the misery of a cold, having paracetamol to hand is simply sensible. You can browse our full range of pain relief products to find the right option for your needs.

Paracetamol is suitable for adults and children aged 16 and over at the 500mg tablet strength. It is available without a prescription and is classified as a General Sale List (GSL) medicine in the UK, meaning you can purchase it easily and safely without needing to see a doctor first.

 

How Does Paracetamol Work to Relieve Pain and Fever?

 

The exact mechanism of paracetamol is still being studied, but it is understood to work primarily within the central nervous system. Here is a simplified breakdown:

  • It inhibits the synthesis of prostaglandins — chemicals in the brain and spinal cord that transmit pain signals and raise body temperature.
  • By reducing prostaglandin activity centrally, it lowers the perception of pain without significantly affecting inflammation at the site of injury (unlike ibuprofen).
  • Its antipyretic effect works by acting on the hypothalamus, the part of the brain that regulates body temperature, helping to bring a fever down.
  • It is absorbed rapidly from the gastrointestinal tract, with effects typically felt within 30–60 minutes of taking a dose.

Because paracetamol does not irritate the stomach lining in the way that non-steroidal anti-inflammatory drugs (NSAIDs) can, it is often the preferred first-line choice for people who have a sensitive stomach or cannot tolerate ibuprofen.

 

Who Is Paracetamol 500mg Suitable For?

 

Paracetamol is one of the most versatile painkillers available. It is appropriate for a wide range of people and conditions, though there are important exceptions to be aware of (covered in Section 2). Generally, it suits:

  • Adults and young people aged 16 and over experiencing mild to moderate pain
  • People with stomach sensitivity who cannot tolerate NSAIDs such as ibuprofen or aspirin
  • Individuals managing cold and flu symptoms, including fever and body aches — see our cold and flu range for complementary products
  • Those with headaches, toothache, period pain, or back pain

It is not suitable for children under 16 at this tablet strength. People with liver or kidney problems, or those who regularly drink alcohol, should seek advice from a pharmacist or GP before use.

 

How Does Crescent Paracetamol 500mg Compare to Other Pain Relievers?

 

Feature Crescent Paracetamol 500mg Ibuprofen 200mg (NSAID)
Mechanism Central prostaglandin inhibition Peripheral & central prostaglandin inhibition
Anti-inflammatory effect Minimal Yes
Suitable for stomach sensitivity Yes No — can irritate stomach lining
Safe in pregnancy (with advice) Generally yes (lowest dose, shortest time) Avoid from 20 weeks onwards
UK classification GSL (General Sale List) GSL / P (Pharmacy)

 

How Should You Store Crescent Paracetamol 500mg?

 

Store your tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep them out of reach and sight of children at all times. Do not use the tablets after the expiry date printed on the packaging — if in doubt, return them to your local pharmacy for safe disposal.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Paracetamol 500mg specifications
Treatment category Pain relief & fever reduction
Mechanism of action Central prostaglandin synthesis inhibition; antipyretic action via hypothalamus
Effective for Mild to moderate pain, headache, toothache, period pain, back pain, cold & flu symptoms, fever
Suitable for Adults and young people aged 16 and over
Active ingredient Paracetamol 500mg
Pack sizes 16 tablets, 32 tablets (varies by retailer)
Strength 500mg per tablet
UK classification GSL (General Sale List)
Drug class Analgesic / Antipyretic
Preparation Film-coated tablet
Route of administration Oral

Specifications of Paracetamol 500mg

 

What Is Paracetamol 500mg and What Is It Used For?

 

Crescent Paracetamol 500mg tablets are an analgesic and antipyretic medicine used to relieve mild to moderate pain and to reduce fever. They are suitable for adults and young people aged 16 and over. Common uses include headaches, migraines, toothache, sore throat, period pain, back pain, joint pain, and the aches and fever associated with colds and flu. Paracetamol is one of the most studied and widely recommended over-the-counter medicines available in the UK.

 

What Do You Need to Know Before Using Paracetamol 500mg?

 

Do not take these tablets if any of the following apply to you:

  • You are allergic to paracetamol or any of the other ingredients in the tablet
  • You have severe liver disease or active liver problems
  • You have severe kidney disease
  • You are already taking another product containing paracetamol (including many cold and flu remedies, combination analgesics, and some prescription medicines)

Speak to your pharmacist or GP before taking paracetamol if you:

  • Regularly drink alcohol (more than 3 units per day)
  • Are underweight or malnourished
  • Have Gilbert's syndrome or any other liver condition
  • Are pregnant or breastfeeding

Drug interactions — tell your pharmacist if you are taking:

  • Warfarin or other anticoagulants — regular paracetamol use may increase bleeding risk
  • Metoclopramide or domperidone — these can speed up paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken at the same time
  • Carbamazepine, phenytoin, or other enzyme-inducing medicines — may increase the risk of liver damage

 

How Should You Use Paracetamol 500mg?

 

Always take paracetamol exactly as directed on the label or as advised by your pharmacist. Do not exceed the stated dose. Here is how to take it correctly:

  1. Check the packaging to confirm you are not already taking another product containing paracetamol.
  2. Swallow 1–2 tablets whole with a glass of water.
  3. Do not crush or chew the tablets.
  4. Wait at least 4 hours before taking your next dose.
  5. Do not take more than 4 doses (8 tablets / 4g) in any 24-hour period.
  6. If symptoms persist for more than 3 days, or worsen, speak to your pharmacist or GP.
Age Group Dose Frequency Maximum in 24 hours
Adults & young people aged 16+ 1–2 tablets (500mg–1g) Every 4–6 hours as needed 8 tablets (4g)
Children under 16 Not suitable — use age-appropriate liquid or lower-strength formulation

If you are managing pain alongside other symptoms such as digestive discomfort, you may find it helpful to explore our indigestion range for additional support.

 

What Are the Possible Side Effects of Paracetamol 500mg?

 

Paracetamol is generally very well tolerated when taken at the recommended dose. However, like all medicines, it can cause side effects in some people.

Common side effects (may affect up to 1 in 10 people):

  • Nausea (feeling sick) — usually mild
  • General feeling of being unwell

Less common or rare side effects:

  • Skin rash, itching, or hives
  • Swelling of the face, lips, tongue, or throat (signs of a serious allergic reaction — stop taking immediately and seek emergency help)
  • Abnormal liver function — particularly with long-term use or overdose
  • Low platelet count (thrombocytopenia) — very rare
  • Low white blood cell count (leucopenia) — very rare

Overdose is the most serious risk associated with paracetamol. Even if you feel well after taking too much, liver damage can develop over the following days. If you suspect an overdose, go to A&E immediately or call 999 — do not wait for symptoms to appear.

 

How Should You Store Paracetamol 500mg?

 

Correct storage helps maintain the quality and safety of your tablets. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not store in a bathroom cabinet — humidity can affect tablet quality
  • Return unused or expired tablets to your local pharmacy for safe disposal — do not put them in household waste or flush them down the toilet

If you are looking for other everyday health essentials, our first aid range and vitamins and supplements collection are worth exploring too.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy paracetamol 500mg online in the UK?

You can buy Crescent Paracetamol 500mg tablets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. Simply add the product to your basket and complete your order for fast, discreet delivery. You can also browse our wider pain relief collection for other analgesic options.

How does paracetamol 500mg work in the body?

Paracetamol works by inhibiting the production of prostaglandins in the brain and spinal cord — chemicals that transmit pain signals and raise body temperature. This reduces your perception of pain and helps bring a fever down. Unlike ibuprofen, it has minimal anti-inflammatory action at the site of injury.

What is the correct dose of paracetamol 500mg for adults?

The standard adult dose is 1–2 tablets (500mg to 1g) every 4–6 hours as needed. You must not take more than 8 tablets (4g total) in any 24-hour period. Always leave at least 4 hours between doses.

How long does paracetamol 500mg take to work?

Paracetamol is typically absorbed within 30–60 minutes of taking a tablet orally, with peak pain-relieving effects usually felt within one hour. The effects generally last between 4 and 6 hours, which is why dosing is spaced accordingly. Taking it with food may slightly slow absorption but does not significantly reduce its effectiveness.

Can I take paracetamol 500mg with ibuprofen?

Yes — paracetamol and ibuprofen work via different mechanisms and can generally be taken together or alternated for more consistent pain relief, as advised by the NHS. However, always check with your pharmacist first, especially if you have any underlying health conditions. Do not exceed the recommended dose of either medicine.

Is paracetamol 500mg safe to take during pregnancy?

Paracetamol is generally considered the first-choice painkiller during pregnancy, but it should be used at the lowest effective dose for the shortest possible time. Some studies have raised questions about prolonged use in pregnancy, so always speak to your midwife or GP before taking any medicine when pregnant. Do not self-medicate throughout pregnancy without professional guidance.

What are the side effects of paracetamol 500mg?

At recommended doses, paracetamol is very well tolerated and serious side effects are rare. Possible side effects include nausea, skin rash, or in very rare cases, allergic reactions such as swelling of the face or throat. Overdose is the most serious risk and can cause severe liver damage — always stick to the stated dose.

What happens if I accidentally take too much paracetamol?

Taking too much paracetamol — even a small amount over the recommended dose — can cause serious and potentially fatal liver damage. Crucially, you may feel fine initially, with symptoms of liver damage only appearing days later. If you think you have taken too much, go to A&E immediately or call 999 — do not wait for symptoms.

Can I take paracetamol 500mg if I drink alcohol regularly?

If you regularly drink more than 3 units of alcohol per day, you should speak to your pharmacist or GP before taking paracetamol, as alcohol can increase the risk of liver damage. Occasional, moderate alcohol consumption is generally considered safe alongside a standard paracetamol dose. However, never take paracetamol specifically to treat a hangover without first checking it is appropriate for you.

Who should not take paracetamol 500mg tablets?

These tablets are not suitable for children under 16, people with severe liver or kidney disease, or anyone allergic to paracetamol. You should also avoid them if you are already taking another product containing paracetamol, such as certain cold and flu remedies. Always read the label carefully and speak to a pharmacist if you are unsure.

What medicines interact with paracetamol 500mg?

The most clinically significant interaction is with warfarin — regular paracetamol use can increase the anticoagulant effect and raise bleeding risk. Other interactions include metoclopramide (speeds absorption), cholestyramine (reduces absorption), and enzyme-inducing medicines such as carbamazepine or phenytoin (may increase liver damage risk). Always tell your pharmacist about all medicines you are taking.

What are the alternatives to paracetamol 500mg for pain relief?

Common alternatives include ibuprofen (an NSAID suitable for inflammatory pain), aspirin (not suitable for under-16s or those with stomach problems), and codeine-containing combination products (available from a pharmacist). The right choice depends on the type of pain and your individual health profile. You can explore our full pain relief range to compare options.

How long can I keep taking paracetamol 500mg?

Paracetamol is intended for short-term use to manage acute pain or fever. If you find you need to take it regularly for more than 3 consecutive days, or if your symptoms are not improving, you should speak to your GP or pharmacist. Long-term, frequent use without medical supervision is not recommended.

What is the difference between branded and generic paracetamol 500mg?

Generic paracetamol tablets, such as those made by Crescent, contain exactly the same active ingredient at the same strength as branded versions like Panadol. The only differences may be in the inactive excipients (fillers and coatings), packaging, and price. Regulatory standards require all licensed paracetamol products to meet the same quality and efficacy criteria.

What are the latest research findings on paracetamol use?

Recent research has prompted some discussion around prolonged paracetamol use in pregnancy and its potential association with neurodevelopmental outcomes in children, though current NHS guidance still recommends it as the first-choice painkiller in pregnancy at the lowest effective dose. Studies have also reinforced that paracetamol is less effective for lower back pain and osteoarthritis than previously thought, with the NHS now recommending other management strategies for these conditions. Always follow current NHS and MHRA guidance, and speak to your GP if you have concerns about long-term use.

How Should You Use Paracetamol 500mg?

Always read the label before taking paracetamol and follow the instructions carefully. These tablets are for oral use only — swallow them whole with a full glass of water. Do not crush, chew, or break the tablets.

Follow these steps each time you take a dose:

What Is the Correct Dose of Paracetamol 500mg?

The dose you take will depend on your age and the condition being treated. Never exceed the maximum daily dose, as doing so significantly increases the risk of liver damage. The table below summarises the recommended doses.

When Is the Best Time to Use Paracetamol 500mg?

Paracetamol can be taken at any time of day, with or without food. Taking it with or after food may help if you have a sensitive stomach, though it is not strictly necessary as paracetamol does not irritate the stomach lining in the way NSAIDs can.

For ongoing pain management, some people find it helpful to take doses at regular intervals throughout the day rather than waiting until pain becomes severe. This approach — sometimes called "around the clock" dosing — can help maintain more consistent pain relief, but must still stay within the maximum daily dose.

How Long Can You Use Paracetamol 500mg For?

Paracetamol 500mg tablets are intended for short-term use only. For most acute conditions such as headaches, toothache, or cold and flu symptoms, you should not need to take it for more than 3 consecutive days without seeking further advice.

If you find that you need paracetamol regularly over a longer period — for example, for chronic pain — speak to your GP. They can assess the underlying cause and recommend a more appropriate long-term management plan. Using paracetamol too frequently can also lead to medication overuse headache (sometimes called rebound headache), particularly in people who take it for headaches more than 10–15 days per month.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Paracetamol 500mg?

Always read the label before taking paracetamol and follow the instructions carefully. These tablets are for oral use only — swallow them whole with a full glass of water. Do not crush, chew, or break the tablets.

Follow these steps each time you take a dose:

What Is the Correct Dose of Paracetamol 500mg?

The dose you take will depend on your age and the condition being treated. Never exceed the maximum daily dose, as doing so significantly increases the risk of liver damage. The table below summarises the recommended doses.

When Is the Best Time to Use Paracetamol 500mg?

Paracetamol can be taken at any time of day, with or without food. Taking it with or after food may help if you have a sensitive stomach, though it is not strictly necessary as paracetamol does not irritate the stomach lining in the way NSAIDs can.

For ongoing pain management, some people find it helpful to take doses at regular intervals throughout the day rather than waiting until pain becomes severe. This approach — sometimes called "around the clock" dosing — can help maintain more consistent pain relief, but must still stay within the maximum daily dose.

How Long Can You Use Paracetamol 500mg For?

Paracetamol 500mg tablets are intended for short-term use only. For most acute conditions such as headaches, toothache, or cold and flu symptoms, you should not need to take it for more than 3 consecutive days without seeking further advice.

If you find that you need paracetamol regularly over a longer period — for example, for chronic pain — speak to your GP. They can assess the underlying cause and recommend a more appropriate long-term management plan. Using paracetamol too frequently can also lead to medication overuse headache (sometimes called rebound headache), particularly in people who take it for headaches more than 10–15 days per month.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Paracetamol 500mg?

When taken at the recommended dose, paracetamol is one of the best-tolerated over-the-counter medicines available. Serious side effects at therapeutic doses are uncommon. That said, some people do experience mild reactions.

  • Nausea or feeling sick — usually mild and short-lived
  • General malaise or feeling unwell
  • Mild stomach discomfort in some individuals

What Are the Less Common Side Effects of Paracetamol 500mg?

Less common side effects are rare but worth being aware of. If you notice any of the following, stop taking the tablets and speak to your pharmacist or GP promptly.

  • Skin rash, redness, or itching
  • Hives (urticaria)
  • Flushing
  • Low blood pressure (hypotension) — very rare, associated with intravenous use rather than oral tablets
  • Abnormal liver function tests — particularly with prolonged use or in those with pre-existing liver conditions
  • Thrombocytopenia (low platelet count) — very rare
  • Leucopenia (low white blood cell count) — very rare

What Are the Serious Side Effects of Paracetamol 500mg?

The most serious risk associated with paracetamol is overdose-related liver damage. This is a medical emergency. Even a relatively small amount above the recommended dose can cause severe, potentially fatal hepatotoxicity (liver damage). What makes this particularly dangerous is that symptoms may not appear for 24–72 hours after the overdose — by which time significant liver damage may already have occurred.

Signs of a serious allergic reaction (anaphylaxis) are also a medical emergency. These include swelling of the face, lips, tongue, or throat, difficulty breathing, and a sudden drop in blood pressure. If you experience any of these, call 999 immediately.

What Should You Do If You Experience Side Effects of Paracetamol 500mg?

For mild side effects such as nausea, try taking your dose with a small amount of food and ensure you are drinking enough water. If a skin rash develops, stop taking the tablets and speak to your pharmacist — this may indicate a sensitivity or allergy.

If you suspect an overdose — even if you feel well — go to your nearest A&E department immediately or call 999. Take the packaging with you so medical staff can see exactly what you have taken and how much. Do not wait for symptoms to develop before seeking help.

Can Paracetamol 500mg Interact With Other Medicines?

Yes. The most clinically important interaction is with warfarin. Regular use of paracetamol (more than a few days) can enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Your GP or anticoagulation clinic should be informed if you need to take paracetamol regularly.

Other notable interactions include metoclopramide and domperidone (which speed up paracetamol absorption), cholestyramine (which reduces absorption if taken simultaneously), and enzyme-inducing medicines such as carbamazepine, phenytoin, and rifampicin, which may increase the risk of liver damage by altering paracetamol metabolism. Always tell your pharmacist about every medicine, supplement, or herbal remedy you are taking before starting paracetamol.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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