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Pantoprazole Gastro Resistant Tablets (20mg & 40mg)

Pantoprazole Gastro Resistant Tablets (20mg & 40mg)

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  • ✔️ Reduces stomach acid production for up to 24 hours
  • ✔️ Relieves heartburn and acid reflux in adults
  • ✔️ Gastro resistant coating ensures correct intestinal absorption
  • ✔️ Available in 20mg and 40mg strengths for flexible dosing
  • ✔️ Clinically used to treat GORD, oesophagitis, and peptic ulcers

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What Are Pantoprazole Tablets and How Do They Help?

 

If you've ever woken up at 3am with that familiar burning sensation creeping up your chest, you'll know how disruptive acid reflux can be. Pantoprazole tablets are a type of medicine called a proton pump inhibitor (PPI), used to reduce the amount of acid your stomach produces. Teva's gastro resistant tablets are available in two strengths — 20mg and 40mg — making them suitable for a range of conditions from occasional heartburn to more persistent gastro-oesophageal reflux disease (GORD). You can explore our full range of indigestion treatments if you're looking for additional digestive support alongside this medicine.

Pantoprazole is one of the most widely used PPIs in the UK, recommended by the NHS for conditions including reflux oesophagitis, GORD, and gastric or duodenal ulcers. The gastro resistant coating on each tablet is important — it stops the medicine dissolving in your stomach before it reaches the small intestine, where it's properly absorbed.

 

How Do Pantoprazole Tablets Work in the Body?

 

Stomach acid is produced by specialised cells in the stomach lining via a mechanism called the proton pump (H+/K+ ATPase). Pantoprazole works by irreversibly binding to and blocking this pump, cutting off acid production at its source. It's not just masking symptoms — it's addressing the underlying mechanism.

  • Pantoprazole is absorbed in the small intestine after passing through the gastro resistant coating.
  • It travels via the bloodstream to the acid-secreting parietal cells in the stomach lining.
  • It binds irreversibly to the proton pump, blocking acid secretion.
  • Acid levels remain reduced for up to 24 hours after a single dose.
  • With regular use, the stomach lining and oesophagus have time to heal.

 

Who Is Pantoprazole Suitable For?

 

Pantoprazole is suitable for adults aged 18 and over who experience symptoms related to excess stomach acid. It's particularly useful for people who haven't found adequate relief from antacids or H2 blockers. That said, it's not right for everyone — always read the patient information leaflet before starting treatment.

  • Adults with frequent heartburn or acid reflux (two or more days per week)
  • People diagnosed with GORD or reflux oesophagitis
  • Patients with gastric or duodenal ulcers (under medical supervision)
  • Those requiring long-term acid suppression as directed by a GP

 

How Do Pantoprazole Tablets Compare to Other PPIs?

 

Feature Pantoprazole (Teva) Omeprazole
Drug class Proton pump inhibitor Proton pump inhibitor
Available strengths 20mg, 40mg 10mg, 20mg, 40mg
Drug interaction profile Lower interaction risk (fewer CYP2C19 interactions) Higher interaction risk (CYP2C19 inhibitor)
Gastro resistant coating Yes Yes

 

How Should Pantoprazole Tablets Be Stored?

 

Store pantoprazole tablets below 25°C in their original packaging, away from direct light and moisture. Keep them out of reach and sight of children at all times. Do not use the tablets after the expiry date printed on the pack — if in doubt, return them to your local pharmacy for safe disposal. If you're managing multiple health conditions and need support with other treatments, our vitamins and supplements range may complement your overall wellness routine.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Pantoprazole Gastro Resistant Tablets (20mg & 40mg) specifications
Treatment category Acid reflux, GORD, gastric ulcers, oesophagitis
Mechanism of action Proton pump inhibitor — blocks H+/K+ ATPase enzyme
Effective for Heartburn, acid reflux, GORD, peptic ulcers
Suitable for Adults aged 18 and over
Active ingredient Pantoprazole sodium sesquihydrate
Pack sizes 7, 14, 28 tablets (varies by supplier)
Strengths 20mg, 40mg
UK classification P (Pharmacy medicine)
Drug class Proton pump inhibitor (PPI)
Preparation Gastro resistant tablet
Route of administration Oral

Specifications of Pantoprazole Gastro Resistant Tablets (20mg & 40mg)

 

What Is Pantoprazole and What Is It Used For?

 

Pantoprazole belongs to a group of medicines called proton pump inhibitors (PPIs). It works by reducing the amount of acid your stomach produces. Teva pantoprazole gastro resistant tablets are used to treat a range of acid-related conditions in adults, including heartburn, acid reflux, gastro-oesophageal reflux disease (GORD), and inflammation of the oesophagus (oesophagitis). They may also be used alongside antibiotics to treat Helicobacter pylori infection, or to prevent and treat ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs).

 

What Do You Need to Know Before Using Pantoprazole?

 

Before taking pantoprazole, it's important to check whether it's appropriate for you. There are certain situations where you should not take it, and others where extra care is needed.

Do not take pantoprazole if you:

  • Are allergic to pantoprazole, substituted benzimidazoles, or any other ingredient in the tablet
  • Are taking medicines containing nelfinavir (used for HIV infection)
  • Are under 18 years of age (for OTC use)

Take care and speak to your doctor or pharmacist if you:

  • Have severe liver problems
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have ever had an allergic reaction to another PPI
  • Are due to have an endoscopy or breath test for H. pylori
  • Have low magnesium levels or are at risk of osteoporosis (long-term use may reduce bone density)
  • Experience unintentional weight loss, difficulty swallowing, or persistent vomiting — these require urgent medical review

Known drug interactions — tell your doctor or pharmacist if you are taking:

  • Methotrexate (used for cancer or autoimmune conditions)
  • Atazanavir or other HIV medicines
  • Warfarin or other anticoagulants
  • Clopidogrel (used to prevent blood clots)
  • Ketoconazole or itraconazole (antifungal medicines)
  • Fluvoxamine (antidepressant)

 

How Should You Use Pantoprazole?

 

Always take pantoprazole exactly as directed by your pharmacist or as described in the patient information leaflet. Swallow the tablet whole — do not crush, chew, or split it, as this will damage the gastro resistant coating. If you have difficulty swallowing, speak to your pharmacist about alternatives.

  1. Take one tablet 30 to 60 minutes before a meal, ideally breakfast.
  2. Swallow the tablet whole with a glass of water.
  3. Do not crush, chew, or break the tablet.
  4. Take at the same time each day for best results.
  5. Complete the full course if prescribed, even if symptoms improve.
Indication Age Group Dose Duration
Heartburn / acid reflux (OTC) Adults 18+ 20mg once daily Up to 4 weeks
GORD / oesophagitis Adults 18+ 40mg once daily 4–8 weeks (as directed by GP)
Gastric or duodenal ulcer Adults 18+ 40mg once daily 4–8 weeks (as directed by GP)
H. pylori eradication (with antibiotics) Adults 18+ 40mg twice daily 7 days (as directed by GP)

 

What Are the Possible Side Effects of Pantoprazole?

 

Like all medicines, pantoprazole can cause side effects, although not everyone gets them. Most are mild and temporary. If you're also managing other digestive symptoms, our IBS and cramps range may offer additional support alongside your treatment.

Common side effects (may affect up to 1 in 10 people):

  • Headache
  • Diarrhoea
  • Nausea or vomiting
  • Abdominal pain or discomfort
  • Flatulence (wind)
  • Constipation

Less common side effects (may affect up to 1 in 100 people):

  • Dizziness or sleep disturbances
  • Dry mouth
  • Skin rash or itching
  • Joint or muscle pain
  • Raised liver enzymes (detected on blood tests)
  • Low magnesium levels with long-term use

Stop taking pantoprazole and seek immediate medical attention if you develop signs of a serious allergic reaction, such as swelling of the face, lips, tongue or throat, difficulty breathing, or a severe skin rash.

 

How Should You Store Pantoprazole?

 

  • Store below 25°C in the original packaging.
  • Keep away from direct light and moisture.
  • Do not store in the bathroom or near a sink.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the pack.
  • Return unused or expired tablets to your pharmacy — do not dispose of them in household waste or down the sink.

If you need support managing pain alongside your digestive condition, you may find our pain relief range helpful for related discomfort.

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Frequently Asked Questions

Where can I buy pantoprazole tablets online in the UK?

You can buy pantoprazole tablets online in the UK from Cured Pharmacy, a GPhC-registered online pharmacy. Both 20mg and 40mg strengths are available subject to a short clinical assessment to confirm suitability. Ordering online is straightforward, discreet, and delivered directly to your door.

How do pantoprazole tablets work in the body?

Pantoprazole works by irreversibly blocking the proton pump (H+/K+ ATPase) in the stomach's parietal cells — the final step in acid production. This significantly reduces the volume of acid your stomach makes, relieving symptoms like heartburn and allowing the oesophagus and stomach lining to heal. Effects can last up to 24 hours from a single dose.

What is the correct dose of pantoprazole for heartburn?

For OTC use in adults, the standard dose for heartburn and acid reflux is 20mg once daily, taken before a meal, for up to 4 weeks. If your GP has prescribed pantoprazole for GORD or an ulcer, the dose is typically 40mg once daily. Never exceed the recommended dose without medical advice.

What is the best time to take pantoprazole tablets?

The best time to take pantoprazole is 30 to 60 minutes before your first meal of the day, usually breakfast. Taking it before eating ensures the drug is active when your stomach is stimulated to produce acid during digestion. Consistency matters — try to take it at the same time each day.

What are the common side effects of pantoprazole?

The most commonly reported side effects of pantoprazole include headache, diarrhoea, nausea, stomach pain, flatulence, and constipation. These are generally mild and tend to resolve without treatment. If side effects are persistent or troublesome, speak to your pharmacist or GP.

Who should not take pantoprazole tablets?

Pantoprazole should not be taken by anyone with a known allergy to pantoprazole, other PPIs, or any excipient in the tablet. It is also contraindicated in people taking nelfinavir (an HIV medicine) and is not recommended for children under 18 for OTC use. Always check with your pharmacist if you are unsure.

What happens if I miss a dose of pantoprazole?

If you miss a dose, take it as soon as you remember — unless it is nearly time for your next scheduled dose, in which case skip the missed one entirely. Never take two doses at the same time to compensate. Carry on with your regular dosing schedule as normal.

How long can you take pantoprazole for?

For OTC use, pantoprazole should not be taken for more than 4 weeks without consulting a GP. If symptoms persist beyond this period, a doctor needs to investigate the underlying cause. Long-term use under medical supervision is possible for certain conditions, but requires regular review due to potential effects on magnesium levels and bone density.

Can I take pantoprazole with other medicines?

Pantoprazole can interact with several medicines, including methotrexate, atazanavir, warfarin, clopidogrel, and certain antifungals like ketoconazole. Always tell your pharmacist or GP about all medicines you are taking, including over-the-counter products and supplements. They can advise whether pantoprazole is safe to use alongside your current treatment.

Is pantoprazole safe to take during pregnancy?

Pantoprazole is not recommended during pregnancy unless clearly necessary and prescribed by a doctor. If you are pregnant or planning to become pregnant, speak to your GP before taking any PPI. There are alternative treatments your doctor may consider safer for managing heartburn during pregnancy.

What are the alternatives to pantoprazole tablets?

Other PPIs available in the UK include omeprazole, lansoprazole, esomeprazole, and rabeprazole — all work in a similar way but have slightly different interaction profiles. For milder symptoms, antacids or H2 blockers such as famotidine may be appropriate. You can browse our indigestion treatments for a range of options.

Can pantoprazole be taken on an empty stomach?

Pantoprazole should ideally be taken before a meal rather than on a completely empty stomach, as food stimulates the proton pumps that pantoprazole needs to bind to in order to work effectively. Taking it 30 to 60 minutes before eating gives the best clinical outcome. Swallow the tablet whole with a glass of water.

Does pantoprazole cause weight gain?

Weight gain is not a commonly reported side effect of pantoprazole. However, if you notice unexplained weight changes while taking this medicine, it is worth mentioning to your GP, as this could indicate an unrelated condition requiring investigation. Do not stop taking prescribed pantoprazole without speaking to your doctor first.

What are the latest studies on long-term pantoprazole use?

Research has highlighted that long-term PPI use may be associated with a modest reduction in magnesium levels, reduced bone density, and a small increased risk of certain gut infections such as Clostridioides difficile. The NHS and MHRA advise that PPIs should be used at the lowest effective dose for the shortest necessary duration. Regular review by a GP is recommended for anyone on long-term treatment.

Can I drink alcohol while taking pantoprazole?

There is no direct interaction between pantoprazole and alcohol, but alcohol can worsen acid reflux and heartburn symptoms, potentially reducing the effectiveness of your treatment. It is sensible to limit alcohol intake while managing acid-related conditions. If you have concerns about lifestyle factors affecting your treatment, speak to your pharmacist for personalised advice. You may also find our IBS and cramps section useful for broader digestive health support.

How Should You Use Pantoprazole Gastro Resistant Tablets?

Always take pantoprazole exactly as directed by your pharmacist or as described in the patient information leaflet. The gastro resistant coating is essential to how this medicine works — it protects the tablet from dissolving in your stomach so it can be absorbed correctly in the small intestine.

If you have difficulty swallowing tablets, speak to your pharmacist before altering the tablet in any way. Some formulations may be dispersed in water — only do this if specifically instructed.

What Is the Correct Dose of Pantoprazole Gastro Resistant Tablets?

The correct dose depends on your condition and whether you are using pantoprazole as an over-the-counter treatment or under medical supervision. Always follow the dose recommended by your GP or pharmacist, and do not increase your dose without advice.

When Is the Best Time to Use Pantoprazole Gastro Resistant Tablets?

Pantoprazole is most effective when taken 30 to 60 minutes before your first meal of the day. This timing allows the medicine to be absorbed and reach the parietal cells in your stomach lining before they are stimulated by food to produce acid. Taking it at the same time each morning helps maintain consistent acid suppression throughout the day.

If you have been prescribed a twice-daily dose, take one tablet before breakfast and one before your evening meal. Avoid taking pantoprazole immediately before bed on an empty stomach, as this is less effective than pre-meal dosing.

How Long Can You Use Pantoprazole Gastro Resistant Tablets For?

For over-the-counter use, pantoprazole should not be taken for longer than 4 weeks without seeking medical advice. If your symptoms have not improved after two weeks of treatment, or if they return shortly after stopping, you should consult your GP. Persistent symptoms may indicate an underlying condition that requires further investigation.

For conditions such as GORD or peptic ulcers, your GP may prescribe pantoprazole for 4 to 8 weeks, or longer in some cases. Long-term use should always be reviewed regularly by a doctor to assess ongoing need and monitor for potential effects such as low magnesium or reduced bone density.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Pantoprazole?

Most people who take pantoprazole tolerate it well, but like all medicines, it can cause side effects in some people. Common side effects affect up to 1 in 10 people and are generally mild and short-lived.

  • Headache
  • Diarrhoea
  • Nausea or vomiting
  • Abdominal pain or discomfort
  • Flatulence (wind)
  • Constipation

These effects usually settle within a few days as your body adjusts to the medicine. If they persist or become bothersome, speak to your pharmacist.

What Are the Less Common Side Effects of Pantoprazole?

Less common side effects affect up to 1 in 100 people. They are worth being aware of, particularly if you are starting treatment for the first time or increasing your dose.

  • Dizziness or vertigo
  • Sleep disturbances or insomnia
  • Dry mouth
  • Skin rash, itching, or hives
  • Joint pain (arthralgia) or muscle pain (myalgia)
  • Raised liver enzymes (detected on blood tests)
  • Low blood magnesium levels (hypomagnesaemia) — more likely with long-term use
  • Peripheral oedema (swelling of the ankles or feet)

If you notice any of these effects and they are causing concern, contact your pharmacist or GP for guidance.

What Are the Serious Side Effects of Pantoprazole?

Serious side effects are rare but require immediate medical attention. Stop taking pantoprazole and seek urgent help if you experience any of the following.

  • Signs of a severe allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash or blistering
  • Severe skin reactions such as Stevens-Johnson syndrome (blistering, peeling skin)
  • Symptoms of low magnesium: muscle cramps, irregular heartbeat, seizures, or unusual fatigue
  • Signs of liver problems: yellowing of the skin or eyes (jaundice), dark urine, or persistent upper abdominal pain
  • Severe diarrhoea that is watery or bloody — this may indicate a Clostridioides difficile infection, which is a rare but known risk with PPI use

What Should You Do If You Experience Side Effects?

If you experience mild side effects, they will often resolve on their own within a few days. You do not usually need to stop taking pantoprazole for minor issues. However, if side effects are severe, persistent, or worrying, stop taking the medicine and contact your GP or pharmacist promptly.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety monitoring across the UK.

Can Pantoprazole Interact With Other Medicines?

Yes. Pantoprazole can interact with a number of medicines, which may affect how well either drug works or increase the risk of side effects. The most clinically significant interactions include methotrexate (used for cancer and autoimmune conditions), atazanavir and other HIV antiretrovirals, warfarin and other anticoagulants, clopidogrel, and antifungal medicines such as ketoconazole and itraconazole. Pantoprazole may reduce the absorption of medicines that depend on stomach acid, such as certain antifungals and some HIV drugs.

Always tell your pharmacist or GP about every medicine you are taking — including over-the-counter products, herbal remedies, and supplements — before starting pantoprazole.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question


It means the tablet has a special coating that prevents it from breaking down in the stomach, ensuring Pantoprazole is absorbed properly in the intestine for maximum effectiveness.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What does gastro-resistant mean?


It means the tablet has a special coating that prevents it from breaking down in the stomach, ensuring Pantoprazole is absorbed properly in the intestine for maximum effectiveness.