Skip to product information
1 of 1

  • Images are for illustration purposes only

Nexium Tablets 40mg

Nexium Tablets 40mg

  • 1. Ozempic®️-equivalent therapy now available for weight management
  • 2. Average weight loss of 17%, with 1 in 3 patients achieving over 20%
  • 3. May help reduce osteoarthritis-related pain
  • 4. Wegovy®️ is not expected to impact the effectiveness of oral contraceptives
  • 5. Supports cardiovascular risk reduction
  • 6. Over 22 million patients treated with semaglutide-based therapies since 2018

Price Checker

Regular price £17.99
Sale price £17.99
Sale Sold out
  • Lowest price guarantee
  • Includes FREE private prescription
View full details

 

What Is Nexium 40mg and How Does It Treat Acid Reflux?

 

If you've ever felt that burning sensation creeping up your chest after a meal, you'll know how disruptive acid reflux can be. Nexium Tablets 40mg contain esomeprazole 40mg, a proton pump inhibitor (PPI) that reduces the amount of acid your stomach produces. It's one of the most widely used treatments for gastro-oesophageal reflux disease (GORD), heartburn, and related conditions in the UK. Whether your symptoms are occasional or persistent, this tablet offers targeted relief by tackling the root cause — excess stomach acid — rather than simply masking the discomfort. You can explore our full range of indigestion treatments if you're looking for additional digestive health support.

Nexium is a well-established medicine with a long track record of clinical use. It's available in gastro-resistant tablet form, meaning the tablet coating protects the active ingredient from breaking down in the stomach before it reaches the small intestine, where it's absorbed. This design helps ensure the medicine works as intended.

 

How Do Nexium Tablets 40mg Work in the Body?

 

Understanding how a medicine works can make it easier to use correctly. Nexium works through a specific, well-understood mechanism:

  • Esomeprazole is absorbed in the small intestine and travels to the stomach lining via the bloodstream.
  • It targets the hydrogen-potassium ATPase enzyme system — commonly called the "proton pump" — found on the surface of acid-secreting cells (parietal cells).
  • By irreversibly binding to these pumps, it blocks the final step of acid production.
  • Acid output is significantly reduced, allowing the oesophagus and stomach lining to heal and symptoms to ease.

Because the tablets are gastro-resistant, they don't dissolve in the stomach. They pass through intact and are absorbed further along the digestive tract. This is why you should swallow them whole — never crush or chew them.

 

Who Should Consider Using Nexium Tablets 40mg?

 

Nexium 40mg is suitable for adults and adolescents aged 12 and over who experience symptoms related to excess stomach acid. It's particularly useful for people who haven't found adequate relief from lower-strength PPIs or antacids. That said, it's not right for everyone — always check with a pharmacist or GP if you're unsure.

This medicine may be appropriate if you:

  • Have been diagnosed with gastro-oesophageal reflux disease (GORD)
  • Experience frequent or severe heartburn (more than twice a week)
  • Have erosive oesophagitis (inflammation or damage to the oesophagus caused by acid)
  • Need to protect your stomach lining while taking non-steroidal anti-inflammatory drugs (NSAIDs)
  • Are being treated for a Helicobacter pylori infection (in combination with antibiotics)

 

How Does Nexium 40mg Compare to Omeprazole?

 

Feature Nexium 40mg (Esomeprazole) Omeprazole 20mg
Active ingredient Esomeprazole magnesium Omeprazole
Drug class Proton pump inhibitor (PPI) Proton pump inhibitor (PPI)
Typical adult dose 40mg once daily 20mg once daily
Gastro-resistant formulation Yes Yes
Suitable for GORD Yes Yes
Available OTC in UK Yes (lower strengths) Yes

 

Is Nexium 40mg Stored and Handled Correctly?

 

Proper storage matters more than people often realise. Keep Nexium Tablets 40mg in their original packaging, stored below 30°C in a dry place away from direct sunlight. Don't store them in the bathroom — humidity can affect the tablet coating. Keep them out of reach of children at all times. If you're managing multiple digestive health conditions, you might also find our IBS and cramps collection useful for complementary support.

Check the expiry date before use. If the tablets have passed their use-by date, return them to your pharmacy for safe disposal — don't flush them or throw them in household waste. Using expired medication is never advisable, as the efficacy and safety of the product cannot be guaranteed beyond that date.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nexium Tablets 40mg specifications
Treatment category Gastro-oesophageal reflux disease (GORD), heartburn, oesophagitis, stomach ulcers
Active ingredient Esomeprazole magnesium trihydrate 40mg
Drug class Proton pump inhibitor (PPI)
Mechanism of action Inhibits hydrogen-potassium ATPase (proton pump) in gastric parietal cells, reducing acid secretion
Preparation Gastro-resistant tablets
Route of administration Oral
Strengths 40mg
Suitable for Adults and adolescents aged 12 and over
UK classification Pharmacy (P) / Prescription Only Medicine (POM) depending on indication and pack size

Specifications of Nexium Tablets 40mg

 

What Is Nexium Tablets 40mg and What Is It Used For?

 

Nexium Tablets 40mg contain esomeprazole, a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It is prescribed or recommended for a range of acid-related conditions. Esomeprazole 40mg is clinically indicated for:

  • Gastro-oesophageal reflux disease (GORD) — where stomach acid leaks back into the oesophagus
  • Erosive reflux oesophagitis — healing and preventing recurrence of acid-damaged oesophageal tissue
  • Symptomatic relief of heartburn and acid regurgitation
  • Prevention of gastric ulcers in patients taking NSAIDs long term
  • Eradication of Helicobacter pylori (in combination with antibiotics and another medicine)
  • Zollinger-Ellison syndrome — a rare condition causing excessive acid production

 

What Do You Need to Know Before Using Nexium Tablets 40mg?

 

Before taking this medicine, it's important to be aware of certain conditions and medicines that may affect whether Nexium is suitable for you. Do not take Nexium Tablets 40mg if any of the following apply:

  • You are allergic to esomeprazole, other PPIs (such as omeprazole, pantoprazole), or any of the tablet's excipients
  • You are taking nelfinavir (used to treat HIV infection)
  • You are under 12 years of age
  • You have severe liver impairment (unless directed by a doctor)

Speak to your doctor or pharmacist before taking Nexium if you have or have had any of the following:

  • Liver problems
  • Low magnesium levels (hypomagnesaemia)
  • Osteoporosis or risk of bone fractures (long-term PPI use has been associated with increased fracture risk)
  • Symptoms such as unintentional weight loss, difficulty swallowing, persistent vomiting, or blood in your stools — these require urgent medical assessment before starting treatment

Drug interactions to be aware of:

  • Clopidogrel — esomeprazole may reduce its antiplatelet effect
  • Methotrexate — PPIs may increase methotrexate levels in the blood
  • Ketoconazole, itraconazole, voriconazole — absorption may be affected
  • Atazanavir and other HIV medicines — reduced effectiveness when taken with PPIs
  • Warfarin — monitor INR if starting or stopping esomeprazole
  • Digoxin — plasma levels may increase slightly

 

How Should You Use Nexium Tablets 40mg?

 

Always use this medicine exactly as directed by your doctor or pharmacist. Do not take more than the recommended dose. Here's how to take Nexium correctly:

  1. Swallow the tablet whole with a glass of water — do not crush, chew, or split it.
  2. Take it at least 30 minutes before eating, ideally in the morning.
  3. If you have difficulty swallowing, you may dissolve the tablet in a glass of still water (not carbonated), stir, and drink immediately.
  4. Take it at the same time each day to maintain consistent acid suppression.
  5. Continue for the full course prescribed, even if symptoms improve early.
Indication Age Group Dose Frequency
GORD / heartburn relief Adults 20–40mg Once daily for 4 weeks
Erosive oesophagitis (healing) Adults 40mg Once daily for 4–8 weeks
H. pylori eradication Adults 20mg Twice daily for 7 days (with antibiotics)
NSAID-associated ulcer prevention Adults 20–40mg Once daily
GORD symptoms Adolescents 12+ 20–40mg Once daily for up to 8 weeks

 

What Are the Possible Side Effects of Nexium Tablets 40mg?

 

Like all medicines, Nexium can cause side effects, although not everyone experiences them. If you're concerned about any reaction, speak to your pharmacist or GP. You might also find it helpful to browse our pain relief range if you're managing associated discomfort.

Common side effects (may affect up to 1 in 10 people):

  • Headache
  • Diarrhoea
  • Nausea or feeling sick
  • Stomach pain or abdominal discomfort
  • Flatulence (wind)
  • Constipation

Less common side effects (may affect up to 1 in 100 people):

  • Dizziness
  • Dry mouth
  • Insomnia or sleep disturbances
  • Peripheral oedema (swelling of the ankles or feet)
  • Raised liver enzymes (detected on blood tests)
  • Skin rash or itching

Rarely, long-term use of PPIs has been associated with low magnesium levels (hypomagnesaemia), increased risk of bone fractures, and Clostridium difficile-associated diarrhoea. Seek immediate medical attention if you develop a severe skin reaction, difficulty breathing, or signs of a serious allergic reaction.

 

How Should You Store Nexium Tablets 40mg?

 

Correct storage keeps the medicine safe and effective for its full shelf life. Follow these guidelines:

  • Store below 30°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Do not store in the bathroom or near a sink
  • Keep the tablets in their original blister packaging until use
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Return unused or expired tablets to your pharmacy — do not dispose of them in household waste or flush them down the toilet

If you're managing other health conditions alongside acid reflux, our vitamins and supplements collection includes magnesium supplements, which may be relevant if you're on long-term PPI therapy — always discuss this with your GP first.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nexium Tablets 40mg online in the UK?

You can buy Nexium Tablets 40mg from Cured Pharmacy, a GPhC-registered online pharmacy. Simply add the product to your basket and complete a short health questionnaire before checkout. Our pharmacists review every order to ensure the medicine is appropriate for you before it's dispatched.

How does esomeprazole 40mg work in the body?

Esomeprazole works by irreversibly blocking the proton pumps (hydrogen-potassium ATPase enzymes) in the stomach's acid-secreting parietal cells. This reduces the volume of acid your stomach produces, giving the oesophagus and stomach lining a chance to heal. The effect builds over a few days of consistent use, so don't be discouraged if you don't feel full relief on day one.

How do I take Nexium Tablets 40mg step by step?

Follow these steps for correct use:

  1. Take one tablet in the morning, at least 30 minutes before eating.
  2. Swallow the tablet whole with a full glass of water — never crush or chew it.
  3. If you struggle to swallow tablets, dissolve it in still water and drink immediately.
  4. Take it at the same time each day for consistent results.

Always follow the instructions given by your pharmacist or doctor, and complete the full course even if you feel better sooner.

What is the best time of day to take Nexium 40mg?

The best time to take Nexium 40mg is in the morning, at least 30 minutes before your first meal of the day. Taking it before food allows the medicine to be absorbed properly and reach peak effectiveness when your stomach is most active. Consistency matters — try to take it at the same time every day.

What are the most common side effects of Nexium 40mg?

The most commonly reported side effects include:

  • Headache
  • Diarrhoea
  • Nausea
  • Stomach pain
  • Flatulence or constipation

These are usually mild and tend to settle within the first week or two. If any side effect is severe or persistent, contact your pharmacist or GP for advice.

How do I manage side effects of Nexium Tablets 40mg?

Most side effects are mild and manageable. For headaches, a simple over-the-counter painkiller (such as paracetamol) can help — you can browse our pain relief range for options. If you experience diarrhoea or stomach discomfort, staying well hydrated and eating bland foods can ease symptoms. Always speak to your pharmacist if side effects are affecting your daily life.

Who is eligible to take Nexium Tablets 40mg?

Nexium 40mg is suitable for adults and adolescents aged 12 and over who have been diagnosed with or are experiencing symptoms of acid reflux, GORD, or related conditions. It is not suitable for people who are allergic to esomeprazole or other PPIs, those taking nelfinavir, or those with certain liver conditions. Always complete the health questionnaire at checkout so our pharmacists can confirm suitability.

What happens if I miss a dose of Nexium 40mg?

If you miss a dose, take it as soon as you remember — provided it's not nearly time for your next scheduled dose. In that case, simply skip the missed dose and carry on as normal. Never take two doses at once to compensate for a missed one, as this increases the risk of side effects without improving effectiveness.

How does Nexium 40mg compare to omeprazole?

Both Nexium (esomeprazole) and omeprazole are proton pump inhibitors that work in the same way. Esomeprazole is the S-isomer of omeprazole and may provide slightly more consistent acid suppression in some individuals, though clinical differences are modest for most patients. Your pharmacist can help you decide which is more appropriate based on your medical history and any other medicines you take.

Can I take Nexium 40mg long term?

Long-term use of esomeprazole is sometimes necessary for conditions like erosive oesophagitis or Zollinger-Ellison syndrome, but it should always be supervised by a GP. Prolonged PPI use has been associated with low magnesium levels, increased fracture risk, and a small risk of certain gut infections. Your doctor will review your treatment periodically to ensure it's still needed at the current dose.

Is Nexium 40mg safe during pregnancy or breastfeeding?

Nexium 40mg is not routinely recommended during pregnancy or breastfeeding without specific medical advice. If you are pregnant, planning to become pregnant, or currently breastfeeding, speak to your GP or midwife before taking esomeprazole. They can advise on the safest option for managing acid reflux during this time.

Can Nexium 40mg interact with other medicines I'm taking?

Yes, esomeprazole can interact with several medicines. Key interactions include:

  • Clopidogrel — reduced antiplatelet effect
  • Methotrexate — increased blood levels
  • Atazanavir and other HIV medicines — reduced effectiveness
  • Warfarin — may affect INR levels
  • Ketoconazole or itraconazole — altered absorption

Always tell your pharmacist about all medicines, supplements, and herbal remedies you're taking before starting Nexium.

What are the alternatives to Nexium 40mg for acid reflux?

Other PPIs such as omeprazole, lansoprazole, and pantoprazole are commonly used alternatives. For milder symptoms, H2 receptor antagonists like famotidine or antacids may be sufficient. If you're exploring digestive health options, our indigestion collection includes a range of products to suit different needs. Your pharmacist can help you choose the most appropriate treatment.

How long does it take for Nexium 40mg to start working?

Some people notice an improvement in heartburn symptoms within 2–3 days of starting Nexium, but it can take up to 4 weeks for the full therapeutic effect to be felt — particularly for healing oesophagitis. It's important to continue taking the tablets for the full prescribed course, even if you start feeling better before it ends.

What are the latest findings on long-term proton pump inhibitor use?

Recent research and NHS guidance highlight that while PPIs like esomeprazole are safe and effective for short-to-medium term use, long-term use should be regularly reviewed. Studies have noted associations between prolonged PPI use and low magnesium, vitamin B12 deficiency, and a modest increase in fracture risk. The NHS recommends using the lowest effective dose for the shortest necessary duration, with regular GP review for anyone on long-term therapy.

How Should You Use Nexium Tablets 40mg?

Using Nexium correctly makes a real difference to how well it works. The tablets are gastro-resistant, which means they must be swallowed whole — crushing or chewing them destroys the protective coating and prevents the medicine from being absorbed properly. Follow these steps each time you take a dose:

What Is the Correct Dose of Nexium Tablets 40mg?

The correct dose depends on your specific condition and age. Always follow the dose recommended by your doctor or pharmacist. The table below outlines standard dosing guidance based on published clinical information:

When Is the Best Time to Use Nexium Tablets 40mg?

Timing genuinely matters with proton pump inhibitors. Nexium 40mg works most effectively when taken in the morning, approximately 30 to 60 minutes before breakfast. This is because proton pumps are most active after a period of fasting — taking the tablet before eating ensures the medicine is present in the bloodstream when the pumps are stimulated by food. Taking it after meals significantly reduces its effectiveness, so try to build it into your morning routine before you eat or drink anything other than water.

How Long Can You Use Nexium Tablets 40mg For?

The duration of treatment depends on your condition. For short-term heartburn relief, a course of 2–4 weeks is typically sufficient. For healing erosive oesophagitis, treatment usually lasts 4–8 weeks. Some patients with chronic conditions such as GORD may require longer-term maintenance therapy, but this should always be supervised by a GP with regular reviews. Do not continue taking Nexium beyond 4 weeks without speaking to a doctor, particularly if your symptoms haven't improved or have worsened. If you experience new symptoms such as difficulty swallowing, unexplained weight loss, or blood in your stools, stop taking the medicine and seek urgent medical advice.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

Be the first to write a review
0%
(0)
0%
(0)
0%
(0)
0%
(0)
0%
(0)

Side Effects Of Nexium Tablets 40mg

Most people tolerate Nexium well, but some may experience side effects.

Common side effects (up to 1 in 10):

  • Headache
  • Diarrhoea or constipation
  • Stomach pain
  • Nausea or vomiting
  • Bloating and gas

Uncommon side effects (up to 1 in 100):

  • Dizziness or tiredness
  • Dry mouth
  • Skin rashes or itching
  • Swelling in the ankles or feet
  • Sleep difficulty

Rare side effects (up to 1 in 1,000):

  • Severe allergic reactions (swelling of face, lips, throat)
  • Liver problems (yellowing skin/eyes)
  • Low magnesium (muscle cramps, irregular heartbeat)
  • Sudden unexplained weight loss or severe stomach pain

Seek medical advice if severe or persistent symptoms occur.

Frequently Asked Question


Nexium treats acid reflux, heartburn, indigestion, stomach ulcers, and inflammation of the oesophagus (oesophagitis). It also helps prevent stomach ulcers for people taking NSAIDs long-term.

Some people feel improvement within 1–3 days, but full relief may take 1–2 weeks.


Some medicines may interact with Nexium, including warfarin, diazepam, HIV medicines, and antifungals. Always check with your pharmacist before combining treatments.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

We’re a safe and
regulated UK service

Registered Pharmacy Badge

Lowest Price Guarantee

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

100% discreet packaging

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

Agent

Need help?
Talk to our friendly experts now

How our service works

Service Setup

Service setup

Discreet Packaging

Discreet packaging

Express Delivery

Express delivery

What is Nexium used for?


Nexium treats acid reflux, heartburn, indigestion, stomach ulcers, and inflammation of the oesophagus (oesophagitis). It also helps prevent stomach ulcers for people taking NSAIDs long-term.

How long does Nexium take to start working?

Some people feel improvement within 1–3 days, but full relief may take 1–2 weeks.

Can I take Nexium with other medication?


Some medicines may interact with Nexium, including warfarin, diazepam, HIV medicines, and antifungals. Always check with your pharmacist before combining treatments.