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Nurofen Express 400mg - 20 Liquid Capsules

Nurofen Express 400mg - 20 Liquid Capsules

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  • ✔️ Relieves headache, period pain, and muscle aches fast
  • ✔️ Liquid-filled capsule absorbs faster than standard tablets
  • ✔️ Each capsule contains 400mg ibuprofen for effective pain control
  • ✔️ Suitable for adults and adolescents aged 12 and over
  • ✔️ Convenient 20-capsule pack for home or on-the-go use

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What Are Nurofen Express Ibuprofen 400mg Liquid Capsules?

 

If you need fast relief from a nagging headache, period pain, or aching muscles, ibuprofen 400mg liquid capsules are a well-established option trusted by millions across the UK. Nurofen Express 400mg contains ibuprofen — a non-steroidal anti-inflammatory drug (NSAID) — in a liquid-filled capsule that is designed to be absorbed into the bloodstream more quickly than a standard solid tablet. Each pack contains 20 capsules, making it a practical choice to keep at home or in your bag for when pain strikes unexpectedly.

Ibuprofen is one of the most widely used over-the-counter pain relievers in the UK, recommended by the NHS for a range of everyday painful conditions. Whether you are dealing with tension headaches, dental pain, or mild to moderate muscle soreness, this product offers targeted relief without the need for a prescription. You can explore the full range of options available at our pain relief collection if you want to compare alternatives.

 

How Do Nurofen Express 400mg Capsules Work?

 

Ibuprofen works by blocking the activity of cyclo-oxygenase (COX) enzymes — specifically COX-1 and COX-2. These enzymes are responsible for producing prostaglandins, which are chemical messengers that trigger pain, inflammation, and fever in the body. By reducing prostaglandin production, ibuprofen helps to ease discomfort and bring down a raised temperature.

  • The liquid fill inside each capsule dissolves rapidly once swallowed.
  • This allows ibuprofen to be absorbed into the bloodstream faster than a conventional compressed tablet.
  • Onset of action can be felt within 15–30 minutes in many people.
  • The anti-inflammatory effect also helps with swelling and redness associated with minor injuries or joint pain.

 

Who Is Nurofen Express 400mg Suitable For?

 

This product is suitable for adults and young people aged 12 years and over who need short-term relief from mild to moderate pain or fever. It is particularly useful for those who find standard tablets slow to take effect or difficult to swallow. That said, it is not appropriate for everyone — always read the label carefully before use.

  • Adults and adolescents aged 12 and over
  • People with headaches, migraines, or tension-type head pain
  • Those experiencing period pain, dental pain, or backache
  • Individuals with mild to moderate muscle or joint pain

 

How Does Nurofen Express Compare to Standard Ibuprofen Tablets?

 

Feature Nurofen Express 400mg Liquid Capsules Standard Ibuprofen 400mg Tablets
Formulation Liquid-filled capsule Compressed solid tablet
Speed of absorption Faster (liquid dissolves quickly) Slower (tablet must disintegrate first)
Active ingredient dose 400mg ibuprofen 400mg ibuprofen
Pack size 20 capsules Typically 16–84 tablets

 

Is Nurofen Express 400mg Safe to Store at Home?

 

Yes, provided you follow the storage instructions. Keep the capsules in their original packaging, stored below 25°C in a dry place away from direct sunlight. Always keep medicines out of the sight and reach of children. Do not use the capsules after the expiry date printed on the pack.

If you are managing multiple health conditions alongside pain, it is worth knowing that Cured Pharmacy also stocks a range of vitamins and supplements that may support your overall wellbeing. As with all NSAIDs, ibuprofen 400mg liquid capsules should be used at the lowest effective dose for the shortest time necessary to control your symptoms.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nurofen Express 400mg - 20 Liquid Capsules specifications
Treatment category Pain relief, antipyretic, anti-inflammatory
Mechanism of action COX-1 and COX-2 enzyme inhibitor; reduces prostaglandin synthesis
Effective for Headache, migraine, period pain, dental pain, muscle pain, fever
Suitable for Adults and adolescents aged 12 years and over
Active ingredient Ibuprofen 400mg
Pack size 20 liquid capsules
Strength 400mg per capsule
UK classification General Sale List (GSL) / Pharmacy (P) medicine
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Liquid-filled hard capsule
Route of administration Oral

Specifications of Nurofen Express 400mg - 20 Liquid Capsules

 

What Is Nurofen Express 400mg and What Is It Used For?

 

Nurofen Express 400mg liquid capsules contain ibuprofen, an NSAID used to relieve mild to moderate pain and reduce fever. The NHS recognises ibuprofen as an effective treatment for a wide range of everyday painful conditions. This product is licensed for use in adults and adolescents aged 12 and over for short-term relief of headache, dental pain, period pain, backache, rheumatic and muscular pain, and the symptoms of cold and flu including fever.

 

What Do You Need to Know Before Using Nurofen Express 400mg?

 

Before taking these capsules, it is important to check whether they are right for you. Do not take Nurofen Express 400mg if any of the following apply:

  • You are allergic to ibuprofen, aspirin, or any other NSAID
  • You have or have had a stomach ulcer or gastrointestinal bleeding
  • You are in the third trimester of pregnancy (after 28 weeks)
  • You have severe heart failure, severe kidney disease, or severe liver disease
  • You are under 12 years of age

Speak to your pharmacist or GP before taking this medicine if you have asthma, high blood pressure, a history of heart disease, inflammatory bowel disease, or if you are trying to conceive. The following medicines may interact with ibuprofen:

  • Aspirin or other NSAIDs (increased risk of side effects)
  • Warfarin or other anticoagulants (increased bleeding risk)
  • SSRIs such as fluoxetine (increased risk of gastrointestinal bleeding)
  • ACE inhibitors, angiotensin II antagonists, or diuretics (reduced effectiveness and kidney risk)
  • Lithium, methotrexate, or ciclosporin (ibuprofen may increase their blood levels)

 

How Should You Use Nurofen Express 400mg Capsules?

 

Always take this medicine exactly as described on the label or as directed by your pharmacist. Do not exceed the stated dose. Taking ibuprofen with food or milk can help protect your stomach lining.

  1. Check you are not allergic to ibuprofen or any other NSAID before taking.
  2. Swallow one capsule whole with a full glass of water — do not chew or crush.
  3. Take with food or milk if your stomach is sensitive.
  4. Wait at least four to six hours before taking another dose.
  5. Do not take more than three capsules (1,200mg) in any 24-hour period.
  6. Use the lowest effective dose for the shortest time needed.
Age Group Dose Frequency Maximum Daily Dose
Adults (18+) 1 capsule (400mg) Up to 3 times daily 1,200mg (3 capsules)
Adolescents (12–17) 1 capsule (400mg) Up to 3 times daily 1,200mg (3 capsules)
Children under 12 Not suitable — do not use

If you are looking for pain relief options for younger children, our baby and toddler range includes age-appropriate formulations.

 

What Are the Possible Side Effects of Nurofen Express 400mg?

 

Like all medicines, ibuprofen can cause side effects, although not everyone experiences them. The most common side effects tend to affect the digestive system and are usually mild.

Common side effects (may affect up to 1 in 10 people):

  • Nausea or vomiting
  • Indigestion or heartburn
  • Stomach pain or discomfort
  • Diarrhoea or constipation
  • Headache or dizziness

Less common side effects (may affect up to 1 in 100 people):

  • Fluid retention (swollen ankles or feet)
  • Raised blood pressure
  • Skin rash or itching
  • Worsening of asthma symptoms
  • Gastric ulcer or gastrointestinal bleeding (seek urgent medical attention if you notice black or bloody stools)

Stop taking the capsules and seek immediate medical help if you experience signs of a serious allergic reaction, such as swelling of the face, lips, or throat, difficulty breathing, or a severe skin reaction.

 

How Should You Store Nurofen Express 400mg Capsules?

 

Correct storage helps maintain the quality and safety of your medicine. If you need additional first aid or emergency supplies, our first aid collection has everything you might need at home.

  • Store below 25°C in a dry place, away from direct heat and sunlight
  • Keep in the original blister packaging until use
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused capsules to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nurofen Express 400mg liquid capsules online in the UK?

You can buy Nurofen Express 400mg liquid capsules directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. Simply add the pack to your basket and complete checkout for fast, discreet UK delivery. Browse our full pain relief collection for more options.

How do Nurofen Express 400mg liquid capsules work in the body?

Nurofen Express capsules contain ibuprofen dissolved in a liquid fill, which is absorbed into the bloodstream faster than a standard compressed tablet. Ibuprofen inhibits COX-1 and COX-2 enzymes, reducing the production of prostaglandins — the chemicals responsible for pain, inflammation, and fever. This dual action makes it effective for a wide range of everyday painful conditions.

How do I take Nurofen Express 400mg capsules step by step?

Swallow one 400mg capsule whole with a full glass of water — never chew or crush it. Take it with food or milk if your stomach tends to be sensitive to ibuprofen. Leave at least four to six hours between doses and do not take more than three capsules in any 24-hour period.

What is the correct dose of Nurofen Express 400mg for adults?

The recommended adult dose is one 400mg capsule taken up to three times daily, with at least four to six hours between each dose. The maximum dose is 1,200mg (three capsules) in 24 hours unless a doctor advises otherwise. Always use the lowest effective dose for the shortest time necessary.

When is the best time to take Nurofen Express 400mg capsules?

Take Nurofen Express as soon as your symptoms begin — the earlier you take it, the more effectively it can get ahead of pain signals. Taking it with or after food is advisable to reduce the chance of stomach irritation. Avoid taking it on an empty stomach if you have a history of digestive sensitivity.

What are the common side effects of Nurofen Express 400mg?

The most common side effects include nausea, indigestion, stomach discomfort, and diarrhoea. These are usually mild and can often be reduced by taking the capsule with food or milk. If side effects persist or worsen, stop taking the medicine and speak to your pharmacist or GP.

How do I manage side effects of Nurofen Express 400mg?

Taking each capsule with a meal or a glass of milk is the simplest way to reduce stomach-related side effects. If you experience persistent indigestion, your pharmacist may suggest taking a stomach-protecting medicine alongside ibuprofen. Stop use immediately and seek medical advice if you notice black or tarry stools, which could indicate gastrointestinal bleeding.

Who should not take Nurofen Express 400mg liquid capsules?

You should not take this product if you are allergic to ibuprofen or aspirin, have a current or previous peptic ulcer, are in the third trimester of pregnancy, or have severe kidney, liver, or heart failure. Children under 12 years of age should not use this product. Always check with your pharmacist if you are unsure.

Can I take Nurofen Express 400mg with paracetamol?

Yes, ibuprofen and paracetamol can generally be taken together because they work through different mechanisms and do not interact directly. This combination is sometimes used for more effective pain control than either medicine alone. Always confirm with your pharmacist before combining medicines, particularly if you are taking other treatments.

Can I take Nurofen Express 400mg if I am pregnant?

Ibuprofen should be avoided during the third trimester of pregnancy (after 28 weeks) as it may harm the unborn baby. Use during the first and second trimesters should only be considered on medical advice, as it may also carry risks. If you are pregnant or trying to conceive, speak to your GP or midwife before taking any NSAID.

What are alternatives to Nurofen Express 400mg liquid capsules?

Alternatives include standard ibuprofen 400mg tablets, paracetamol 500mg tablets, or aspirin 300mg for adults. For muscle and joint pain, topical ibuprofen gels are another option that avoids systemic absorption. Your pharmacist can help you choose the most suitable alternative based on your symptoms and medical history.

How long can you take Nurofen Express 400mg for?

Nurofen Express 400mg is intended for short-term use only — typically no more than three days for fever and no more than ten days for pain without medical supervision. If your symptoms do not improve or worsen within this time, consult your GP. Long-term use of NSAIDs without medical oversight carries risks including stomach ulcers and kidney problems.

What happens if I miss a dose of Nurofen Express 400mg?

If you miss a dose and your pain or fever returns, take one capsule as soon as you need it, provided at least four to six hours have passed since your last dose. Do not double up to make up for a missed dose. Nurofen Express is taken as needed rather than on a strict schedule, so missing a dose is not usually a concern.

Is Nurofen Express 400mg suitable for people with asthma?

Ibuprofen can trigger bronchospasm in some people with asthma, particularly those who are sensitive to aspirin or other NSAIDs. If you have asthma, speak to your GP or pharmacist before taking Nurofen Express. In some cases, paracetamol may be a safer alternative for pain relief.

What are the latest studies on ibuprofen liquid capsules?

Research consistently supports that liquid-filled ibuprofen capsules achieve faster peak plasma concentrations compared to standard compressed tablets, contributing to quicker onset of pain relief. Studies published in clinical pharmacology journals confirm that the liquid formulation does not alter the overall safety profile of ibuprofen. The NHS continues to recommend ibuprofen as a first-line OTC analgesic for mild to moderate pain in eligible adults. If you are also managing digestive discomfort alongside pain, our indigestion collection may be helpful.

How Should You Use Nurofen Express 400mg Liquid Capsules?

Nurofen Express 400mg liquid capsules are taken orally. Always swallow each capsule whole — do not chew, crush, or open it, as this can affect how quickly the medicine is absorbed and may irritate your mouth or throat.

Follow these steps each time you take a dose:

What Is the Correct Dose of Nurofen Express 400mg?

The dose depends on your age. Always use the lowest dose that controls your symptoms and take it for the shortest time necessary. Do not exceed the maximum daily dose under any circumstances without medical advice.

When Is the Best Time to Use Nurofen Express 400mg?

Take Nurofen Express as soon as your symptoms begin — acting early generally means you need less medicine to achieve relief. If you are prone to stomach sensitivity, taking the capsule with your main meal of the day is a practical approach that reduces the risk of indigestion without delaying absorption significantly.

Avoid taking a dose late at night on an empty stomach if possible, as this is when gastrointestinal side effects are most likely to be noticed. If you are using it for period pain, starting a dose at the first sign of discomfort — rather than waiting until pain is severe — tends to give better results.

How Long Can You Use Nurofen Express 400mg For?

This medicine is intended for short-term use only. For fever, do not use for more than three days without consulting a doctor. For pain, do not use for more than ten days without seeking medical advice. If your symptoms worsen, do not improve, or if new symptoms develop, stop taking the capsules and speak to your GP.

Long-term or frequent use of ibuprofen without medical supervision increases the risk of stomach ulcers, kidney problems, and cardiovascular events. If you find yourself needing pain relief regularly, it is worth discussing the underlying cause with your doctor rather than relying on over-the-counter medicines indefinitely.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Nurofen Express 400mg Liquid Capsules?

Nurofen Express 400mg liquid capsules are taken orally. Always swallow each capsule whole — do not chew, crush, or open it, as this can affect how quickly the medicine is absorbed and may irritate your mouth or throat.

Follow these steps each time you take a dose:

What Is the Correct Dose of Nurofen Express 400mg?

The dose depends on your age. Always use the lowest dose that controls your symptoms and take it for the shortest time necessary. Do not exceed the maximum daily dose under any circumstances without medical advice.

When Is the Best Time to Use Nurofen Express 400mg?

Take Nurofen Express as soon as your symptoms begin — acting early generally means you need less medicine to achieve relief. If you are prone to stomach sensitivity, taking the capsule with your main meal of the day is a practical approach that reduces the risk of indigestion without delaying absorption significantly.

Avoid taking a dose late at night on an empty stomach if possible, as this is when gastrointestinal side effects are most likely to be noticed. If you are using it for period pain, starting a dose at the first sign of discomfort — rather than waiting until pain is severe — tends to give better results.

How Long Can You Use Nurofen Express 400mg For?

This medicine is intended for short-term use only. For fever, do not use for more than three days without consulting a doctor. For pain, do not use for more than ten days without seeking medical advice. If your symptoms worsen, do not improve, or if new symptoms develop, stop taking the capsules and speak to your GP.

Long-term or frequent use of ibuprofen without medical supervision increases the risk of stomach ulcers, kidney problems, and cardiovascular events. If you find yourself needing pain relief regularly, it is worth discussing the underlying cause with your doctor rather than relying on over-the-counter medicines indefinitely.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Nurofen Express 400mg?

Like all NSAIDs, ibuprofen can cause side effects, though not everyone experiences them. The most frequently reported side effects affect the gastrointestinal system and are generally mild when the medicine is taken correctly — particularly with food.

  • Nausea or feeling sick
  • Indigestion or heartburn
  • Stomach pain or cramping
  • Diarrhoea
  • Constipation
  • Bloating or wind

What Are the Less Common Side Effects of Nurofen Express 400mg?

Less common side effects occur in fewer people but are still worth being aware of. If you notice any of the following, reduce your dose or stop taking the capsules and speak to your pharmacist or GP.

  • Headache or dizziness
  • Fluid retention (swollen ankles, feet, or hands)
  • Raised blood pressure
  • Skin rash, itching, or hives
  • Worsening of asthma symptoms or breathlessness
  • Fatigue or drowsiness
  • Ringing in the ears (tinnitus)

What Are the Serious Side Effects of Nurofen Express 400mg?

Serious side effects are rare but require immediate medical attention. Stop taking Nurofen Express and call 999 or go to your nearest A&E if you experience any of the following:

  • Signs of a severe allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash
  • Black, tarry, or bloody stools — this may indicate gastrointestinal bleeding
  • Vomiting blood or material that looks like coffee grounds
  • Chest pain, sudden shortness of breath, or signs of a heart attack or stroke
  • Severe skin reactions such as blistering or peeling
  • Signs of kidney problems: significantly reduced urine output, swelling, or extreme fatigue

What Should You Do If You Experience Side Effects of Nurofen Express 400mg?

For mild gastrointestinal side effects, try taking the capsule with food or a glass of milk at your next dose. If symptoms persist beyond a day or two, stop taking the medicine and consult your pharmacist. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk — this helps improve medicine safety for everyone.

Never take a higher dose in the hope of faster relief, as this significantly increases the risk of side effects without providing proportionally greater benefit. If your pain is not controlled at the recommended dose, speak to your GP about alternative options.

Can Nurofen Express 400mg Interact With Other Medicines?

Yes. Ibuprofen has several clinically significant interactions that you should be aware of before taking it alongside other medicines. Always tell your pharmacist about everything you are currently taking, including prescription medicines, over-the-counter products, and herbal supplements.

  • Aspirin or other NSAIDs: Increased risk of gastrointestinal side effects and bleeding
  • Warfarin or anticoagulants: Ibuprofen can increase bleeding risk
  • SSRIs (e.g. fluoxetine, sertraline): Combined use raises the risk of gastrointestinal bleeding
  • ACE inhibitors, angiotensin II antagonists, or diuretics: Ibuprofen may reduce their effectiveness and increase the risk of kidney problems
  • Lithium or methotrexate: Ibuprofen can raise blood levels of these medicines to potentially harmful levels
  • Corticosteroids: Increased risk of gastrointestinal ulceration or bleeding

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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