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Nurofen Day & Night Cold & Flu 200mg - 16 Tablets

Nurofen Day & Night Cold & Flu 200mg - 16 Tablets

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  • ✔️ Relieves cold and flu headache, fever, and body aches
  • ✔️ Dual-action formula targets symptoms day and night
  • ✔️ Night tablet clears nasal congestion for easier breathing
  • ✔️ Contains ibuprofen 200mg for clinically recognised pain relief
  • ✔️ Suitable for adults and young people aged 12 and over

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What Is Nurofen Cold and Flu Day and Night?

 

When a cold or flu hits, it rarely arrives with just one symptom. You might wake up with a pounding head, a blocked nose, aching muscles, and a temperature — all at once. Nurofen cold and flu day and night is a dual-action pack designed to tackle exactly that combination, offering targeted relief across the clock. Each pack of 16 tablets contains two distinct formulations: daytime tablets to keep you functional, and a night-time tablet to help you rest more comfortably. You can find this and other cold and flu remedies in our Cold and Flu collection.

The product is available over the counter without a prescription and is suitable for adults and young people aged 12 and over. At just £5.29 for 16 tablets, it offers a practical, clinically recognised approach to managing cold and flu symptoms at home.

 

How Does Nurofen Day & Night Cold & Flu Work?

 

This product works through two complementary mechanisms, one for daytime and one for night-time use.

  • Ibuprofen (200mg) — Day & Night tablets: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). It works by inhibiting cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins — the chemicals responsible for pain, inflammation, and fever. This helps relieve headache, sore throat, body aches, and raised temperature.
  • Pseudoephedrine hydrochloride (30mg) — Night tablets only: Pseudoephedrine is a sympathomimetic decongestant. It acts on alpha-adrenergic receptors in the nasal mucosa, causing vasoconstriction that reduces swelling and congestion in the nasal passages, making it easier to breathe.
  • Combined effect: Together, these two active ingredients address the multi-symptom nature of cold and flu — pain, fever, and congestion — without the need for multiple separate products.

 

Who Should Use Nurofen Day & Night Cold & Flu?

 

This product is intended for adults and young people aged 12 and over who are experiencing the typical cluster of cold or flu symptoms. It is particularly useful if you need to remain alert during the day while also wanting relief at night. That said, it is not appropriate for everyone.

  • Adults aged 18 and over with cold or flu symptoms including headache, fever, and congestion
  • Young people aged 12–17 (under adult supervision, following pack dosage guidance)
  • People who prefer a single pack covering both day and night symptom relief
  • Those without contraindications to ibuprofen or pseudoephedrine (see Section 2 for full details)

 

How Does Nurofen Day & Night Compare to Plain Ibuprofen Tablets?

 

Feature Nurofen Day & Night Cold & Flu Plain Ibuprofen 200mg Tablets
Active ingredients Ibuprofen + Pseudoephedrine (night) Ibuprofen only
Relieves congestion Yes (night tablets) No
Day & night formulation Yes No
Suitable for 12+ Yes Yes (check individual product)

 

How Should You Store Nurofen Day & Night Cold & Flu?

 

Store this product below 25°C in a dry place, away from direct sunlight. Keep it out of the reach and sight of children at all times. Do not use the tablets after the expiry date printed on the pack. If you are managing multiple medicines at home, our Pain Relief collection includes a range of options to suit different needs and circumstances.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nurofen Day & Night Cold & Flu 200mg - 16 Tablets specifications
Treatment category Cold and flu symptom relief
Mechanism of action COX enzyme inhibition (ibuprofen); alpha-adrenergic vasoconstriction (pseudoephedrine)
Effective for Headache, fever, body aches, nasal congestion
Suitable for Adults and young people aged 12 and over
Active ingredient (Day) Ibuprofen 200mg
Active ingredient (Night) Ibuprofen 200mg + Pseudoephedrine hydrochloride 30mg
Pack size 16 tablets (12 day + 4 night)
UK classification Pharmacy (P) medicine
Drug class NSAID + Sympathomimetic decongestant
Preparation Film-coated tablets
Route of administration Oral

Specifications of Nurofen Day & Night Cold & Flu 200mg - 16 Tablets

 

What Is Nurofen Day & Night Cold & Flu and What Is It Used For?

 

Nurofen Day & Night Cold & Flu 200mg is a combination over-the-counter medicine used to relieve the symptoms of colds and flu in adults and young people aged 12 and over. The pack contains two types of tablet: daytime tablets containing ibuprofen 200mg, and night-time tablets containing ibuprofen 200mg plus pseudoephedrine hydrochloride 30mg. Together, they address headache, fever, muscular aches and pains, sore throat, and nasal congestion — the hallmark symptoms of cold and flu.

 

What Do You Need to Know Before Using Nurofen Day & Night Cold & Flu?

 

Do not take this product if any of the following apply to you:

  • You are allergic to ibuprofen, pseudoephedrine, aspirin, or any other NSAID
  • You have or have had a peptic ulcer or gastrointestinal bleeding
  • You have severe heart failure, severe kidney disease, or severe liver disease
  • You have uncontrolled high blood pressure or severe cardiovascular disease
  • You are in the third trimester of pregnancy
  • You are taking or have taken monoamine oxidase inhibitors (MAOIs) within the last 14 days
  • You are under 12 years of age

Speak to your pharmacist or GP before taking this product if you have asthma, diabetes, thyroid problems, glaucoma, an enlarged prostate, or a history of heart or kidney problems. The following medicines may interact with this product:

  • Warfarin and other anticoagulants — increased bleeding risk
  • Other NSAIDs (e.g. aspirin, naproxen) — increased risk of side effects
  • Antihypertensives (e.g. ACE inhibitors, beta-blockers) — reduced effectiveness
  • Lithium — ibuprofen may increase lithium levels
  • Methotrexate — ibuprofen may increase toxicity
  • Other sympathomimetics or decongestants — additive effects with pseudoephedrine
  • Tricyclic antidepressants — may interact with pseudoephedrine

 

How Should You Use Nurofen Day & Night Cold & Flu?

 

  1. Read the patient information leaflet inside the pack before use.
  2. Swallow tablets whole with a full glass of water.
  3. Take day tablets with or after food to reduce the risk of stomach upset.
  4. Take the night tablet at bedtime only — do not take it during the day.
  5. Do not exceed the recommended dose (see table below).
  6. Do not take for more than three days without consulting a doctor or pharmacist.
Tablet Type Age Group Dose Frequency
Day tablet (Ibuprofen 200mg) 12 years and over 1–2 tablets Up to 3 times daily (every 4–6 hours)
Night tablet (Ibuprofen 200mg + Pseudoephedrine 30mg) 12 years and over 1 tablet Once at bedtime only
Day or Night tablet Under 12 years Not suitable — do not use

If you are also managing other symptoms such as sinus discomfort or ear pain, you may find our Ear, Nose & Throat collection helpful for complementary products.

 

What Are the Possible Side Effects of Nurofen Day & Night Cold & Flu?

 

Like all medicines, this product can cause side effects, although not everyone experiences them. Stop taking the tablets and seek medical advice if you notice signs of an allergic reaction such as skin rash, swelling of the face or throat, or difficulty breathing.

Common side effects (may affect up to 1 in 10 people):

  • Nausea or indigestion
  • Stomach discomfort or heartburn
  • Headache
  • Dizziness

Less common side effects (may affect up to 1 in 100 people):

  • Difficulty sleeping (insomnia) — more likely with the night tablet
  • Raised blood pressure
  • Palpitations
  • Dry mouth
  • Skin rash or itching

 

How Should You Store Nurofen Day & Night Cold & Flu?

 

  • Store below 25°C in a dry place away from direct heat and sunlight
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not store in a bathroom or near a sink — moisture can degrade the tablets
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you are looking to support your recovery with additional vitamins or immune support, browse our Vitamins and Supplements collection for options that may complement your cold and flu management.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nurofen Day & Night Cold & Flu online in the UK?

You can buy Nurofen Day & Night Cold & Flu 200mg 16 Tablets online from Cured Pharmacy for just £5.29, with convenient home delivery. It is a Pharmacy (P) medicine available without a prescription. Browse our full Cold and Flu collection for related products.

How does Nurofen Day & Night Cold & Flu work in the body?

The day tablets contain ibuprofen, which inhibits COX enzymes to reduce prostaglandins — the chemicals that cause pain, inflammation, and fever. The night tablets add pseudoephedrine hydrochloride, a decongestant that narrows blood vessels in the nasal lining to relieve congestion. Together, they address the full range of cold and flu symptoms across the day and night.

How do I use Nurofen Day & Night Cold & Flu step by step?

Take one or two day tablets up to three times daily (every 4–6 hours) with food and a full glass of water. Take one night tablet at bedtime only — never during the day. Do not exceed the stated dose and do not use for more than three days without speaking to a pharmacist or doctor.

What is the correct dose of Nurofen Day & Night Cold & Flu for adults?

Adults and young people aged 12 and over should take one to two day tablets up to three times daily, with a minimum of four hours between doses. One night tablet should be taken at bedtime. The maximum daily dose of ibuprofen from this product must not exceed 1,200mg — always check the pack for full guidance.

What is the best time to take the Nurofen night tablet?

The night tablet should be taken at bedtime only, as it contains pseudoephedrine which can cause difficulty sleeping if taken earlier in the day — though paradoxically, some people find it mildly stimulating. Taking it just before you go to sleep allows the decongestant effect to work while you rest, helping you breathe more easily overnight. Never take the night tablet during the daytime.

Who should not take Nurofen Day & Night Cold & Flu?

This product is not suitable for children under 12, people with peptic ulcers, severe kidney or liver disease, uncontrolled high blood pressure, or those currently taking or who have recently taken MAOIs. It should also be avoided in the third trimester of pregnancy. Always read the full list of contraindications on the pack or speak to your pharmacist if you are unsure.

Can I take Nurofen Day & Night Cold & Flu with paracetamol?

Ibuprofen and paracetamol have different mechanisms of action and can generally be used together for short-term symptom relief, as they do not interact directly. However, you should always check with your pharmacist before combining medicines, particularly if you are taking other products that may already contain paracetamol or ibuprofen. Never take this product alongside other ibuprofen-containing medicines.

What are the common side effects of Nurofen Day & Night Cold & Flu?

Common side effects include nausea, indigestion, stomach discomfort, and headache. The night tablets may additionally cause difficulty sleeping, palpitations, or a dry mouth in some people due to the pseudoephedrine content. If side effects are troublesome or persistent, stop taking the product and speak to your pharmacist or GP.

How do I manage side effects of Nurofen Day & Night Cold & Flu?

Taking the day tablets with food or milk can help reduce stomach discomfort and indigestion. If you experience dizziness, avoid driving or operating machinery until the feeling passes. For persistent or severe side effects — particularly signs of an allergic reaction such as facial swelling or breathing difficulty — stop the medicine immediately and seek urgent medical attention.

How long can you take Nurofen Day & Night Cold & Flu for?

This product is intended for short-term use only — do not take it for more than three days without consulting a doctor or pharmacist. If your symptoms worsen or do not improve within three days, seek medical advice. Prolonged use of ibuprofen without medical supervision can increase the risk of gastrointestinal and cardiovascular side effects.

What happens if I miss a dose of Nurofen Day & Night Cold & Flu?

If you miss a dose, simply take the next one when it is due — do not double up to make up for a missed tablet. Because this product is used for symptom relief rather than as a scheduled treatment, missing a single dose is unlikely to cause any harm. Just continue with the normal dosing schedule as directed on the pack.

Is Nurofen Day & Night Cold & Flu safe during pregnancy?

This product is not recommended during the third trimester of pregnancy, as ibuprofen can affect foetal kidney function and may cause complications during labour. Use during the first and second trimesters should only be considered on medical advice. If you are pregnant or trying to conceive, always speak to your GP or midwife before taking any over-the-counter medicine.

Can I take Nurofen Day & Night Cold & Flu if I have high blood pressure?

You should not take this product if you have uncontrolled high blood pressure, as both ibuprofen and pseudoephedrine can raise blood pressure and may reduce the effectiveness of antihypertensive medicines. If your blood pressure is well controlled and you are on medication, speak to your pharmacist or GP before use. They can advise on a safer alternative for your cold and flu symptoms.

What are alternatives to Nurofen Day & Night Cold & Flu?

Alternatives include paracetamol-based cold and flu products, plain ibuprofen tablets, or single-ingredient decongestants. If you cannot take ibuprofen or pseudoephedrine, a pharmacist can recommend a suitable substitute. You can also explore our Ear, Nose & Throat collection for nasal sprays and other congestion relief options.

What are the latest findings on ibuprofen for cold and flu symptoms?

Ibuprofen remains a well-established and widely recommended option for relieving cold and flu symptoms including fever, headache, and body aches, as supported by NHS guidance. Current evidence does not support the idea that ibuprofen worsens cold or flu outcomes in otherwise healthy adults, though it should still be used at the lowest effective dose for the shortest time necessary. Always follow current NHS and MHRA guidance when using any NSAID.

How Should You Use Nurofen Day & Night Cold & Flu?

Always read the patient information leaflet supplied with the pack before you start taking this medicine. Swallow the tablets whole — do not crush or chew them — and take them with a full glass of water to help absorption and reduce the risk of stomach irritation.

Follow these steps for correct use:

What Is the Correct Dose of Nurofen Day & Night Cold & Flu?

The dosage differs between the day and night tablets, so it is important to follow the guidance below carefully. Do not exceed the maximum daily dose of ibuprofen from all sources combined.

When Is the Best Time to Use Nurofen Day & Night Cold & Flu?

Take the day tablets when your symptoms are at their most disruptive — typically in the morning and afternoon when you need to remain alert and functional. Taking them with food is advisable to protect the stomach lining from ibuprofen's irritant effect.

The night tablet is specifically designed for bedtime use. Taking it just before you sleep allows the decongestant to work through the night, helping you breathe more easily and rest more comfortably. Avoid taking the night tablet any earlier than your intended bedtime, as pseudoephedrine can be mildly stimulating in some people.

How Long Can You Use Nurofen Day & Night Cold & Flu For?

This product is intended for short-term use only. Do not take it for more than three consecutive days without seeking advice from a pharmacist or GP. If your symptoms have not improved after three days, or if they worsen at any point, stop taking the medicine and seek medical attention promptly.

Prolonged use of ibuprofen without medical supervision increases the risk of gastrointestinal, renal, and cardiovascular side effects. This product is not suitable for ongoing or chronic symptom management.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Nurofen Day & Night Cold & Flu?

Like all medicines, Nurofen Day & Night Cold & Flu can cause side effects, though not everyone will experience them. The most frequently reported side effects are related to the ibuprofen component and affect the digestive system.

  • Nausea or feeling sick
  • Indigestion or heartburn
  • Stomach discomfort or abdominal pain
  • Headache
  • Dizziness

Taking the day tablets with food or milk can help reduce stomach-related side effects. If indigestion is persistent, speak to your pharmacist — they may suggest a suitable antacid or alternative product.

What Are the Less Common Side Effects of Nurofen Day & Night Cold & Flu?

Less common side effects may affect up to 1 in 100 people. Some of these are associated specifically with the pseudoephedrine in the night tablet rather than the ibuprofen.

  • Difficulty sleeping (insomnia)
  • Palpitations or a racing heartbeat
  • Raised blood pressure
  • Dry mouth
  • Skin rash or itching
  • Restlessness or anxiety
  • Urinary retention (particularly in men with an enlarged prostate)

If you notice any of these effects and find them troublesome, stop taking the product and speak to your pharmacist or GP for guidance.

What Are the Serious Side Effects of Nurofen Day & Night Cold & Flu?

Serious side effects are rare but require immediate medical attention. Stop taking this medicine straight away and seek urgent help if you experience any of the following:

  • Signs of an allergic reaction — swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash
  • Black or tarry stools, or vomiting blood — which may indicate gastrointestinal bleeding
  • Chest pain, shortness of breath, or sudden weakness — which may indicate a cardiovascular event
  • Severe skin reactions such as blistering or peeling
  • Significant reduction in urine output — which may indicate kidney problems

What Should You Do If You Experience Side Effects?

For mild side effects such as nausea or indigestion, taking the tablets with food usually helps. If you feel dizzy, avoid driving or operating machinery until the sensation passes. For any side effect that is severe, unexpected, or does not resolve, stop taking the medicine and contact your pharmacist or GP promptly.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. Reporting helps improve medicine safety for everyone.

Can Nurofen Day & Night Cold & Flu Interact With Other Medicines?

Yes — this product has several clinically significant interactions. Ibuprofen can increase the effects of anticoagulants such as warfarin, raising the risk of bleeding. It may also reduce the effectiveness of antihypertensive medicines including ACE inhibitors and beta-blockers, and can increase the toxicity of lithium and methotrexate. Pseudoephedrine interacts with MAOIs and tricyclic antidepressants, and should not be combined with other sympathomimetic medicines or decongestants.

Always tell your pharmacist about all medicines, supplements, and herbal remedies you are taking before starting this product.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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