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Emla 5% Numbing Cream (5g)

Emla 5% Numbing Cream (5g)

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  • ✔️ Numbs skin within 60 minutes for needle procedures
  • ✔️ Contains lidocaine and prilocaine for dual anaesthetic action
  • ✔️ Suitable for adults and children aged one year and over
  • ✔️ Reduces pain and anxiety before blood tests and cannulation
  • ✔️ Topical application — no systemic effects when used correctly

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What Is EMLA Numbing Cream and How Does It Help?

 

Nobody enjoys the sharp sting of a needle. Whether it's a blood test, a vaccination, or a minor skin procedure, that moment of anticipation can feel worse than the procedure itself. That's exactly where EMLA numbing cream comes in. EMLA 5% is a topical local anaesthetic cream containing two active ingredients — lidocaine 25 mg/g and prilocaine 25 mg/g — that work together to temporarily numb the surface of the skin before a procedure takes place. It's been used in NHS settings for decades and is now available over the counter for home use, making it one of the most trusted options for needle anxiety and minor skin discomfort.

EMLA is suitable for adults and children alike, and it's particularly useful for anyone who finds needle procedures distressing. You can browse our wider range of pain relief products if you're looking for additional comfort options alongside your treatment.

 

How Does EMLA 5% Cream Work on the Skin?

 

EMLA cream works through a process called eutectic mixture formation. When lidocaine and prilocaine are combined at a 1:1 ratio, they form a mixture with a lower melting point than either ingredient alone. This allows both anaesthetics to penetrate the outer layers of intact skin more effectively than they would individually.

  • Lidocaine and prilocaine diffuse through the epidermis and into the dermis.
  • Once absorbed, they block voltage-gated sodium channels in sensory nerve endings.
  • This prevents the generation and conduction of nerve impulses — essentially switching off pain signals at the source.
  • The result is a localised, temporary loss of sensation at the application site.

The depth of anaesthesia depends on how long the cream is left on. A 60-minute application typically provides adequate numbness for needle insertion, while longer application times of up to two hours may be needed for deeper procedures.

 

Who Is EMLA Cream Suitable For?

 

EMLA cream is suitable for a wide range of people. It's commonly used before blood tests, cannula insertion, vaccinations, and minor dermatological procedures. It can also be used before certain cosmetic treatments such as laser therapy or tattooing, where skin sensitivity is a concern.

  • Adults and children aged 1 year and over (for needle-related procedures)
  • People with needle phobia or high pain sensitivity
  • Patients undergoing repeated venepuncture, such as those on dialysis
  • Individuals preparing for minor cosmetic or dermatological skin treatments

It is not suitable for use on broken, inflamed, or infected skin, and should never be applied near the eyes or on mucous membranes.

 

How Does EMLA Cream Compare to Other Numbing Options?

 

Feature EMLA 5% Cream Ametop Gel (Tetracaine 4%)
Active ingredient(s) Lidocaine + Prilocaine Tetracaine
Application time needed 60–120 minutes 30–45 minutes
Suitable for children Yes (aged 1 year+) Yes (aged 1 month+)
Available OTC in UK Yes Yes

 

Is EMLA Cream Safe to Store at Home?

 

Yes — EMLA numbing cream is straightforward to store safely at home. Keep it below 25°C and do not freeze it. The tube should be kept tightly closed when not in use, and always stored out of the reach and sight of children. Once opened, use within the period indicated on the packaging. If you're managing a skin condition alongside your treatment, our skin care collection includes a range of products that may complement your routine.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Emla 5% Numbing Cream specifications
Treatment category Topical local anaesthetic
Mechanism of action Sodium channel blockade via lidocaine and prilocaine
Effective Within 60–120 minutes of application
Suitable for Adults and children aged 1 year and over
Active ingredient Lidocaine 25 mg/g, Prilocaine 25 mg/g
Pack sizes 5 g tube
Strengths 5% (2.5% lidocaine + 2.5% prilocaine)
UK classification Pharmacy (P) medicine
Drug class Local anaesthetic
Preparation Cream (oil-in-water emulsion)
Route of administration Topical (intact skin only)

Specifications of Emla 5% Numbing Cream

 

What Is EMLA Cream and What Is It Used For?

 

EMLA 5% cream is a topical local anaesthetic used to numb intact skin before minor painful procedures. It contains two active substances — lidocaine and prilocaine — each at a concentration of 25 mg per gram of cream. The NHS uses EMLA routinely in clinical settings to reduce pain and distress associated with needle insertion, and it is now available over the counter for appropriate home use.

Common uses include numbing the skin before blood tests, intravenous cannula insertion, vaccinations, and minor dermatological procedures such as curettage or laser treatment. It may also be used before certain cosmetic procedures where surface anaesthesia is required.

 

What Do You Need to Know Before Using EMLA Cream?

 

Before applying EMLA cream, it's important to check whether it is appropriate for you. Do not use this product if any of the following apply:

  • You are allergic to lidocaine, prilocaine, or any other local anaesthetic of the amide type
  • You are allergic to any other ingredient in the cream
  • You have congenital or idiopathic methaemoglobinaemia
  • The skin at the application site is broken, infected, or inflamed
  • You intend to apply it to the eyes or mucous membranes
  • You are using it on a premature infant or neonate under 37 weeks gestational age without medical supervision

The following medicines may interact with EMLA cream and you should inform your pharmacist or doctor if you are taking any of them:

  • Antiarrhythmic drugs (e.g. mexiletine, amiodarone) — risk of additive cardiac effects
  • Other local anaesthetics — risk of increased systemic toxicity
  • Medicines that can cause methaemoglobinaemia, such as sulphonamides, dapsone, or nitrates
  • Cimetidine or beta-blockers — may increase plasma levels of lidocaine

 

How Should You Apply EMLA Cream Correctly?

 

Always use EMLA cream exactly as described in the patient information leaflet or as directed by your pharmacist. The cream must only be applied to intact, unbroken skin.

  1. Identify the area of skin to be numbed and ensure it is clean and dry.
  2. Apply a thick layer of EMLA cream — approximately 1.5 to 2 g per 10 cm² of skin — directly to the site.
  3. Cover the cream with an occlusive dressing (such as the Tegaderm dressing sometimes included in the pack) to keep it in place and prevent evaporation.
  4. Leave in place for at least 60 minutes for needle procedures, or up to 120 minutes for deeper procedures.
  5. Remove the dressing and wipe away the cream immediately before the procedure begins.
  6. Do not rub the cream in — it should sit on the skin surface under the dressing.
Indication Age Group Dose Application Time
Needle insertion (e.g. blood test) Adults 1.5–2 g per 10 cm² 60 minutes minimum
Minor skin procedures Adults 1.5–2 g per 10 cm² 120 minutes
Needle insertion Children aged 1–12 years 1 g per 10 cm² (max 1 site) 60 minutes minimum

If you're looking for additional support for minor skin discomfort or wound care, our first aid collection has a range of useful products to keep at home.

 

What Are the Possible Side Effects of EMLA Cream?

 

Like all medicines, EMLA cream can cause side effects, although not everyone experiences them. Most reactions are mild and localised to the area where the cream was applied.

Common side effects (may affect more than 1 in 10 people):

  • Temporary paleness (blanching) of the skin at the application site
  • Redness (erythema) after the cream is removed
  • Mild swelling or oedema at the site
  • Mild burning or itching sensation during application

Less common side effects (may affect up to 1 in 100 people):

  • Small areas of bruising or petechiae, particularly in children
  • Methaemoglobinaemia — a rare but serious condition where the blood's ability to carry oxygen is reduced; more likely with excessive use or in young infants
  • Allergic skin reactions such as contact dermatitis
  • Systemic effects (e.g. dizziness, headache) if large amounts are absorbed — very rare with correct use

 

How Should You Store EMLA Cream?

 

  • Store below 25°C — do not refrigerate or freeze
  • Keep the tube tightly closed after each use
  • Store out of the sight and reach of children
  • Do not use after the expiry date printed on the tube and carton
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

For other topical treatments and skin preparations, you might find our creams and ointments collection helpful when managing a range of skin concerns.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy EMLA numbing cream online in the UK?

You can buy EMLA numbing cream directly from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. It is available without a prescription as a Pharmacy (P) medicine. Simply add it to your basket and complete a short suitability check at checkout.

How does EMLA cream work in the body?

EMLA cream contains lidocaine and prilocaine, which penetrate the skin and block sodium channels in sensory nerve endings. This stops pain signals from being generated and transmitted to the brain, producing temporary numbness at the application site. The effect is entirely localised — it does not affect the rest of your body.

How do I use EMLA cream step by step?

Apply a thick layer of EMLA cream to clean, dry, intact skin and cover it with an occlusive dressing. Leave it in place for at least 60 minutes before a needle procedure, or up to 120 minutes for deeper skin work. Remove the dressing and wipe away the cream immediately before your procedure begins — do not rub it in.

How long before a needle should I put EMLA cream on?

For most needle procedures such as blood tests or vaccinations, apply EMLA cream at least 60 minutes beforehand under an occlusive dressing. For deeper procedures or minor skin surgery, an application time of up to 120 minutes is recommended. Always check the patient information leaflet for guidance specific to your procedure.

How long does the numbing effect of EMLA cream last?

After removing EMLA cream, the numbing effect at the skin surface typically lasts for 1 to 2 hours. The duration can vary depending on how long the cream was applied and the thickness of the skin at the treated area. Plan your procedure to take place as soon as possible after removing the cream for the best effect.

Can children use EMLA numbing cream?

Yes — EMLA cream is suitable for children aged 1 year and over when used for needle-related procedures. It should not be used in premature infants or neonates under 37 weeks gestational age without direct medical supervision. Always use the correct dose for your child's age and weight as described in the leaflet. You can also browse our baby and toddler collection for other child-appropriate health products.

Who should not use EMLA cream?

EMLA cream is not suitable for people who are allergic to lidocaine, prilocaine, or any other amide-type local anaesthetic. It should also be avoided by anyone with congenital methaemoglobinaemia, or if the skin at the application site is broken, infected, or inflamed. Always read the full list of contraindications in the patient information leaflet before use.

What are the side effects of EMLA cream?

The most common side effects are temporary and localised — you may notice paleness, redness, or mild swelling at the site where the cream was applied. These effects usually resolve within a couple of hours without any treatment. Rarely, allergic reactions or methaemoglobinaemia can occur, particularly if the cream is used incorrectly or in excessive amounts.

Can I use EMLA cream before a tattoo?

EMLA cream is sometimes used before tattooing to reduce discomfort, though it is not specifically licensed for this use. It should only be applied to intact skin and removed before the tattooing begins. Speak to your tattoo artist and pharmacist before using it for this purpose, as some artists advise against topical anaesthetics due to potential effects on skin texture.

Can I use EMLA cream on my face?

EMLA cream can be applied to facial skin for certain cosmetic or dermatological procedures, but it must be kept well away from the eyes and mucous membranes at all times. Use only on intact skin and follow the recommended application time. If you are unsure whether it is appropriate for your specific facial treatment, consult your pharmacist or treating clinician first.

Does EMLA cream interact with any medicines?

EMLA cream can interact with antiarrhythmic drugs such as mexiletine or amiodarone, other local anaesthetics, and medicines that can cause methaemoglobinaemia — including sulphonamides, dapsone, and certain nitrates. Cimetidine and beta-blockers may also affect how lidocaine is processed in the body. Always tell your pharmacist about all medicines you are taking before using EMLA cream.

Is EMLA cream safe to use during pregnancy?

EMLA cream should only be used during pregnancy if it is clearly necessary and under the guidance of a healthcare professional. There is limited data on its use in pregnancy, and both lidocaine and prilocaine can cross the placenta. Speak to your GP or midwife before using any topical anaesthetic while pregnant or breastfeeding.

What are the alternatives to EMLA cream for numbing skin?

The main alternative available over the counter in the UK is Ametop gel, which contains tetracaine 4% and works slightly faster than EMLA — typically within 30 to 45 minutes. Both products are effective for needle-related procedures, though they have slightly different suitability profiles. Your pharmacist can help you decide which is more appropriate for your situation. You can also explore our pain relief collection for other options.

How long can you use EMLA cream for?

EMLA cream is intended for short-term, occasional use before specific procedures — it is not designed for daily or long-term application. If you find yourself needing to use it frequently, speak to your GP or pharmacist to discuss the underlying reason and whether an alternative approach might be more appropriate. Repeated use on the same area of skin should be discussed with a healthcare professional.

What does the latest research say about EMLA cream?

EMLA cream has been extensively studied since its introduction and remains one of the most well-evidenced topical anaesthetics available. Clinical literature consistently supports its effectiveness for reducing pain during venepuncture, cannulation, and minor dermatological procedures in both adults and children. It continues to be recommended in NHS clinical guidelines for procedural pain management in paediatric and adult settings.

How Should You Use EMLA Cream?

EMLA 5% cream is applied directly to intact, unbroken skin at the site where numbing is required. It must always be covered with an occlusive dressing after application — this keeps the cream in contact with the skin and prevents it from drying out or evaporating. Never rub the cream in; it should sit as a thick layer on the skin surface beneath the dressing. Remove the dressing and wipe away all remaining cream immediately before your procedure begins.

Follow these steps each time you use EMLA cream:

What Is the Correct Dose of EMLA Cream?

The correct dose depends on the type of procedure and the age of the person being treated. Always use the smallest effective amount and do not apply to more than one site at a time unless directed by a healthcare professional. The table below summarises the recommended doses for the most common uses.

When Is the Best Time to Use EMLA Cream?

Timing is everything with EMLA cream. For needle procedures such as blood tests or vaccinations, apply the cream at least 60 minutes before your appointment. If you are having a deeper procedure — such as minor skin surgery or laser treatment — apply it up to 120 minutes beforehand to allow adequate depth of anaesthesia to develop. Set a reminder so you don't apply it too late and miss the window of maximum effect.

It's worth planning ahead, especially if you are using EMLA cream for a child before a hospital appointment. Apply it at home before you leave, so the full application time is used productively during your journey or waiting time.

How Long Can You Use EMLA Cream For?

EMLA cream is intended for occasional, short-term use before specific procedures — it is not designed for daily or prolonged application. Each application should be limited to the recommended time (no more than 120 minutes on any single site) to minimise the risk of systemic absorption. If you need to use EMLA cream frequently or on a regular basis, speak to your GP or pharmacist to discuss whether this is appropriate for your situation.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of EMLA Cream?

Most people who use EMLA cream experience only mild, localised reactions at the site of application. These are generally short-lived and resolve on their own once the cream is removed and the procedure is complete.

  • Temporary paleness (blanching) of the skin
  • Redness (erythema) after the cream is wiped away
  • Mild swelling or puffiness at the treated area
  • Slight burning or itching sensation during application

What Are the Less Common Side Effects of EMLA Cream?

Less frequently, some people may notice more noticeable skin reactions or, in rare cases, signs that the active ingredients have been absorbed beyond the skin surface. These are more likely if the cream is applied to a large area, left on for too long, or used on damaged skin.

  • Small bruise-like spots (petechiae), particularly in children
  • Contact dermatitis or localised allergic skin reaction
  • Mild headache or dizziness if excessive absorption occurs
  • Methaemoglobinaemia — a rare condition where the blood's oxygen-carrying capacity is reduced; more likely in young infants or with excessive use

What Are the Serious Side Effects of EMLA Cream?

Serious side effects from EMLA cream are rare when it is used correctly on intact skin in the recommended amounts. However, you should seek urgent medical attention if you or your child develops any of the following after using EMLA cream:

  • Bluish discolouration of the lips, fingernails, or skin (a sign of methaemoglobinaemia)
  • Difficulty breathing or shortness of breath
  • Rapid or irregular heartbeat
  • Severe allergic reaction (anaphylaxis) — swelling of the face, throat, or tongue, or sudden collapse

What Should You Do If You Experience Side Effects?

If you notice any mild skin reactions such as redness or swelling at the application site, these will usually settle within a few hours without any treatment. Simply remove the cream and dressing, and avoid applying anything else to the area until the reaction has resolved.

If you experience any serious symptoms — particularly signs of methaemoglobinaemia or a severe allergic reaction — remove the cream immediately and call 999 or go to your nearest A&E department. Do not wait to see if symptoms improve on their own.

Can EMLA Cream Interact With Other Medicines?

Yes — EMLA cream can interact with certain medicines, particularly those that affect the heart's electrical system or that can also cause methaemoglobinaemia. If you are taking antiarrhythmic drugs (such as mexiletine or amiodarone), sulphonamide antibiotics, dapsone, nitrates, or cimetidine, speak to your pharmacist before using EMLA cream. Using other local anaesthetics at the same time may also increase the risk of side effects. Always give your pharmacist or doctor a full list of your current medicines before using this product.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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