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E45 Moisturising Lotion

E45 Moisturising Lotion

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  • ✔️ Soothes and relieves dry, itchy, and sensitive skin
  • ✔️ Restores the skin's natural moisture barrier effectively
  • ✔️ Fragrance-free and hypoallergenic — suitable for sensitive skin
  • ✔️ Clinically established emollient for eczema and dermatitis
  • ✔️ Lightweight lotion absorbs quickly for all-over body use

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What Is E45 Moisturising Lotion for Dry Skin?

 

E45 moisturising lotion is one of the UK's most widely recognised emollient products, used by millions of people to manage dry, itchy, and sensitive skin. Whether you're dealing with a diagnosed skin condition or simply struggling with skin that feels tight and uncomfortable, this lotion offers a clinically established way to restore moisture and protect the skin barrier. It's available over the counter — no prescription needed — and suitable for everyday use on the face and body. You can find it alongside other skin care products at Cured Pharmacy.

The lotion contains three active emollient ingredients: light liquid paraffin (12.8%), white soft paraffin (14.5%), and hypoallergenic anhydrous lanolin (1%). Together, these work to soften the skin, reduce water loss, and soothe irritation. It's fragrance-free and formulated to be gentle enough for sensitive skin types, including those prone to eczema and dermatitis.

 

How Does E45 Moisturising Lotion Work on the Skin?

 

Emollients like E45 work by targeting the outermost layer of the skin — the stratum corneum — where moisture loss typically begins. When skin is dry or damaged, this barrier becomes compromised, leading to tightness, flaking, and itching. E45 addresses this directly.

  • Light liquid paraffin softens and lubricates the skin surface, reducing friction and discomfort.
  • White soft paraffin forms an occlusive layer that slows transepidermal water loss (TEWL), keeping moisture locked in.
  • Hypoallergenic lanolin acts as an emollient and humectant, helping the skin feel smoother and more supple.
  • Together, these ingredients restore the skin's natural lipid barrier without causing irritation in most users.

The lotion texture is lighter than E45 cream, making it easier to spread over larger body areas and quicker to absorb — particularly useful if you need to apply it frequently throughout the day.

 

Who Should Use E45 Moisturising Lotion?

 

This lotion is suitable for a wide range of people. The NHS recommends emollients as a first-line treatment for dry skin conditions, and E45 is one of the most commonly suggested options. It's appropriate for:

  • Adults and children with dry, flaky, or itchy skin
  • People managing eczema, dermatitis, or psoriasis (as a moisturiser, not a treatment)
  • Those with sensitive skin who need a fragrance-free, hypoallergenic option
  • Individuals whose skin has become dry due to frequent handwashing, cold weather, or ageing

It is not suitable for use on infected, broken, or weeping skin without medical advice. If you're unsure whether it's right for your skin condition, speak to your pharmacist before use.

 

How Does E45 Moisturising Lotion Compare to E45 Cream?

 

Feature E45 Moisturising Lotion E45 Cream
Texture Light, fluid lotion Thicker cream
Absorption speed Faster Slower
Best for Larger body areas, frequent use Very dry or localised patches
Fragrance-free Yes Yes

 

Is E45 Moisturising Lotion Suitable for Long-Term Use?

 

Yes. Emollients are designed for regular, ongoing use — and the NHS actively encourages people with chronic dry skin conditions to apply them frequently, even when the skin appears to have improved. There is no maximum duration of use for E45 moisturising lotion, and it can safely be incorporated into your daily routine. You'll find a range of supporting creams and ointments at Cured Pharmacy if you need additional options for different skin areas or severities.

Store the lotion below 25°C, away from direct sunlight and out of reach of children. Do not use past the expiry date printed on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

E45 Moisturising Lotion specifications
Treatment category Emollient / Dry skin treatment
Mechanism of action Occlusive and emollient barrier to reduce transepidermal water loss
Effective for Dry skin, eczema, dermatitis, sensitive skin
Suitable for Adults, children, and babies (with pharmacist advice)
Active ingredients Light liquid paraffin 12.8%, white soft paraffin 14.5%, hypoallergenic anhydrous lanolin 1%
UK classification General Sale List (GSL)
Drug class Emollient
Preparation Lotion
Route of administration Topical (applied to skin)

Specifications of E45 Moisturising Lotion

 

What Is E45 Moisturising Lotion and What Is It Used For?

 

E45 Moisturising Lotion is a topical emollient used to relieve and manage dry, itchy, and sensitive skin. It is suitable for a range of skin conditions including eczema, contact dermatitis, ichthyosis, and pruritus (itching) associated with dry skin. It can also be used as a general daily moisturiser for anyone whose skin becomes dry due to environmental factors, frequent washing, or ageing. The NHS recommends emollients as a cornerstone of dry skin management, particularly for conditions like eczema where regular moisturisation helps reduce flare frequency and severity.

The lotion is for external use only and should not be applied near the eyes, mouth, or on infected skin without medical guidance. It is not a steroid and does not treat the underlying cause of inflammatory skin conditions — it works by supporting the skin barrier and reducing moisture loss.

 

What Do You Need to Know Before Using E45 Moisturising Lotion?

 

Before using this lotion, read the following carefully. Most people tolerate it well, but there are some important considerations.

Do not use E45 Moisturising Lotion if you:

  • Are allergic to any of the ingredients, particularly lanolin (wool fat)
  • Have infected, weeping, or broken skin — seek medical advice first
  • Have a known sensitivity to paraffin-based products

Warnings and precautions:

  • Paraffin-based emollients can be a fire hazard — keep away from naked flames and do not smoke while applying
  • Avoid contact with eyes
  • If your skin condition worsens or does not improve within a few weeks, consult your GP
  • Use with caution in babies — always seek pharmacist or GP advice before applying to infants
  • Emollients can make surfaces slippery — take care in the bath or shower

Known drug interactions:

  • No significant drug interactions are known for topical emollients
  • If you are using topical corticosteroids or other prescribed skin treatments, apply emollients first and allow them to absorb before applying other products

 

How Should You Use E45 Moisturising Lotion?

 

Using an emollient correctly makes a real difference to how effective it is. Apply generously and regularly — the NHS advises that emollients should be used even when the skin looks and feels better, to maintain the skin barrier. You can explore additional skin care options at Cured Pharmacy to complement your routine.

  1. Wash and gently pat your skin dry before applying.
  2. Take a generous amount of lotion and apply it directly to the affected area.
  3. Smooth it in the direction of hair growth to reduce the risk of folliculitis (blocked hair follicles).
  4. Allow the lotion to absorb before dressing or applying other topical products.
  5. Repeat as often as needed — at least two to four times daily for dry skin conditions.
Indication Age Group Dose Frequency
Dry / sensitive skin Adults Apply liberally to affected area 2–4 times daily
Eczema / dermatitis Adults & children Apply liberally to affected area As often as required
General moisturisation All ages (with advice for infants) Apply to face and body Once or twice daily

 

What Are the Possible Side Effects of E45 Moisturising Lotion?

 

Side effects from E45 Moisturising Lotion are uncommon. Most people use it without any problems. However, as with any topical product, reactions can occasionally occur.

Common side effects:

  • Mild stinging or tingling immediately after application (usually temporary)
  • Skin feeling greasy or heavy if applied too thickly

Less common side effects:

  • Skin redness or irritation at the application site
  • Allergic contact dermatitis — particularly in those sensitive to lanolin
  • Folliculitis (inflammation of hair follicles) if applied against the direction of hair growth

If you notice any signs of an allergic reaction — such as rash, swelling, or difficulty breathing — stop using the product immediately and seek urgent medical attention. Lanolin sensitivity, while uncommon, is a recognised cause of contact allergy and should be considered if your skin worsens after use. If you're also managing a baby or toddler's skin, always check with a healthcare professional before use.

 

How Should You Store E45 Moisturising Lotion?

 

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the cap tightly closed when not in use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the bottle
  • Do not store in the bathroom — humidity can affect the product
  • Do not freeze

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy E45 Moisturising Lotion online in the UK?

You can buy E45 Moisturising Lotion directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, with fast home delivery available. It is a General Sale List (GSL) medicine, so no prescription is required. Simply add it to your basket and check out — it's that straightforward.

How does E45 Moisturising Lotion work in the body?

E45 Moisturising Lotion works topically — it doesn't enter the bloodstream. Its emollient ingredients form a protective film over the skin surface, reducing transepidermal water loss and softening the outer skin layer. This helps restore the skin's natural barrier function, which is often compromised in conditions like eczema and dermatitis.

How do I use E45 Moisturising Lotion step by step?

Using E45 Moisturising Lotion correctly is simple:

  1. Cleanse and gently pat the skin dry.
  2. Apply a generous amount of lotion to the affected area.
  3. Smooth in the direction of hair growth.
  4. Allow to absorb before dressing or applying other products.

Repeat at least two to four times daily, or as often as your skin needs it.

What is the best time to apply E45 Moisturising Lotion?

The best times to apply E45 Moisturising Lotion are immediately after bathing or washing, when the skin is still slightly damp — this helps lock in moisture more effectively. Applying before bed is also beneficial, as the skin repairs itself overnight. For very dry or eczema-prone skin, applying throughout the day as needed is perfectly safe and encouraged.

What are the side effects of E45 Moisturising Lotion?

Most people experience no side effects. Occasionally, mild stinging or temporary redness may occur after application, particularly on very sensitive or broken skin. Rarely, a lanolin allergy can cause contact dermatitis — if your skin becomes more irritated after use, stop applying and speak to your pharmacist or GP.

How do I manage side effects of E45 Moisturising Lotion?

If you experience mild stinging, try applying the lotion to slightly damp skin rather than completely dry skin, which can reduce the sensation. If you suspect a lanolin allergy, discontinue use and consult a healthcare professional who may recommend a lanolin-free alternative. Always patch test a new emollient on a small area of skin before widespread use.

Who is eligible to use E45 Moisturising Lotion?

E45 Moisturising Lotion is suitable for most adults and children with dry, sensitive, or eczema-prone skin. It can be used on babies, though you should always check with a GP or pharmacist first. It is not suitable for anyone with a known allergy to lanolin or any other listed ingredient, or for use on infected or broken skin without medical advice.

Can I use E45 Moisturising Lotion on my face?

Yes, E45 Moisturising Lotion can be applied to the face as well as the body. Avoid the eye area and do not apply to broken or infected facial skin without first seeking medical advice. Its fragrance-free, hypoallergenic formulation makes it a reasonable choice for facial dryness and sensitivity.

Is E45 Moisturising Lotion safe to use during pregnancy?

Topical emollients like E45 Moisturising Lotion are generally considered safe to use during pregnancy, as they are not absorbed into the bloodstream. However, it is always sensible to check with your midwife or GP before introducing any new product during pregnancy, particularly if you have a pre-existing skin condition.

What are the alternatives to E45 Moisturising Lotion?

Common alternatives include Diprobase lotion, Aveeno Daily Moisturising Lotion, and Cetraben lotion — all of which are emollients used for similar indications. The right choice depends on your skin type, any known allergies, and personal preference. You can browse a range of options in our creams and ointments collection.

How long can you use E45 Moisturising Lotion for?

There is no maximum duration of use for E45 Moisturising Lotion. Emollients are designed for long-term, ongoing use and the NHS actively recommends continuing to apply them even when skin appears to have improved. If your skin condition changes significantly or worsens, consult your GP for a review of your skincare routine.

Can E45 Moisturising Lotion be used for eczema?

Yes — E45 Moisturising Lotion is widely used as part of eczema management. The NHS recommends regular emollient use as a key strategy for reducing eczema flares and maintaining skin comfort. It does not treat the underlying inflammation of eczema, but it helps protect and hydrate the skin barrier, which is central to managing the condition day to day.

Is E45 Moisturising Lotion a fire hazard?

Yes — like all paraffin-based emollients, E45 Moisturising Lotion can be a fire hazard. The MHRA has issued guidance warning that paraffin-containing emollients can soak into fabric such as clothing and bedding, creating a fire risk. Do not smoke or go near naked flames while using this product, and wash clothing and bedding regularly.

What are the latest studies on emollients like E45 for eczema?

Research continues to support the regular use of emollients as a first-line approach in eczema management. Studies have shown that consistent emollient use can reduce the frequency of flares and decrease the need for topical corticosteroids. NICE guidelines and NHS clinical guidance both recommend emollients as an essential part of eczema treatment plans.

Can I use E45 Moisturising Lotion alongside prescribed skin treatments?

Yes, emollients are commonly used alongside prescribed treatments such as topical corticosteroids. The general advice is to apply the emollient first, allow it to absorb for around 30 minutes, and then apply the prescribed treatment. Always follow your GP or pharmacist's specific instructions. You can also explore our wider skin care range for complementary products.

How Should You Use E45 Moisturising Lotion?

E45 Moisturising Lotion is designed for topical application to the skin. It should be applied gently and smoothed in the direction of hair growth to minimise the risk of folliculitis. Always ensure the skin is clean before applying, and allow the lotion to absorb fully before putting on clothing.

What Is the Correct Dose of E45 Moisturising Lotion?

There is no fixed dose for emollients — the key is to apply liberally and frequently. The NHS advises that emollients should be used generously, as under-application reduces their effectiveness. The table below provides general guidance based on indication and age group.

When Is the Best Time to Use E45 Moisturising Lotion?

The most effective time to apply E45 Moisturising Lotion is immediately after bathing or washing, while the skin is still slightly damp. This helps the emollient seal in residual moisture and maximise hydration. Applying before bed is also particularly beneficial, as the skin undergoes natural repair processes overnight and benefits from sustained moisture.

For those managing eczema or very dry skin, applying throughout the day — whenever the skin feels tight, itchy, or uncomfortable — is both safe and recommended. Consistency matters more than timing.

How Long Can You Use E45 Moisturising Lotion For?

E45 Moisturising Lotion can be used indefinitely as part of a daily skincare routine. Unlike some topical medicines, emollients do not carry a risk of skin thinning or tolerance with prolonged use. The NHS actively encourages people with chronic dry skin conditions to continue using emollients long-term, even during periods when the skin appears to have improved, to maintain the skin barrier and prevent flares.

If your skin condition does not improve after several weeks of regular use, or if it worsens at any point, consult your GP or pharmacist for further assessment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of E45 Moisturising Lotion?

E45 Moisturising Lotion is well tolerated by the vast majority of people. Serious side effects are rare. That said, as with any topical product, some individuals may notice mild reactions, particularly when first starting use or if the skin is already very sensitive.

  • Mild stinging or tingling immediately after application
  • Temporary sensation of greasiness or heaviness on the skin
  • Slight redness at the application site that resolves quickly

What Are the Less Common Side Effects of E45 Moisturising Lotion?

Less commonly, some people may experience reactions that persist or worsen over time. These are more likely in individuals with a known sensitivity to one of the ingredients, particularly lanolin.

  • Contact dermatitis — skin redness, itching, or a rash that develops after repeated use
  • Folliculitis — inflammation of hair follicles, often caused by applying the lotion against the direction of hair growth
  • Skin that feels more irritated rather than soothed after application

What Are the Serious Side Effects of E45 Moisturising Lotion?

Serious side effects are uncommon but can occur. The most significant risk is an allergic reaction, most commonly associated with the lanolin (wool fat) component. Lanolin sensitivity is a recognised cause of allergic contact dermatitis and may not become apparent until after several uses.

Signs of a serious allergic reaction include widespread rash, swelling of the face or throat, difficulty breathing, or a sudden worsening of skin symptoms. If you experience any of these, stop using the product immediately and seek urgent medical attention or call 999.

What Should You Do If You Experience Side Effects?

For mild reactions such as temporary stinging, try applying the lotion to slightly damp rather than completely dry skin, which can reduce the sensation. If you suspect a lanolin allergy, discontinue use and speak to your pharmacist, who can recommend a lanolin-free alternative emollient. Always patch test any new emollient on a small area of skin — such as the inner forearm — for 24 hours before applying more widely.

Keep a note of when symptoms started and what the skin looked like, as this information will help your GP or pharmacist identify the cause and recommend the most appropriate next step.

Can E45 Moisturising Lotion Interact With Other Medicines?

No significant drug interactions are known for E45 Moisturising Lotion. However, if you are using prescribed topical treatments — such as corticosteroids, tacrolimus, or antibiotics — apply the emollient first and allow it to absorb for at least 30 minutes before applying the prescribed product. This prevents the emollient from diluting or interfering with the absorption of your medication. Always follow the specific instructions given by your GP or pharmacist regarding the order and timing of topical applications.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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