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Difflam Throat Numbing Spray - 30ml

Difflam Throat Numbing Spray - 30ml

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  • ✔️ Targets sore throat pain and inflammation directly at source
  • ✔️ Contains benzydamine HCl, a clinically established NSAID
  • ✔️ Suitable for adults and children aged six and over
  • ✔️ Provides temporary numbing relief within minutes of application
  • ✔️ Convenient 30ml spray bottle for precise, mess-free dosing

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What Is Difflam Throat Spray and How Does It Help?

 

Difflam throat spray is a trusted, clinically established over-the-counter treatment for sore throat pain and inflammation. Each 30ml bottle contains benzydamine hydrochloride 0.15% w/v, a locally acting non-steroidal anti-inflammatory drug (NSAID) that targets discomfort right where you feel it — at the back of the throat. Whether your sore throat has come on after a cold, following dental work, or as a result of a minor mouth infection, this spray offers targeted, fast-acting relief without the need for a prescription. If you're also dealing with other cold and flu symptoms alongside your sore throat, you might find our cold and flu range useful too.

Sore throats are one of the most common reasons people visit a pharmacist in the UK. The NHS notes that most sore throats clear up on their own within a week, but in the meantime, the pain can make eating, drinking, and even talking feel like a real effort. That's where a targeted throat spray can make a genuine difference to your day-to-day comfort.

 

How Does Difflam Throat Numbing Spray Work?

 

Benzydamine hydrochloride, the active ingredient in Difflam, works locally in the oropharyngeal area — that's the back of your mouth and upper throat. It doesn't need to be swallowed or absorbed into the bloodstream to do its job. Here's how it works:

  • It inhibits the production of prostaglandins, the chemicals responsible for triggering inflammation and pain in irritated tissue.
  • It has a mild local anaesthetic effect, which is why you may notice a temporary numbing sensation after spraying.
  • It acts directly on the inflamed mucous membranes lining the throat, reducing swelling and discomfort at the source.
  • Because it works topically, systemic side effects are minimal when used as directed.

This dual anti-inflammatory and analgesic action makes it particularly useful for conditions where the throat lining itself is irritated or swollen.

 

Who Should Use Difflam Throat Numbing Spray?

 

This spray is suitable for a wide range of people dealing with throat and mouth discomfort. It's particularly helpful if you need relief that works locally without taking oral painkillers. That said, it's not right for everyone — see below.

  • Adults and teenagers aged 12 and over experiencing sore throat pain.
  • Children aged 6 to 11 years, under appropriate dosing guidance from a pharmacist.
  • People recovering from dental procedures or minor oral surgery who have throat or mouth soreness.
  • Those who prefer a topical treatment rather than systemic oral analgesics such as ibuprofen or paracetamol.

It is not suitable for children under 6 years of age. People with known hypersensitivity to benzydamine or other NSAIDs should also avoid this product.

 

How Does Difflam Throat Spray Compare to Other Sore Throat Treatments?

 

Feature Difflam Throat Spray 30ml Throat Lozenges (e.g. Strepsils)
Active ingredient Benzydamine HCl 0.15% Amylmetacresol / 2,4-dichlorobenzyl alcohol
Route of administration Oropharyngeal spray Oral (dissolved in mouth)
Anti-inflammatory action Yes (NSAID) Mild antiseptic only
Suitable for children under 12 Ages 6+ (with guidance) Varies by product

 

Is Difflam Throat Spray Suitable for Long-Term Use and How Should It Be Stored?

 

Difflam throat spray is intended for short-term use only. You should not use it for more than 7 days without speaking to a doctor or pharmacist. If your sore throat persists beyond a week, worsens significantly, or is accompanied by a high fever, difficulty breathing, or a rash, you should seek medical advice promptly — these could be signs of a more serious condition requiring treatment. For broader pain management needs, our pain relief collection includes a range of options your pharmacist can help you choose from.

Store the spray below 25°C, away from direct sunlight and out of the reach of children. Do not freeze. Check the expiry date before use and do not use the product after the date shown on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Difflam Throat Numbing Spray 30ml specifications
Treatment category Sore throat / oropharyngeal pain relief
Active ingredient Benzydamine hydrochloride 0.15% w/v
Mechanism of action Locally acting NSAID; inhibits prostaglandin synthesis and provides local anaesthesia
Effective for Sore throat, mouth inflammation, post-dental procedure discomfort
Suitable for Adults and children aged 6 and over
Pack size 30ml
UK classification General Sale List (GSL) / Pharmacy (P) medicine
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Oropharyngeal spray solution
Route of administration Topical oropharyngeal

Specifications of Difflam Throat Numbing Spray 30ml

 

What Is Difflam Throat Numbing Spray and What Is It Used For?

 

Difflam Throat Numbing Spray 30ml is an over-the-counter oropharyngeal spray containing benzydamine hydrochloride 0.15% w/v. It is used to relieve the pain and inflammation associated with sore throats, including those caused by pharyngitis, tonsillitis, and minor mouth infections. It is also used to ease discomfort following dental procedures or oral surgery. The spray works locally in the throat and mouth, meaning it does not need to be absorbed into the bloodstream to provide relief. You can also explore our ear, nose and throat range for related products that may complement your treatment.

 

What Do You Need to Know Before Using Difflam Throat Numbing Spray?

 

Before using this spray, read the following carefully. Do not use Difflam throat spray if any of the following apply to you:

  • You are allergic to benzydamine hydrochloride or any other ingredient in the product.
  • You have a known hypersensitivity to aspirin or other NSAIDs (e.g. ibuprofen).
  • You are under 6 years of age.
  • You have been told by a doctor to avoid NSAIDs.

Speak to your pharmacist or GP before using this spray if:

  • You are pregnant, planning to become pregnant, or breastfeeding — NSAIDs are generally not recommended during the third trimester of pregnancy.
  • You have asthma, as some people with asthma may be sensitive to NSAIDs.
  • Your sore throat is severe, lasts longer than 7 days, or is accompanied by a high fever, headache, nausea, or rash.

Drug interactions: No clinically significant interactions have been identified at OTC doses when used topically. However, always inform your pharmacist of all medicines you are currently taking.

  • No significant interactions with common OTC medicines are currently documented for topical benzydamine at standard doses.

 

How Should You Use Difflam Throat Numbing Spray?

 

Always use this spray exactly as described in the patient information leaflet or as directed by your pharmacist. Do not exceed the recommended number of doses in any 24-hour period.

  1. Remove the cap from the spray nozzle.
  2. Hold the bottle upright and point the nozzle towards the back of your throat.
  3. Press the pump firmly to release the spray — each press delivers one metered dose.
  4. Apply the number of sprays appropriate for your age group (see table below).
  5. Do not inhale the spray. Avoid contact with the eyes.
  6. Replace the cap after use.
  7. Repeat every 1.5 to 3 hours as needed, up to a maximum of 8 times per day.
Age Group Number of Sprays per Dose Frequency Maximum Daily Doses
Adults and children 12+ 4 sprays Every 1.5–3 hours 8 times per day
Children aged 6–11 4 sprays Every 1.5–3 hours 8 times per day (seek pharmacist advice)
Children under 6 Not recommended

 

What Are the Possible Side Effects of Difflam Throat Numbing Spray?

 

Like all medicines, Difflam throat spray can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the mouth and throat.

Common side effects:

  • Temporary numbness or tingling in the mouth or throat.
  • Mild stinging or burning sensation immediately after spraying.

Less common side effects:

  • Hypersensitivity reactions such as skin rash or itching.
  • Bronchospasm (narrowing of the airways) — particularly in people with asthma or NSAID sensitivity.
  • Photosensitisation (increased sensitivity to sunlight) — rare with topical use.

Stop using the spray and seek medical attention immediately if you experience swelling of the face, lips, tongue, or throat, difficulty breathing, or a severe skin reaction. These may be signs of a serious allergic reaction (anaphylaxis), which requires urgent treatment. If you are managing other health concerns alongside a sore throat, our oral health collection has additional products that may support your recovery.

 

How Should You Store Difflam Throat Numbing Spray?

 

  • Store below 25°C in a cool, dry place.
  • Do not freeze the product.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the label or carton.
  • Do not store near heat sources or in direct sunlight.
  • Do not transfer the contents to another container.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Difflam throat spray online in the UK?

You can buy Difflam Throat Numbing Spray 30ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £7.09. It is dispatched quickly and discreetly to your door. It is also available from some high street pharmacies and larger supermarkets across the UK.

How does Difflam throat spray work in the body?

Difflam contains benzydamine hydrochloride, a locally acting NSAID that inhibits prostaglandin synthesis in the inflamed throat tissue, reducing both pain and swelling. It also has a mild local anaesthetic effect, which is why you may notice a brief numbing sensation after use. Because it works topically, it does not need to enter the bloodstream to be effective.

How do I use Difflam throat spray step by step?

Remove the cap, hold the bottle upright, and direct the nozzle towards the back of your throat. Press the pump to release 4 sprays per dose, then replace the cap. Repeat every 1.5 to 3 hours as needed, but do not exceed 8 doses in any 24-hour period.

What is the correct dose of Difflam throat spray for adults?

Adults and young people aged 12 and over should use 4 sprays directed to the affected area of the throat per dose. This can be repeated every 1.5 to 3 hours, with a maximum of 8 doses in 24 hours. Do not exceed this dose unless advised by a healthcare professional.

Can children use Difflam throat spray?

Difflam throat spray can be used in children aged 6 and over, using the same 4-spray dose as adults under pharmacist guidance. It is not suitable for children under 6 years of age. If you are unsure whether it is appropriate for your child, speak to a pharmacist before use.

What are the side effects of Difflam throat spray?

The most common side effects are a temporary numbing or stinging sensation in the mouth and throat immediately after spraying — this is normal and usually passes quickly. Less commonly, some people may experience a hypersensitivity reaction such as a rash or, rarely, bronchospasm. Stop use and seek medical advice if you develop swelling of the face or difficulty breathing.

How long can you use Difflam throat spray for?

Difflam throat spray should not be used for more than 7 days continuously without consulting a doctor or pharmacist. If your symptoms have not improved within this time, or if they worsen at any point, you should seek medical advice. Prolonged sore throats can occasionally indicate an underlying condition that needs further investigation.

Is Difflam throat spray safe to use during pregnancy?

If you are pregnant, planning to become pregnant, or breastfeeding, you should speak to your doctor or pharmacist before using Difflam throat spray. NSAIDs are generally not recommended during the third trimester of pregnancy due to potential risks to the baby. Your healthcare provider can advise on the safest option for you.

Who is eligible to use Difflam throat spray?

Difflam throat spray is suitable for adults and children aged 6 and over who are experiencing sore throat pain, mouth inflammation, or discomfort following dental procedures. It is not suitable for those with a known allergy to benzydamine or other NSAIDs, or for children under 6. People with asthma should consult a pharmacist before use, as NSAID sensitivity can occasionally trigger bronchospasm.

What happens if I use too much Difflam throat spray?

Using more than the recommended number of sprays or doses in a 24-hour period is unlikely to cause serious harm when used topically, but it may increase the risk of side effects such as prolonged numbness or irritation. If you accidentally swallow a large amount of the spray or are concerned about overuse, contact NHS 111 or your nearest pharmacist for advice.

What are the alternatives to Difflam throat spray?

Alternatives include throat lozenges containing antiseptic ingredients such as amylmetacresol (e.g. Strepsils), or oral analgesics such as paracetamol or ibuprofen for systemic pain relief. For a broader selection of throat and mouth care options, browse our ear, nose and throat collection. Your pharmacist can help you choose the most appropriate product for your specific symptoms.

Can I use Difflam throat spray alongside other medicines?

No clinically significant interactions have been identified for topical benzydamine at OTC doses. However, if you are taking prescribed NSAIDs or anticoagulants, or have any chronic health conditions, always check with your pharmacist before adding any new medicine. It is always safer to disclose your full medication list when seeking advice.

Does Difflam throat spray help with tonsillitis?

Difflam throat spray can help relieve the pain and inflammation associated with tonsillitis, but it does not treat the underlying cause — particularly if tonsillitis is bacterial in origin and requires antibiotics. The NHS advises that most cases of tonsillitis are viral and resolve on their own, but you should see a GP if symptoms are severe or persistent. Use Difflam to manage discomfort while your body recovers.

What is the best time to use Difflam throat spray?

You can use Difflam throat spray at any time of day when you experience throat pain or discomfort, spacing doses at least 1.5 hours apart. Many people find it particularly helpful before meals to make eating and swallowing more comfortable. Using it before bed may also help ease overnight throat irritation, though you should not exceed 8 doses in 24 hours.

Are there any latest studies on benzydamine throat spray?

Benzydamine hydrochloride has been used clinically for several decades and its efficacy and safety profile are well established in published literature. It is included in the British National Formulary (BNF) as a recognised treatment for oropharyngeal pain. For the most current clinical guidance, refer to the BNF or speak to a qualified pharmacist. You can also find related health information through our oral health section.

How Should You Use Difflam Throat Numbing Spray?

Using Difflam throat spray correctly ensures you get the most effective relief with the lowest risk of side effects. Always read the patient information leaflet before use and follow the steps below carefully.

If you are using the spray for the first time, you may need to prime the pump by pressing it once or twice before the first dose is delivered. Do not swallow large amounts of the spray solution.

What Is the Correct Dose of Difflam Throat Numbing Spray?

The dose varies depending on your age. Always follow the guidance below and never exceed the maximum daily dose. If you are unsure about the correct dose for yourself or your child, speak to a pharmacist before use.

When Is the Best Time to Use Difflam Throat Numbing Spray?

You can use Difflam throat spray at any point during the day when throat pain or discomfort is present, as long as you space doses at least 1.5 hours apart. Many people find it particularly helpful to use a dose approximately 15 to 20 minutes before meals, as this can make swallowing significantly more comfortable when the throat is inflamed. Using a dose before bed may also help reduce overnight discomfort, though you should not exceed 8 doses in any 24-hour period regardless of timing.

How Long Can You Use Difflam Throat Numbing Spray For?

Difflam throat spray is designed for short-term use only and should not be used continuously for more than 7 days. Most sore throats caused by viral infections resolve within this timeframe without further treatment. If your symptoms persist beyond 7 days, worsen at any point, or are accompanied by a high fever, difficulty swallowing, or a rash, you should stop using the spray and consult a GP or pharmacist promptly. These signs may indicate a bacterial infection or another condition that requires a different approach to treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Difflam Throat Numbing Spray?

Using Difflam throat spray correctly ensures you get the most effective relief with the lowest risk of side effects. Always read the patient information leaflet before use and follow the steps below carefully.

If you are using the spray for the first time, you may need to prime the pump by pressing it once or twice before the first dose is delivered. Do not swallow large amounts of the spray solution.

What Is the Correct Dose of Difflam Throat Numbing Spray?

The dose varies depending on your age. Always follow the guidance below and never exceed the maximum daily dose. If you are unsure about the correct dose for yourself or your child, speak to a pharmacist before use.

When Is the Best Time to Use Difflam Throat Numbing Spray?

You can use Difflam throat spray at any point during the day when throat pain or discomfort is present, as long as you space doses at least 1.5 hours apart. Many people find it particularly helpful to use a dose approximately 15 to 20 minutes before meals, as this can make swallowing significantly more comfortable when the throat is inflamed. Using a dose before bed may also help reduce overnight discomfort, though you should not exceed 8 doses in any 24-hour period regardless of timing.

How Long Can You Use Difflam Throat Numbing Spray For?

Difflam throat spray is designed for short-term use only and should not be used continuously for more than 7 days. Most sore throats caused by viral infections resolve within this timeframe without further treatment. If your symptoms persist beyond 7 days, worsen at any point, or are accompanied by a high fever, difficulty swallowing, or a rash, you should stop using the spray and consult a GP or pharmacist promptly. These signs may indicate a bacterial infection or another condition that requires a different approach to treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Difflam Throat Numbing Spray?

Most people who use Difflam throat spray tolerate it well, and side effects are generally mild and short-lived. The most frequently reported effects are localised to the mouth and throat and typically resolve on their own within a few minutes of application.

  • Temporary numbness or tingling in the mouth and throat.
  • Mild stinging or burning sensation immediately after spraying.
  • Altered taste sensation shortly after use.

What Are the Less Common Side Effects of Difflam Throat Numbing Spray?

Less commonly, some people may experience reactions that go beyond the immediate area of application. These are not typical but are worth being aware of before you start using the spray.

  • Skin rash or itching — may indicate a mild hypersensitivity reaction.
  • Photosensitisation — increased sensitivity of the skin to sunlight (rare with topical use).
  • Nausea — particularly if a significant amount of the spray is accidentally swallowed.
  • Dry mouth or throat irritation beyond the expected numbing effect.

What Are the Serious Side Effects of Difflam Throat Numbing Spray?

Serious side effects are rare but require immediate medical attention if they occur. People with a known sensitivity to NSAIDs or aspirin are at slightly higher risk of experiencing these reactions.

  • Bronchospasm — sudden narrowing of the airways, particularly in people with asthma or NSAID hypersensitivity.
  • Angioedema — swelling of the face, lips, tongue, or throat, which can interfere with breathing.
  • Severe allergic reaction (anaphylaxis) — symptoms include difficulty breathing, rapid heartbeat, dizziness, and collapse.

If you experience any of these serious reactions, stop using the spray immediately and call 999 or go to your nearest A&E department without delay.

What Should You Do If You Experience Side Effects of Difflam Throat Numbing Spray?

For mild side effects such as temporary numbness or stinging, no action is usually needed — these effects pass quickly and are a normal result of the spray's local anaesthetic properties. If you develop a rash, persistent irritation, or any unusual symptoms, stop using the product and speak to your pharmacist. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. Keeping a note of when symptoms started and what you were using can help your pharmacist or GP advise you more effectively.

Can Difflam Throat Numbing Spray Interact With Other Medicines?

No clinically significant drug interactions have been identified for benzydamine hydrochloride when used topically at OTC doses. However, if you are already taking systemic NSAIDs (such as ibuprofen or naproxen) prescribed by a doctor, or if you are on anticoagulant therapy, you should inform your pharmacist before using this spray. People with a history of NSAID-induced asthma or urticaria should exercise particular caution and seek advice before use. Always disclose your full medication list — including herbal remedies and supplements — when speaking to a healthcare professional.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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