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Difflam Spray

Difflam Spray

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  • ✔️ Relieves sore throat pain and inflammation rapidly
  • ✔️ Contains benzydamine, a clinically proven anti-inflammatory NSAID
  • ✔️ Spray format ideal when swallowing lozenges is painful
  • ✔️ Suitable for adults and children aged 6 years and over
  • ✔️ Targets mouth ulcers, pharyngitis, and post-dental discomfort

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What Is Difflam Spray and How Does It Help?

 

Difflam spray is an over-the-counter oropharyngeal spray used to relieve pain and inflammation in the mouth and throat. It contains benzydamine hydrochloride 0.15%, a non-steroidal anti-inflammatory drug (NSAID) that acts locally — meaning it works directly at the site of discomfort rather than being absorbed into your bloodstream in significant amounts. Whether you're dealing with a sore throat from a cold, post-dental procedure soreness, or mouth ulcers, this spray offers targeted, fast-acting relief. You can browse our full range of cold and flu products if you need additional support alongside your throat treatment.

Sore throats are one of the most common reasons people visit a pharmacist in the UK. Most cases are caused by viral infections and resolve on their own, but the pain in the meantime can be genuinely miserable. That's where a localised treatment like this spray can make a real difference to your day-to-day comfort.

 

How Does Difflam Spray Work to Relieve Throat Pain?

 

Benzydamine hydrochloride, the active ingredient, works through a combination of anti-inflammatory, analgesic (pain-relieving), and mild local anaesthetic actions. Here's what happens when you use it:

  • Benzydamine inhibits the production of prostaglandins — chemicals your body releases during inflammation that cause pain and swelling.
  • It stabilises cell membranes in the inflamed tissue, reducing local irritation.
  • Its mild anaesthetic effect numbs the surface of the throat and mouth, providing almost immediate comfort.
  • Because it acts locally, systemic side effects are far less likely compared to oral NSAIDs taken by mouth.

The spray format allows the medicine to coat the back of the throat evenly, which is particularly useful when swallowing is painful and lozenges feel difficult to manage.

 

Who Is Difflam Spray Suitable For?

 

This spray is suitable for a wide range of people experiencing oral or throat discomfort. It's available without a prescription, making it easy to access when you need it quickly. It may be appropriate for you if you have:

  • A sore throat caused by a viral infection such as a cold or flu
  • Mouth ulcers or oral mucositis (including that caused by radiotherapy or chemotherapy — though always check with your clinical team first)
  • Post-operative or post-dental soreness in the mouth or throat
  • Pharyngitis or tonsillitis (where bacterial infection has been ruled out or treated)

It is not suitable for children under 6 years of age. Adults and children aged 6 and over can use it, though the dose differs by age group — more on that in the dosage section below.

 

How Does Difflam Spray Compare to Other Sore Throat Treatments?

 

Feature Difflam Spray Throat Lozenges
Active ingredient Benzydamine HCl 0.15% Varies (e.g. lidocaine, flurbiprofen)
Route of action Local (topical spray) Local (dissolves in mouth)
Suitable for difficulty swallowing Yes — spray format ideal May be difficult if swallowing is painful
Anti-inflammatory action Yes (NSAID) Depends on product

 

How Should You Store Difflam Spray and Is It Right for You?

 

Store Difflam spray below 25°C, away from direct sunlight and out of reach of children. Do not freeze the product. Once opened, check the expiry date on the packaging and do not use beyond it. If you're managing multiple symptoms — for example, a sore throat alongside general pain relief needs — it's worth speaking to your pharmacist about combining treatments safely.

Difflam spray is a well-established option for localised throat and mouth pain, but it isn't right for everyone. If you have a known allergy to aspirin or other NSAIDs, you should avoid it. Likewise, if your sore throat is severe, accompanied by a high fever, or hasn't improved after 7 days, please see your GP rather than continuing to self-treat.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Difflam Spray specifications
Treatment category Throat and mouth pain relief
Active ingredient Benzydamine hydrochloride 0.15%
Mechanism of action NSAID — inhibits prostaglandin synthesis; local anaesthetic and anti-inflammatory
Suitable for Adults and children aged 6 years and over
UK classification General Sale List (GSL) / Pharmacy (P) medicine
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Oropharyngeal spray solution
Route of administration Oropharyngeal (sprayed into mouth/throat)
Strengths 0.15% w/v benzydamine hydrochloride
Pack sizes 30 ml

Specifications of Difflam Spray

 

What Is Difflam Spray and What Is It Used For?

 

Difflam spray is a topical oropharyngeal spray containing benzydamine hydrochloride 0.15%. It is used to relieve pain, soreness, and inflammation in the mouth and throat. Common conditions it is used for include sore throats associated with colds and flu, mouth ulcers, pharyngitis, tonsillitis, and post-operative or post-dental discomfort. It is not an antibiotic and will not treat bacterial infections — it simply manages the pain and inflammation while your body heals.

 

What Do You Need to Know Before Using Difflam Spray?

 

Before using this spray, read the following carefully. There are certain situations where it should not be used, and others where caution is needed.

Do not use Difflam spray if you:

  • Are allergic to benzydamine hydrochloride or any other ingredient in the product
  • Have a known hypersensitivity to aspirin or other NSAIDs (e.g. ibuprofen)
  • Are under 6 years of age

Use with caution and speak to your pharmacist or GP if you:

  • Are pregnant or breastfeeding
  • Have asthma — some people with asthma are sensitive to NSAIDs
  • Have a history of allergic reactions to medicines
  • Have severe or worsening symptoms, or a high fever alongside your sore throat

Drug interactions:

  • No clinically significant interactions are known at standard OTC doses, as systemic absorption is minimal
  • Always tell your pharmacist about any other medicines you are taking, including herbal remedies

 

How Should You Use Difflam Spray Correctly?

 

Using the spray correctly ensures you get the most benefit from each dose. Follow these steps carefully:

  1. Remove the cap from the spray nozzle.
  2. If using for the first time, prime the pump by pressing it a few times until a fine mist appears.
  3. Open your mouth and point the nozzle towards the back of your throat.
  4. Press the pump firmly to release the spray — each press delivers one metered dose.
  5. Repeat to reach the correct number of sprays for your age group (see table below).
  6. Do not inhale the spray into your lungs.
  7. Replace the cap after use.
Age Group Dose Frequency
Adults and children over 12 years 4–8 sprays Every 1.5–3 hours as needed
Children aged 6–12 years 4 sprays Every 1.5–3 hours as needed
Children under 6 years Not recommended

If you're also managing other symptoms during a cold or flu episode, our ear, nose and throat range includes additional products that may help alongside Difflam spray.

 

What Are the Possible Side Effects of Difflam Spray?

 

Like all medicines, Difflam spray can cause side effects, although not everyone experiences them. Because the medicine acts locally, systemic side effects are uncommon.

Common side effects:

  • Temporary numbness or tingling in the mouth or throat
  • Mild burning sensation on application

Less common side effects:

  • Hypersensitivity reactions including skin rash or itching
  • Bronchospasm (particularly in people with aspirin-sensitive asthma)
  • Photosensitisation (increased sensitivity to sunlight) — rare

If you experience any signs of a serious allergic reaction — such as swelling of the face, lips, or throat, difficulty breathing, or a severe rash — stop using the spray immediately and seek urgent medical attention. You can also find further guidance on managing throat and mouth conditions through our oral health collection.

 

How Should You Store Difflam Spray Safely?

 

  • Store below 25°C in a cool, dry place
  • Do not freeze
  • Keep away from direct sunlight and heat sources
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the label
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Difflam spray online in the UK?

You can buy Difflam spray online from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available without a prescription as an over-the-counter medicine. Simply add it to your basket and it will be dispatched directly to your door.

How does Difflam spray work in the body?

Difflam spray contains benzydamine hydrochloride, an NSAID that works locally in the mouth and throat. It reduces inflammation by inhibiting prostaglandin production and provides mild local anaesthetic relief. Because it acts topically, it does not significantly enter the bloodstream at normal doses.

How do I use Difflam spray step by step?

Remove the cap, prime the pump if using for the first time, then point the nozzle towards the back of your throat and press to release the spray. Adults should use 4–8 sprays per dose, and children aged 6–12 should use 4 sprays. Repeat every 1.5 to 3 hours as needed, and do not swallow large amounts of the spray.

What is the correct dose of Difflam spray for adults?

Adults and young people over 12 years should use 4–8 sprays every 1.5 to 3 hours. You should not exceed this dose or use it more frequently than directed. If your symptoms are not improving after 7 days, consult your GP or pharmacist.

Can children use Difflam spray?

Children aged 6 to 12 years can use Difflam spray at a dose of 4 sprays every 1.5 to 3 hours. It must not be used in children under 6 years of age. Always supervise children when using any throat spray, and keep the product out of their reach when not in use.

What are the side effects of Difflam spray?

The most commonly reported side effect is temporary numbness or tingling in the mouth, which is generally harmless and short-lived. Rarely, some people may experience hypersensitivity reactions such as a rash or, in those with aspirin-sensitive asthma, bronchospasm. Stop use and seek medical advice if you notice any signs of an allergic reaction.

Who should not use Difflam spray?

Difflam spray should not be used by children under 6 years, or by anyone with a known allergy to benzydamine, aspirin, or other NSAIDs such as ibuprofen. People with aspirin-sensitive asthma should also avoid it. If you are pregnant, breastfeeding, or taking other medicines, speak to your pharmacist before use.

Is Difflam spray safe to use during pregnancy?

The safety of benzydamine during pregnancy has not been fully established, so you should speak to your GP or midwife before using Difflam spray if you are pregnant. The same applies if you are breastfeeding. Your healthcare professional can advise on the safest option for managing throat pain during this time.

How long can you use Difflam spray for?

Difflam spray is intended for short-term use only. If your symptoms have not improved within 7 days of starting treatment, you should stop using it and consult your GP. Prolonged self-treatment of a sore throat without medical review is not recommended, as it could mask a more serious underlying condition.

What happens if I use too much Difflam spray?

Using more than the recommended dose is unlikely to cause serious harm, but it may increase the risk of side effects such as numbness or irritation. If you accidentally swallow a large amount or a child ingests the product, contact NHS 111 or your nearest A&E for advice. Always keep medicines stored safely away from children.

Can I use Difflam spray for mouth ulcers?

Yes — Difflam spray is commonly used to relieve the pain associated with mouth ulcers. Its anti-inflammatory and mild anaesthetic properties help reduce discomfort directly at the ulcer site. If your mouth ulcers are large, persistent, or recurring frequently, it is worth speaking to your dentist or GP to rule out an underlying cause.

Does Difflam spray treat the infection causing my sore throat?

No — Difflam spray is not an antibiotic and does not treat bacterial or viral infections. It relieves the pain and inflammation associated with a sore throat while your immune system fights the underlying cause. If you have a bacterial throat infection, your GP may prescribe antibiotics separately.

What are alternatives to Difflam spray for a sore throat?

Alternatives include Difflam mouthwash (also containing benzydamine), flurbiprofen throat lozenges (such as Strefen), anaesthetic lozenges containing lidocaine, or simple saltwater gargles. You can explore a wider range of options in our ear, nose and throat collection. Your pharmacist can help you choose the most appropriate product for your specific symptoms.

Can I use Difflam spray alongside paracetamol or ibuprofen?

Difflam spray acts locally and is not significantly absorbed into the bloodstream, so using it alongside oral paracetamol is generally considered safe. However, if you are already taking oral ibuprofen or another NSAID, speak to your pharmacist before also using Difflam spray. You can find a range of suitable options in our pain relief collection.

What is the latest research on benzydamine for sore throat?

Benzydamine has been used clinically for several decades and is well-established in the management of oropharyngeal pain and inflammation. Published clinical literature supports its use for sore throat, oral mucositis (particularly in patients undergoing radiotherapy), and post-operative throat pain. It remains a recommended option in UK pharmacy practice for short-term symptomatic relief.

How Should You Use Difflam Spray?

Difflam spray is designed to be applied directly into the mouth and throat. Using it correctly ensures the active ingredient reaches the affected area and provides the relief you need. Always read the patient information leaflet supplied with your product before use.

Try to avoid eating or drinking immediately after using the spray, as this may wash away the medicine before it has had time to work. If you accidentally get the spray in your eyes, rinse thoroughly with clean water.

What Is the Correct Dose of Difflam Spray?

The dose varies depending on your age. Always follow the dosage instructions on the packaging or as directed by your pharmacist. Do not exceed the recommended number of sprays per dose or use the spray more frequently than advised.

When Is the Best Time to Use Difflam Spray?

There is no fixed time of day for using Difflam spray — you should use it when your symptoms are most troublesome. Many people find it particularly helpful before meals, as throat pain can make eating and swallowing uncomfortable. Using it shortly before eating may help make mealtimes more manageable.

You can also use it before bed if a sore throat is disrupting your sleep. Just ensure you do not exceed the maximum frequency of one dose every 1.5 hours, and do not use more than the recommended number of sprays per dose.

How Long Can You Use Difflam Spray For?

Difflam spray is intended for short-term use only. Most sore throats caused by viral infections resolve within 7 to 10 days. If your symptoms have not improved after 7 days of using the spray, you should stop treatment and consult your GP, as a more serious underlying cause may need to be investigated.

Do not use Difflam spray continuously for extended periods without medical advice. It is not a long-term treatment and should not replace a proper medical assessment if your symptoms are persistent or worsening.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Difflam Spray?

Most people who use Difflam spray tolerate it well. Because benzydamine hydrochloride acts locally in the mouth and throat rather than being absorbed into the bloodstream in significant amounts, systemic side effects are uncommon. That said, some people do notice mild effects at the site of application.

  • Temporary numbness or tingling in the mouth or throat
  • Mild burning or stinging sensation on application
  • Dry mouth

These effects are generally short-lived and resolve on their own. They are not usually a reason to stop using the spray unless they are particularly bothersome.

What Are the Less Common Side Effects of Difflam Spray?

Less commonly, some people may experience reactions that go beyond mild local discomfort. These are worth being aware of, particularly if you have a history of sensitivity to NSAIDs or aspirin.

  • Skin rash or itching (urticaria)
  • Photosensitisation — increased sensitivity of the skin to sunlight
  • Nausea
  • Bronchospasm — particularly in people with aspirin-sensitive asthma

If you notice any of these less common effects, stop using the spray and speak to your pharmacist or GP. They can advise on whether you should continue treatment or switch to an alternative.

What Are the Serious Side Effects of Difflam Spray?

Serious side effects are rare but can occur. The most significant risk is a hypersensitivity or allergic reaction. This is more likely in people who are already known to be sensitive to aspirin or other NSAIDs.

Signs of a serious allergic reaction include:

  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Difficulty breathing or wheezing
  • Severe skin rash or hives
  • Dizziness or feeling faint

If you experience any of these symptoms, stop using Difflam spray immediately and call 999 or go to your nearest A&E. Do not wait to see if symptoms improve on their own.

What Should You Do If You Experience Side Effects?

For mild side effects such as numbness or tingling, no specific action is usually needed — these typically resolve within a few minutes. If the sensation is uncomfortable, you may wish to rinse your mouth with water. For any side effect that concerns you, or that does not resolve, contact your pharmacist or GP for guidance.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps the MHRA monitor the safety of medicines used in the UK.

Can Difflam Spray Interact With Other Medicines?

Because Difflam spray is applied topically and systemic absorption is minimal at standard OTC doses, clinically significant drug interactions are not commonly reported. However, if you are already taking an oral NSAID such as ibuprofen or naproxen, it is worth mentioning this to your pharmacist before using Difflam spray as well. People taking anticoagulants or medicines that affect platelet function should also seek pharmacist advice before use.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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