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Difflam 3mg Lozenges Orange & Honey Flavour - 20 Lozenges

Difflam 3mg Lozenges Orange & Honey Flavour - 20 Lozenges

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  • ✔️ Relieves sore throat pain and inflammation locally
  • ✔️ Contains benzydamine hydrochloride 3mg per lozenge
  • ✔️ Suitable for adults and children aged 6 and over
  • ✔️ Sugar-free formula with pleasant orange and honey flavour
  • ✔️ Works directly in the throat without systemic absorption

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Are Difflam Sore Throat Lozenges Right for You?

 

A sore throat can make even the simplest things — swallowing, talking, drinking a cup of tea — genuinely uncomfortable. Difflam sore throat lozenges offer targeted, localised relief by delivering an anti-inflammatory medicine directly to the affected area. Each lozenge contains 3mg of benzydamine hydrochloride, a non-steroidal anti-inflammatory drug (NSAID) that works right where you need it. At £8.99 for a pack of 20, they're a practical, pharmacy-trusted option for managing throat discomfort without a prescription. If you're looking for other throat and upper respiratory remedies, you'll find a wide range in our ear, nose and throat collection.

Sore throats are one of the most common reasons people visit a pharmacist in the UK. Most cases are caused by viral infections and resolve on their own within a week, but that doesn't make the discomfort any easier to live with in the meantime. Difflam lozenges are designed to ease that discomfort quickly and conveniently, with a pleasant orange and honey flavour that makes them easy to use throughout the day.

 

How Do Difflam Lozenges Work in the Throat?

 

Benzydamine hydrochloride, the active ingredient in Difflam lozenges, is an NSAID with both analgesic (pain-relieving) and anti-inflammatory properties. Unlike systemic NSAIDs such as ibuprofen, benzydamine acts locally — it's absorbed through the mucous membranes of the mouth and throat rather than through the gut. This means it gets to work directly at the site of inflammation.

  • Benzydamine inhibits the production of prostaglandins, the chemicals responsible for triggering pain and swelling in inflamed tissue.
  • It also has a mild local anaesthetic effect, which helps to temporarily numb the throat and reduce the sensation of pain.
  • The lozenge format ensures slow, sustained release as it dissolves, prolonging contact time with the throat mucosa.
  • The orange and honey flavour makes the experience more pleasant, which encourages consistent use throughout the day.

 

Who Should Use Difflam 3mg Lozenges?

 

These lozenges are suitable for adults and children aged 6 years and over who are experiencing a sore throat due to infection, irritation, or inflammation. They're particularly useful when you want targeted throat relief without taking a systemic painkiller. That said, they're not appropriate for everyone — always check the label and speak to a pharmacist if you're unsure.

  • Adults and teenagers aged 12 and over with a painful or inflamed sore throat
  • Children aged 6 to 11 years (under adult supervision, with age-appropriate dosing)
  • People who prefer a localised treatment rather than oral tablets or liquids
  • Those managing sore throat discomfort alongside a cold or flu

 

How Do Difflam Lozenges Compare to Other Sore Throat Remedies?

 

Feature Difflam 3mg Lozenges Standard Antiseptic Lozenges (e.g. Strepsils)
Active ingredient Benzydamine hydrochloride 3mg (NSAID) Amylmetacresol / 2,4-dichlorobenzyl alcohol (antiseptic)
Mechanism Anti-inflammatory + local anaesthetic Antiseptic action only
Suitable age 6 years and over Typically 6 years and over (varies by product)
Sugar-free Yes (contains isomalt and aspartame) Varies by product

 

How Should You Store Difflam Lozenges and Who Should Avoid Them?

 

Store Difflam 3mg lozenges below 25°C in a dry place, away from direct sunlight. Keep them out of the reach and sight of children. Do not use after the expiry date printed on the packaging. If you're also managing symptoms like a blocked nose or congestion alongside your sore throat, it may be worth exploring our cold and flu range for complementary products.

These lozenges are not suitable for people with known hypersensitivity to benzydamine or any other ingredient in the formulation. They contain aspartame, so they must not be used by anyone with phenylketonuria (PKU). People with asthma or a history of NSAID sensitivity should seek pharmacist advice before use. This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Difflam 3mg Lozenges Orange & Honey Flavour - 20 Lozenges specifications
Treatment category Sore throat relief
Mechanism of action NSAID — inhibits prostaglandin synthesis; local anaesthetic effect
Effective for Pain and inflammation of the mouth and throat
Suitable for Adults and children aged 6 years and over
Active ingredient Benzydamine hydrochloride 3mg
Pack size 20 lozenges
Strength 3mg per lozenge
UK classification General Sale List (GSL)
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Lozenge
Route of administration Oral (dissolved slowly in the mouth)

Specifications of Difflam 3mg Lozenges Orange & Honey Flavour - 20 Lozenges

 

What Is Difflam and What Is It Used For?

 

Difflam 3mg Lozenges Orange & Honey Flavour contain benzydamine hydrochloride, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in the mouth and throat. They are indicated for the symptomatic relief of sore throats caused by infection or irritation. The lozenges are dissolved slowly in the mouth, allowing the active ingredient to act directly on the inflamed tissue of the throat. They do not treat the underlying cause of a sore throat — they manage the symptoms while your body recovers.

 

What Do You Need to Know Before Using Difflam Lozenges?

 

Before using these lozenges, it's important to check whether they are appropriate for you. Do not use Difflam 3mg lozenges if any of the following apply:

  • You are allergic to benzydamine hydrochloride or any other ingredient in the lozenge
  • You have phenylketonuria (PKU) — these lozenges contain aspartame
  • You are under 6 years of age
  • You have a known hypersensitivity to aspirin or other NSAIDs, including a history of asthma triggered by NSAIDs

Speak to your pharmacist or GP before using these lozenges if you have asthma, as some people with asthma may be sensitive to NSAIDs. Pregnant or breastfeeding women should also seek medical advice before use.

There are no clinically significant drug interactions known at the doses used in these lozenges. However, as a general precaution:

  • Inform your pharmacist of all medicines you are currently taking, including herbal remedies
  • If you are taking other NSAIDs (such as ibuprofen or aspirin), seek advice before combining treatments

 

How Should You Use Difflam 3mg Lozenges?

 

Always use Difflam lozenges exactly as described in the patient information leaflet or as directed by your pharmacist. Do not chew or swallow the lozenge whole — it must be dissolved slowly in the mouth to allow the active ingredient to reach the throat.

  1. Place one lozenge in your mouth.
  2. Allow it to dissolve slowly — do not chew or swallow it whole.
  3. Repeat every 1.5 to 3 hours as needed.
  4. Do not exceed the maximum daily dose for your age group (see table below).
  5. If symptoms persist beyond 3 days, consult a pharmacist or GP.
Age Group Dose Frequency Maximum Daily Dose
Adults and children aged 12+ 1 lozenge Every 1.5–3 hours 8 lozenges in 24 hours
Children aged 6–11 years 1 lozenge Every 1.5–3 hours 4 lozenges in 24 hours
Children under 6 years Not recommended

 

What Are the Possible Side Effects of Difflam Lozenges?

 

Like all medicines, Difflam lozenges can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the mouth and throat. If you experience a serious reaction such as swelling of the face, lips, or throat, stop use immediately and seek urgent medical attention.

Common side effects (may affect up to 1 in 10 people):

  • Temporary numbness or tingling sensation in the mouth or throat
  • Mild burning sensation in the mouth

Less common side effects (may affect up to 1 in 100 people):

  • Nausea
  • Hypersensitivity reactions, including skin rash or itching
  • Photosensitivity (increased sensitivity to sunlight) — rare

If you are concerned about any side effect, stop using the lozenges and speak to your pharmacist or GP. You can also report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. For broader pain relief options, you may also wish to browse our pain relief collection.

 

How Should You Store Difflam Lozenges?

 

  • Store below 25°C in a dry place
  • Keep away from direct sunlight and moisture
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via wastewater or household waste — return unused lozenges to your pharmacy

If you're managing a sore throat alongside other symptoms such as mouth ulcers or dental discomfort, it's worth exploring our oral health range for additional support products.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Difflam sore throat lozenges online in the UK?

You can buy Difflam 3mg Lozenges Orange & Honey Flavour directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. They are dispatched quickly and no prescription is required. They are also available from most high street pharmacies and supermarkets across the UK.

How do Difflam lozenges work in the body?

Difflam lozenges contain benzydamine hydrochloride, an NSAID that is absorbed through the mucous membranes of the mouth and throat. It works locally to inhibit prostaglandin production, reducing inflammation and pain at the site of irritation. It also has a mild local anaesthetic effect that temporarily numbs the throat.

How do I use Difflam 3mg lozenges step by step?

Place one lozenge in your mouth and allow it to dissolve slowly — do not chew or swallow it whole. Repeat every 1.5 to 3 hours as needed, up to the maximum daily dose for your age group. Adults and those aged 12 and over should not exceed 8 lozenges in 24 hours.

What is the correct dose of Difflam lozenges for adults?

Adults and children aged 12 and over should take one lozenge every 1.5 to 3 hours as needed. The maximum dose is 8 lozenges in any 24-hour period. Always read the patient information leaflet before use and do not exceed the stated dose.

Are Difflam lozenges suitable for children?

Yes, Difflam 3mg lozenges are suitable for children aged 6 years and over, but the maximum daily dose is lower — no more than 4 lozenges in 24 hours for children aged 6 to 11. They are not recommended for children under 6 years of age. Always supervise children when using lozenges.

What are the side effects of Difflam lozenges and how do I manage them?

The most common side effect is a temporary numbing or tingling sensation in the mouth, which is expected and harmless. Less commonly, some people experience nausea or a mild burning feeling. If you develop a rash, swelling, or difficulty breathing, stop use immediately and seek urgent medical attention.

Who should not use Difflam 3mg lozenges?

These lozenges are not suitable for children under 6 years, people with phenylketonuria (PKU), or anyone with a known allergy to benzydamine or other NSAIDs. People with asthma or NSAID sensitivity should speak to a pharmacist before use. Pregnant or breastfeeding women should also seek medical advice first.

What happens if I take too many Difflam lozenges?

Taking more than the recommended number of lozenges in 24 hours may increase the risk of side effects. If you think you or someone else has taken too many, contact NHS 111 or your nearest A&E department for advice. Always keep medicines out of the reach of children.

Can I use Difflam lozenges if I am pregnant or breastfeeding?

The safety of benzydamine during pregnancy and breastfeeding has not been fully established, so you should consult your GP or pharmacist before using these lozenges if you are pregnant or nursing. There may be alternative sore throat remedies that are more appropriate for your situation. Your pharmacist can advise you on the safest option.

How long can I use Difflam lozenges for?

Difflam lozenges are intended for short-term use only. If your sore throat has not improved within 3 days of starting treatment, or if symptoms worsen, you should stop using the lozenges and seek advice from a pharmacist or GP. Prolonged use without medical supervision is not recommended.

Do Difflam lozenges contain sugar?

Difflam 3mg lozenges do not contain sucrose — they are sweetened with isomalt and aspartame, making them suitable for people who are managing their sugar intake. However, because they contain aspartame, they are not suitable for people with phenylketonuria (PKU). Check the full ingredient list on the packaging if you have any dietary concerns.

What are the alternatives to Difflam lozenges for a sore throat?

Alternatives include antiseptic lozenges such as Strepsils (amylmetacresol/2,4-dichlorobenzyl alcohol), which work via a different mechanism. Systemic pain relief such as paracetamol or ibuprofen tablets can also help with throat pain. You can browse a wider selection of sore throat and upper respiratory products in our ear, nose and throat collection.

Can I use Difflam lozenges alongside other cold and flu medicines?

There are no clinically significant interactions known at OTC doses, but you should be cautious about combining Difflam lozenges with other NSAID-containing products such as ibuprofen tablets or aspirin. Always check with your pharmacist before combining medicines. If you're managing a full cold, our cold and flu range has a variety of complementary options.

What is the latest research on benzydamine for sore throat?

Benzydamine has been used clinically for several decades and is well-established as a localised anti-inflammatory and analgesic for oropharyngeal conditions. Published clinical literature supports its efficacy in reducing throat pain and inflammation. It continues to be recommended in UK pharmacy practice for short-term symptomatic relief of sore throats.

Is Difflam available on the NHS?

Difflam products are generally available as over-the-counter medicines and are not routinely prescribed on the NHS for sore throat, in line with NHS guidance on self-care for minor ailments. You can purchase them without a prescription from Cured Pharmacy or any registered UK pharmacy. For ongoing or severe throat conditions, your GP may consider other treatments.

How Should You Use Difflam 3mg Lozenges?

Difflam 3mg lozenges are designed to be dissolved slowly in the mouth — not chewed or swallowed whole. Allowing the lozenge to dissolve gradually ensures the active ingredient, benzydamine hydrochloride, makes prolonged contact with the inflamed throat tissue, giving you the best chance of effective relief.

Follow these steps each time you use a lozenge:

What Is the Correct Dose of Difflam 3mg Lozenges?

The dose varies depending on age. It is important not to exceed the maximum number of lozenges in any 24-hour period. Always read the patient information leaflet supplied with the product before use.

When Is the Best Time to Use Difflam Lozenges?

You can use Difflam lozenges at any point during the day when your sore throat symptoms are causing discomfort. Many people find it helpful to use a lozenge before meals to make eating and swallowing more comfortable, or before bed to ease nighttime throat irritation. There is no fixed schedule — use them as needed within the dosing limits.

Try to space each lozenge at least 1.5 hours apart to maintain consistent symptom relief throughout the day without exceeding the recommended daily dose.

How Long Can You Use Difflam Lozenges For?

These lozenges are intended for short-term use only. Most sore throats caused by viral infections resolve within 7 to 10 days, but you should see improvement within the first few days. If your symptoms have not improved after 3 days of using Difflam lozenges, or if they are getting worse, stop use and consult a pharmacist or GP.

Do not use these lozenges continuously for longer than recommended without seeking medical advice. Prolonged or repeated use without improvement may indicate an underlying condition that requires further assessment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Difflam 3mg Lozenges?

Difflam 3mg lozenges are designed to be dissolved slowly in the mouth — not chewed or swallowed whole. Allowing the lozenge to dissolve gradually ensures the active ingredient, benzydamine hydrochloride, makes prolonged contact with the inflamed throat tissue, giving you the best chance of effective relief.

Follow these steps each time you use a lozenge:

What Is the Correct Dose of Difflam 3mg Lozenges?

The dose varies depending on age. It is important not to exceed the maximum number of lozenges in any 24-hour period. Always read the patient information leaflet supplied with the product before use.

When Is the Best Time to Use Difflam Lozenges?

You can use Difflam lozenges at any point during the day when your sore throat symptoms are causing discomfort. Many people find it helpful to use a lozenge before meals to make eating and swallowing more comfortable, or before bed to ease nighttime throat irritation. There is no fixed schedule — use them as needed within the dosing limits.

Try to space each lozenge at least 1.5 hours apart to maintain consistent symptom relief throughout the day without exceeding the recommended daily dose.

How Long Can You Use Difflam Lozenges For?

These lozenges are intended for short-term use only. Most sore throats caused by viral infections resolve within 7 to 10 days, but you should see improvement within the first few days. If your symptoms have not improved after 3 days of using Difflam lozenges, or if they are getting worse, stop use and consult a pharmacist or GP.

Do not use these lozenges continuously for longer than recommended without seeking medical advice. Prolonged or repeated use without improvement may indicate an underlying condition that requires further assessment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Difflam Lozenges?

Most people tolerate Difflam 3mg lozenges well. The most frequently reported side effect is a temporary numbing or tingling sensation in the mouth and throat. This is a direct result of the local anaesthetic action of benzydamine hydrochloride and is generally harmless. It usually passes quickly once the lozenge has fully dissolved.

  • Temporary numbness or tingling in the mouth
  • Mild burning sensation on the tongue or throat lining

What Are the Less Common Side Effects of Difflam Lozenges?

Less commonly, some people may experience gastrointestinal or skin-related reactions. These are not expected in most users but are worth being aware of before you start treatment.

  • Nausea
  • Skin rash or itching (hypersensitivity reaction)
  • Photosensitivity — increased sensitivity of the skin to sunlight (rare)
  • Dry mouth

What Are the Serious Side Effects of Difflam Lozenges?

Serious side effects are rare but can occur, particularly in people with a known sensitivity to NSAIDs. If you experience any of the following, stop using the lozenges immediately and seek urgent medical attention:

  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Difficulty breathing or wheezing — particularly in people with asthma
  • Severe skin reactions such as blistering or peeling

These symptoms may indicate a serious allergic reaction (anaphylaxis) and require immediate emergency treatment. Call 999 or go to your nearest A&E if you experience these symptoms.

What Should You Do If You Experience Side Effects?

For mild side effects such as tingling or nausea, you may simply wish to stop using the lozenges and allow the sensation to pass. If a side effect is persistent, worsening, or causing you concern, contact your pharmacist or GP for advice. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk — this helps improve medicine safety for everyone.

Do not ignore side effects that feel unusual or severe. Your pharmacist is always a good first point of contact for guidance on managing any unwanted effects from over-the-counter medicines.

Can Difflam Lozenges Interact With Other Medicines?

There are no clinically significant drug interactions known at the doses used in Difflam 3mg lozenges. However, you should exercise caution if you are already taking other NSAID-containing medicines such as ibuprofen tablets or aspirin, as combining NSAIDs may increase the risk of side effects. Always inform your pharmacist of all medicines you are currently taking, including prescription medicines, over-the-counter products, and herbal supplements, before starting a new treatment.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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