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Conotrane Antiseptic Cream - 500g

Conotrane Antiseptic Cream - 500g

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  • ✔️ Soothes and protects sore, irritated nappy rash skin
  • ✔️ Forms a moisture-repelling barrier at every nappy change
  • ✔️ Benzalkonium chloride fights bacteria on vulnerable skin
  • ✔️ Suitable for babies, toddlers, and adults with incontinence
  • ✔️ Large 500g tub ideal for frequent, everyday use

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What Is Conotrane Cream for Nappy Rash?

 

If you've ever dealt with an angry, red nappy rash on your baby's skin, you'll know how distressing it can be — for both of you. Conotrane cream nappy rash treatment is a trusted, dual-action topical cream that has been used by parents and carers in the UK for decades. Available in a generous 500g tub, it combines an antiseptic agent with a silicone-based barrier to both protect and soothe vulnerable skin. At just £13.99, it offers excellent value for everyday use. You can find it alongside other trusted products in our skin care collection.

Conotrane Antiseptic Cream contains two active ingredients: benzalkonium chloride 0.1% and dimethicone 22%. These work together to address the two main problems associated with nappy rash — moisture damage and bacterial irritation. It's classified as a pharmacy (P) medicine in the UK and is available without a prescription.

 

How Does Conotrane Antiseptic Cream Work?

 

The mechanism behind Conotrane is straightforward but effective. Dimethicone is a silicone-based emollient that sits on the surface of the skin, forming a water-repellent layer. This physical barrier reduces the contact between the skin and urine or faeces — the primary cause of nappy rash. Benzalkonium chloride is a quaternary ammonium antiseptic that disrupts the cell membranes of bacteria and some fungi, reducing the risk of secondary infection in already-irritated skin.

  • Dimethicone creates a protective, moisture-repelling barrier on the skin surface
  • Benzalkonium chloride provides antiseptic action against common skin bacteria
  • Together, they reduce friction, moisture exposure, and microbial risk
  • The cream base also has mild emollient properties, helping to soften and condition the skin

 

Who Should Use Conotrane Antiseptic Cream?

 

Conotrane is primarily used for babies and young children, but it's not limited to that age group. Adults with incontinence, or those who have skin folds prone to moisture and friction, can also benefit from its barrier properties. It's particularly useful for anyone whose skin is regularly exposed to prolonged wetness.

  • Babies and infants with nappy rash or at risk of developing it
  • Toddlers during potty training when skin irritation is common
  • Adults with incontinence-associated dermatitis
  • Carers managing skin integrity in bedridden or immobile patients

If you're looking for additional products to support your baby's skin health, our baby and toddler collection includes a range of suitable options.

 

How Does Conotrane Compare to Other Nappy Rash Creams?

 

Feature Conotrane Antiseptic Cream Sudocrem Antiseptic Healing Cream
Active ingredients Benzalkonium chloride 0.1%, Dimethicone 22% Zinc oxide 15.25%, Benzyl alcohol 0.39%
Barrier protection Yes — silicone-based (dimethicone) Yes — zinc oxide-based
Antiseptic action Yes — benzalkonium chloride Mild — benzyl alcohol
Pack size available 500g 60g, 125g, 250g, 400g

 

Is Conotrane Cream Suitable for Broken or Infected Skin?

 

Conotrane cream nappy rash treatment is designed for use on intact or mildly irritated skin. If the skin appears broken, weeping, or shows signs of a fungal or bacterial infection (such as satellite lesions or pustules), you should consult your GP or pharmacist before applying. Using a barrier cream on infected skin without treating the underlying infection first may delay recovery.

Store the cream below 25°C, away from direct sunlight, and keep the lid tightly closed between uses. The 500g tub is ideal for regular, repeated use — making it a practical choice for families who go through barrier cream quickly.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Conotrane Antiseptic Cream 500g specifications
Treatment category Nappy rash, skin barrier protection
Mechanism of action Barrier protection (dimethicone) and antiseptic action (benzalkonium chloride)
Effective for Nappy rash prevention and treatment, incontinence-associated dermatitis
Suitable for Babies, toddlers, adults with incontinence
Active ingredient Benzalkonium chloride 0.1%, Dimethicone 22%
Pack size 500g
UK classification Pharmacy (P) medicine
Drug class Topical antiseptic and barrier cream
Preparation Cream
Route of administration Topical (cutaneous)

Specifications of Conotrane Antiseptic Cream 500g

 

What Is Conotrane Antiseptic Cream and What Is It Used For?

 

Conotrane Antiseptic Cream is a topical barrier and antiseptic preparation used primarily to prevent and treat nappy rash in babies and young children. It can also be used to protect and soothe skin that is regularly exposed to moisture, friction, or irritants — including in adults with incontinence. The NHS recognises nappy rash as a very common condition, affecting most babies at some point, and recommends barrier creams as a key part of prevention and management.

The cream works by combining dimethicone — a silicone that physically shields the skin from wetness — with benzalkonium chloride, an antiseptic that reduces bacterial load on the skin surface. It is available over the counter without a prescription and is suitable for use at every nappy change as a preventative measure, or as a treatment once rash has developed.

 

What Do You Need to Know Before Using Conotrane Antiseptic Cream?

 

Before using Conotrane, it's important to check whether it's appropriate for your situation. Do not use this cream if any of the following apply:

  • You are allergic to benzalkonium chloride, dimethicone, or any other ingredient in the cream
  • The skin is severely broken, infected, or showing signs of a fungal infection (e.g. satellite lesions around the rash)
  • The affected area has been diagnosed as requiring prescription antifungal or antibiotic treatment
  • You are using other topical preparations on the same area without pharmacist advice

Drug interactions with topical barrier creams are uncommon. However, be aware of the following:

  • Benzalkonium chloride may reduce the effectiveness of some topical antibiotics if applied simultaneously — apply at different times if both are prescribed
  • Avoid using with latex products (e.g. certain medical gloves or condoms) as dimethicone-based creams may affect latex integrity

 

How Should You Use Conotrane Antiseptic Cream?

 

Using Conotrane correctly makes a real difference to how well it works. Follow these steps at each nappy change or as directed by your healthcare professional:

  1. Gently clean the nappy area with warm water and a soft cloth or fragrance-free wipe
  2. Pat the skin completely dry — do not rub, as this can worsen irritation
  3. Apply a thin, even layer of Conotrane cream to the entire nappy area
  4. Allow a moment for the cream to settle before fastening the nappy
  5. Repeat at every nappy change, or as often as needed for adults
Indication Age Group Dose Frequency
Nappy rash prevention Babies and toddlers Thin layer to nappy area At every nappy change
Nappy rash treatment Babies and toddlers Thin layer to affected area At every nappy change
Incontinence-associated dermatitis Adults Thin layer to affected skin As needed, or after each episode

For more products to support skin health and wound care, browse our first aid collection.

 

What Are the Possible Side Effects of Conotrane Antiseptic Cream?

 

Conotrane is generally well tolerated. Side effects are uncommon, but as with any topical product, some people may experience a reaction. Stop using the cream and seek advice from your pharmacist or GP if you notice anything unusual.

Common side effects:

  • Mild stinging or burning sensation immediately after application
  • Temporary redness at the application site

Less common side effects:

  • Contact dermatitis (skin inflammation caused by sensitivity to an ingredient)
  • Allergic skin reaction — rash, itching, or hives beyond the application area
  • Worsening of the original skin condition

If you experience swelling of the face, lips, or throat, or have difficulty breathing, seek emergency medical attention immediately, as this may indicate a serious allergic reaction.

 

How Should You Store Conotrane Antiseptic Cream?

 

Proper storage helps maintain the cream's effectiveness and safety throughout its shelf life. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Always replace the lid firmly after use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tub
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

If you're managing multiple skin conditions, you may also find useful products in our creams and ointments collection.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Conotrane Antiseptic Cream online in the UK?

You can buy Conotrane Antiseptic Cream 500g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available without a prescription as an over-the-counter product. Simply add it to your basket and it will be dispatched to your door.

How does Conotrane cream work on nappy rash?

Conotrane cream works through two complementary mechanisms. Dimethicone forms a physical, water-repellent barrier on the skin that prevents urine and faeces from irritating the surface. Benzalkonium chloride then provides antiseptic action, reducing the bacterial load that can worsen or infect an existing rash.

How do I apply Conotrane cream correctly?

Clean and thoroughly dry the nappy area before each application. Apply a thin, even layer of the cream to the skin and allow it to settle before fastening the nappy. Repeat at every nappy change for best results.

How often should I use Conotrane cream on my baby?

Conotrane cream should be applied at every nappy change to maintain a continuous protective barrier on the skin. Consistent use is key — both for treating an existing rash and for preventing one from developing in the first place. If you're unsure about frequency, your pharmacist or health visitor can advise.

What are the side effects of Conotrane Antiseptic Cream?

Side effects are uncommon but can include mild stinging, temporary redness, or skin irritation at the application site. In rare cases, an allergic reaction may occur — if you notice worsening rash, swelling, or hives, stop use and consult your pharmacist or GP promptly.

Is Conotrane cream safe to use on newborns?

Conotrane cream is commonly used on babies, including newborns, for nappy rash prevention and treatment. However, if your baby's skin is broken, weeping, or shows signs of infection, consult your GP or health visitor before applying. Newborn skin is particularly delicate, so professional guidance is always worthwhile.

Can adults use Conotrane cream for incontinence-related skin problems?

Yes — Conotrane cream is suitable for adults whose skin is regularly exposed to moisture, such as those managing incontinence. It helps protect skin folds and vulnerable areas from irritation and breakdown. If you're managing a more complex skin condition, speak to your GP or a tissue viability nurse for tailored advice.

What is the difference between Conotrane cream and Sudocrem?

Conotrane contains benzalkonium chloride and dimethicone, offering silicone-based barrier protection alongside antiseptic action. Sudocrem uses zinc oxide as its primary barrier agent with benzyl alcohol as a mild antiseptic. The two products have different active ingredients, textures, and formulations — neither is universally better, but they suit different preferences and skin types.

How long can I use Conotrane cream for?

Conotrane cream can be used for as long as needed to protect and maintain skin integrity. If you're using it to treat an active nappy rash and there is no improvement after 7 days, or if the condition worsens, consult your GP or pharmacist. Long-term preventative use at nappy changes is generally considered safe.

What happens if I accidentally apply too much Conotrane cream?

Applying more cream than needed is unlikely to cause harm, but it can make the nappy area feel greasy and may reduce breathability. Simply use a soft cloth to gently remove the excess before fastening the nappy. There is no known toxicity from topical overuse of this product.

Can I use Conotrane cream if my baby has a fungal nappy rash?

Conotrane cream is not an antifungal treatment. If your baby's nappy rash is caused by Candida (thrush) — often identified by a bright red rash with satellite spots — you will need a specific antifungal cream, which your GP can prescribe. Using a barrier cream alone on a fungal rash is unlikely to resolve it.

Is Conotrane cream suitable for use during pregnancy?

Conotrane cream is applied topically and is not expected to pose a risk during pregnancy when used as directed. However, as with any medicine during pregnancy, it is sensible to consult your midwife or GP before use, particularly if you have sensitive skin or a history of allergic reactions.

What are the alternatives to Conotrane cream for nappy rash?

Common alternatives include Sudocrem (zinc oxide-based), Metanium (titanium salts), and Bepanthen (dexpanthenol). Each has a slightly different formulation and mechanism. You can explore a range of suitable options in our baby and toddler collection to find the right fit for your child's skin.

Does Conotrane cream contain any known allergens?

Conotrane cream contains benzalkonium chloride, which can occasionally cause contact sensitivity in some individuals. If you or your baby have a known sensitivity to quaternary ammonium compounds or any other ingredient in the formulation, do not use this product and speak to your pharmacist about alternatives.

What are the latest recommendations for treating nappy rash in the UK?

The NHS recommends keeping the nappy area clean and dry, changing nappies frequently, and applying a barrier cream at each change as the cornerstone of nappy rash management. Barrier creams containing dimethicone or zinc oxide are widely recommended by UK healthcare professionals. For persistent or severe cases, a GP assessment is advised to rule out infection. You can also find additional skin care support in our skin care collection.

How Should You Use Conotrane Antiseptic Cream?

Conotrane Antiseptic Cream is applied directly to the skin. Always clean and dry the affected area before applying, and use a thin, even layer rather than a thick coating — more is not necessarily better with barrier creams. Follow these steps for correct application:

Avoid applying the cream to the eyes, mouth, or inside the nose. If accidental contact occurs, rinse thoroughly with water.

What Is the Correct Dose of Conotrane Antiseptic Cream?

There is no fixed measured dose for topical barrier creams — the amount used depends on the size of the area being treated. A thin, even layer sufficient to cover the affected skin is all that is needed. Applying more than this does not improve effectiveness and may make the skin feel uncomfortably greasy.

When Is the Best Time to Use Conotrane Antiseptic Cream?

The best time to apply Conotrane cream is immediately after cleaning and drying the skin — whether that's at a nappy change, after bathing, or following an episode of incontinence. Applying the cream to clean, dry skin ensures the barrier layer adheres properly and provides maximum protection. For babies, building application into your nappy-changing routine makes it easy to stay consistent.

If you are using Conotrane alongside other topical treatments (such as a prescribed antifungal or steroid cream), apply those first and allow them to absorb before applying Conotrane as the final layer. This ensures the active treatments reach the skin effectively.

How Long Can You Use Conotrane Antiseptic Cream For?

Conotrane cream can be used for as long as skin protection is needed. For nappy rash prevention, it is safe to use at every nappy change throughout the nappy-wearing years. If you are using it to treat an active rash, you should see improvement within a few days. If the rash has not improved after 7 days of consistent use, or if it worsens at any point, stop using the cream and consult your GP or pharmacist — there may be an underlying cause such as a fungal or bacterial infection that requires specific treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Conotrane Antiseptic Cream?

Conotrane Antiseptic Cream is generally well tolerated when used as directed. Most people — including babies — experience no side effects at all. However, as with any topical product, some individuals may notice a mild reaction, particularly when first using the cream.

  • Mild stinging or burning sensation immediately after application
  • Temporary redness or warmth at the application site
  • Slight greasiness or residue on the skin

These effects are usually short-lived and resolve on their own. If stinging persists beyond a few minutes or worsens with repeated use, discontinue the cream and seek pharmacist advice.

What Are the Less Common Side Effects of Conotrane Antiseptic Cream?

Less commonly, some people may develop a sensitivity reaction to one of the ingredients in Conotrane. Benzalkonium chloride, in particular, is a known contact sensitiser in a small proportion of users.

  • Contact dermatitis — localised skin inflammation, itching, or scaling
  • Allergic skin reaction — rash or hives spreading beyond the application area
  • Worsening of the original skin condition rather than improvement
  • Dry or flaking skin around the treated area

If you notice any of these effects, stop using the cream and consult your pharmacist or GP. They can help identify whether the reaction is due to an ingredient in Conotrane or an underlying skin condition that needs different treatment.

What Are the Serious Side Effects of Conotrane Antiseptic Cream?

Serious side effects from topical Conotrane cream are rare. However, a severe allergic reaction (anaphylaxis) is possible with any medicine, even when applied to the skin. Seek emergency medical attention immediately if you or your child experiences any of the following:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Sudden widespread rash or hives across the body
  • Dizziness, rapid heartbeat, or collapse

Call 999 or go to your nearest A&E department without delay if a serious allergic reaction is suspected.

What Should You Do If You Experience Side Effects of Conotrane Cream?

For mild side effects such as temporary stinging or redness, you can usually continue using the cream and monitor whether the reaction settles. If it does not improve within 24–48 hours, stop use and speak to your pharmacist. For any sign of allergic reaction or worsening skin condition, discontinue immediately and seek professional advice.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps the UK medicines regulator monitor the safety of products available to the public.

Can Conotrane Cream Interact With Other Medicines?

Significant drug interactions with topical barrier creams are uncommon. That said, benzalkonium chloride may reduce the local effectiveness of certain topical antibiotics if applied at the same time — if you are using a prescribed topical antibiotic, apply it first and allow it to absorb before applying Conotrane. Additionally, dimethicone-based creams can affect the integrity of latex products, so bear this in mind if latex gloves or other latex items are being used in the same area.

If you are using any other topical preparations on the same area of skin, always check with your pharmacist before combining them with Conotrane.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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