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Anadin Original - 16 Capsules

Anadin Original - 16 Capsules

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  • ✔️ Relieves headaches and mild to moderate pain fast
  • ✔️ Contains aspirin and caffeine for enhanced pain relief
  • ✔️ Suitable for adults and young people aged 16 and over
  • ✔️ Effective for migraines, muscular aches, and cold symptoms
  • ✔️ Convenient 16-capsule pack for on-the-go pain relief

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What Are Anadin Original Capsules Used For?

 

If you've ever reached for something familiar when a headache strikes, you'll know the name. Anadin Original capsules have been a trusted household name in the UK for decades, offering fast-acting relief from mild to moderate pain. Each pack contains 16 capsules, making it a convenient option to keep in your medicine cabinet or bag. At just £2.79, it's an accessible choice for everyday pain management without needing a prescription.

Anadin Original contains two active ingredients: aspirin 325 mg and caffeine 15 mg. Aspirin is a well-established non-steroidal anti-inflammatory drug (NSAID) that has been used clinically for over a century. The caffeine component is included because research suggests it can enhance the analgesic effect of aspirin, meaning you may need a lower dose to achieve the same level of relief. If you're looking for a broader range of options, our pain relief collection includes a variety of OTC analgesics to suit different needs.

 

How Do Anadin Original Capsules Work?

 

Aspirin works by blocking the production of prostaglandins — chemical messengers in the body that trigger pain, inflammation, and fever. It does this by inhibiting the enzymes cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2). The result? Reduced pain signalling and, where relevant, a lowering of raised temperature.

  • Aspirin inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis
  • Prostaglandin reduction leads to decreased pain and inflammation at the site of injury or irritation
  • Caffeine (15 mg per capsule) acts as an adjuvant analgesic, boosting aspirin's effectiveness
  • Onset of action is typically within 30 to 60 minutes of taking the capsules orally

 

Who Should Use Anadin Original Capsules?

 

Anadin Original is suitable for adults and young people aged 16 and over who need short-term relief from a range of common painful conditions. It's particularly well suited to those who prefer a capsule format over tablets. That said, it's not appropriate for everyone — always read the label carefully.

  • Adults aged 16 and over experiencing headaches or migraines
  • People with mild to moderate muscular aches or joint pain
  • Those suffering from cold or flu symptoms including fever and body aches
  • Individuals who find aspirin-based products more effective than paracetamol for their pain type

 

How Do Anadin Original Capsules Compare to Paracetamol Capsules?

 

Feature Anadin Original Capsules Standard Paracetamol Capsules
Active ingredient Aspirin 325 mg + Caffeine 15 mg Paracetamol 500 mg
Anti-inflammatory action Yes (NSAID) No
Suitable for under 16s No Yes (age-appropriate dose)
Safe in pregnancy Not recommended Generally considered safe (consult GP)

 

Is Anadin Original Suitable for Long-Term Use?

 

Anadin Original capsules are designed for short-term use only. Taking aspirin regularly over a prolonged period can increase the risk of gastrointestinal side effects, including stomach irritation and, in rare cases, bleeding. If you find yourself relying on pain relief frequently, it's worth speaking to your GP to identify any underlying cause. You might also find it helpful to explore our first aid collection for complementary products that support everyday health management.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Anadin Original 16 Capsules specifications
Treatment category General pain relief, headache relief
Mechanism of action COX-1 and COX-2 inhibition (NSAID); caffeine adjuvant analgesia
Effective for Headaches, migraine, muscular aches, cold and flu symptoms, mild to moderate pain
Suitable for Adults and young people aged 16 and over
Active ingredient Aspirin 325 mg, Caffeine 15 mg
Pack size 16 capsules
UK classification General Sale List (GSL)
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Capsule
Route of administration Oral

Specifications of Anadin Original 16 Capsules

 

What Is Anadin Original and What Is It Used For?

 

Anadin Original 16 Capsules is an over-the-counter analgesic and antipyretic medicine containing aspirin 325 mg and caffeine 15 mg per capsule. It is used to relieve mild to moderate pain, including headaches, migraine headaches, dental pain, period pain, muscular aches, and the aches and fever associated with colds and flu. It is classified as a General Sale List (GSL) medicine in the UK, meaning it can be purchased without a prescription from pharmacies, supermarkets, and registered online pharmacies.

 

What Do You Need to Know Before Using Anadin Original?

 

Before taking Anadin Original capsules, it's important to check whether this medicine is right for you. There are certain conditions and circumstances where aspirin-containing products should be avoided entirely.

Do not take Anadin Original if you:

  • Are allergic to aspirin, any other NSAID, or any ingredient in the capsule
  • Are under 16 years of age (risk of Reye's syndrome)
  • Have or have had a stomach ulcer or gastrointestinal bleeding
  • Are in the third trimester of pregnancy
  • Have severe kidney, liver, or heart failure
  • Have haemophilia or another bleeding disorder

Known drug interactions — tell your pharmacist if you are taking:

  • Anticoagulants such as warfarin or heparin
  • Other NSAIDs including ibuprofen or naproxen
  • Methotrexate (used for arthritis and some skin conditions)
  • Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine
  • Antidiabetic medicines (aspirin may affect blood glucose levels)
  • Corticosteroids, which can increase the risk of gastrointestinal bleeding

If you are unsure whether Anadin Original is suitable for you, speak to your pharmacist before taking it. You can also browse our cold and flu collection for alternative symptom relief options.

 

How Should You Use Anadin Original Capsules?

 

  1. Read the patient information leaflet inside the pack before taking any capsules
  2. Swallow the capsules whole with a full glass of water
  3. Take with or after food to reduce the risk of stomach irritation
  4. Use the lowest effective dose for the shortest time necessary
  5. Wait at least 4 hours between doses
  6. Do not exceed 8 capsules in any 24-hour period
Indication Age Group Dose Frequency
Headache / mild to moderate pain Adults and young people 16+ 1–2 capsules Every 4 hours (max 8 capsules/24 hrs)
Under 16 years Children under 16 Not suitable — do not use

 

What Are the Possible Side Effects of Anadin Original?

 

Like all medicines, Anadin Original can cause side effects, although not everyone will experience them. Aspirin is generally well tolerated at recommended doses, but it's worth knowing what to look out for.

Common side effects:

  • Stomach irritation or discomfort
  • Nausea or indigestion
  • Heartburn

Less common side effects:

  • Gastrointestinal bleeding (black or tarry stools — seek medical attention immediately)
  • Allergic reactions including skin rash, itching, or swelling
  • Bronchospasm in people with aspirin-sensitive asthma
  • Tinnitus (ringing in the ears) with prolonged or high-dose use

If you experience any serious side effects, stop taking the capsules and seek medical advice promptly. For those managing ongoing pain conditions, it may be worth exploring our vitamins and supplements collection for supportive options alongside conventional pain relief.

 

How Should You Store Anadin Original Capsules?

 

  • Store below 25°C in a dry place away from direct sunlight
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not store in a bathroom or near a sink — moisture can degrade the capsules
  • Return unused or expired medicines to your local pharmacy for safe disposal

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Anadin Original capsules online in the UK?

You can buy Anadin Original 16 Capsules directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £2.79. They are also available from most high street pharmacies and supermarkets without a prescription. Buying online is a convenient option if you want to have them delivered to your door quickly.

How do Anadin Original capsules work in the body?

Anadin Original capsules contain aspirin, which inhibits the COX-1 and COX-2 enzymes responsible for producing prostaglandins — the chemicals that cause pain, inflammation, and fever. The caffeine included in each capsule acts as an adjuvant, enhancing aspirin's analgesic effect. Together, they provide relief from mild to moderate pain within approximately 30 to 60 minutes.

How do I use Anadin Original capsules step by step?

Take 1 to 2 capsules with a full glass of water, ideally with or after food to protect your stomach. Wait at least 4 hours before taking another dose, and never exceed 8 capsules in a 24-hour period. Always read the patient information leaflet before use.

What is the correct dose of Anadin Original for adults?

The recommended adult dose is 1 to 2 capsules every 4 hours when needed for pain relief. The maximum dose is 8 capsules in any 24-hour period. Do not take more than this, and if your pain is not controlled, speak to your pharmacist or GP.

What is the best time to take Anadin Original capsules?

Take Anadin Original as soon as your pain begins — early intervention tends to be more effective than waiting until pain becomes severe. Taking the capsules with food or a meal helps to reduce the risk of stomach irritation. Avoid taking them on an empty stomach if possible.

What are the side effects of Anadin Original capsules?

Common side effects include stomach irritation, nausea, heartburn, and indigestion. Less commonly, aspirin can cause gastrointestinal bleeding, allergic reactions, or bronchospasm in people with aspirin-sensitive asthma. If you notice black or tarry stools, stop taking the capsules and seek medical attention immediately.

How do I manage side effects of Anadin Original?

The most effective way to reduce stomach-related side effects is to take Anadin Original with food and a full glass of water. If you experience persistent indigestion or stomach discomfort, stop taking the capsules and speak to your pharmacist. You should not take antacids at the same time without checking with a healthcare professional first.

Who is eligible to take Anadin Original capsules?

Anadin Original is suitable for adults and young people aged 16 and over who need short-term relief from mild to moderate pain. It is not suitable for children under 16, pregnant women (especially in the third trimester), or people with certain conditions such as stomach ulcers, bleeding disorders, or severe kidney or liver disease. Our pain relief collection includes alternatives that may be more appropriate for those who cannot take aspirin.

Can children take Anadin Original capsules?

No — Anadin Original must not be given to anyone under 16 years of age. This is because aspirin use in children and teenagers has been associated with a rare but serious condition called Reye's syndrome, which can affect the brain and liver. For children's pain relief, speak to your pharmacist about age-appropriate alternatives.

Is Anadin Original safe to take during pregnancy?

Anadin Original is not recommended during pregnancy, particularly in the third trimester, as aspirin can affect the baby's circulation and may cause complications during labour. If you are pregnant or breastfeeding, always consult your GP or midwife before taking any pain relief. There are safer alternatives available that your healthcare provider can advise on.

Can I take Anadin Original with other medicines?

Anadin Original can interact with several medicines, including warfarin and other anticoagulants, other NSAIDs such as ibuprofen, methotrexate, SSRIs, and corticosteroids. Always tell your pharmacist about all medicines you are currently taking before starting Anadin Original. Combining aspirin with other blood-thinning medicines in particular can significantly increase the risk of bleeding.

What happens if I miss a dose of Anadin Original?

Anadin Original is taken as needed for pain rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. Simply take a dose when your pain returns, provided at least 4 hours have passed since your last dose. Never double up to make up for a missed dose.

What are the alternatives to Anadin Original capsules?

Common alternatives include paracetamol-based products, ibuprofen, or combination analgesics containing codeine (available from a pharmacist). Paracetamol is often preferred for those who cannot tolerate NSAIDs or who are pregnant. You can explore a range of options in our pain relief collection to find the most suitable product for your needs.

How long can you take Anadin Original for?

Anadin Original is intended for short-term use only — generally no more than 3 consecutive days for pain relief without medical advice. If your symptoms persist beyond this, you should consult your GP to rule out an underlying cause. Long-term regular use of aspirin without medical supervision increases the risk of gastrointestinal side effects.

What are the latest studies on aspirin for headache relief?

Aspirin remains one of the most studied analgesics in the world, and clinical evidence continues to support its effectiveness for mild to moderate pain including tension headaches and migraine. The NHS recommends aspirin as one of the first-line treatments for migraine in adults aged 16 and over. Research also confirms that combining aspirin with caffeine, as in Anadin Original capsules, can improve pain relief outcomes compared to aspirin alone.

How Should You Use Anadin Original Capsules?

Always read the patient information leaflet before taking Anadin Original. Take the capsules with a full glass of water, and wherever possible, take them with or after food to help protect your stomach lining from irritation.

Follow these steps each time you take a dose:

What Is the Correct Dose of Anadin Original?

The dose varies depending on the age of the person taking it. Anadin Original is not suitable for anyone under 16 years of age. For adults and young people aged 16 and over, the following dosing guidance applies.

When Is the Best Time to Use Anadin Original?

Take Anadin Original as soon as your pain or fever begins. Acting early — before pain becomes severe — tends to produce better results than waiting. If you are prone to morning headaches, taking a dose with breakfast (alongside food) can be an effective approach, provided you have not already taken a dose within the previous 4 hours.

Avoid taking Anadin Original late at night on an empty stomach, as this increases the risk of stomach irritation. If you need pain relief overnight, ensure you have eaten something beforehand.

How Long Can You Use Anadin Original For?

Anadin Original is intended for short-term use only. For pain relief, do not use it for more than 3 consecutive days without speaking to your GP or pharmacist. For fever, do not use for more than 3 days without seeking medical advice.

If your headaches are occurring frequently — more than 10 to 15 days per month — this could indicate medication overuse headache (also known as rebound headache), and you should speak to your GP. Long-term regular use of aspirin without supervision can increase the risk of gastrointestinal side effects and other complications.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Anadin Original?

Most people who take Anadin Original at the recommended dose tolerate it well. However, because aspirin is an NSAID, it can irritate the lining of the stomach and gastrointestinal tract, particularly if taken on an empty stomach.

  • Stomach discomfort or pain
  • Nausea
  • Indigestion or heartburn
  • Feeling of fullness or bloating

Taking the capsules with food and a full glass of water significantly reduces the likelihood of these effects occurring.

What Are the Less Common Side Effects of Anadin Original?

Less frequently, some people may experience more notable reactions. These are not common at standard doses but are worth being aware of, particularly if you are taking Anadin Original regularly or at higher doses.

  • Tinnitus (ringing or buzzing in the ears) — particularly with prolonged use
  • Skin rash or itching
  • Dizziness or headache (paradoxically, with overuse)
  • Increased tendency to bruise or bleed
  • Worsening of asthma symptoms in aspirin-sensitive individuals

What Are the Serious Side Effects of Anadin Original?

Serious side effects are rare but require immediate medical attention if they occur. Gastrointestinal bleeding is the most significant risk associated with aspirin use, especially in people with a history of stomach ulcers or those taking other medicines that affect bleeding.

  • Black, tarry, or blood-streaked stools — a sign of gastrointestinal bleeding
  • Vomiting blood or material that looks like coffee grounds
  • Severe allergic reaction (anaphylaxis): swelling of the face, lips, or throat, difficulty breathing
  • Bronchospasm (sudden tightening of the airways) in aspirin-sensitive asthma

If you experience any of these symptoms, stop taking Anadin Original immediately and call 999 or go to your nearest A&E department.

What Should You Do If You Experience Side Effects?

For mild side effects such as stomach discomfort, try taking the capsules with food and plenty of water. If symptoms persist or worsen, stop taking the medicine and speak to your pharmacist. You should not take antacids alongside Anadin Original without first checking with a healthcare professional, as some antacids can affect how aspirin is absorbed.

You can report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety for everyone.

Can Anadin Original Interact With Other Medicines?

Yes. Aspirin has a number of clinically significant interactions. It can enhance the blood-thinning effect of anticoagulants such as warfarin, increasing the risk of serious bleeding. Taking aspirin alongside other NSAIDs like ibuprofen or naproxen also raises the risk of gastrointestinal side effects. Aspirin can affect the way methotrexate, antidiabetic medicines, and certain antidepressants (SSRIs) work in the body.

Always tell your pharmacist or GP about every medicine, supplement, or herbal remedy you are taking before starting Anadin Original. This includes over-the-counter products you may not think of as "medicines."

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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