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Aciclovir Cold Sore Cream - 2g

Aciclovir Cold Sore Cream - 2g

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  • ✔️ Targets herpes simplex virus to reduce cold sore duration
  • ✔️ Apply at first tingle for fastest outbreak control
  • ✔️ Clinically established aciclovir 5% antiviral formula
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ Compact 2g tube — discreet and easy to carry anywhere

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What Is Aciclovir Cold Sore Cream and How Does It Help?

 

Cold sores are one of those things that always seem to appear at the worst possible moment — before a big event, during a stressful week, or right when you thought your skin was behaving itself. They're caused by the herpes simplex virus type 1 (HSV-1), and once you've had one, the virus stays dormant in your body, ready to flare up again when your immune system is under pressure. Aciclovir cold sore cream is a clinically established antiviral treatment that targets the virus directly, helping to reduce the severity and duration of an outbreak when applied early. You can browse our wider range of skin care products if you're looking for additional support for your skin.

This 2g tube contains aciclovir 5% w/w as the active ingredient. It's available over the counter in the UK without a prescription for adults and young people aged 12 and over, making it a convenient and accessible option when a cold sore strikes.

 

How Does Aciclovir Cold Sore Cream Work Against the Virus?

 

Aciclovir belongs to a class of medicines called antivirals. It works by interfering with the herpes simplex virus's ability to copy itself. Here's the mechanism in simple terms:

  • Aciclovir is taken up by cells infected with the herpes simplex virus.
  • Inside those cells, it's converted into its active form — aciclovir triphosphate — by a viral enzyme called thymidine kinase.
  • This active form then blocks DNA polymerase, the enzyme the virus needs to replicate its genetic material.
  • Without the ability to replicate, the virus cannot spread further or worsen the outbreak.

Because the activation step relies on a viral enzyme, aciclovir acts selectively on infected cells rather than healthy ones. This targeted approach is why it's well tolerated when used topically.

 

Who Is Aciclovir Cold Sore Cream Suitable For?

 

This cream is suitable for most adults and young people who experience recurrent cold sores on the lips or around the mouth. It's particularly useful if you can recognise your early warning signs — that familiar tingling or itching before a blister appears. Acting quickly really does make a difference.

  • Adults aged 18 and over with recurrent cold sores
  • Young people aged 12–17 (under pharmacist or medical guidance)
  • People who experience cold sores triggered by sun exposure, stress, or illness
  • Those who prefer a topical treatment over oral antiviral tablets

It is not suitable for treating cold sores inside the mouth, on the genitals, or near the eyes. If you have a weakened immune system — for example, due to HIV, chemotherapy, or immunosuppressant medicines — speak to your GP before using this product.

 

How Does Aciclovir Cold Sore Cream Compare to Other Cold Sore Treatments?

 

Feature Aciclovir Cold Sore Cream 5% Penciclovir Cream 1%
Active ingredient Aciclovir 5% w/w Penciclovir 1% w/w
Application frequency 5 times daily for 5 days Every 2 hours (while awake) for 4 days
Available OTC in UK Yes Yes
Suitable for children under 12 No (without medical advice) No (without medical advice)

 

How Should You Store Aciclovir Cold Sore Cream?

 

Store this cream below 25°C in a cool, dry place away from direct sunlight. Keep the tube tightly closed when not in use, and always keep it out of the reach and sight of children. Do not use the cream after the expiry date printed on the tube or carton. If you're unsure whether a product is still safe to use, your pharmacist can advise you. For other topical treatments, take a look at our creams and ointments collection.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Aciclovir Cold Sore Cream 2g specifications
Treatment category Antiviral / Cold sore treatment
Mechanism of action Inhibits herpes simplex virus DNA polymerase, preventing viral replication
Effective against Herpes simplex virus type 1 (HSV-1) — cold sores on lips and face
Suitable for Adults and young people aged 12 and over
Active ingredient Aciclovir 5% w/w
Pack size 2g tube
Strength 5% w/w
UK classification Pharmacy (P) medicine
Drug class Antiviral (nucleoside analogue)
Preparation Topical cream
Route of administration Topical (cutaneous)

Specifications of Aciclovir Cold Sore Cream 2g

 

What Is Aciclovir Cold Sore Cream and What Is It Used For?

 

Aciclovir Cold Sore Cream 2g is a topical antiviral medicine used to treat cold sores (herpes labialis) on the lips and surrounding skin. It contains aciclovir 5% w/w as its active ingredient. Cold sores are caused by the herpes simplex virus type 1 (HSV-1), which can be triggered by factors such as stress, illness, fatigue, or sun exposure. This cream is intended for use at the first sign of a cold sore — tingling, itching, or redness — to help reduce the duration and severity of the outbreak. It is not a cure for the herpes simplex virus, but it can make individual episodes more manageable.

 

What Do You Need to Know Before Using Aciclovir Cold Sore Cream?

 

Before using this cream, read the following carefully. There are situations where this product may not be appropriate for you.

Do not use this cream if you:

  • Are allergic to aciclovir, valaciclovir, propylene glycol, or any other ingredient in the formulation
  • Are under 12 years of age (without medical advice)
  • Have cold sores inside the mouth, on the genitals, or near the eyes
  • Have a severely weakened immune system without first consulting your GP

Warnings and precautions:

  • Avoid contact with the eyes — rinse thoroughly with water if accidental contact occurs
  • Do not apply inside the mouth or on mucous membranes
  • Wash hands before and after each application to avoid spreading the virus
  • Do not share this product with others — cold sores are contagious
  • If your cold sore does not improve after 10 days, consult your GP
  • Speak to your doctor if you are pregnant or breastfeeding before use

Drug interactions:

  • No clinically significant interactions are known for topical aciclovir at standard doses
  • If you are taking oral antiviral medicines or immunosuppressants, inform your pharmacist before use

 

How Should You Use Aciclovir Cold Sore Cream?

 

Using this cream correctly gives you the best chance of a shorter, less severe cold sore. Apply it as soon as you notice the first warning signs — don't wait for a blister to form. If you're also dealing with discomfort around the affected area, our pain relief range may offer additional support.

  1. Wash your hands thoroughly with soap and water before applying.
  2. Squeeze a small amount of cream (approximately 1cm) onto a clean fingertip or cotton bud.
  3. Apply gently to the cold sore and the area immediately surrounding it.
  4. Do not rub vigorously — dab lightly to avoid irritating the skin.
  5. Wash your hands again immediately after application.
  6. Apply five times daily, roughly every four hours (excluding night-time sleep).
  7. Continue for five days. If the cold sore has not healed, you may continue for a further five days.
Indication Age Group Dose Frequency
Cold sore (herpes labialis) Adults & young people 12+ Small amount (~1cm strip) 5 times daily for 5 days (max 10 days)
Cold sore (herpes labialis) Under 12 Not recommended without medical advice

 

What Are the Possible Side Effects of Aciclovir Cold Sore Cream?

 

Like all medicines, aciclovir cold sore cream can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the area of application.

Common side effects (may affect up to 1 in 10 people):

  • Mild burning or stinging sensation at the application site
  • Itching or tingling of the skin
  • Skin dryness or flaking around the treated area

Less common side effects (may affect up to 1 in 100 people):

  • Temporary redness or mild skin irritation
  • Contact dermatitis (skin inflammation) — particularly in those sensitive to propylene glycol
  • Oedema (swelling) at the application site

Serious allergic reactions (anaphylaxis) are very rare but require immediate medical attention. Signs include swelling of the face, lips, or throat, difficulty breathing, or a widespread skin rash. Stop using the cream and call 999 or go to your nearest A&E if this occurs.

 

How Should You Store Aciclovir Cold Sore Cream?

 

  • Store below 25°C in a cool, dry place
  • Do not refrigerate or freeze
  • Keep the tube tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tube or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

If you're looking for other topical treatments for skin conditions, explore our skin care collection for a range of options.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy aciclovir cold sore cream online in the UK?

You can buy aciclovir cold sore cream directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £4.29. It is available without a prescription as an over-the-counter (P) medicine for adults and young people aged 12 and over. Simply add it to your basket and it will be dispatched from our UK-registered pharmacy.

How does aciclovir cold sore cream work in the body?

Aciclovir is an antiviral nucleoside analogue that is selectively activated inside cells infected with the herpes simplex virus. Once activated by the viral enzyme thymidine kinase, it blocks DNA polymerase — the enzyme the virus needs to replicate its genetic material. This stops the virus from spreading and helps the cold sore heal more quickly.

How do I apply aciclovir cold sore cream step by step?

Wash your hands, then apply a small amount of cream to the cold sore and the surrounding skin five times a day, roughly every four hours. Avoid touching your eyes after application, and wash your hands again immediately afterwards. Continue for five days, or up to ten days if the sore has not fully healed.

When is the best time to start using aciclovir cold sore cream?

The earlier you start, the better — ideally at the very first sign of a cold sore, such as tingling, itching, or a burning sensation on the lip. Applying the cream during this prodromal stage can significantly reduce the severity of the outbreak. Waiting until a blister has fully formed reduces how effective the treatment can be.

What are the side effects of aciclovir cold sore cream and how do I manage them?

The most common side effects are mild and localised — you might notice a brief stinging or burning sensation when you first apply the cream, along with some skin dryness or flaking. These usually settle on their own without any need to stop treatment. If you develop significant redness, swelling, or signs of an allergic reaction, stop using the cream and speak to your pharmacist or GP.

Who should not use aciclovir cold sore cream?

This cream is not suitable for anyone with a known allergy to aciclovir, valaciclovir, or propylene glycol. It should not be used on cold sores inside the mouth, near the eyes, or on genital herpes. Children under 12 should only use it under medical supervision, and people with a weakened immune system should consult their GP first.

How long does aciclovir cold sore cream take to work?

When started at the first sign of a cold sore, aciclovir cream can reduce the healing time and lessen symptoms over a five-day course. Clinical evidence suggests it can shorten the duration of an episode by around half a day to one day compared with no treatment. Results vary depending on how early you start and how severe the outbreak is.

Can I use aciclovir cold sore cream during pregnancy or while breastfeeding?

Topical aciclovir is minimally absorbed through the skin, so systemic exposure is very low. However, you should still speak to your doctor or pharmacist before using this cream if you are pregnant or breastfeeding, as they can weigh up the benefits and any potential risks for your individual situation. Do not self-treat without professional guidance during pregnancy.

What happens if I miss a dose of aciclovir cold sore cream?

If you forget to apply the cream at one of your scheduled times, apply it as soon as you remember and then continue with your usual schedule. Do not apply a double amount to make up for a missed application. Consistency is important — try to space your five daily applications as evenly as possible throughout the day.

Is aciclovir cold sore cream the same as aciclovir tablets?

No — they are different formulations of the same active ingredient. The cream is applied directly to the skin and works locally at the site of the cold sore, with very little absorption into the bloodstream. Aciclovir tablets are taken orally and work systemically throughout the body, and are typically reserved for more severe or frequent outbreaks, or for people with weakened immune systems.

What are the alternatives to aciclovir cold sore cream?

The main alternative topical antiviral available over the counter in the UK is penciclovir 1% cream (such as Vectavir), which is applied every two hours while awake for four days. Other options include cold sore patches that protect the area and create a moist healing environment. For frequent or severe outbreaks, your GP may prescribe oral aciclovir or valaciclovir tablets. You can also explore our oral health range for complementary lip and mouth care products.

How long can I keep using aciclovir cold sore cream?

Each course of treatment should last five days, with a maximum of ten days if the cold sore has not fully healed. This cream is intended for episodic use — meaning you use it when a cold sore appears, not continuously. If you are getting cold sores very frequently (more than six times a year), speak to your GP about whether a suppressive antiviral therapy might be more appropriate for you.

Can aciclovir cold sore cream be used on children?

This cream is not recommended for children under 12 years of age without specific medical advice. For young people aged 12 and over, it can be used under pharmacist guidance following the same dosage instructions as adults. If your child is under 12 and has a cold sore, speak to your GP or pharmacist for appropriate advice.

Does aciclovir cold sore cream prevent cold sores from coming back?

No — aciclovir cold sore cream treats an active outbreak but does not prevent future cold sores or eliminate the herpes simplex virus from your body. The virus remains dormant in nerve cells and can reactivate when triggered by factors like stress, illness, or sun exposure. Protecting your lips from UV light with an SPF lip balm may help reduce sun-triggered outbreaks.

What are the latest findings on aciclovir cold sore cream?

Aciclovir 5% cream remains a well-established, evidence-based treatment for herpes labialis and continues to be recommended by the NHS and BNF for episodic cold sore management. Research consistently supports early application as the key factor in treatment success. For the most up-to-date clinical guidance, the NHS and NICE provide regularly reviewed information on antiviral treatments. You can also find related products in our creams and ointments collection.

How Should You Use Aciclovir Cold Sore Cream?

Apply this cream at the first sign of a cold sore — don't wait for a blister to appear. The tingling or itching you feel before a cold sore breaks out is your cue to start treatment. Using it early gives the active ingredient the best opportunity to limit the outbreak.

Follow these steps each time you apply the cream:

What Is the Correct Dose of Aciclovir Cold Sore Cream?

The standard dose is a small amount of cream applied five times daily, spaced approximately four hours apart. Do not apply more than this — using extra cream will not speed up healing and may increase the risk of skin irritation.

When Is the Best Time to Use Aciclovir Cold Sore Cream?

Timing really matters with this treatment. The ideal moment to start is during the prodromal phase — that early tingling, itching, or warmth you feel before any visible blister appears. Many people learn to recognise this sensation after their first few outbreaks.

Space your five daily applications evenly throughout your waking hours. For example, if you wake at 7am, you might apply at 7am, 11am, 3pm, 7pm, and 11pm. You do not need to set an alarm during the night — simply resume your schedule the following morning.

How Long Can You Use Aciclovir Cold Sore Cream For?

The standard treatment course is five days. If the cold sore has not fully healed after five days, you may continue for a further five days — giving a maximum of ten days in total. Do not use the cream for longer than ten days without speaking to your pharmacist or GP.

This cream is for episodic use only — meaning you use it when a cold sore appears, not as a daily preventative. If you find yourself needing treatment more than six times a year, speak to your GP about whether a longer-term antiviral strategy might be more suitable for you.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Aciclovir Cold Sore Cream?

Most people tolerate aciclovir cold sore cream well, and side effects — when they do occur — are usually mild and confined to the area where the cream has been applied. You might notice a brief stinging or burning sensation immediately after application, particularly if the skin around the cold sore is already broken or inflamed. This typically settles within a few minutes.

  • Mild burning or stinging at the application site
  • Itching or tingling of the skin
  • Skin dryness or flaking around the treated area

What Are the Less Common Side Effects of Aciclovir Cold Sore Cream?

Less commonly, some people experience a more noticeable skin reaction. This can happen if you have a sensitivity to one of the inactive ingredients — in particular, propylene glycol, which is used as a base in the cream formulation. If you notice persistent redness or irritation that doesn't settle, stop using the cream and speak to your pharmacist.

  • Temporary redness or erythema at the application site
  • Contact dermatitis — an inflammatory skin reaction
  • Localised swelling (oedema) around the treated area
  • Skin peeling beyond normal dryness

What Are the Serious Side Effects of Aciclovir Cold Sore Cream?

Serious side effects from topical aciclovir are very rare. However, a small number of people may experience a hypersensitivity or allergic reaction. This is more likely if you have a known allergy to aciclovir, valaciclovir, or related compounds. Symptoms of a serious allergic reaction include swelling of the face, lips, tongue, or throat, difficulty breathing, a widespread skin rash, or dizziness.

If you experience any of these symptoms, stop using the cream immediately, call 999, or go to your nearest accident and emergency department. Do not attempt to manage a suspected anaphylactic reaction at home.

What Should You Do If You Experience Side Effects of Aciclovir Cold Sore Cream?

For mild side effects such as stinging or dryness, you can usually continue treatment — these often resolve on their own as your skin adjusts. Avoid applying the cream to broken or severely inflamed skin beyond the cold sore itself, as this can increase irritation. If side effects are persistent, worsening, or causing you significant discomfort, stop using the cream and seek advice from your pharmacist or GP.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety information for everyone.

Can Aciclovir Cold Sore Cream Interact With Other Medicines?

No clinically significant drug interactions have been identified for topical aciclovir at standard doses, because systemic absorption through the skin is very low. However, if you are taking oral antiviral medicines, immunosuppressants, or medicines that affect kidney function, it is always worth mentioning this to your pharmacist before starting any new treatment — even a topical one. This is especially important if you are using multiple topical products on the same area of skin at the same time.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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