Wegovy Versus Mounjaro UK - Compare Prices & Effectiveness

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Wegovy vs Mounjaro - Compare Prices & Cheapest UK Option

Compare Wegovy and Mounjaro at the cheapest UK price — Save £20 off with code Weightlossnew.

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£145.00 From £124.99 £20 discount using discount code Weightlossnew
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Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£109 £89.00

£22.25 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £109
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy (Oral Pill)
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00 £63.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £83.00
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Wegovy (Oral Pill)
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00 £90.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £110.00
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Wegovy (Oral Pill)
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00 £120.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £140.00
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Wegovy (Oral Pill)
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00 £179.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199.00
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Wegovy Versus Mounjaro: Which Weight Loss Injection Works Best?

When comparing wegovy versus mounjaro, both are highly effective GLP-1 receptor agonist injections licensed in the UK for chronic weight management, but they differ in their mechanisms, efficacy rates, and dosing schedules. Wegovy (semaglutide) acts on GLP-1 receptors alone, while Mounjaro (tirzepatide) is a dual GIP/GLP-1 receptor agonist that targets two incretin pathways simultaneously. Clinical trial data shows Mounjaro typically produces greater average weight loss, though both medications require prescription assessment by a UK-registered prescriber and are subject to individual response and tolerability.

How Do Wegovy Versus Mounjaro Work Differently?

Understanding wegovy versus mounjaro begins with their distinct mechanisms of action. Wegovy contains semaglutide, a selective GLP-1 (glucagon-like peptide-1) receptor agonist that mimics the natural incretin hormone released after eating [1]. This action slows gastric emptying, reduces appetite signals to the brain, and enhances feelings of satiety, leading to reduced caloric intake over time.

Mounjaro contains tirzepatide, the first dual GIP/GLP-1 receptor agonist approved for weight management in the UK. By activating both glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors, tirzepatide offers a synergistic effect on appetite regulation, insulin secretion, and energy expenditure [2]. This dual mechanism may explain why Mounjaro often achieves higher average weight loss percentages in head-to-head comparisons, though individual responses vary considerably based on metabolic factors, adherence, and lifestyle modifications.

Wegovy Versus Mounjaro: Clinical Trial Efficacy Data

When evaluating wegovy versus mounjaro for weight loss outcomes, clinical trial data provides essential context. The STEP programme trials for Wegovy demonstrated an average weight loss of 15% of initial body weight over 68 weeks in adults without diabetes, with participants losing approximately 15.3 kg on average [1]. These results established semaglutide as one of the most effective pharmacological weight loss interventions available in the UK.

The SURPASS trials for Mounjaro showed even more substantial results, with the highest dose (15 mg weekly) producing average weight loss up to 22.5% of baseline body weight over 72 weeks in participants with type 2 diabetes [2]. The SURMOUNT-1 trial, which studied tirzepatide specifically for weight management in adults without diabetes, reported average weight reductions of 15%, 19.5%, and 20.9% for the 5 mg, 10 mg, and 15 mg doses respectively [3]. While these figures suggest Mounjaro may offer superior weight loss potential on average, individual results depend on numerous factors including starting BMI, adherence to dosing schedules, dietary modifications, and physical activity levels.

Real-World Effectiveness Considerations

Beyond controlled trial environments, real-world effectiveness of wegovy versus mounjaro depends on patient-specific factors such as tolerance to gastrointestinal side effects, injection frequency preferences, and previous treatment history. Both medications require gradual dose escalation to minimise adverse effects, and some patients may achieve optimal results on lower maintenance doses than the maximum studied in trials. UK prescribers assess individual suitability during clinical consultations, considering medical history, contraindications, and weight loss goals before recommending either treatment.

Dosing Schedules: Wegovy Versus Mounjaro Administration

The dosing regimens for wegovy versus mounjaro differ in their escalation protocols and final maintenance doses. Wegovy follows a monthly dose escalation starting at 0.25 mg weekly, increasing through 0.5 mg, 1 mg, and 1.7 mg, before reaching the maintenance dose of 2.4 mg once weekly [1]. This gradual titration over approximately 16-20 weeks helps minimise gastrointestinal side effects such as nausea and vomiting, which are the most common reasons for treatment discontinuation.

Mounjaro uses a similar escalation approach but with different dose increments: starting at 2.5 mg weekly, then increasing every four weeks through 5 mg, 7.5 mg, 10 mg, 12.5 mg, to a maximum of 15 mg weekly [2]. The slower titration allows the body to adjust to the dual receptor activation, and many patients achieve satisfactory weight loss on intermediate doses without requiring the maximum 15 mg. Both treatments are administered via subcutaneous injection in the abdomen, thigh, or upper arm, and patients can self-administer after initial training from a healthcare professional.

Feature Wegovy (Semaglutide) Mounjaro (Tirzepatide)
Active Ingredient Semaglutide Tirzepatide
Mechanism GLP-1 receptor agonist Dual GIP/GLP-1 receptor agonist
Dosing Frequency Once weekly injection Once weekly injection
Starting Dose 0.25 mg weekly 2.5 mg weekly
Maintenance Dose 2.4 mg weekly 5-15 mg weekly
Average Weight Loss 15% body weight (68 weeks) Up to 20.9% body weight (72 weeks)
Price at Cured Pharmacy From £89.00 From £145.00
Common Side Effects Nausea, diarrhoea, vomiting Nausea, diarrhoea, vomiting
Prescription Required Yes - UK prescriber assessment Yes - UK prescriber assessment

Side Effects: Wegovy Versus Mounjaro Tolerability

Comparing side effects in wegovy versus mounjaro reveals similar gastrointestinal adverse event profiles, as both medications slow gastric emptying and affect gut motility. The most frequently reported side effects for both treatments include nausea (occurring in 20-44% of patients), diarrhoea, vomiting, constipation, and abdominal discomfort [1][2]. These effects are typically most pronounced during dose escalation phases and often diminish as the body adapts to treatment over several weeks.

Mounjaro's dual receptor mechanism may produce slightly higher rates of gastrointestinal side effects in some studies, though the difference is not always clinically significant when compared at equivalent weight loss magnitudes [3]. Both medications carry warnings for potential thyroid C-cell tumours (observed in rodent studies but not conclusively demonstrated in humans), pancreatitis, gallbladder disease, and hypoglycaemia when used with other glucose-lowering medications. Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use either medication [4]. UK prescribers conduct thorough medical history assessments to identify contraindications before initiating treatment.

Managing Side Effects During Treatment

When experiencing side effects with wegovy versus mounjaro, several strategies can improve tolerability: eating smaller, more frequent meals; avoiding high-fat or greasy foods; staying well-hydrated; and injecting at consistent times each week. If side effects become severe or persistent, UK prescribers may recommend remaining at the current dose for an additional month before escalating, or in some cases, reducing to the previous tolerated dose. Never adjust dosing without consulting your prescriber, as proper titration is essential for both safety and optimal weight loss outcomes.

Cost Comparison: Wegovy Versus Mounjaro UK Pricing

When evaluating wegovy versus mounjaro from a cost perspective, Wegovy is currently priced from £124.99 at Cured Pharmacy, while Mounjaro starts from £124.99, reflecting differences in formulation complexity and market positioning [5]. Both prices include free online consultation with a UK-registered prescriber and discreet next-day delivery across the UK. New patients can Save £20 on their first order using code Weightlossnew, making Wegovy available from £124.99 and Mounjaro from £124.99 for initial treatment.

The total cost over a full treatment course depends on the maintenance dose achieved and treatment duration, which typically ranges from 6 to 12 months or longer for sustained weight management. While Mounjaro carries a higher per-dose price, some patients may achieve their target weight loss on lower maintenance doses due to its enhanced efficacy, potentially offsetting the initial cost difference. UK patients should discuss both clinical suitability and financial considerations during their prescriber consultation to determine the most appropriate and sustainable treatment option. Neither medication is routinely available on NHS prescription for weight management alone, though availability varies by local Integrated Care Board criteria.

Which Is Right for You: Wegovy Versus Mounjaro Selection

Choosing between wegovy versus mounjaro requires individualised clinical assessment by a UK-registered prescriber who considers your medical history, weight loss goals, previous treatment responses, and tolerance for potential side effects. Wegovy may be preferred for patients seeking a well-established treatment with extensive real-world safety data and lower cost, particularly if modest to moderate weight loss (10-15% of body weight) aligns with their goals.

Mounjaro may be more suitable for patients who require maximal weight loss efficacy, have not achieved adequate results with GLP-1 agonists alone, or have concurrent type 2 diabetes that would benefit from the dual receptor mechanism's glucose-lowering effects [2]. However, the higher incidence of gastrointestinal side effects and increased cost must be weighed against potential benefits. Both treatments are contraindicated in pregnancy, and effective contraception is essential for women of childbearing potential due to the extended elimination half-life of these medications [4].

At Cured Pharmacy, our UK-registered clinical team conducts comprehensive online assessments to determine eligibility and recommend the most appropriate treatment based on your individual circumstances. The consultation process takes under three minutes, and our superintendent pharmacist Tarun Kumar (GPhC 2233073) oversees all clinical decisions to ensure safe, evidence-based prescribing. All medications are genuine UK-licensed products dispensed from our GPhC-registered pharmacy (9012511), with transparent pricing displayed before consultation and no hidden fees.

Starting Your Weight Loss Journey

Whether you choose Wegovy or Mounjaro after clinical assessment, successful weight loss requires commitment to lifestyle modifications alongside medication. Both treatments work best when combined with a reduced-calorie diet and increased physical activity, as demonstrated in clinical trials where all participants received nutritional counselling [1][2]. Regular follow-up with your prescriber allows for dose adjustments, side effect management, and monitoring of weight loss progress to optimise outcomes throughout your treatment course.

Scientific References

  1. Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., ... & Kushner, R. F. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989-1002.
  2. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., ... & Garvey, W. T. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205-216.
  3. Rosenstock, J., Wysham, C., Frías, J. P., Kaneko, S., Lee, C. J., Fernández Landó, L., ... & Garvey, W. T. (2021). Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial. The Lancet, 398(10295), 143-155.
  4. Medicines and Healthcare products Regulatory Agency. (2023). Semaglutide and tirzepatide: Important safety information for healthcare professionals. MHRA Drug Safety Update.
  5. Cured Pharmacy. (2025). Weight Loss Treatment Pricing. Retrieved from https://curedpharmacy.com/collections/weight-loss

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication.

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Faq

Is Mounjaro more effective than Wegovy for weight loss?
Clinical trial data suggests Mounjaro (tirzepatide) produces higher average weight loss percentages than Wegovy (semaglutide), with the highest Mounjaro dose achieving up to 20.9% body weight reduction compared to Wegovy's 15% average. However, individual responses vary, and both medications are highly effective when combined with lifestyle modifications and prescribed appropriately by a UK clinician.
Can I switch from Wegovy to Mounjaro or vice versa?
Switching between wegovy versus mounjaro is possible under prescriber supervision, though it requires careful dose adjustment and monitoring. Your UK prescriber will assess your response to the initial treatment, reasons for switching, and determine the appropriate starting dose of the new medication to minimise side effects and maintain weight loss progress.
Do Wegovy and Mounjaro have the same side effects?
Wegovy versus mounjaro share similar side effect profiles, predominantly gastrointestinal symptoms including nausea, diarrhoea, vomiting, and constipation. Mounjaro's dual receptor mechanism may produce slightly higher rates of these effects in some patients, though both medications typically see side effects diminish after the initial dose escalation period.
Which is cheaper in the UK: Wegovy or Mounjaro?
Wegovy is more affordable, starting from £124.99 at Cured Pharmacy, while Mounjaro starts from £124.99. New patients can Save £20 on their first order with code Weightlossnew, and both prices include free UK prescriber consultation and next-day delivery.
How long does it take to see results with Wegovy versus Mounjaro?
Most patients begin noticing weight loss within 4-8 weeks of starting either wegovy versus mounjaro, with progressive weight reduction continuing throughout dose escalation and maintenance phases. Maximum weight loss typically occurs between 60-72 weeks of continuous treatment when combined with dietary modifications and increased physical activity.
Can I use Wegovy or Mounjaro if I have type 2 diabetes?
Both Wegovy and Mounjaro are suitable for patients with type 2 diabetes, though Mounjaro is specifically licensed for diabetes management as well as weight loss. Your UK prescriber will assess your current diabetes medications, HbA1c levels, and hypoglycaemia risk before prescribing either treatment, as dose adjustments to other glucose-lowering medications may be necessary.
Do I need to inject Wegovy and Mounjaro in the same way?
Yes, both wegovy versus mounjaro are administered as once-weekly subcutaneous injections in the abdomen, thigh, or upper arm using pre-filled injection pens. The injection technique is identical for both medications, and patients receive training on proper administration during their initial consultation with the prescribing clinician.
What happens if I stop taking Wegovy or Mounjaro?
Weight regain is common after discontinuing either wegovy versus mounjaro, as the appetite-suppressing effects diminish once the medication clears from your system. Clinical trials show many patients regain a significant portion of lost weight within one year of stopping treatment. Long-term weight maintenance typically requires continued medication use alongside sustained lifestyle modifications, though individual responses vary.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Last reviewed: 29 July 2026