Mysimba vs Mounjaro UK: Prices from £135.00 | Cured Pharmacy

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Mysimba vs Mounjaro - Cheapest UK Price £124.99

Compare Mysimba and Mounjaro costs with the cheapest UK price from £124.99 plus £20 off your first order with code Weightlossnew.

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£145.00 From £124.99 £10 discount using discount code Weightlossnew
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Our Pricing

Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£99 £79.00

£19.75 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £99
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Mysimba vs Mounjaro: Lowest Prices in the UK

When searching for mysimba vs mounjaro uk price comparison, understanding the clinical differences between these two MHRA-licensed weight loss treatments is essential. At Cured Pharmacy, our UK-registered clinical team helps you choose between oral Mysimba tablets and injectable Mounjaro based on your medical history, weight loss goals, and lifestyle preferences—with transparent pricing and free online consultations under three minutes.

How Mysimba and Mounjaro Work Differently

Mysimba (naltrexone/bupropion) is an oral tablet combining two active ingredients that work on the central nervous system to reduce appetite and food cravings [1]. Taken twice daily, it modulates reward pathways in the brain associated with eating behaviour, making it easier to adhere to reduced-calorie diets.

Mounjaro contains tirzepatide, the first dual GIP/GLP-1 receptor agonist licensed by the MHRA for weight management [2]. Administered as a once-weekly subcutaneous injection, tirzepatide activates two complementary hormone pathways that regulate blood glucose, slow gastric emptying, and suppress appetite. In the SURMOUNT-1 trial, participants achieved an average body weight reduction of 22.5% over 72 weeks on the highest maintenance dose [2].

The fundamental difference lies in mechanism: Mysimba acts centrally on brain receptors controlling hunger signals, whilst Mounjaro mimics natural gut hormones to regulate appetite, satiety, and glucose metabolism peripherally. Both require prescription assessment by a UK prescriber before dispensing.

Mysimba vs Mounjaro: Clinical Efficacy Compared

Clinical trial data demonstrates distinct efficacy profiles. In the COR-I trial, Mysimba patients achieved an average weight loss of 5-6% of initial body weight over 56 weeks when combined with lifestyle modification [1]. Approximately 42% of participants lost at least 5% of their body weight, and 21% achieved 10% or greater reduction.

Mounjaro's SURMOUNT trial programme showed substantially greater weight reduction, with participants on the 15mg maintenance dose losing an average of 22.5% of their starting weight over 72 weeks [2]. Approximately 91% of participants achieved at least 5% weight loss, and 57% reached 20% or greater reduction. These results represent some of the highest efficacy figures observed in obesity pharmacotherapy trials to date.

Your UK prescriber will consider these efficacy differences alongside your BMI, comorbidities, previous treatment responses, and personal preferences. Patients who prefer oral medication and have contraindications to injectable treatments may find Mysimba more suitable, whilst those seeking maximum weight reduction potential may be better candidates for Mounjaro, subject to clinical assessment.

Real-World Effectiveness Considerations

Clinical trial results represent controlled conditions with intensive lifestyle support. Real-world effectiveness depends on adherence, dietary modifications, physical activity levels, and individual metabolic responses. Our superintendent pharmacist Tarun Kumar (GPhC 2233073) emphasises that neither medication replaces the need for sustainable behaviour change—both work best as part of a comprehensive weight management programme including nutritional counselling and increased physical activity.

Administration, Dosing, and Treatment Duration

Mysimba requires twice-daily oral administration, with a gradual dose escalation over four weeks to minimise side effects. The maintenance dose is two tablets twice daily (naltrexone 16mg/bupropion 180mg per dose). Treatment should be discontinued if patients have not lost at least 5% of initial body weight after 16 weeks at the maintenance dose, as per MHRA guidance.

Mounjaro is administered as a once-weekly subcutaneous injection using a pre-filled KwikPen device. Treatment begins at 2.5mg weekly for four weeks, then increases to 5mg weekly. The dose may be further escalated in 2.5mg increments every four weeks based on individual response and tolerability, up to a maximum of 15mg weekly [2]. Injections are self-administered into the abdomen, thigh, or upper arm.

Many patients find the once-weekly injection schedule more convenient than twice-daily tablets, though needle anxiety remains a consideration for some individuals. Your UK prescriber will discuss administration preferences during your clinical assessment to determine which regimen aligns better with your lifestyle and medical history.

What to Expect During Treatment Initiation

Both medications require gradual dose escalation to improve gastrointestinal tolerability. With Mysimba, the first week involves one tablet daily, increasing weekly until reaching the full four-tablet daily dose by week four. Mounjaro's escalation occurs monthly rather than weekly, allowing the body to adjust to each dose increment before progression. Our clinical team provides detailed administration guidance and ongoing support throughout your treatment journey.

Treatment Type Frequency Starting Price
Mounjaro (Tirzepatide) Injectable GLP-1/GIP Once weekly From £124.99
Wegovy (Semaglutide) Injectable GLP-1 Once weekly From £69.00
Saxenda (Liraglutide) Injectable GLP-1 Daily injection From £68.00
Orlistat Oral fat blocker Three times daily From £32.00
Xenical (Orlistat) Oral fat blocker Three times daily From £32.00

Side Effects and Safety Profiles

Mysimba's most common side effects include nausea, constipation, headache, vomiting, dizziness, insomnia, and dry mouth [1]. These typically diminish after the first few weeks. Mysimba carries contraindications including uncontrolled hypertension, seizure disorders, eating disorders, and concurrent use of opioid medications. It should not be used during pregnancy or by patients with severe hepatic or renal impairment.

Mounjaro's side effect profile centres on gastrointestinal symptoms: nausea, diarrhoea, vomiting, constipation, and abdominal discomfort [2]. These effects are generally dose-dependent and improve with continued use. Mounjaro carries warnings regarding thyroid C-cell tumours (based on rodent studies), pancreatitis risk, and gallbladder disease. It is contraindicated in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.

Both medications require blood pressure monitoring, and patients with cardiovascular disease require careful assessment. Your UK prescriber will review your complete medical history, current medications, and contraindications before determining suitability for either treatment. All prescription medicines dispensed by Cured Pharmacy require prior clinical assessment by our UK-registered prescribers.

Mysimba vs Mounjaro UK Pricing and Value

At Cured Pharmacy, Mounjaro is available from £124.99 for UK patients following successful clinical assessment. We guarantee the lowest prices in the UK with transparent upfront pricing displayed before your consultation—no hidden fees or surprise charges at checkout.

Pricing for weight loss medications varies based on dose strength and treatment duration. Our comparison table below shows starting prices for all weight loss treatments available through Cured Pharmacy, allowing you to make informed decisions about cost alongside clinical suitability. Remember that the most expensive option is not always the most appropriate—your UK prescriber will recommend treatment based on medical factors, not price alone.

We offer genuine UK-licensed medicines only, dispensed by our GPhC-registered pharmacy (9012511) with discreet packaging and reliable delivery. Unlike some providers, we display prices transparently before you begin your consultation, so you know exactly what to expect. Our clinical team provides free online assessments typically completed in under three minutes, with no obligation to proceed if the recommended treatment doesn't suit your budget or preferences.

Understanding Treatment Costs Over Time

Weight loss treatment represents an ongoing investment in your health. Most patients require several months of continuous therapy to achieve and maintain meaningful weight reduction. When comparing costs, consider the total programme duration recommended by your prescriber, not just the initial month's price. Our team can discuss flexible treatment plans and help you understand the long-term financial commitment involved in either option.

Choosing Between Mysimba and Mounjaro: Clinical Guidance

The choice between Mysimba and Mounjaro depends on multiple clinical and personal factors. Mounjaro may be more suitable for patients seeking maximum weight loss potential, those with type 2 diabetes (as tirzepatide also improves glycaemic control), or individuals who prefer once-weekly administration [2]. Mysimba may be preferred by patients with needle phobia, those who have contraindications to GLP-1 receptor agonists, or individuals seeking an oral treatment option.

Your BMI, medical history, concurrent medications, and previous weight loss attempts all influence treatment selection. Patients with cardiovascular disease, for example, require careful assessment for both options, whilst those with seizure history cannot use Mysimba. Our UK prescribers evaluate these factors during your free online consultation to recommend the most appropriate and safe option.

Neither treatment is suitable for everyone, and some patients may not be candidates for either medication. Alternative options available through Cured Pharmacy include Wegovy (semaglutide) injections, Saxenda (liraglutide) daily injections, and Orlistat capsules—each with distinct mechanisms, efficacy profiles, and pricing. Our clinical team will discuss all suitable alternatives during your assessment to ensure you receive the treatment best aligned with your medical needs and personal circumstances.

Next Steps: Starting Your Weight Loss Journey

Begin by completing our free online consultation, which takes under three minutes and involves answering questions about your medical history, current medications, and weight loss goals. A UK-registered prescriber will review your assessment and determine whether Mysimba, Mounjaro, or an alternative treatment is clinically appropriate. If approved, your medication is dispensed from our GPhC-registered pharmacy and delivered discreetly to your address. Ongoing support from our clinical team ensures you achieve the best possible outcomes throughout your treatment journey.

Scientific References

  1. Greenway, F. L., et al. (2010). Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet, 376(9741), 595–605. https://doi.org/10.1016/S0140-6736(10)60888-4
  2. Jastreboff, A. M., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038
  3. Wilding, J. P. H., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/NEJMoa2032183
  4. Medicines and Healthcare products Regulatory Agency (MHRA). (2023). Public Assessment Report: Mounjaro 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg and 15 mg solution for injection in pre-filled pen. GOV.UK. https://www.gov.uk/government/publications/mounjaro-tirzepatide

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Individual results may vary, and weight loss outcomes depend on adherence to lifestyle modifications alongside prescribed treatment.

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Faq

Is Mysimba or Mounjaro better for weight loss?
Clinical trials show Mounjaro produces greater average weight loss (up to 22.5% in SURMOUNT-1) compared to Mysimba (5-6% in COR-I trials). However, 'better' depends on individual medical suitability, preferences, and tolerability—your UK prescriber will recommend the most appropriate option during your clinical assessment.
Can I switch from Mysimba to Mounjaro?
Switching between weight loss medications is possible subject to clinical assessment by a UK prescriber. Your prescriber will evaluate your response to Mysimba, reasons for switching, and medical suitability for Mounjaro before approving any treatment change.
How much does Mounjaro cost in the UK?
Mounjaro starts from £124.99 at Cured Pharmacy, with final pricing dependent on your prescribed dose strength. We guarantee the lowest prices in the UK with transparent upfront pricing displayed before your consultation.
Do I need a prescription for Mysimba or Mounjaro?
Yes, both Mysimba and Mounjaro are prescription-only medicines in the UK and require clinical assessment by a UK-registered prescriber before dispensing. Cured Pharmacy provides free online consultations typically completed in under three minutes.
What are the main side effects of Mysimba vs Mounjaro?
Mysimba commonly causes nausea, constipation, headache, and insomnia. Mounjaro's main side effects are gastrointestinal—nausea, diarrhoea, vomiting, and abdominal discomfort. Both medications' side effects typically improve after the initial weeks of treatment.
How long does it take to see results with Mysimba vs Mounjaro?
Most patients begin noticing weight loss within 4-8 weeks of starting either medication, though individual responses vary. Mysimba guidelines recommend discontinuation if less than 5% weight loss occurs after 16 weeks at maintenance dose, whilst Mounjaro's effects typically become more pronounced with dose escalation over several months.
Can I get Mysimba vs Mounjaro on the NHS?
NHS availability varies by region and depends on local commissioning decisions and eligibility criteria. Private prescription through registered UK pharmacies like Cured Pharmacy offers guaranteed access subject to clinical suitability, with transparent pricing and rapid treatment initiation.
Are Mysimba and Mounjaro safe for long-term use?
Both medications have been studied for extended periods in clinical trials and can be used long-term under medical supervision. Regular monitoring by your prescriber ensures ongoing safety and effectiveness, with treatment adjustments made as needed based on your response and any emerging side effects.
Which is cheaper in the UK - Mysimba or Mounjaro?
Mysimba is generally cheaper upfront at around £39.99-£49.99 per month, while Mounjaro starts at £124.99 monthly. However, Mounjaro typically delivers greater weight loss results, making it more cost-effective per kilogram lost when comparing Mysimba vs Mounjaro UK price.
Can I switch from Mysimba to Mounjaro with Cured Pharmacy?
Yes, you can switch from Mysimba to Mounjaro through Cured Pharmacy after a consultation with our UK-registered prescribers. Many patients transition to Mounjaro for improved results, and we'll assess your suitability and provide guidance on safely stopping Mysimba before starting Mounjaro.
How does the Mysimba vs Mounjaro UK price comparison work across all doses?
Mysimba has a fixed monthly cost, while Mounjaro pricing increases with dose escalation from £124.99 (2.5mg) to £267.00 (15mg). Though Mounjaro becomes more expensive at higher doses, most patients achieve their goals on mid-range doses, with Cured Pharmacy offering £20 off your first order.
Does Mounjaro work faster than Mysimba for weight loss?
Clinical studies show Mounjaro typically produces faster and greater weight loss than Mysimba, with patients losing 15-20% body weight versus 5-10% with Mysimba. While Mysimba works through appetite suppression alone, Mounjaro targets multiple pathways including blood sugar control and satiety hormones for more comprehensive results.
Can I use the Weightlossnew discount code for both Mysimba and Mounjaro?
Yes, Cured Pharmacy's Weightlossnew code gives you £20 off your first order of either Mysimba or Mounjaro. This discount makes trying Mounjaro more affordable at £124.99 (reduced from £144.99) for the 2.5mg starting dose, helping you compare both treatments cost-effectively.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Last reviewed: 17 July 2026