Mounjaro vs Wegovy UK - Compare Prices & Efficacy

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Mounjaro vs Wegovy - Compare Cheapest UK Prices

Compare Mounjaro vs Wegovy at the cheapest UK prices from £124.99 — Save £20 off with code Weightlossnew.

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Woman using Cured Pharmacy online consultation for weight loss treatment

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Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£109 £89.00

£22.25 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £109
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy (Oral Pill)
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00 £63.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £83.00
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Wegovy (Oral Pill)
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00 £90.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £110.00
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Wegovy (Oral Pill)
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00 £120.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £140.00
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Wegovy (Oral Pill)
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00 £179.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199.00
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Mounjaro vs Wegovy: Clinical Comparison & Evidence-Based Guide

When comparing Mounjaro vs Wegovy, UK patients often ask which weight loss injection delivers superior results. Both are licensed GLP-1 receptor agonists manufactured by Novo Nordisk and Eli Lilly respectively, but they differ significantly in mechanism, efficacy, and cost. This evidence-based comparison examines clinical trial data, real-world outcomes, and practical considerations to help you make an informed choice with your prescriber.

Mounjaro vs Wegovy: Active Ingredients & Mechanism of Action

The fundamental difference in the Mounjaro vs Wegovy comparison lies in their active ingredients and pharmacological mechanisms. Mounjaro contains tirzepatide, a dual GLP-1 and GIP receptor agonist, whilst Wegovy contains semaglutide, a selective GLP-1 receptor agonist [1]. This dual-action mechanism gives Mounjaro a theoretical advantage in metabolic regulation, targeting both incretin pathways simultaneously rather than one.

Tirzepatide's dual agonism means it activates both glucose-dependent insulinotropic polypeptide (GIP) receptors and glucagon-like peptide-1 (GLP-1) receptors, enhancing insulin secretion, suppressing glucagon, and slowing gastric emptying through two complementary pathways [1]. Semaglutide works exclusively through GLP-1 receptors, achieving similar metabolic effects but through a single mechanism. Both medications reduce appetite centrally via hypothalamic pathways, but tirzepatide's additional GIP activity may contribute to enhanced fat metabolism and improved insulin sensitivity [2].

Mounjaro vs Wegovy Weight Loss Results: Clinical Trial Data

Head-to-head clinical data comparing Mounjaro vs Wegovy directly is limited, but individual trial programmes provide robust comparative context. The SURMOUNT-1 trial demonstrated that tirzepatide (Mounjaro) achieved average weight loss of 15-22.5% of body weight over 72 weeks, depending on dose [2]. By comparison, the STEP 1 trial showed semaglutide 2.4mg (Wegovy) delivered average weight loss of 14.9% over 68 weeks [3].

At maximum doses, Mounjaro 15mg produced superior weight reduction compared to Wegovy 2.4mg in indirect comparisons, with approximately 22.5% versus 14.9% total body weight loss respectively [2][3]. However, individual response varies significantly based on baseline BMI, adherence, lifestyle modifications, and metabolic factors. Both medications require concurrent dietary changes and increased physical activity to optimise outcomes, as confirmed by NICE guidance on weight management interventions [4].

Real-World Effectiveness Beyond Trials

Real-world evidence suggests both Mounjaro and Wegovy maintain clinically significant weight loss beyond controlled trial settings, though adherence rates and tolerability influence long-term outcomes. UK prescribers report that patients on tirzepatide may experience slightly greater weight reduction in the first six months, but semaglutide often demonstrates better gastrointestinal tolerability in clinical practice. Subject to individual assessment, your prescriber will consider your medical history, previous medication responses, and weight loss goals when recommending between these options.

Mounjaro vs Wegovy Dosing & Treatment Schedules

Dosing protocols differ substantially in the Mounjaro vs Wegovy comparison, affecting both convenience and tolerability. Mounjaro follows a monthly escalation schedule starting at 2.5mg weekly, increasing to 5mg, 7.5mg, 10mg, 12.5mg, and maximum 15mg over approximately five months [1]. Wegovy uses a faster escalation: 0.25mg weekly for four weeks, then 0.5mg, 1mg, 1.7mg, reaching maintenance dose of 2.4mg within 16-20 weeks [3].

Both medications are administered as once-weekly subcutaneous injections using pre-filled pens. The slower titration schedule of Mounjaro may reduce gastrointestinal side effects during dose escalation, whilst Wegovy's faster ramp-up allows patients to reach therapeutic doses sooner. UK prescribers typically assess tolerability at each dose increase and may pause escalation if side effects occur, ensuring treatment remains tolerable whilst maximising efficacy.

Feature Mounjaro Wegovy
Active Ingredient Tirzepatide Semaglutide
Mechanism Dual GLP-1/GIP agonist GLP-1 agonist
Average Weight Loss 15-22.5% (72 weeks) 14.9% (68 weeks)
Starting Dose 2.5mg weekly 0.25mg weekly
Maximum Dose 15mg weekly 2.4mg weekly
Dose Escalation Monthly (5 months) Monthly (4-5 months)
UK Price (Cured Pharmacy) From £145.00 From £89.00
Administration Weekly injection Weekly injection
Common Side Effects Nausea, diarrhoea, vomiting Nausea, diarrhoea, vomiting
UK Availability Consistent supply Improved availability 2024

Mounjaro vs Wegovy Side Effects & Safety Profile

The side effect profiles of Mounjaro vs Wegovy are broadly similar, reflecting their shared GLP-1 mechanism. The most common adverse effects for both medications include nausea, diarrhoea, vomiting, constipation, and abdominal discomfort, typically most pronounced during dose escalation [2][3]. In clinical trials, approximately 44% of Mounjaro patients and 44% of Wegovy patients experienced nausea, though severity varied.

Serious but rare side effects include pancreatitis, gallbladder disease, and thyroid C-cell tumours (observed in rodent studies but not confirmed in humans). Both medications carry a boxed warning regarding thyroid medullary carcinoma risk and are contraindicated in patients with personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 [1][3]. UK prescribers conduct thorough medical history reviews during consultation to identify contraindications before prescribing either medication.

Managing Side Effects in Clinical Practice

UK clinical experience suggests gastrointestinal side effects can be minimised through slower dose escalation, smaller meal portions, and avoiding high-fat foods. Patients should report persistent vomiting, severe abdominal pain, or signs of pancreatitis immediately to their prescriber. Both Mounjaro and Wegovy require ongoing clinical monitoring, with regular review of tolerability, weight loss progress, and metabolic parameters throughout treatment.

Mounjaro vs Wegovy Cost & UK Availability

Cost represents a significant consideration in the Mounjaro vs Wegovy comparison for UK patients. At Cured Pharmacy, Mounjaro is available from £124.99 per month following online clinical assessment, whilst Wegovy starts from £124.99 monthly, making it the more affordable option for many patients [5]. Both medications require private prescription in the UK, as NHS availability remains limited to specialist weight management services meeting strict eligibility criteria.

Supply stability has historically favoured Mounjaro, which has maintained consistent UK availability since launch. Wegovy experienced significant supply disruptions throughout 2022-2023 due to global demand, though availability has improved substantially in 2024. When comparing Mounjaro vs Wegovy, patients should consider both upfront cost and long-term treatment sustainability, as weight loss medications typically require 12-24 months of continuous use to achieve and maintain optimal results [4].

Mounjaro vs Wegovy: Which Should You Choose?

Choosing between Mounjaro vs Wegovy depends on individual clinical factors, budget, and treatment goals. Mounjaro may be preferable for patients seeking maximum weight loss potential and who can accommodate the higher cost, whilst Wegovy offers proven efficacy at a more accessible price point. Both medications require commitment to lifestyle modification, regular clinical monitoring, and long-term adherence to maintain weight loss.

Your UK prescriber will assess your BMI, medical history, previous weight loss attempts, contraindications, and personal preferences during consultation. At Cured Pharmacy, our clinical team provides personalised recommendations based on your individual circumstances, ensuring you receive the most appropriate treatment under ongoing pharmacist supervision. All prescriptions are subject to clinical approval by our UK-registered prescribers, with Superintendent Pharmacist Tarun Kumar (GPhC 2233073) overseeing dispensing and patient safety protocols.

Starting Your Weight Loss Journey

Whether you choose Mounjaro or Wegovy, success requires combining medication with sustainable dietary changes and increased physical activity. UK clinical guidelines recommend structured weight management programmes alongside pharmacotherapy, targeting 5-10% weight loss initially with potential for greater reduction over extended treatment [4]. Our clinical team provides ongoing support throughout your treatment journey, with regular check-ins to monitor progress, manage side effects, and adjust treatment as needed.

Scientific References

  1. Frias, J. P., Davies, M. J., Rosenstock, J., et al. (2021). Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes. New England Journal of Medicine, 385(6), 503-515. [accessed 15 August 2026]
  2. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., et al. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205-216. [accessed 15 August 2026]
  3. Wilding, J. P., Batterham, R. L., Calanna, S., et al. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989-1002. [accessed 15 August 2026]
  4. National Institute for Health and Care Excellence. (2023). Obesity: identification, assessment and management. NICE Clinical Guideline [CG189]. [accessed 15 August 2026]
  5. Cured Pharmacy. (2024). Weight loss treatment pricing and availability. Retrieved from https://curedpharmacy.com/collections/weight-loss [accessed 15 August 2026]
  6. NHS. (2026). Tirzepatide: a medicine to manage type 2 diabetes and treat obesity. https://www.nhs.uk/medicines/tirzepatide/ Accessed 15 August 2026.
  7. NHS. (2026). Overweight and obesity in adults. https://www.nhs.uk/conditions/overweight-and-obesity/ Accessed 15 August 2026.
  8. NHS England. (2026). Weight management injections. https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/weight-management-injections/ Accessed 15 August 2026.

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication.

Trusted by thousands

Real people, real results

Jane L.

"Brilliant. Lost 4 stone on mounjaro no side effects at all. Cured pharmacy are excellent. Always helpful pens sent out quickly always comes with needles and sterile wipes. If you want to go on GLP-1 go to cured pharmacy. So professional. Thank you cured pharmacy you changed my health and well being."

Ann-Marie

"I absolutely love this product, I have been using 2.5mg as maintenance dose and have managed to control my weight without any side effects and can still eat well balanced meals. The pharmacy is very efficient friendly and helpful I would not purchase from anywhere else."

Sacha W.

"So far I'm really impressed by my results it's crazy cause I'm not snacking like how I used to do and I see my face slimming down already and it's only been 2 and a half weeks. Can't wait to give my feedback in 5 months time thank you cured pharmacy."

Kimberly G.

"Mounjaro has corrected my hormonal weight gain during menopause. I am using it now to maintain that balance. The results for me have been exceptional!"

Jennifer

"Great really helps cure those nasty habits can't wait for my next mounjaro pen."

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Faq

Is Mounjaro better than Wegovy for weight loss?
Clinical trials suggest Mounjaro achieves slightly greater average weight loss (15-22.5%) compared to Wegovy (14.9%), though individual results vary significantly based on adherence, lifestyle factors, and metabolic response.
Can I switch from Wegovy to Mounjaro or vice versa?
Switching between Mounjaro and Wegovy is possible under prescriber supervision, typically with dose adjustment to account for different potencies and mechanisms. Your UK prescriber will determine appropriate transition protocols based on your current dose and tolerability.
Which has fewer side effects, Mounjaro or Wegovy?
Both medications have similar side effect profiles, with nausea, diarrhoea, and vomiting being most common. Some patients tolerate one better than the other, but overall safety profiles are comparable in clinical trials.
How much does Mounjaro vs Wegovy cost in the UK?
At Cured Pharmacy, Wegovy starts from £124.99 monthly whilst Mounjaro costs from £124.99 monthly, both requiring online clinical assessment and prescription approval from UK-registered prescribers.
Do Mounjaro and Wegovy work the same way?
No—Mounjaro is a dual GLP-1/GIP receptor agonist whilst Wegovy works exclusively through GLP-1 receptors, giving Mounjaro an additional metabolic pathway that may contribute to enhanced weight loss.
How long does it take to see results with Mounjaro vs Wegovy?
Most patients notice appetite reduction within 1-2 weeks of starting either medication, with measurable weight loss typically evident by 4-8 weeks. Maximum weight loss occurs over 12-18 months of continuous treatment combined with lifestyle modification.
Are Mounjaro and Wegovy available on the NHS?
NHS availability for both medications is extremely limited, restricted to specialist weight management clinics for patients meeting strict eligibility criteria. Most UK patients access these treatments privately through registered pharmacies like Cured Pharmacy.
Can I use Mounjaro or Wegovy if I have diabetes?
Mounjaro is licensed for type 2 diabetes treatment (at different doses), whilst Wegovy is licensed specifically for weight management. Your prescriber will assess your diabetic status, current medications, and glycaemic control when determining suitability for either treatment.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Reviewed on: June 03, 2026

Last reviewed: 15 August 2026

Last updated on 15 August 2026.

Review History

Our experts continually monitor new findings in health and medicine, and we update our articles when new information becomes available.

Why this page was updated on 15 August 2026

Content checked and updated as part of our periodic review, to ensure accuracy and currentness.

Current version (15 August 2026)

Edited by: The Editorial Team

Medically reviewed by:

Tarun Kumar, GPhC No. 2233073, Prescribing Pharmacist


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