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Tetralysal (Lymecycline) 408mg Capsules

Tetralysal (Lymecycline) 408mg Capsules

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Tetralysal (Lymecycline) 408mg Capsules

 

What is Tetralysal and How Does it Work

Tetralysal contains lymecycline, a tetracycline antibiotic specifically formulated to treat moderate to severe acne. Lymecycline works by inhibiting bacterial protein synthesis, which reduces the growth of Propionibacterium acnes bacteria that contribute to acne formation. This antibiotic also has anti-inflammatory properties that help reduce the redness and swelling associated with acne lesions.

Each Tetralysal capsule contains 408mg of lymecycline, which is equivalent to approximately 300mg of tetracycline base. This formulation provides sustained antibacterial activity throughout the day, making it an effective oral treatment for persistent acne that has not responded to topical treatments alone.

 

Who Can Use Tetralysal Capsules

Tetralysal is prescribed for patients aged 12 years and older who have moderate to severe acne vulgaris. Your doctor will typically prescribe this medication when topical treatments have not provided sufficient improvement or when acne covers a large area of your body. The medication is particularly effective for inflammatory acne, including papules, pustules, and cysts.

You should not take Tetralysal if you are pregnant, breastfeeding, or trying to conceive, as tetracycline antibiotics can affect developing teeth and bones. Children under 12 years should not use this medication. Your doctor will assess your medical history and current medications before prescribing Tetralysal to ensure it is suitable for you.

 

Expected Treatment Timeline and Results

  • Initial improvement may be visible after 6-8 weeks of consistent treatment
  • Significant results typically occur after 12-16 weeks of continuous use
  • Treatment courses usually last 12-24 weeks depending on your response
  • Your doctor will monitor your progress and may adjust treatment duration accordingly

You must complete the full course of treatment as prescribed, even if your acne appears to improve earlier. Stopping treatment too early may result in acne returning or bacterial resistance developing. Your doctor will gradually reduce your dose or switch to maintenance therapy once your acne is under control.

 

Important Safety Information and Precautions

Before starting Tetralysal, inform your doctor about any liver or kidney problems, as these conditions may affect how your body processes the medication. You should also mention any previous allergic reactions to tetracycline antibiotics or any other medications you are currently taking, including supplements and herbal remedies.

Tetralysal can increase your skin's sensitivity to sunlight, making you more prone to sunburn. You should use adequate sun protection, including sunscreen and protective clothing, while taking this medication. Additionally, this antibiotic may reduce the effectiveness of hormonal contraceptives, so discuss alternative contraception methods with your healthcare provider. For those seeking skincare products, you might consider browsing items like aftershave products that complement your treatment routine.

 

Storage and Handling Instructions

Store your Tetralysal capsules in their original packaging at room temperature, away from heat, moisture, and direct sunlight. The medication should be kept in a cool, dry place such as a medicine cabinet or drawer. Do not store the capsules in bathrooms or kitchens where humidity levels may be high.

Check the expiry date on the packaging before taking any capsules, and dispose of any expired medication safely through your local pharmacy's disposal service. Keep the medication in its original container with the patient information leaflet, as this contains important safety and dosage information you may need to reference during treatment.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Store all medicines out of sight and reach of children.

Please read the included leaflet carefully.

Please contact your GP if appropriate.

 

How to Take Tetralysal Capsules

Take one Tetralysal 408mg capsule once daily, preferably at the same time each day to maintain consistent levels in your body. Swallow the capsule whole with a full glass of water while sitting or standing upright. Do not crush, chew, or open the capsules as this may affect how the medication is absorbed and could cause irritation to your mouth and throat.

You should take Tetralysal on an empty stomach, ideally one hour before meals or two hours after eating. This ensures optimal absorption of the medication. Avoid taking the capsule just before lying down, as this may increase the risk of oesophageal irritation. If you experience stomach upset, you may take the capsule with a small amount of food, but this may reduce its effectiveness slightly.

Important Timing and Food Interactions

Do not take Tetralysal with dairy products, antacids, iron supplements, or calcium supplements, as these can significantly reduce the absorption of lymecycline. Leave at least two hours between taking Tetralysal and consuming these products. Similarly, avoid taking the medication with milk, yoghurt, cheese, or calcium-fortified foods within this timeframe.

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In this case, skip the missed dose and continue with your regular schedule. Never take two capsules together to make up for a forgotten dose. Continue taking Tetralysal for the full duration prescribed by your doctor, even if your acne improves before completing the course.

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Side Effects

Like all medicines, Tetralysal (Lymecycline) 408mg Capsules can have side effects, although not everyone will experience them. Most side effects are mild and temporary, occurring most commonly during the first few weeks of treatment as your body adjusts to the medication. If you experience persistent digestive issues, you might find it helpful to maintain good overall health with products like natural health supplements alongside your prescribed treatment.

The most frequently reported side effects include gastrointestinal disturbances such as nausea, stomach pain, and changes in bowel habits. Skin-related reactions, particularly increased sun sensitivity, are also common during treatment.

  • Nausea and stomach discomfort
  • Diarrhoea or loose stools
  • Loss of appetite
  • Headache
  • Dizziness
  • Increased sensitivity to sunlight
  • Skin rash or itching
  • Vaginal thrush in women
  • Tooth discolouration (rare in adults)
  • Oesophageal irritation if not taken correctly
  • Changes in gut bacteria causing digestive upset
  • Temporary worsening of acne in early treatment

If you experience these or any other side effects, speak to your doctor or pharmacist right away. For more information about reporting side effects please see the MHRA Yellow Card Scheme.

Frequently Asked Question

This medicine treats acne by killing (Cutibacterium acnes) the leading bacteria that causes acne and by keeping your pores open. Not only does Tetralysal support the reduction of bacteria growth, it also stops new pores from opening up.

Most people notice results only after 6–8 weeks. But most likely your pharmacist will recommend you keep using the medication for a few months to achieve the best results.

Avoid taking Tetralysal with milk, cheese, or other dairy products close to your dose, as calcium can reduce how well the medicine is absorbed.

Yes, some people notice their acne slightly worsening in the first few weeks of treatment. This is normal and usually settles as the medication starts to work.

Tetralysal works by preventing the bacteria that cause acne from producing the proteins they need to grow and multiply. By stopping this process, the infection gradually clears and inflammation around spots reduces.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What is Tetralysal used for?

This medicine treats acne by killing (Cutibacterium acnes) the leading bacteria that causes acne and by keeping your pores open. Not only does Tetralysal support the reduction of bacteria growth, it also stops new pores from opening up.

How long does it take for Tetralysal to work?

Most people notice results only after 6–8 weeks. But most likely your pharmacist will recommend you keep using the medication for a few months to achieve the best results.

What should I avoid while taking Tetralysal?

Avoid taking Tetralysal with milk, cheese, or other dairy products close to your dose, as calcium can reduce how well the medicine is absorbed.

Can Tetralysal make my skin worse before it gets better?

Yes, some people notice their acne slightly worsening in the first few weeks of treatment. This is normal and usually settles as the medication starts to work.

How Does Tetralysal Work? Tetralysal works by preventing the bacteria that cause acne from producing the proteins they need to grow and multiply. By stopping this process, the infection gradually clears and inflammation around spots reduces.