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Ryaltris Nasal Spray (240 doses)

Ryaltris Nasal Spray (240 doses)

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  • ✔️ Dual-action formula targets sneezing, itch, and congestion simultaneously
  • ✔️ Contains olopatadine and mometasone furoate in one convenient spray
  • ✔️ Suitable for both seasonal hay fever and year-round perennial rhinitis
  • ✔️ 240-dose pack provides a full allergy season supply
  • ✔️ Licensed for adults and adolescents aged 12 and over

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What Is Ryaltris Nasal Spray and How Does It Relieve Allergies?

 

If you've ever tried to manage hay fever with a single nasal spray and still found yourself sneezing through the day, you'll understand the frustration. Ryaltris nasal spray takes a different approach. It combines two active ingredients — olopatadine hydrochloride and mometasone furoate — in a single bottle, targeting both the histamine response and the underlying nasal inflammation that drives allergic rhinitis symptoms. Each actuation delivers 665 micrograms of olopatadine and 25 micrograms of mometasone furoate, working together to address sneezing, itching, a runny nose, and congestion in one go. You can browse our full range of allergy and hay fever treatments if you'd like to compare options before deciding.

Allergic rhinitis affects roughly one in five people in the UK, according to the NHS, and symptoms can significantly disrupt sleep, concentration, and daily life. Whether your rhinitis is seasonal — triggered by tree or grass pollen — or perennial, caused by dust mites or pet dander, Ryaltris nasal spray is licensed for both. The 240-dose pack is particularly practical for longer treatment courses, giving you a consistent supply without needing to reorder frequently.

 

How Does Ryaltris Nasal Spray Work in the Body?

 

The dual-action mechanism is what sets this spray apart from most over-the-counter options. Here's how each ingredient contributes:

  • Olopatadine hydrochloride is a selective H1-receptor antagonist. It blocks histamine from binding to receptors in the nasal mucosa, which reduces sneezing, itching, and a runny nose relatively quickly after application.
  • Mometasone furoate is an intranasal corticosteroid. It works by suppressing the inflammatory cascade in the nasal lining — reducing swelling, mucus production, and congestion. Its effects build over several days of consistent use.
  • Together, these two mechanisms complement each other: the antihistamine provides faster symptom relief while the corticosteroid addresses the deeper inflammatory process.
  • Because mometasone furoate has very low systemic absorption when used intranasally, the risk of steroid-related side effects is considered low at the recommended dose.

 

Who Should Use Ryaltris Nasal Spray?

 

Ryaltris nasal spray is suitable for adults and adolescents aged 12 years and over who experience moderate to severe symptoms of seasonal or perennial allergic rhinitis. It's particularly worth considering if a single-ingredient spray hasn't given you adequate relief, or if you'd prefer the convenience of one product rather than using a separate antihistamine and steroid spray.

It may be a good fit if you:

  • Suffer from hay fever with both nasal congestion and sneezing or itching
  • Have year-round (perennial) allergic rhinitis triggered by indoor allergens
  • Have previously used intranasal corticosteroids or antihistamines separately and want to simplify your routine
  • Are aged 12 or over and have no contraindications to either active ingredient

 

How Does Ryaltris Nasal Spray Compare to Other Allergy Nasal Sprays?

 

Feature Ryaltris Nasal Spray Mometasone-only Spray (e.g. Nasonex)
Active ingredients Olopatadine + Mometasone furoate Mometasone furoate only
Targets sneezing & itch Yes (via antihistamine) Partially (via anti-inflammatory)
Targets congestion Yes (via corticosteroid) Yes
Suitable age 12 years and over Varies by product (some from 3 years)

 

Is Ryaltris Nasal Spray Suitable for Long-Term Use and How Should It Be Stored?

 

Ryaltris nasal spray should be stored below 25°C, kept upright, and never frozen. Keep it away from direct sunlight and out of reach of children. Once opened, use within the period stated on the packaging — typically within 6 months. If you're managing perennial rhinitis and considering longer-term use, it's worth discussing this with your GP or pharmacist, as prolonged intranasal corticosteroid use warrants periodic review. You might also find it helpful to explore our ear, nose and throat products for complementary options.

The Ryaltris nasal spray 240-dose pack is designed to last a full treatment course at the recommended dose, making it a cost-effective choice for seasonal allergy sufferers. Always check the expiry date before use and discard any remaining product after the stated period.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Ryaltris Nasal Spray 240 doses specifications
Treatment category Allergic rhinitis (seasonal and perennial)
Mechanism of action H1-receptor antagonist (olopatadine) + intranasal corticosteroid (mometasone furoate)
Effective for Sneezing, nasal itching, runny nose, nasal congestion
Suitable for Adults and adolescents aged 12 years and over
Active ingredients Olopatadine hydrochloride 665 mcg, Mometasone furoate 25 mcg per actuation
Pack size 240 doses
Strengths Olopatadine 665 mcg / Mometasone furoate 25 mcg per spray
UK classification P (Pharmacy medicine)
Drug class Antihistamine + corticosteroid combination
Preparation Aqueous nasal suspension
Route of administration Intranasal

Specifications of Ryaltris Nasal Spray 240 doses

 

What Is Ryaltris Nasal Spray and What Is It Used For?

 

Ryaltris nasal spray is a combination intranasal medicine used to relieve the symptoms of allergic rhinitis in adults and adolescents aged 12 and over. It contains two active ingredients: olopatadine hydrochloride, an antihistamine, and mometasone furoate, a corticosteroid. Together, they address the full range of nasal allergy symptoms — including sneezing, an itchy or runny nose, and nasal congestion — that can make daily life genuinely difficult during allergy season or year-round. The NHS notes that allergic rhinitis is one of the most common allergic conditions in the UK, affecting a significant proportion of the population at some point in their lives.

 

What Do You Need to Know Before Using Ryaltris Nasal Spray?

 

Before using this spray, read the following carefully. Do not use Ryaltris nasal spray if any of the contraindications below apply to you:

  • You are allergic to olopatadine, mometasone furoate, or any other ingredient in the formulation
  • You are under 12 years of age
  • You have a current nasal infection that has not been treated
  • You have recently had nasal surgery or a nasal injury — wait until healing is complete
  • You are pregnant or breastfeeding (seek medical advice first)
  • You have tuberculosis (active or latent) or any untreated fungal, bacterial, or viral infection

Speak to your pharmacist or GP before using this spray if you have liver problems, as mometasone furoate is metabolised hepatically and exposure may be increased. Also inform your doctor if you are taking any of the following, as interactions are possible:

  • Ketoconazole or other strong CYP3A4 inhibitors (may increase mometasone blood levels)
  • Other corticosteroids (risk of additive systemic effects)
  • Ritonavir or cobicistat-containing HIV medicines

 

How Should You Use Ryaltris Nasal Spray?

 

Always use this spray exactly as directed on the label or as advised by your pharmacist. The standard dosing regimen for adults and adolescents aged 12 and over is as follows:

  1. Blow your nose gently before use to clear the nasal passages.
  2. Shake the bottle well before each use.
  3. Remove the dust cap and, if using for the first time, prime the pump by pressing it down firmly several times until a fine mist appears.
  4. Tilt your head slightly forward and insert the nozzle gently into one nostril, pointing it slightly away from the nasal septum.
  5. Press the pump down once while breathing in gently through your nose.
  6. Repeat for the second spray in the same nostril, then repeat both steps in the other nostril.
  7. Breathe out through your mouth. Avoid blowing your nose immediately after use.
  8. Replace the dust cap after use and store the bottle upright.
Indication Age Group Dose Frequency
Seasonal allergic rhinitis Adults & adolescents ≥12 years 2 sprays per nostril Twice daily
Perennial allergic rhinitis Adults & adolescents ≥12 years 2 sprays per nostril Twice daily
Children under 12 Not applicable Not recommended

If you are also managing eye symptoms alongside nasal allergy, you may find our eye care range helpful for complementary relief.

 

What Are the Possible Side Effects of Ryaltris Nasal Spray?

 

Like all medicines, Ryaltris nasal spray can cause side effects, although not everyone experiences them. The NHS advises that you should always read the patient information leaflet supplied with your medicine and report any unexpected effects to your pharmacist or GP.

Common side effects (may affect up to 1 in 10 people):

  • Nasal irritation or discomfort
  • Epistaxis (nosebleeds)
  • Headache
  • Unpleasant taste or smell

Less common side effects (may affect up to 1 in 100 people):

  • Throat irritation or dryness
  • Nasal ulceration (with prolonged use)
  • Nasal septal perforation (rare, with long-term use)
  • Raised intraocular pressure or glaucoma (rare, with prolonged corticosteroid use)
  • Hypersensitivity reactions including rash or urticaria

If you experience any signs of a serious allergic reaction — such as swelling of the face, lips, or throat, or difficulty breathing — stop using the spray immediately and seek urgent medical attention.

 

How Should You Store Ryaltris Nasal Spray?

 

Correct storage helps maintain the effectiveness of the spray throughout its shelf life. Follow these instructions:

  • Store below 25°C
  • Keep the bottle upright at all times
  • Do not freeze
  • Keep away from direct sunlight and heat sources
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the label
  • Discard any remaining product 6 months after first opening, or as stated on the packaging
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

If you're looking for additional support during allergy season, our allergy and hay fever collection includes a range of complementary products to help manage your symptoms.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Ryaltris nasal spray online in the UK?

You can buy Ryaltris nasal spray directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available as a Pharmacy (P) medicine for adults and adolescents aged 12 and over without a prescription. Simply add it to your basket and complete a short suitability check at checkout. You can also browse our wider allergy and hay fever range for additional products to support your treatment.

How does Ryaltris nasal spray work in the body?

Ryaltris contains two active ingredients that work through different but complementary mechanisms. Olopatadine is an antihistamine that blocks H1 receptors in the nasal lining, reducing sneezing, itching, and a runny nose relatively quickly. Mometasone furoate is an intranasal corticosteroid that suppresses the inflammatory response in the nasal mucosa, helping to relieve congestion and swelling with regular use over several days. Together, they provide broader symptom coverage than either ingredient alone.

How do I use Ryaltris nasal spray step by step?

Start by blowing your nose gently, then shake the bottle well. If it's your first use, prime the pump by pressing it several times until a fine mist appears. Tilt your head slightly forward, insert the nozzle into one nostril pointing slightly away from the septum, and press the pump once while breathing in gently. Repeat for a second spray in the same nostril, then do the same in the other nostril. Breathe out through your mouth and replace the dust cap after use.

What is the correct dose of Ryaltris nasal spray for adults?

The recommended dose for adults and adolescents aged 12 and over is two sprays into each nostril twice daily. That equates to a total of eight actuations per day. Do not exceed this dose unless specifically advised by a healthcare professional, and always follow the instructions provided with the product.

When is the best time to use Ryaltris nasal spray?

There is no single fixed time that is clinically mandated, but many people find it helpful to use one dose in the morning and one in the evening to maintain consistent coverage throughout the day. If you have seasonal allergic rhinitis, starting treatment a few days before your expected pollen exposure may help the mometasone component build up its anti-inflammatory effect before symptoms peak. Consistency is key — try to use it at roughly the same times each day.

What are the side effects of Ryaltris nasal spray?

The most commonly reported side effects include nasal irritation, nosebleeds, headache, and an unpleasant taste or smell after use. Less commonly, some people experience throat dryness or irritation. Rare but more serious effects with prolonged use include nasal ulceration or raised intraocular pressure. If you notice any unusual or persistent symptoms, stop using the spray and speak to your pharmacist or GP promptly.

How do I manage a nosebleed caused by Ryaltris nasal spray?

Minor nosebleeds are a known side effect of intranasal corticosteroid sprays and are usually mild. To reduce the risk, make sure you are directing the nozzle slightly away from the nasal septum rather than straight up the nose. If nosebleeds are frequent or heavy, stop using the spray and consult your pharmacist or GP, as they may recommend a short break or an alternative treatment.

Who is eligible to use Ryaltris nasal spray?

Ryaltris nasal spray is suitable for adults and adolescents aged 12 years and over with seasonal or perennial allergic rhinitis. It is not recommended for children under 12, and it should be used with caution in people with liver impairment, active nasal infections, or a history of nasal surgery. Pregnant or breastfeeding individuals should seek medical advice before use. If you have any underlying health conditions or take regular medicines, speak to your pharmacist first.

Can I use Ryaltris nasal spray during pregnancy?

There is limited clinical data on the use of Ryaltris specifically during pregnancy. The NHS advises that you should always consult your doctor or midwife before using any nasal spray during pregnancy, including those containing corticosteroids or antihistamines. Your healthcare professional can weigh up the potential benefits against any risks and suggest the most appropriate option for you.

What happens if I miss a dose of Ryaltris nasal spray?

If you miss a dose, simply use it as soon as you remember — unless it is nearly time for your next scheduled dose, in which case skip the missed one and carry on as normal. Do not use a double dose to make up for a missed one. Missing an occasional dose is unlikely to significantly affect your overall symptom control, but consistent daily use gives the best results, particularly for the mometasone component.

How long can I use Ryaltris nasal spray for?

For seasonal allergic rhinitis, Ryaltris is typically used throughout the relevant pollen season. For perennial rhinitis, longer-term use may be appropriate under medical supervision. The NHS recommends periodic review of intranasal corticosteroid use to ensure it remains necessary and appropriate. If your symptoms are not improving after two weeks of regular use, speak to your GP.

Does Ryaltris nasal spray cause drowsiness?

Olopatadine, the antihistamine in Ryaltris, is applied directly to the nasal mucosa rather than taken orally, which means systemic absorption is very low. As a result, drowsiness is not a commonly reported side effect with intranasal use, unlike oral antihistamines. However, if you do notice any unusual drowsiness or cognitive effects, mention this to your pharmacist.

What are the alternatives to Ryaltris nasal spray for hay fever?

Alternatives include single-ingredient intranasal corticosteroids such as mometasone or fluticasone sprays, antihistamine nasal sprays such as azelastine, or oral antihistamines for milder symptoms. Ryaltris is distinctive in combining both drug classes in one spray, which may suit people who have not achieved adequate relief from a single-ingredient product. You can explore our ear, nose and throat range for further options.

Can Ryaltris nasal spray interact with other medicines?

Yes, interactions are possible. Strong CYP3A4 inhibitors — such as ketoconazole, ritonavir, or cobicistat — can increase the systemic exposure to mometasone furoate, potentially raising the risk of corticosteroid-related side effects. Other corticosteroids used concurrently may also have additive effects. Always tell your pharmacist about all medicines, supplements, and herbal remedies you are taking before starting Ryaltris.

What are the latest findings on combination nasal sprays like Ryaltris?

Clinical studies published in peer-reviewed journals have demonstrated that the combination of olopatadine and mometasone furoate in a single nasal spray provides statistically significant improvements in total nasal symptom scores compared to either ingredient used alone. Regulatory approval by the MHRA for use in the UK was based on this clinical evidence. Ongoing real-world data continues to support its use as an effective option for moderate to severe allergic rhinitis in eligible patients.

How Should You Use Ryaltris Nasal Spray?

Using Ryaltris nasal spray correctly makes a real difference to how well it works. Before you start, blow your nose gently to clear the nasal passages, and always shake the bottle well before each use.

If the pump has not been used for several days, re-prime it with one or two test sprays before use. Clean the nozzle regularly by removing it and rinsing under warm water, then allow it to dry before replacing.

What Is the Correct Dose of Ryaltris Nasal Spray?

Always follow the dosage instructions on the label or as directed by your pharmacist. The table below summarises the recommended doses by indication and age group.

Each dose delivers 665 micrograms of olopatadine and 25 micrograms of mometasone furoate per actuation. The 240-dose pack provides a full course at the recommended dose for the allergy season.

When Is the Best Time to Use Ryaltris Nasal Spray?

There is no single clinically mandated time of day, but spacing your two daily doses approximately 12 hours apart — for example, once in the morning and once in the evening — helps maintain consistent levels of both active ingredients throughout the day. If you have seasonal allergic rhinitis, starting treatment a few days before your expected pollen exposure allows the mometasone component to begin reducing nasal inflammation before symptoms peak. Try to use the spray at the same times each day to build a routine and avoid missed doses.

How Long Can You Use Ryaltris Nasal Spray For?

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What Are the Most Common Side Effects of Ryaltris Nasal Spray?

Most people tolerate Ryaltris nasal spray well, but as with all medicines, side effects can occur. The most frequently reported effects are localised to the nose and are generally mild. They are more likely to occur in the first few weeks of use and often settle as your body adjusts.

  • Nasal irritation or discomfort
  • Epistaxis (nosebleeds)
  • Headache
  • Unpleasant or bitter taste after use
  • Unpleasant smell

What Are the Less Common Side Effects of Ryaltris Nasal Spray?

Less common side effects affect a smaller proportion of users but are still worth being aware of. If any of the following persist or become bothersome, speak to your pharmacist or GP.

  • Throat irritation or dryness
  • Nasal dryness or crusting
  • Sneezing immediately after application
  • Nasal ulceration (particularly with prolonged use)
  • Mild skin reactions such as rash or urticaria

What Are the Serious Side Effects of Ryaltris Nasal Spray?

Serious side effects are rare but require prompt medical attention if they occur. Prolonged use of intranasal corticosteroids, including mometasone furoate, has been associated in rare cases with nasal septal perforation — a hole in the wall between the nostrils. There is also a small risk of raised intraocular pressure or glaucoma with long-term use, particularly in people with a personal or family history of glaucoma. Systemic corticosteroid effects such as adrenal suppression are very unlikely at the recommended intranasal dose, but remain a theoretical concern with prolonged high-dose use. Stop using the spray and seek urgent medical attention if you experience swelling of the face, lips, tongue, or throat, difficulty breathing, or a severe skin reaction — these may indicate a serious allergic reaction (anaphylaxis).

What Should You Do If You Experience Side Effects of Ryaltris Nasal Spray?

For mild side effects such as nasal irritation or nosebleeds, check that you are using the correct technique — directing the nozzle slightly away from the nasal septum rather than straight up the nose can significantly reduce local irritation. If side effects are persistent, moderate, or affecting your quality of life, stop using the spray and consult your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Ryaltris Nasal Spray Interact With Other Medicines?

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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