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Pirinase Hayfever Relief Nasal Spray - 60 Sprays

Pirinase Hayfever Relief Nasal Spray - 60 Sprays

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  • ✔️ Targets nasal inflammation directly with fluticasone propionate 50 mcg
  • ✔️ Relieves sneezing, congestion, and runny nose caused by hayfever
  • ✔️ Once-daily dosing for convenient, consistent symptom control
  • ✔️ 60-spray pack provides a full month's hayfever treatment
  • ✔️ Suitable for adults 18+ with seasonal allergic rhinitis

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Is Pirinase the Right Fluticasone Nasal Spray Hayfever Treatment for You?

 

Hayfever affects millions of people across the UK every year, and for many, it's far more than just a minor inconvenience. Sneezing fits, a constantly blocked or runny nose, itchy eyes — it can genuinely disrupt your day. Pirinase Hayfever Relief Nasal Spray is a clinically established option that tackles nasal symptoms at their source. Each actuation delivers 50 micrograms of fluticasone propionate, a corticosteroid that reduces inflammation in the nasal lining caused by allergens like grass pollen, tree pollen, and dust mites.

This 60-spray bottle provides a full month's supply when used at the standard adult dose. It's available over the counter for adults aged 18 and over, making it straightforward to access without needing a GP appointment. If you've been struggling through hayfever season with antihistamines alone and not getting enough relief, a fluticasone nasal spray hayfever treatment like Pirinase may be worth considering.

 

How Does Pirinase Hayfever Relief Nasal Spray Work?

 

Fluticasone propionate belongs to a class of medicines called corticosteroids. When you spray it into your nostrils, it acts locally on the nasal mucosa — the lining of your nose — rather than being absorbed significantly into the bloodstream. This local action is what makes it both effective and generally well tolerated for seasonal use.

  • Allergens (such as pollen) trigger an immune response in the nasal lining, causing inflammation.
  • Fluticasone propionate inhibits the release of inflammatory mediators, including histamine and leukotrienes.
  • This reduces swelling, mucus production, and the hypersensitivity of nasal tissues.
  • Symptoms — sneezing, congestion, runny nose, and nasal itching — gradually improve with regular use.

It's worth knowing that Pirinase doesn't work instantly. Unlike antihistamine tablets, which can act within an hour, corticosteroid nasal sprays typically take three to four days of consistent use before you notice a meaningful difference, with full effect often reached after one to two weeks.

 

Who Should Use Pirinase Hayfever Relief Nasal Spray?

 

Pirinase is designed for adults aged 18 and over who experience the nasal symptoms of seasonal allergic rhinitis — commonly known as hayfever. It's particularly useful if your symptoms are predominantly nasal rather than ocular. If itchy, watery eyes are your main complaint, you might also want to explore our eye care range for complementary relief.

  • Adults (18+) with seasonal hayfever triggered by pollen
  • People whose symptoms are not adequately controlled by antihistamines alone
  • Those who prefer a once-daily nasal treatment rather than oral tablets
  • Individuals looking to start treatment before the pollen season begins, as preventative use is effective

 

How Does Pirinase Compare to Other Hayfever Nasal Sprays?

 

Feature Pirinase Hayfever Relief (Fluticasone) Beconase (Beclometasone)
Active ingredient Fluticasone propionate 50 mcg Beclometasone dipropionate 50 mcg
Dosing frequency Once daily (2 sprays per nostril) Twice daily (2 sprays per nostril)
Age suitability (OTC) 18 years and over 18 years and over
Onset of action 3–4 days (full effect 1–2 weeks) 3–7 days

 

Is Pirinase Suitable for Long-Term Use and How Should It Be Stored?

 

For most adults, fluticasone nasal spray hayfever treatment is safe to use throughout the pollen season. However, if you find yourself needing it for more than three months, or if your symptoms don't improve within two weeks, it's sensible to speak to your GP or pharmacist. Prolonged use without review isn't recommended, as there is a small risk of nasal septum changes with very long-term use.

Store Pirinase below 30°C, away from direct sunlight, and keep the bottle upright. Do not freeze it. Keep it out of the reach and sight of children. Check the expiry date before use — an expired spray may not deliver the correct dose per actuation.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Pirinase Hayfever Relief Nasal Spray 60 Sprays specifications
Treatment category Seasonal allergic rhinitis (hayfever)
Active ingredient Fluticasone propionate 50 micrograms per actuation
Mechanism of action Intranasal corticosteroid; reduces nasal inflammation
Drug class Corticosteroid
Preparation Aqueous nasal spray suspension
Route of administration Intranasal
Pack size 60 sprays
Strengths 50 mcg per actuation
UK classification Pharmacy (P) medicine
Suitable for Adults aged 18 and over
Effective for Sneezing, nasal congestion, runny nose, nasal itching due to hayfever

Specifications of Pirinase Hayfever Relief Nasal Spray 60 Sprays

 

What Is Pirinase Hayfever Relief Nasal Spray and What Is It Used For?

 

Pirinase Hayfever Relief Nasal Spray contains fluticasone propionate 50 micrograms per actuation. It is used to relieve and prevent the nasal symptoms of seasonal allergic rhinitis in adults aged 18 and over. Seasonal allergic rhinitis — more commonly called hayfever — is an allergic reaction to airborne substances such as grass pollen, tree pollen, or mould spores. Symptoms typically include sneezing, a blocked or runny nose, and nasal itching. Pirinase works by reducing the inflammation that causes these symptoms, rather than simply masking them.

You can browse our full allergy and hayfever range if you need additional products to manage your symptoms alongside this spray.

 

What Do You Need to Know Before Using Pirinase Hayfever Relief Nasal Spray?

 

Before using Pirinase, it's important to check whether it is appropriate for you. Do not use this spray if any of the following apply:

  • You are allergic to fluticasone propionate or any other ingredient in the spray
  • You have a current nasal infection (bacterial, fungal, or viral)
  • You have recently had nasal surgery or a nasal injury — wait until fully healed
  • You are under 18 years of age (OTC use is not recommended)
  • You are pregnant or breastfeeding — seek medical advice before use

Take care and speak to your pharmacist or GP if you have tuberculosis, or if you are being treated for any other infection. Also tell your doctor or pharmacist if you are taking any other corticosteroid medicines, as combined use may increase the risk of systemic side effects.

Regarding drug interactions, the following are clinically relevant:

  • Ritonavir (used in HIV treatment) — can significantly increase fluticasone blood levels; avoid combination if possible
  • Ketoconazole and other strong CYP3A4 inhibitors — may increase fluticasone exposure
  • Other inhaled or systemic corticosteroids — combined use increases risk of adrenal suppression

 

How Should You Use Pirinase Hayfever Relief Nasal Spray?

 

Always use Pirinase exactly as directed on the label or as advised by your pharmacist. The spray is for nasal use only — do not swallow it or use it in your eyes.

  1. Shake the bottle gently before each use.
  2. Blow your nose gently to clear the nasal passages.
  3. Remove the protective cap from the nozzle.
  4. Tilt your head slightly forward and insert the nozzle into one nostril, pointing it slightly away from the nasal septum.
  5. Close the other nostril with a finger.
  6. Press the pump firmly and breathe in gently through your nose at the same time.
  7. Breathe out through your mouth.
  8. Repeat for the second nostril.
  9. Replace the cap after use and wipe the nozzle clean.
Age Group Dose Frequency Maximum daily dose
Adults (18+) 2 sprays into each nostril Once daily (morning) 200 mcg (4 sprays total)
Under 18 Not recommended OTC

 

What Are the Possible Side Effects of Pirinase Hayfever Relief Nasal Spray?

 

Like all medicines, Pirinase can cause side effects, although not everyone gets them. Most side effects are mild and affect the nose or throat locally.

Common side effects (may affect up to 1 in 10 people):

  • Nosebleeds (epistaxis)
  • Nasal dryness or irritation
  • Unpleasant taste or smell
  • Headache

Less common side effects (may affect up to 1 in 100 people):

  • Nasal ulceration
  • Throat irritation or hoarseness
  • Skin rash or itching (possible allergic reaction)
  • Nasal septum perforation — rare, associated with prolonged use or incorrect technique

If you experience a severe allergic reaction (swelling of the face, lips, or throat, difficulty breathing), stop using the spray and seek emergency medical help immediately. You can also find complementary products in our ear, nose and throat range if you need additional support for nasal symptoms.

 

How Should You Store Pirinase Hayfever Relief Nasal Spray?

 

  • Store below 30°C
  • Do not freeze
  • Keep the bottle upright
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the label
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Pirinase Hayfever Relief Nasal Spray online in the UK?

You can buy Pirinase Hayfever Relief Nasal Spray 60 sprays directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £9.50. It is available without a prescription for adults aged 18 and over. Simply add it to your basket and it will be dispatched to your door.

How does Pirinase Hayfever Relief Nasal Spray work in the body?

Pirinase contains fluticasone propionate, a corticosteroid that acts locally on the nasal lining to reduce inflammation caused by allergens such as pollen. It inhibits the release of inflammatory chemicals like histamine and leukotrienes, which are responsible for sneezing, congestion, and nasal itching. Because it acts locally rather than systemically, it has a good safety profile when used as directed.

How do I use Pirinase Hayfever Relief Nasal Spray step by step?

Shake the bottle, blow your nose gently, then insert the nozzle into one nostril while closing the other and press the pump as you breathe in slowly through your nose. Use two sprays in each nostril once daily. Always wipe the nozzle and replace the cap after use to keep it clean.

How long does Pirinase take to start working?

Pirinase does not provide instant relief — it typically takes three to four days of regular daily use before you notice a meaningful improvement in symptoms. Full benefit is usually achieved after one to two weeks of consistent use. For best results, start using it a few days before the pollen season begins if possible.

What is the correct dose of Pirinase for adults?

The standard adult dose is two sprays into each nostril once daily, giving a total of four sprays (200 micrograms of fluticasone propionate) per day. Do not exceed this dose unless directed by a doctor. Once symptoms are well controlled, your pharmacist may advise reducing to one spray per nostril daily as a maintenance dose.

What are the side effects of Pirinase Hayfever Relief Nasal Spray?

The most common side effects include nosebleeds, nasal dryness or irritation, and headache. Less commonly, some people experience an unpleasant taste or smell, throat irritation, or nasal ulceration. Serious side effects such as nasal septum perforation are rare and are more likely with prolonged use or incorrect spray technique.

Who is Pirinase Hayfever Relief Nasal Spray suitable for?

Pirinase is suitable for adults aged 18 and over who experience the nasal symptoms of seasonal allergic rhinitis (hayfever). It is not recommended for children under 18 without medical supervision, or for people with active nasal infections, recent nasal surgery, or known allergy to fluticasone propionate. If you are pregnant or breastfeeding, speak to your GP before use.

Can I use Pirinase if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should seek medical advice before using Pirinase. While fluticasone propionate has low systemic absorption when used intranasally, it is still important to discuss the risks and benefits with your GP or midwife before starting treatment. Do not self-medicate during pregnancy without professional guidance.

What happens if I miss a dose of Pirinase?

If you forget to use Pirinase, use it as soon as you remember — unless it is nearly time for your next dose, in which case simply skip the missed dose and carry on as normal. Never use a double dose to compensate for a missed one. Consistent daily use is important for the spray to work effectively.

How long can you use Pirinase Hayfever Relief Nasal Spray for?

Pirinase can be used throughout the hayfever season, typically for up to three months. If you need to use it for longer, or if your symptoms have not improved after two weeks of regular use, speak to your pharmacist or GP for a review. Long-term unsupervised use is not recommended.

Can Pirinase be used alongside antihistamine tablets?

Yes, Pirinase can generally be used alongside oral antihistamines for more complete hayfever symptom control — the nasal spray targets nasal inflammation while antihistamines address sneezing and itching more broadly. However, always check with your pharmacist before combining treatments to ensure they are appropriate for you. You can explore our full allergy and hayfever range for complementary options.

Does Pirinase interact with any other medicines?

The most clinically significant interaction is with ritonavir (used in HIV treatment), which can substantially increase fluticasone levels in the blood and should be avoided if possible. Strong CYP3A4 inhibitors such as ketoconazole may also increase fluticasone exposure. Always tell your pharmacist about all medicines you are taking, including over-the-counter products.

What are the alternatives to Pirinase Hayfever Relief Nasal Spray?

Alternatives include other intranasal corticosteroid sprays such as Beconase (beclometasone dipropionate), which is dosed twice daily, or Nasacort (triamcinolone acetonide). Antihistamine nasal sprays such as azelastine are also available and work more quickly, though they are generally considered less effective for nasal congestion. Your pharmacist can help you choose the most suitable option for your symptoms.

Is Pirinase safe to use if I have asthma?

Many people with hayfever also have asthma, and intranasal fluticasone is commonly used in this group. However, if you are already using an inhaled corticosteroid for asthma, your total corticosteroid exposure increases, so it is worth discussing this with your GP or pharmacist. Do not adjust your asthma medicines without medical advice.

What are the latest findings on fluticasone nasal spray for hayfever?

Intranasal corticosteroids like fluticasone propionate remain the most clinically effective first-line treatment for moderate-to-severe allergic rhinitis according to current NHS and NICE guidance. Evidence consistently shows they outperform oral antihistamines for nasal congestion in particular. If you also experience eye symptoms alongside nasal ones, consider pairing this spray with products from our eye care range for broader relief.

How Should You Use Pirinase Hayfever Relief Nasal Spray?

Pirinase is for nasal use only. Before using for the first time, prime the pump by pressing it several times until a fine mist appears — this ensures you receive the correct dose with each actuation.

Follow these steps each time you use the spray:

If the spray has not been used for several days, re-prime it with one or two test sprays before use.

What Is the Correct Dose of Pirinase Hayfever Relief Nasal Spray?

The recommended dose for adults is two sprays into each nostril once daily. This delivers a total of 200 micrograms of fluticasone propionate per day. Do not exceed this dose unless specifically advised by your doctor.

When Is the Best Time to Use Pirinase Hayfever Relief Nasal Spray?

The best time to use Pirinase is in the morning, ideally before you go outdoors or are exposed to pollen. Using it at a consistent time each day helps maintain steady levels of the medicine in the nasal tissues, which is important for it to work effectively. If you know the pollen season is approaching, starting treatment a few days early can help prevent symptoms from taking hold in the first place.

Try to avoid blowing your nose immediately after using the spray, as this can reduce how much of the medicine is absorbed by the nasal lining.

How Long Can You Use Pirinase Hayfever Relief Nasal Spray For?

Pirinase is intended for use during the hayfever season, which in the UK typically runs from late March through to September depending on which pollens trigger your symptoms. Most people use it for up to three months at a time. If your symptoms have not improved after two weeks of regular use, or if you feel you need to use it for longer than three months, speak to your pharmacist or GP for a review of your treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Pirinase Hayfever Relief Nasal Spray?

Most people who use Pirinase tolerate it well, but like all medicines it can cause side effects. The most frequently reported ones are local to the nose and throat, and they are usually mild.

  • Nosebleeds (epistaxis) — the most commonly reported side effect
  • Nasal dryness or irritation inside the nose
  • Unpleasant taste or smell after using the spray
  • Headache

Nosebleeds are more likely if you spray directly onto the nasal septum rather than angling the nozzle slightly outward. Adjusting your technique often reduces this problem significantly.

What Are the Less Common Side Effects of Pirinase Hayfever Relief Nasal Spray?

Less common side effects occur in fewer than 1 in 100 people. They are still worth being aware of, particularly if you plan to use the spray over an extended period.

  • Nasal ulceration — small sores inside the nose
  • Throat irritation or hoarseness
  • Skin rash or itching, which may indicate a mild allergic reaction
  • Nasal septum perforation — rare, associated with prolonged use or poor technique
  • Blurred vision — reported rarely; seek medical advice if this occurs

What Are the Serious Side Effects of Pirinase Hayfever Relief Nasal Spray?

Serious side effects are uncommon when Pirinase is used at the recommended dose for a normal hayfever season. However, there are a few situations that require prompt medical attention. A severe allergic reaction (anaphylaxis) is rare but possible — signs include swelling of the face, lips, tongue or throat, difficulty breathing, or a sudden drop in blood pressure. Stop using the spray immediately and call 999 if you experience these symptoms.

With very prolonged use, there is a theoretical risk of systemic corticosteroid effects such as adrenal suppression, particularly if you are also using other corticosteroid medicines. This is why regular review is important if you use Pirinase for more than three months.

What Should You Do If You Experience Side Effects of Pirinase?

For mild side effects such as nasal dryness or occasional nosebleeds, try adjusting your spray technique — aim the nozzle slightly away from the septum and avoid sniffing hard after spraying. If nosebleeds are frequent or heavy, stop using the spray and speak to your pharmacist. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

For any side effect that concerns you, or that does not resolve on its own, contact your pharmacist or GP for advice before continuing treatment.

Can Pirinase Hayfever Relief Nasal Spray Interact With Other Medicines?

The most clinically important interaction is with ritonavir, an antiretroviral medicine used in HIV treatment. Ritonavir inhibits the enzyme CYP3A4, which breaks down fluticasone in the body. When taken together, fluticasone levels in the blood can rise significantly, increasing the risk of systemic corticosteroid side effects. Other strong CYP3A4 inhibitors such as ketoconazole (an antifungal) carry a similar risk. If you are taking any of these medicines, speak to your doctor before using Pirinase.

Using Pirinase alongside other inhaled or topical corticosteroids also increases your total corticosteroid exposure, which is worth discussing with your pharmacist or GP, particularly if you have asthma and are already using a corticosteroid inhaler.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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