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Piriton Tablets - 500

Piriton Tablets - 500

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  • ✔️ Relieves hay fever, urticaria, and allergic rhinitis symptoms
  • ✔️ Contains 4mg chlorpheniramine maleate per tablet
  • ✔️ Starts working within approximately 30 minutes of ingestion
  • ✔️ Suitable for adults and children aged 6 and over
  • ✔️ 500-tablet pack ideal for households with regular allergy needs

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What Are Piriton Tablets and What Do They Treat?

 

If you suffer from hay fever, skin rashes, or allergic reactions, you will probably have heard of piriton tablets. Each tablet contains 4mg of chlorpheniramine maleate, a first-generation antihistamine that has been used in the UK for decades to manage a wide range of allergic conditions. Whether your symptoms flare up seasonally or appear out of nowhere, this 500-tablet pack offers a practical, cost-effective supply for households that rely on antihistamine relief regularly. You can browse our full range of treatments in our allergy and hay fever collection if you want to compare options before buying.

Chlorpheniramine maleate is the active ingredient in piriton tablets and is listed in the British National Formulary as a sedating antihistamine. It works by competing with histamine at H1 receptor sites throughout the body, reducing the cascade of symptoms that histamine triggers during an allergic response. The NHS recognises chlorpheniramine as an effective short-term treatment for allergic conditions including urticaria, allergic rhinitis, and insect bite reactions.

 

How Do Piriton Tablets Work to Relieve Allergy Symptoms?

 

When your immune system encounters an allergen — pollen, pet dander, dust mites, or certain foods — it releases histamine. That histamine binds to H1 receptors in your skin, airways, and eyes, producing the familiar symptoms: sneezing, itching, watery eyes, and a runny nose. Chlorpheniramine steps in and blocks those receptors before histamine can bind, reducing the severity of the reaction.

  • Chlorpheniramine crosses the blood-brain barrier, which is why it can cause drowsiness — a known effect of first-generation antihistamines.
  • It begins to take effect within 30 minutes of ingestion in most people.
  • The antihistamine effect typically lasts four to six hours per dose.
  • It also has mild anticholinergic properties, which can reduce secretions (helpful for a runny nose, but may cause dry mouth).

 

Who Is Suitable for Using Piriton Tablets?

 

Piriton tablets are suitable for adults and children aged 6 and over. They are particularly useful for people who need rapid relief from acute allergic symptoms, or those who find the sedating effect helpful — for example, when itching is disrupting sleep. That said, they are not the right choice for everyone.

  • Adults aged 18 and over experiencing hay fever, urticaria, or allergic rhinitis.
  • Children aged 6–12 years at a reduced dose (under pharmacist or GP guidance).
  • People with insect bite reactions or mild food allergy symptoms (not anaphylaxis).
  • Those who need short-term relief from itching caused by chickenpox or eczema flares.

They are not suitable for children under 6, pregnant or breastfeeding women without medical advice, or people with certain medical conditions such as glaucoma, urinary retention, or epilepsy.

 

How Do Piriton Tablets Compare to Non-Sedating Antihistamines?

 

Feature Piriton Tablets (Chlorpheniramine 4mg) Cetirizine 10mg (Non-Sedating)
Generation First-generation (sedating) Second-generation (non-sedating)
Onset of action ~30 minutes ~1 hour
Duration of effect 4–6 hours Up to 24 hours
Drowsiness risk High — avoid driving Low in most people
Suitable for driving? No Generally yes (check individual response)

 

How Should You Store Piriton Tablets and Are They Safe Long-Term?

 

Store your piriton tablets below 25°C in a dry place, away from direct sunlight and out of reach of children. The 500-tablet pack is ideal for bulk storage, but always check the expiry date printed on the packaging before use. Do not use tablets that appear discoloured or damaged.

Long-term daily use of sedating antihistamines is generally not recommended without medical supervision. If you find yourself relying on them every day for weeks at a time, it is worth speaking to your GP about whether a longer-acting, non-sedating option or a different treatment approach might suit you better. If you experience symptoms that go beyond allergy — such as persistent skin reactions — you may also want to explore our skin care collection for complementary products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Piriton Tablets 500 specifications
Treatment category Allergy and hay fever
Active ingredient Chlorpheniramine maleate 4mg
Mechanism of action H1 histamine receptor antagonist (sedating)
Drug class First-generation antihistamine
Preparation Tablet
Route of administration Oral
Strengths 4mg
Pack sizes 500 tablets
Suitable for Adults and children aged 6 and over
UK classification Pharmacy (P) medicine
Effective for Hay fever, urticaria, allergic rhinitis, insect bites, chickenpox itching

Specifications of Piriton Tablets 500

 

What Are Piriton Tablets and What Are They Used For?

 

Piriton tablets contain chlorpheniramine maleate 4mg per tablet. They belong to a class of medicines called first-generation antihistamines and are used to relieve symptoms caused by allergic reactions. The NHS lists chlorpheniramine as a treatment option for a range of allergic conditions, including hay fever, urticaria (hives), allergic rhinitis, and reactions to insect bites or stings. They may also be used to relieve itching associated with chickenpox, though this should be discussed with a pharmacist or GP first, particularly in children.

 

What Do You Need to Know Before Using Piriton Tablets?

 

Before taking piriton tablets, it is important to check whether they are appropriate for you. Certain conditions and medicines can make chlorpheniramine unsuitable or require extra caution.

Do not take Piriton tablets if you:

  • Are allergic to chlorpheniramine maleate or any other ingredient in the tablet.
  • Are under 6 years of age.
  • Are taking or have recently taken monoamine oxidase inhibitors (MAOIs).
  • Have angle-closure glaucoma.
  • Have urinary retention or an enlarged prostate.
  • Are in the first trimester of pregnancy (seek medical advice).

Use with caution if you have:

  • Epilepsy or a history of seizures.
  • Liver or kidney impairment.
  • Cardiovascular disease or hypertension.
  • Hyperthyroidism.

Known drug interactions — avoid or seek advice before combining with:

  • Alcohol — increases sedative effect significantly.
  • Other CNS depressants (e.g. benzodiazepines, opioids, sleeping tablets).
  • Tricyclic antidepressants — enhanced anticholinergic effects.
  • MAOIs — risk of serious adverse reactions; do not use within 14 days of stopping an MAOI.
  • Other antihistamines — additive sedation and anticholinergic effects.

 

How Should You Use Piriton Tablets Correctly?

 

Always take piriton tablets exactly as directed on the patient information leaflet or as advised by your pharmacist. Swallow the tablet whole with a glass of water. Do not crush or chew unless advised to do so.

  1. Check you are not contraindicated before taking your first dose.
  2. Take one tablet (4mg) with a full glass of water.
  3. Repeat every four to six hours as needed.
  4. Do not exceed the maximum daily dose for your age group (see table below).
  5. Avoid alcohol and driving for the duration of treatment.
  6. If symptoms persist beyond a few days, consult your pharmacist or GP.
Age Group Dose Frequency Maximum Daily Dose
Adults and children 12+ 1 tablet (4mg) Every 4–6 hours 6 tablets (24mg)
Children aged 6–12 ½ tablet (2mg) Every 4–6 hours 3 tablets (12mg)
Children under 6 Not recommended

If you are managing multiple symptoms — for example, allergy alongside a cold — you may find it helpful to explore our cold and flu collection for additional support products.

 

What Are the Possible Side Effects of Piriton Tablets?

 

Like all medicines, piriton tablets can cause side effects, though not everyone experiences them. Because chlorpheniramine is a sedating antihistamine, drowsiness is the most frequently reported effect. The NHS advises patients not to drive or operate machinery while taking this medicine.

Common side effects:

  • Drowsiness and sedation
  • Dry mouth, nose, or throat
  • Blurred vision
  • Difficulty passing urine
  • Constipation

Less common side effects:

  • Headache or dizziness
  • Nausea or stomach upset
  • Palpitations
  • Paradoxical excitability (particularly in children — restlessness, insomnia)
  • Skin rashes or photosensitivity

Stop taking the tablets and seek immediate medical attention if you experience difficulty breathing, swelling of the face or throat, or a severe skin reaction — these may indicate a rare but serious allergic response.

 

How Should You Store Piriton Tablets Safely?

 

Correct storage helps maintain the quality and safety of your tablets throughout the pack's shelf life. Follow these guidelines:

  • Store below 25°C in a cool, dry place.
  • Keep away from direct sunlight and moisture.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the packaging.
  • Do not store in a bathroom cabinet — humidity can degrade tablets.
  • Dispose of unused or expired tablets via your local pharmacy's medicine return scheme — do not flush or bin them.

If you are looking for additional allergy management tools or complementary treatments, our eye care collection includes antihistamine eye drops that can be used alongside oral tablets for more complete symptom relief.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Piriton tablets online in the UK?

You can buy Piriton tablets from Cured Pharmacy, a GPhC-registered UK online pharmacy. The 500-tablet pack is available for £29.99 and is dispatched from a UK-registered dispensary. Browse our full allergy and hay fever collection for related products.

How do Piriton tablets work in the body?

Piriton tablets contain chlorpheniramine maleate, which blocks H1 histamine receptors throughout the body. When histamine is prevented from binding to these receptors, the allergic response — sneezing, itching, watery eyes — is significantly reduced. Because chlorpheniramine also crosses the blood-brain barrier, it can cause drowsiness as a side effect.

What is the correct dose of Piriton tablets for adults?

Adults and children aged 12 and over should take one 4mg tablet every four to six hours as needed. The maximum dose is six tablets (24mg) in any 24-hour period. Never exceed the recommended dose, and always read the patient information leaflet before use.

Can children take Piriton tablets?

Piriton tablets are suitable for children aged 6 and over at a reduced dose of half a tablet (2mg) every four to six hours, up to a maximum of three doses in 24 hours. They are not recommended for children under 6 years of age. Always consult a pharmacist or GP before giving antihistamines to a child.

Do Piriton tablets cause drowsiness?

Yes — drowsiness is one of the most common side effects of Piriton tablets because chlorpheniramine is a sedating, first-generation antihistamine. You should not drive, cycle, or operate heavy machinery while taking them. Alcohol significantly worsens the sedative effect and should be avoided entirely during treatment.

What is the best time to take Piriton tablets for hay fever?

For hay fever, taking a Piriton tablet around 30 minutes before you expect to be exposed to pollen — such as before going outdoors — can help reduce symptoms proactively. Because the effect lasts four to six hours, you may need to repeat the dose during the day. Taking a dose at bedtime can also help if itching or sneezing is disrupting your sleep.

What are the side effects of Piriton tablets and how do I manage them?

Common side effects include drowsiness, dry mouth, blurred vision, and difficulty urinating. Staying well hydrated and avoiding alcohol can help reduce the severity of these effects. If side effects are troublesome or persistent, speak to your pharmacist — a non-sedating antihistamine may be a more suitable alternative for daytime use.

Who should not take Piriton tablets?

Piriton tablets are not suitable for children under 6, people with angle-closure glaucoma, urinary retention, or those taking MAOIs. Pregnant or breastfeeding women should seek medical advice before use. People with epilepsy, liver disease, or cardiovascular conditions should also consult their GP or pharmacist first.

What happens if I miss a dose of Piriton tablets?

If you miss a dose, simply take the next one when your symptoms return or when your next scheduled dose is due — whichever comes first. Do not double up to make up for a missed dose. Piriton tablets are taken as needed rather than on a strict schedule for most people, so missing a dose is rarely a concern.

How long can you take Piriton tablets for?

Piriton tablets are intended for short-term use to manage acute allergic symptoms. If you find you need them daily for more than a few weeks, it is worth speaking to your GP or pharmacist. Long-term daily use of sedating antihistamines is not generally recommended without medical review, and a non-sedating alternative may be more appropriate for ongoing management.

Can I take Piriton tablets with other medicines?

Piriton tablets can interact with several medicines, including MAOIs, tricyclic antidepressants, other antihistamines, and CNS depressants such as sleeping tablets or opioid painkillers. Always tell your pharmacist about all medicines you are taking — including herbal remedies — before starting Piriton tablets. If you are managing pain alongside your allergy, our pain relief collection lists options your pharmacist can help you combine safely.

Are Piriton tablets safe during pregnancy or breastfeeding?

Piriton tablets are not recommended during the first trimester of pregnancy, and caution is advised throughout pregnancy and breastfeeding. Chlorpheniramine can pass into breast milk and may cause drowsiness in a nursing infant. Always seek advice from your GP or midwife before taking any antihistamine during pregnancy or while breastfeeding.

What are the alternatives to Piriton tablets for allergy relief?

Non-sedating antihistamines such as cetirizine (10mg), loratadine (10mg), and fexofenadine (120mg) are widely used alternatives that are less likely to cause drowsiness and are generally suitable for daytime use. Nasal corticosteroid sprays are also recommended by the NHS for persistent hay fever. Your pharmacist can help you choose the most appropriate option for your symptoms and lifestyle.

Can Piriton tablets be used for insect bites and stings?

Yes — the NHS recommends antihistamines such as chlorpheniramine to relieve itching, swelling, and redness caused by insect bites and stings. Piriton tablets can be taken orally to reduce the allergic response. However, if you experience signs of a severe allergic reaction — such as swelling of the face, difficulty breathing, or dizziness — call 999 immediately, as this may indicate anaphylaxis.

What are the latest findings on chlorpheniramine use in adults?

Current NHS and BNF guidance continues to support chlorpheniramine as an effective short-term antihistamine for acute allergic conditions, though non-sedating second-generation antihistamines are generally preferred for daytime use due to their improved tolerability profile. Research also highlights caution around long-term use of sedating antihistamines in older adults, given the increased risk of falls and cognitive effects. Always discuss ongoing antihistamine use with your GP if you are over 65.

How Should You Use Piriton Tablets?

Piriton tablets should be swallowed whole with a full glass of water. They can be taken with or without food, though taking them with a small snack may help if you experience any stomach discomfort. Always read the patient information leaflet supplied with your pack before starting treatment.

Follow these steps each time you take a dose:

What Is the Correct Dose of Piriton Tablets?

The dose of Piriton tablets varies depending on age. Never exceed the maximum daily dose for your age group. If you are unsure about the correct dose for a child, speak to a pharmacist before administering.

When Is the Best Time to Use Piriton Tablets?

For hay fever and seasonal allergies, taking a tablet around 30 minutes before anticipated pollen exposure — such as before going outdoors — can help reduce the onset of symptoms. Because the effect lasts four to six hours, you may need to repeat the dose during the day if symptoms return. Many people also find a dose at bedtime helpful, as the sedating effect of chlorpheniramine can aid sleep when itching or sneezing is disruptive.

For acute reactions such as insect bites or urticaria, take a dose as soon as symptoms appear and repeat every four to six hours as needed until the reaction settles.

How Long Can You Use Piriton Tablets For?

Piriton tablets are suitable for short-term use during acute allergic episodes. Most people use them for a few days to a couple of weeks during peak allergy season or following an allergic reaction. If you find you need to take them every day for longer than two to three weeks, it is important to speak to your GP or pharmacist. Prolonged daily use of sedating antihistamines — particularly in older adults — is not recommended without medical supervision due to the risk of cumulative side effects including cognitive effects and increased fall risk.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Piriton Tablets?

Because chlorpheniramine maleate is a sedating, first-generation antihistamine, drowsiness is by far the most frequently reported side effect. This is not necessarily a problem if you are taking the tablets at night, but it is important to be aware of it if you need to drive or concentrate during the day.

  • Drowsiness and sedation
  • Dry mouth, nose, or throat
  • Blurred vision
  • Difficulty passing urine (urinary retention)
  • Constipation
  • Thickening of bronchial secretions

What Are the Less Common Side Effects of Piriton Tablets?

Some people experience side effects that are less frequent but still worth knowing about. These tend to be more likely at higher doses or in people who are more sensitive to anticholinergic medicines.

  • Headache or dizziness
  • Nausea, vomiting, or stomach upset
  • Palpitations or tachycardia
  • Skin rash or photosensitivity
  • Paradoxical excitability — particularly in children, presenting as restlessness, irritability, or insomnia
  • Tremor or muscle weakness

What Are the Serious Side Effects of Piriton Tablets?

Serious side effects are rare but require immediate medical attention. Stop taking Piriton tablets and call 999 or go to your nearest A&E if you experience any of the following:

  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Difficulty breathing or wheezing
  • Severe skin reactions such as blistering or peeling
  • Seizures or convulsions
  • Severe dizziness or loss of consciousness

These symptoms may indicate a serious allergic reaction to the medicine itself, which — while uncommon — requires urgent assessment.

What Should You Do If You Experience Side Effects?

For mild side effects such as dry mouth or drowsiness, staying well hydrated and avoiding alcohol can help. If drowsiness is affecting your daily activities, consider switching to a non-sedating antihistamine for daytime use and speak to your pharmacist about the best approach. Do not drive or operate machinery until you know how the tablets affect you.

You can report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety monitoring across the UK.

Can Piriton Tablets Interact With Other Medicines?

Yes — chlorpheniramine has several clinically significant interactions. Taking Piriton tablets alongside other medicines that cause sedation — such as opioid painkillers, benzodiazepines, or sleeping tablets — can significantly increase drowsiness and impair your ability to function safely. Tricyclic antidepressants can enhance the anticholinergic effects of chlorpheniramine, increasing the risk of dry mouth, urinary retention, and constipation. MAOIs must not be taken within 14 days of Piriton tablets due to the risk of serious adverse reactions. Always tell your pharmacist or GP about every medicine you are taking before starting Piriton tablets.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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