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Pernaton Gel 50ml

Pernaton Gel 50ml

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  • ✔️ Targets joint pain and stiffness directly at the source
  • ✔️ Contains green lipped mussel extract for joint lubrication
  • ✔️ Suitable for osteoarthritis and muscle soreness relief
  • ✔️ Topical application avoids need for oral pain medicines
  • ✔️ Compact 50ml tube ideal for home and on-the-go use

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What Is Pernaton Gel and How Does It Help Joint Pain?

 

If you live with joint stiffness, muscle aches, or the nagging discomfort that comes with conditions like osteoarthritis, you'll know how much it can affect your day-to-day life. Pernaton gel is a topical gel containing green lipped mussel extract — a natural ingredient that has been used for decades to support joint comfort and mobility. At just £3.99 for a 50ml tube, it offers an accessible option for those looking for everyday joint support without a prescription. You can browse our wider range of pain relief products if you're exploring other options alongside this gel.

Pernaton Gel is applied directly to the skin over the affected area, making it a convenient choice for people who prefer a targeted, localised approach. It's not a medicine in the traditional sense — it's classified as a medical device in some markets — but it has a well-established history of use for joint and muscle discomfort across Europe.

 

How Does Pernaton Gel Work on Joints and Muscles?

 

The key ingredient in Pernaton Gel is an extract from the green lipped mussel (Perna canaliculus), a shellfish native to New Zealand. This extract contains glycosaminoglycans — compounds that are naturally found in joint cartilage and synovial fluid. When applied topically, the gel is thought to help support the lubrication of joints and may assist in reducing localised inflammation and stiffness.

  • Green lipped mussel extract provides glycosaminoglycans to support cartilage health
  • The gel base helps the active components penetrate the skin at the site of application
  • Regular massage during application may improve local circulation
  • The cooling gel texture can provide immediate soothing comfort on application

 

Who Should Consider Using Pernaton Gel?

 

Pernaton Gel is suitable for adults who experience joint pain, stiffness, or muscle discomfort. It's particularly popular among people managing the everyday symptoms of osteoarthritis, sports-related muscle soreness, or general joint wear. That said, it's not a replacement for prescribed treatments — if your symptoms are severe or worsening, always speak to your GP.

  • Adults with mild to moderate joint pain or stiffness
  • People with osteoarthritis looking for topical support
  • Those experiencing muscle soreness after physical activity
  • Individuals who prefer a non-oral approach to joint comfort

 

How Does Pernaton Gel Compare to Other Topical Joint Gels?

 

Feature Pernaton Gel 50ml Ibuprofen Gel (e.g. Ibuleve)
Active ingredient Green lipped mussel extract Ibuprofen (NSAID)
Mechanism Glycosaminoglycan support, joint lubrication Anti-inflammatory (COX inhibition)
Suitable for long-term use Generally yes, as directed Short-term use recommended
Shellfish allergy risk Yes — not suitable if allergic No shellfish content

 

Is Pernaton Gel Safe to Store and Use at Home?

 

Yes — pernaton gel is straightforward to store and use at home. Keep the tube below 25°C, away from direct sunlight, and out of reach of children. Do not apply to broken, irritated, or infected skin, and avoid contact with your eyes. If you have a shellfish allergy, this product is not suitable for you — speak to your pharmacist about alternatives. You might also find our vitamins and supplements collection useful if you're looking to support joint health from the inside as well.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Pernaton Gel 50ml specifications
Treatment category Joint and muscle pain relief
Active ingredient Green lipped mussel extract (Perna canaliculus)
Mechanism of action Topical glycosaminoglycan support for joint lubrication and comfort
Suitable for Adults with joint pain, stiffness, or muscle discomfort
Pack size 50ml
UK classification General Sale / Medical Device
Preparation Topical gel
Route of administration Topical (applied to skin)

Specifications of Pernaton Gel 50ml

 

What Is Pernaton Gel and What Is It Used For?

 

Pernaton Gel 50ml is a topical gel containing green lipped mussel extract (Perna canaliculus). It is used to help relieve joint pain, stiffness, and muscle discomfort associated with conditions such as osteoarthritis, rheumatic complaints, and sports-related muscle soreness. The NHS notes that joint pain is extremely common, particularly in the knees, hips, and hands, and that many people seek topical products to help manage day-to-day symptoms alongside lifestyle measures. Pernaton Gel is applied directly to the skin over the affected area, providing localised support without the need to take an oral medicine.

 

What Do You Need to Know Before Using Pernaton Gel?

 

Before using Pernaton Gel, it's important to check whether it's appropriate for you. There are a few situations where you should not use this product or should seek advice first.

Do not use Pernaton Gel if you:

  • Have a known allergy to shellfish or seafood — the gel contains green lipped mussel extract
  • Have broken, infected, or inflamed skin at the application site
  • Are pregnant or breastfeeding — speak to your GP or midwife before use
  • Are under 18 years of age — this product is intended for adult use

Drug interactions:

  • No significant drug interactions are currently documented for topical green lipped mussel extract
  • If you are using other topical preparations on the same area, avoid applying simultaneously
  • Always inform your pharmacist of all medicines you are taking, including herbal products

 

How Should You Use Pernaton Gel Correctly?

 

Using Pernaton Gel correctly will help you get the most from it. The gel is designed for external use only — never swallow it or apply it near your mouth or eyes. If you're also managing broader musculoskeletal discomfort, our creams and ointments collection includes a range of complementary topical products.

  1. Wash and dry the affected area before application
  2. Squeeze a small amount of gel (approximately 2–3cm) onto your fingertips
  3. Apply the gel directly to the skin over the painful joint or muscle
  4. Massage gently in a circular motion until the gel is fully absorbed
  5. Wash your hands thoroughly after application
  6. Repeat up to three times daily, or as directed on the product packaging
Indication Age Group Dose Frequency
Joint pain / stiffness Adults (18+) Small amount (2–3cm strip) Up to 3 times daily
Muscle soreness Adults (18+) Small amount (2–3cm strip) Up to 3 times daily
Children under 18 Not recommended

 

What Are the Possible Side Effects of Pernaton Gel?

 

Like all topical products, Pernaton Gel can occasionally cause side effects, although not everyone experiences them. Most reactions are mild and localised to the area of application. If you notice anything unusual or concerning, stop using the gel and speak to your pharmacist or GP.

Common side effects:

  • Mild skin irritation at the application site
  • Temporary redness or warmth of the skin
  • Slight tingling sensation after application

Less common side effects:

  • Allergic skin reaction (rash, itching, or swelling) — stop use immediately if this occurs
  • Contact dermatitis in individuals with sensitive skin

If you experience signs of a serious allergic reaction — such as difficulty breathing, swelling of the face or throat, or widespread rash — seek emergency medical attention immediately by calling 999 or going to your nearest A&E.

 

How Should You Store Pernaton Gel?

 

Storing Pernaton Gel correctly helps maintain its quality and safety. If you're also taking oral supplements for joint health, our vitamins and supplements collection has options worth exploring alongside topical products.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the cap tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tube
  • Do not freeze

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Pernaton Gel online in the UK?

You can buy Pernaton Gel 50ml online from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £3.99. No prescription is needed, and it can be ordered quickly and conveniently from home. If you're looking for other topical options, our creams and ointments collection has a wide range of products to explore.

How does Pernaton Gel work on joints?

Pernaton Gel contains green lipped mussel extract, which provides glycosaminoglycans — compounds naturally found in joint cartilage and synovial fluid. When massaged into the skin over an affected joint, the gel is thought to support joint lubrication and help ease localised stiffness and discomfort. It works topically rather than systemically, so its effects are concentrated at the site of application.

How do I use Pernaton Gel step by step?

Start by washing and drying the affected area, then squeeze a small amount of gel onto your fingertips and massage it gently into the skin in circular motions until fully absorbed. Wash your hands after application and repeat up to three times daily. Always follow the instructions on the product packaging and avoid applying to broken or irritated skin.

What is the correct dose of Pernaton Gel?

The recommended dose is a small amount — roughly a 2–3cm strip of gel — applied to the affected area up to three times daily. There is no benefit to applying more than directed, and doing so will not speed up results. If you are unsure about how much to use, speak to your pharmacist for guidance.

Is Pernaton Gel suitable for people with shellfish allergies?

No — Pernaton Gel is not suitable for anyone with a known allergy to shellfish or seafood, as it contains green lipped mussel extract derived from shellfish. Using it if you have a shellfish allergy could trigger an allergic skin reaction. Speak to your pharmacist or GP about alternative topical products for joint pain if this applies to you.

Can I use Pernaton Gel for arthritis?

Yes, Pernaton Gel is commonly used to help relieve the joint pain and stiffness associated with osteoarthritis and other rheumatic conditions. It is a topical product and is not a substitute for prescribed arthritis treatments — if your symptoms are severe, persistent, or worsening, you should consult your GP. You can also explore our pain relief collection for additional options.

What are the side effects of Pernaton Gel?

Side effects are uncommon but may include mild skin irritation, temporary redness, or a slight tingling sensation at the application site. In rare cases, an allergic skin reaction such as a rash or itching may occur — if this happens, stop using the gel immediately and speak to your pharmacist. Seek emergency help if you experience any signs of a serious allergic reaction such as swelling of the face or difficulty breathing.

How long does it take for Pernaton Gel to work?

Results vary between individuals. Some people notice an improvement in comfort and mobility within a few days of regular use, while others may need to apply the gel consistently for several weeks before experiencing the full benefit. Consistent daily use as directed gives the best chance of a positive outcome.

How long can I use Pernaton Gel for?

Pernaton Gel can be used as part of an ongoing routine for joint and muscle support, and there is no strict maximum duration for most adults. However, if your symptoms do not improve after several weeks of regular use, or if they worsen at any point, you should consult your GP or pharmacist. Long-term joint pain should always be properly assessed by a healthcare professional.

Can I use Pernaton Gel during pregnancy or breastfeeding?

There is insufficient evidence to confirm that Pernaton Gel is safe to use during pregnancy or breastfeeding. As a precaution, you should speak to your GP or midwife before using this product if you are pregnant, planning to become pregnant, or currently breastfeeding. They can advise on the most appropriate options for managing joint or muscle discomfort during this time.

What are the alternatives to Pernaton Gel for joint pain?

Alternatives include topical ibuprofen gels (such as Ibuleve or Voltarol), topical diclofenac, or capsaicin cream — each works through a different mechanism. Oral options such as paracetamol or ibuprofen tablets are also commonly used for joint pain. The right choice depends on your individual health profile, so speak to your pharmacist if you're unsure which product suits you best.

Is Pernaton Gel a prescription medicine?

No — Pernaton Gel is available without a prescription and can be purchased over the counter or online from a registered pharmacy. It is classified as a general sale product in the UK, meaning you do not need to see a doctor to buy it. However, if your joint pain is severe or unexplained, it's always worth getting a professional assessment.

Can I use Pernaton Gel alongside other topical gels or creams?

It is generally advisable not to apply multiple topical products to the same area at the same time, as this can affect absorption and increase the risk of skin irritation. If you are using another topical preparation on the same joint, allow it to fully absorb before applying Pernaton Gel, or apply them to different areas. Ask your pharmacist for personalised advice if you are using several topical products.

What are the latest studies on green lipped mussel extract for joint pain?

Research into green lipped mussel extract has shown some promising results for joint pain and stiffness, particularly in osteoarthritis, with studies suggesting it may have anti-inflammatory properties linked to its omega-3 fatty acid and glycosaminoglycan content. However, the evidence base for topical application specifically is more limited than for oral supplementation, and further large-scale clinical trials are needed. Always discuss supplement or topical choices with your GP or pharmacist in the context of your overall treatment plan.

Does Pernaton Gel have any known drug interactions?

No significant drug interactions are currently documented for topically applied green lipped mussel extract. Because the gel is applied to the skin rather than taken orally, systemic absorption is minimal, which reduces the likelihood of interactions with other medicines. That said, always inform your pharmacist of all medicines and supplements you are taking, just to be safe.

How Should You Use Pernaton Gel?

Pernaton Gel is designed for external use only and should be applied directly to the skin over the affected joint or muscle. Always read the product label before use, and make sure the skin is clean and dry before applying. Never apply the gel to broken, infected, or inflamed skin, and keep it well away from your eyes and mouth.

What Is the Correct Dose of Pernaton Gel?

The correct dose depends on the size of the area being treated and the severity of your discomfort. As a general guide, a 2–3cm strip of gel per application is sufficient for most joints. Do not apply more than directed — using a larger amount will not improve results and may increase the risk of skin irritation.

When Is the Best Time to Use Pernaton Gel?

There is no single "best" time to apply Pernaton Gel — it can be used at any point during the day when you experience joint pain or stiffness. Many people find it helpful to apply the gel in the morning to ease early-morning stiffness, again after physical activity, and once more in the evening before bed. Spacing applications evenly throughout the day helps maintain consistent comfort.

If you are using the gel to manage exercise-related muscle soreness, applying it shortly after activity — once the skin has cooled — may help ease discomfort more quickly. Consistency is key: regular daily use tends to produce better results than occasional application.

How Long Can You Use Pernaton Gel For?

Pernaton Gel can be used as part of a regular routine for ongoing joint and muscle support. There is no fixed maximum duration for most adults, and many people use it continuously as part of their joint care regimen. However, if your symptoms have not improved after four to six weeks of consistent use, or if they worsen at any point, you should stop using the gel and consult your GP or pharmacist.

Long-term or unexplained joint pain should always be properly assessed by a healthcare professional to rule out underlying conditions that may require specific treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Pernaton Gel?

Most people use Pernaton Gel without experiencing any side effects. When reactions do occur, they are usually mild and limited to the area of skin where the gel has been applied. These typically resolve on their own once you stop using the product or reduce the frequency of application.

  • Mild skin irritation at the application site
  • Temporary redness or warmth of the skin
  • Slight tingling or cooling sensation immediately after application

What Are the Less Common Side Effects of Pernaton Gel?

Less commonly, some individuals — particularly those with sensitive skin — may experience a more noticeable skin reaction. If you notice any of the following, stop using the gel and speak to your pharmacist before continuing.

  • Itching or a rash at the application site
  • Contact dermatitis (dry, flaky, or inflamed skin)
  • Persistent redness that does not settle within a few hours
  • Localised swelling around the treated area

What Are the Serious Side Effects of Pernaton Gel?

Serious side effects are rare but can occur, particularly in people who have an undiagnosed allergy to shellfish or seafood. Because Pernaton Gel contains green lipped mussel extract — a shellfish-derived ingredient — there is a risk of an allergic reaction in susceptible individuals. Signs of a serious allergic reaction (anaphylaxis) include difficulty breathing, swelling of the face, lips, or throat, widespread hives, or a sudden drop in blood pressure. If you experience any of these symptoms, stop using the gel immediately and call 999 or go to your nearest A&E department without delay.

What Should You Do If You Experience Side Effects of Pernaton Gel?

For mild side effects such as skin irritation or redness, simply stop applying the gel to the affected area and allow the skin to recover. Rinsing the area with cool water may help soothe any discomfort. If the reaction is more significant — such as a spreading rash, blistering, or persistent swelling — seek advice from your pharmacist or GP promptly. Do not continue using the product if you suspect you are having an allergic reaction.

You should also report any suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk, which helps monitor the safety of medicines and healthcare products in the UK.

Can Pernaton Gel Interact With Other Medicines?

No significant interactions between topically applied Pernaton Gel and other medicines are currently documented. Because the gel is applied to the skin rather than taken orally, systemic absorption is minimal, which greatly reduces the likelihood of interactions with oral or injectable medicines. However, you should avoid applying Pernaton Gel to the same area as another topical product at the same time, as this may affect how well each product is absorbed and could increase the risk of skin irritation. Always tell your pharmacist about all medicines, supplements, and topical products you are currently using.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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