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Otrivine Sinusitis Spray - 10ml

Otrivine Sinusitis Spray - 10ml

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  • ✔️ Relieves sinusitis nasal congestion within minutes of use
  • ✔️ Contains xylometazoline 0.1% for targeted sinus relief
  • ✔️ Reduces sinus pressure caused by colds and allergic rhinitis
  • ✔️ Suitable for adults and adolescents aged 12 and over
  • ✔️ Compact 10ml bottle — convenient for home or travel use

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What Is Otrivine Sinusitis Nasal Spray?

 

If you've ever had sinusitis, you'll know how miserable it can be. The pressure behind your eyes, the blocked nose that makes sleeping feel impossible — it's exhausting. Sinusitis nasal spray like Otrivine Sinusitis Spray 10ml offers targeted, fast-acting relief right where you need it. Available over the counter for just £5.50, it's a practical option for adults and young people aged 12 and over who need to get on with their day. If you're also dealing with hay fever or allergic rhinitis alongside your sinus symptoms, you might find our allergy and hay fever range useful too.

Otrivine Sinusitis Spray contains xylometazoline hydrochloride 0.1% as its active ingredient. This is a well-established nasal decongestant that has been used in the UK for decades. The spray is designed specifically for sinusitis — the inflammation of the sinuses that often follows a cold, flu, or allergic reaction. It comes in a convenient 10ml bottle with a metered-dose pump, making it easy to use at home or on the go.

 

How Does Otrivine Sinusitis Spray Work?

 

Xylometazoline is a sympathomimetic agent — it mimics the action of adrenaline on the blood vessels inside your nasal passages. When you spray it into your nose, it causes the blood vessels in the nasal mucosa to constrict. This reduces swelling and congestion, opening up the nasal passages so air can flow freely again. The mechanism is straightforward but genuinely effective for short-term relief.

  • Xylometazoline binds to alpha-adrenergic receptors in the nasal blood vessels
  • Blood vessels constrict, reducing blood flow to the swollen nasal lining
  • Swelling decreases, opening the nasal passages
  • Sinus drainage improves, helping to relieve pressure and discomfort
  • Relief typically begins within a few minutes and can last several hours

 

Who Should Use Otrivine Sinusitis Spray?

 

This spray is suitable for adults and adolescents aged 12 years and over who are experiencing nasal congestion due to sinusitis, the common cold, or allergic rhinitis. It's particularly helpful when congestion is making it difficult to sleep, work, or breathe comfortably. That said, it's not a long-term solution — it's intended for short-term symptom relief only.

  • Adults and young people aged 12 and over with acute sinusitis
  • People with nasal congestion caused by colds or flu
  • Those with allergic rhinitis causing blocked sinuses
  • Anyone needing fast, temporary relief from sinus pressure and congestion

 

How Does Otrivine Sinusitis Spray Compare to a Saline Nasal Spray?

 

Feature Otrivine Sinusitis Spray Saline Nasal Spray
Active ingredient Xylometazoline HCl 0.1% Sodium chloride (salt water)
Speed of relief Within minutes Gradual, gentle
Maximum duration of use 7 consecutive days No restriction
Suitable for children under 12 No Yes (age-appropriate products)
Risk of rebound congestion Yes, if overused No

 

Is Otrivine Sinusitis Spray Safe to Store at Home?

 

Yes — storing this sinusitis nasal spray correctly is simple. Keep it below 25°C, away from direct sunlight, and out of reach of children. Do not freeze the product. Once opened, check the expiry date on the packaging and do not use it beyond that date. If you're managing multiple health products at home, our ear, nose and throat range includes a variety of products that can be stored safely alongside this spray.

Each bottle is for single-person use only — do not share it with others, as this can spread infection. The nozzle should be cleaned regularly with a clean tissue to maintain hygiene. This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Otrivine Sinusitis Spray 10ml specifications
Treatment category Nasal decongestant / Sinusitis relief
Active ingredient Xylometazoline hydrochloride 0.1%
Mechanism of action Alpha-adrenergic agonist — constricts nasal blood vessels to reduce swelling
Effective for Nasal congestion, sinusitis, allergic rhinitis, common cold
Suitable for Adults and adolescents aged 12 years and over
Pack size 10ml
Strength 0.1% xylometazoline hydrochloride
UK classification General Sale List (GSL) / Pharmacy (P) medicine
Drug class Sympathomimetic nasal decongestant
Preparation Nasal spray solution
Route of administration Intranasal

Specifications of Otrivine Sinusitis Spray 10ml

 

What Is Otrivine Sinusitis Spray and What Is It Used For?

 

Otrivine Sinusitis Spray 10ml is an over-the-counter nasal decongestant containing xylometazoline hydrochloride 0.1%. It is used to relieve the symptoms of nasal congestion and sinus pressure associated with sinusitis, the common cold, and allergic rhinitis. The NHS describes sinusitis as inflammation of the sinuses, often triggered by a viral infection, which causes the nasal passages to become blocked and painful. This spray helps to temporarily open those passages, making breathing easier and reducing that uncomfortable feeling of pressure around the nose and forehead.

It is not a treatment for the underlying cause of sinusitis — it simply manages the symptom of congestion while your body recovers. For most people, sinusitis caused by a cold will resolve on its own within two to three weeks, according to NHS guidance.

 

What Do You Need to Know Before Using Otrivine Sinusitis Spray?

 

Before using this spray, it's important to check whether it's right for you. There are certain conditions and medicines that mean you should avoid it or seek advice first.

Do not use Otrivine Sinusitis Spray if you:

  • Are under 12 years of age
  • Have atrophic rhinitis (dry, crusting nasal mucosa)
  • Have had trans-sphenoidal hypophysectomy or other surgical procedures exposing the dura mater
  • Are allergic to xylometazoline or any other ingredient in the spray
  • Are currently taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days

Speak to your pharmacist or GP before use if you have:

  • High blood pressure (hypertension)
  • Heart disease or irregular heartbeat
  • An overactive thyroid (hyperthyroidism)
  • Diabetes mellitus
  • Glaucoma
  • An enlarged prostate (benign prostatic hyperplasia)
  • Phaeochromocytoma

Known drug interactions — use with caution alongside:

  • Tricyclic antidepressants (e.g. amitriptyline)
  • MAOIs (e.g. phenelzine, tranylcypromine)
  • Other sympathomimetic medicines
  • Antihypertensive medicines — xylometazoline may reduce their effectiveness

If you are pregnant or breastfeeding, speak to your GP or midwife before using this spray. The NHS advises caution with decongestant medicines during pregnancy.

 

How Should You Use Otrivine Sinusitis Spray?

 

Always use this spray exactly as directed on the label or as advised by your pharmacist. Do not exceed the stated dose. If you're also managing cold and flu symptoms more broadly, our cold and flu range includes complementary products that may help.

  1. Blow your nose gently to clear the nasal passages before use
  2. Remove the protective cap from the nozzle
  3. Hold the bottle upright and insert the nozzle carefully into one nostril
  4. Press the pump firmly once while breathing in gently through your nose
  5. Repeat in the other nostril if needed
  6. Replace the cap after use and wipe the nozzle clean with a tissue
Indication Age Group Dose Frequency
Sinusitis / nasal congestion Adults and adolescents (12+) 1 spray per nostril Up to 2–3 times daily
Not recommended Children under 12

 

What Are the Possible Side Effects of Otrivine Sinusitis Spray?

 

Like all medicines, Otrivine Sinusitis Spray can cause side effects, although not everyone experiences them. Most side effects are mild and related to local irritation in the nasal passages.

Common side effects:

  • Temporary burning or stinging sensation in the nose
  • Nasal dryness or irritation
  • Increased nasal discharge initially
  • Sneezing

Less common side effects:

  • Headache
  • Nausea
  • Palpitations or increased heart rate
  • Rebound congestion (rhinitis medicamentosa) — particularly with use beyond 7 days
  • Raised blood pressure
  • Insomnia or restlessness

If you experience any serious side effects such as chest pain, severe headache, or difficulty breathing, stop using the spray and seek medical attention immediately.

 

How Should You Store Otrivine Sinusitis Spray?

 

Correct storage keeps the spray effective and safe to use. If you're looking for other health products to keep at home, our first aid range has everything you might need alongside your medicine cabinet essentials.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Do not freeze
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the packaging
  • Do not share the bottle with other people — for single-person use only
  • Dispose of unused medicine responsibly — return to your local pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Otrivine Sinusitis Spray online in the UK?

You can buy Otrivine Sinusitis Spray 10ml online from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £5.50. It is dispatched quickly and discreetly to your door. It is also available from most high street pharmacies and supermarkets without a prescription.

How does Otrivine Sinusitis Spray work in the body?

Otrivine Sinusitis Spray contains xylometazoline hydrochloride 0.1%, which acts as an alpha-adrenergic agonist. It constricts the blood vessels in the nasal lining, reducing swelling and opening the nasal passages so you can breathe more freely. Relief typically begins within a few minutes of application and can last for several hours.

How do I use Otrivine Sinusitis Spray step by step?

Start by blowing your nose gently to clear the passages. Insert the nozzle into one nostril, press the pump once while breathing in gently, then repeat in the other nostril. Replace the cap and wipe the nozzle clean after each use — and never share the bottle with anyone else.

How quickly does Otrivine Sinusitis Spray start to work?

Most people notice relief from nasal congestion within a few minutes of using the spray. The decongestant effect can last for several hours, which makes it useful both during the day and before bed if congestion is disrupting your sleep. Individual responses can vary slightly depending on the severity of your symptoms.

What is the correct dose of Otrivine Sinusitis Spray for adults?

The recommended dose for adults and adolescents aged 12 and over is one spray into each nostril, up to two to three times daily. Do not use more than the stated dose, and do not use the spray for more than 7 consecutive days. If your symptoms persist beyond this, speak to your GP or pharmacist.

Can I use Otrivine Sinusitis Spray for more than 7 days?

No — you should not use Otrivine Sinusitis Spray for more than 7 consecutive days. Using it for longer than this can cause rebound congestion, known medically as rhinitis medicamentosa, where the nasal passages become more blocked than before once you stop using the spray. If your sinusitis symptoms persist beyond a week, see your GP for further assessment.

Is Otrivine Sinusitis Spray safe to use during pregnancy?

If you are pregnant or breastfeeding, you should speak to your GP or midwife before using Otrivine Sinusitis Spray. The NHS advises caution with decongestant medicines during pregnancy, as the safety of xylometazoline in pregnancy has not been fully established. Your healthcare provider can recommend a safer alternative if needed.

Who should not use Otrivine Sinusitis Spray?

This spray is not suitable for children under 12 years of age, people with atrophic rhinitis, or those taking MAOIs or tricyclic antidepressants. People with high blood pressure, heart disease, glaucoma, an overactive thyroid, or diabetes should speak to their pharmacist or GP before use. Always read the full patient information leaflet before starting any new medicine.

What are the side effects of Otrivine Sinusitis Spray?

Common side effects include temporary nasal burning, stinging, dryness, or sneezing. Less commonly, some people experience headache, nausea, palpitations, or raised blood pressure. Rebound congestion can occur if the spray is used for longer than 7 days — this is why sticking to the recommended duration is so important.

How do I manage side effects of Otrivine Sinusitis Spray?

Mild nasal irritation usually settles on its own and does not require treatment. If you experience more troublesome side effects such as palpitations, severe headache, or chest discomfort, stop using the spray immediately and seek medical advice. To reduce the risk of rebound congestion, always use the lowest effective dose for the shortest possible time.

Can I use Otrivine Sinusitis Spray alongside other cold and flu medicines?

Be cautious — many over-the-counter cold and flu remedies already contain a decongestant such as pseudoephedrine or phenylephrine. Using Otrivine Sinusitis Spray at the same time could mean you're taking more than one decongestant, which increases the risk of side effects. Always check the ingredients of any other medicines you're taking and ask your pharmacist if you're unsure. You can browse our cold and flu range for guidance on suitable combinations.

What happens if I miss a dose of Otrivine Sinusitis Spray?

If you forget to use the spray at your usual time, simply use it when you remember — unless it's nearly time for your next dose, in which case skip the missed one. Do not use a double dose to make up for a missed one. This spray is used as needed for symptom relief, so strict timing is less critical than with some other medicines.

What are the alternatives to Otrivine Sinusitis Spray?

Alternatives include other xylometazoline-based sprays such as Sudafed Blocked Nose Spray, or oxymetazoline-based products like Vicks Sinex. Saline nasal sprays are a gentler, drug-free option with no restriction on duration of use, making them suitable for longer-term management or for children. You can explore related products in our ear, nose and throat range.

Is Otrivine Sinusitis Spray suitable for children?

No — Otrivine Sinusitis Spray 0.1% is not suitable for children under 12 years of age. A lower-strength formulation (0.05%) is available for children aged 2 to 11 years, but this should only be used under the guidance of a pharmacist or GP. Always check the age suitability on the packaging before giving any nasal spray to a child.

What does the latest research say about xylometazoline nasal sprays?

Xylometazoline has been used as a nasal decongestant for many decades and its efficacy and safety profile are well established in clinical literature. Current evidence supports its short-term use (up to 7 days) for relieving nasal congestion in adults. The main concern highlighted in research remains the risk of rebound congestion with prolonged use, which is why the 7-day limit is consistently recommended by healthcare professionals and regulatory bodies.

How Should You Use Otrivine Sinusitis Spray?

Using Otrivine Sinusitis Spray correctly makes a real difference to how well it works. Always read the patient information leaflet before use, and follow these steps carefully to get the most from each dose.

If the pump has not been used recently, prime it by pressing it a few times into the air before use. This ensures a consistent, accurate dose with each application.

What Is the Correct Dose of Otrivine Sinusitis Spray?

Always use the lowest dose that relieves your symptoms. Do not exceed the recommended number of applications per day, and never use the spray for longer than 7 consecutive days without speaking to a healthcare professional.

If you accidentally use more than the recommended dose, contact your pharmacist or NHS 111 for advice. Symptoms of overuse may include increased heart rate, raised blood pressure, or agitation.

When Is the Best Time to Use Otrivine Sinusitis Spray?

There is no single "best" time — it really depends on when your symptoms are most troublesome. Many people find it most helpful to use the spray before bed, as nasal congestion can make sleeping particularly difficult. Using it in the morning can also help you start the day breathing more comfortably.

If you're using it up to three times a day, try to space doses evenly throughout the day. Avoid using it immediately before lying down flat, as this can affect how the spray distributes in the nasal passages. Sitting upright or standing for a few minutes after use is ideal.

How Long Can You Use Otrivine Sinusitis Spray For?

Otrivine Sinusitis Spray should not be used for more than 7 consecutive days. This is a firm limit — not a guideline. Using it beyond this period significantly increases the risk of rebound congestion (rhinitis medicamentosa), where the nasal passages become more congested than before once you stop the spray.

If your sinusitis symptoms have not improved after 7 days, or if they worsen at any point, stop using the spray and consult your GP. Persistent sinusitis may require further investigation or a different treatment approach, such as a steroid nasal spray prescribed by your doctor.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Otrivine Sinusitis Spray?

Most people use Otrivine Sinusitis Spray without experiencing significant problems. However, like all medicines, it can cause side effects in some people. The most common ones are localised to the nose and are usually mild and short-lived.

  • Temporary burning or stinging sensation inside the nose
  • Nasal dryness or irritation
  • Increased nasal discharge shortly after application
  • Sneezing

These effects typically settle quickly on their own. If nasal dryness is particularly uncomfortable, a saline nasal spray used at a different time of day may help to keep the nasal passages moist.

What Are the Less Common Side Effects of Otrivine Sinusitis Spray?

Less commonly, some people experience side effects that go beyond the nose. These are more likely to occur if the spray is used more frequently than recommended or for longer than 7 days.

  • Headache
  • Nausea
  • Palpitations or a faster-than-normal heartbeat
  • Raised blood pressure
  • Insomnia or difficulty sleeping
  • Restlessness or agitation
  • Rebound nasal congestion (rhinitis medicamentosa) — particularly with prolonged use

Rebound congestion is one of the most important risks to be aware of. It happens when the nasal blood vessels become dependent on the decongestant effect, causing them to dilate more than usual once the spray wears off. This creates a cycle of worsening congestion that can be difficult to break.

What Are the Serious Side Effects of Otrivine Sinusitis Spray?

Serious side effects from Otrivine Sinusitis Spray are rare when it is used correctly and within the recommended 7-day limit. However, in people with pre-existing cardiovascular conditions or those who use the spray excessively, more significant effects can occur. Stop using the spray and seek urgent medical attention if you experience any of the following:

  • Chest pain or tightness
  • Severe or sudden headache
  • Difficulty breathing
  • Significant rise in blood pressure
  • Irregular or very rapid heartbeat

These symptoms may indicate a cardiovascular reaction to the sympathomimetic effects of xylometazoline and should be assessed by a healthcare professional without delay.

What Should You Do If You Experience Side Effects?

For mild side effects such as nasal irritation or sneezing, no specific action is usually needed — they tend to resolve on their own. If you find the side effects uncomfortable, reduce the frequency of use or stop the spray and allow your nasal passages to recover naturally. For any side effect that concerns you, or if symptoms worsen rather than improve, contact your pharmacist or GP for advice. You can also call NHS 111 for guidance at any time.

If you suspect you have used too much of the spray, contact NHS 111 or your nearest pharmacist immediately, even if you feel well.

Can Otrivine Sinusitis Spray Interact With Other Medicines?

Yes — xylometazoline can interact with certain medicines, and these interactions can be clinically significant. The most important interactions are with monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine, and with tricyclic antidepressants such as amitriptyline. Using Otrivine alongside these medicines can cause a dangerous rise in blood pressure. Other sympathomimetic medicines — including some cold and flu remedies — may also interact, increasing the risk of cardiovascular side effects. Always tell your pharmacist about all medicines you are taking, including herbal remedies and supplements, before starting this spray.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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