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Otrivine Congestion Relief Nasal Spray 0.1% – 10ml

Otrivine Congestion Relief Nasal Spray 0.1% – 10ml

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  • ✔️ Relieves blocked nose caused by colds, sinusitis, and hay fever
  • ✔️ Contains xylometazoline 0.1% for fast-acting nasal decongestion
  • ✔️ Works within minutes; decongestant effect lasts up to 10 hours
  • ✔️ Suitable for adults and children aged 12 years and over
  • ✔️ Compact 10ml bottle — easy to carry and use on the go

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What Is Otrivine Nasal Spray and How Does It Relieve Congestion?

 

If you have ever had a cold that left you unable to breathe through your nose, you will know how miserable nasal congestion can be. Otrivine nasal spray is a well-established, over-the-counter decongestant that provides fast, targeted relief from a blocked nose. Each 10ml bottle contains xylometazoline hydrochloride at a concentration of 0.1%, making it suitable for adults and children aged 12 and over. Whether your congestion is triggered by a cold, sinusitis, allergic rhinitis, or hay fever, this spray works directly at the source of the problem — the swollen blood vessels lining your nasal passages.

Nasal congestion occurs when the blood vessels inside the nose become inflamed and engorged, narrowing the airway and making breathing difficult. The NHS notes that a blocked nose is one of the most common symptoms of colds and upper respiratory infections. You can find a range of products to help manage these symptoms in our Cold and Flu collection.

 

How Does Otrivine Congestion Relief Nasal Spray Work?

 

Xylometazoline hydrochloride, the active ingredient in this spray, belongs to a class of medicines called sympathomimetic decongestants. It works by stimulating alpha-adrenergic receptors in the walls of the small blood vessels (arterioles) inside the nasal mucosa. This causes vasoconstriction — the vessels narrow — which reduces swelling of the nasal lining and decreases mucus secretion. The result is a noticeably clearer airway, usually within minutes of use.

  • Xylometazoline binds to alpha-1 and alpha-2 adrenergic receptors in nasal blood vessels
  • Vasoconstriction reduces mucosal oedema (swelling of the nasal lining)
  • Mucus production decreases, reducing the sensation of a runny or blocked nose
  • Relief typically begins within a few minutes and can last up to 10 hours

 

Who Should Use Otrivine Congestion Relief Nasal Spray?

 

This spray is intended for adults and adolescents aged 12 years and above. It is particularly useful for people who need short-term relief from nasal congestion and want a fast-acting, locally applied option rather than an oral decongestant. If your congestion is linked to seasonal allergies, you might also want to explore our Allergy and Hay Fever range for complementary treatments.

  • Adults and children aged 12 and over with a blocked nose due to a cold or upper respiratory infection
  • People with allergic rhinitis or hay fever causing nasal congestion
  • Those with sinusitis who need short-term symptomatic relief
  • Individuals who prefer a topical nasal spray over oral decongestant tablets

 

How Does Otrivine Nasal Spray Compare to Other Decongestant Sprays?

 

Feature Otrivine 0.1% Nasal Spray Sudafed Blocked Nose Spray (0.1% Xylometazoline)
Active ingredient Xylometazoline HCl 0.1% Xylometazoline HCl 0.1%
Suitable age 12 years and over 12 years and over
Duration of action Up to 10 hours Up to 10 hours
Max duration of use 7 consecutive days 7 consecutive days

 

Is Otrivine Nasal Spray Suitable for Long-Term Use and How Should It Be Stored?

 

This is an important question. Otrivine nasal spray is designed for short-term use only — no more than 7 consecutive days. Using it beyond this period can lead to a condition called rhinitis medicamentosa, or rebound congestion, where the nasal passages become more blocked than before once the spray wears off. If your congestion persists beyond a week, speak to your GP or pharmacist rather than continuing to use the spray.

Store the bottle below 25°C, away from direct sunlight, and keep it out of the reach of children. Do not share the spray with others, as this can spread infection. The Otrivine nasal spray bottle should be discarded after the recommended period of use stated on the packaging. If you are managing multiple symptoms alongside nasal congestion — such as sinus pain — you may also find relevant options in our Ear, Nose and Throat collection.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Otrivine Congestion Relief Nasal Spray 0.1% – 10ml specifications
Treatment category Nasal decongestant
Mechanism of action Alpha-adrenergic receptor agonist; causes nasal vasoconstriction
Effective for Nasal congestion due to colds, sinusitis, allergic rhinitis, hay fever
Suitable for Adults and children aged 12 years and over
Active ingredient Xylometazoline hydrochloride 0.1%
Pack size 10ml
Strength 0.1% (1mg/ml)
UK classification General Sale List (GSL)
Drug class Sympathomimetic decongestant
Preparation Nasal solution
Route of administration Intranasal

Specifications of Otrivine Congestion Relief Nasal Spray 0.1% – 10ml

 

What Is Otrivine Congestion Relief Nasal Spray and What Is It Used For?

 

Otrivine Congestion Relief Nasal Spray 0.1% is an over-the-counter nasal decongestant containing xylometazoline hydrochloride. It is used to relieve the symptoms of nasal congestion — that uncomfortable, stuffy feeling that makes it hard to breathe through your nose. The NHS identifies nasal congestion as a hallmark symptom of the common cold, sinusitis, and allergic rhinitis, including hay fever. This spray works locally inside the nose, so very little of the active ingredient is absorbed into the bloodstream compared to oral decongestants.

 

What Do You Need to Know Before Using Otrivine Congestion Relief Nasal Spray?

 

Before using this spray, it is important to check whether it is appropriate for you. There are certain conditions and medicines that mean you should seek advice first.

Do not use this spray if you:

  • Are allergic to xylometazoline hydrochloride or any other ingredient in the product
  • Have dry nasal inflammation (atrophic rhinitis)
  • Have had a trans-sphenoidal hypophysectomy or any other surgical procedure exposing the dura mater
  • Are under 12 years of age (the 0.1% strength is not suitable for children under 12)
  • Are taking or have taken monoamine oxidase inhibitors (MAOIs) within the last 14 days

Use with caution and speak to your pharmacist or GP if you have:

  • High blood pressure (hypertension)
  • Heart disease or angina
  • An overactive thyroid (hyperthyroidism)
  • Diabetes mellitus
  • Glaucoma (raised pressure in the eye)
  • An enlarged prostate (benign prostatic hyperplasia)
  • Phaeochromocytoma

Known drug interactions:

  • MAOIs — risk of hypertensive crisis; do not use together
  • Tricyclic antidepressants — may enhance the cardiovascular effects of xylometazoline
  • Other sympathomimetic medicines — additive effects possible

 

How Should You Use Otrivine Congestion Relief Nasal Spray?

 

Always use this spray exactly as directed on the label or as advised by your pharmacist. Do not exceed the stated dose. If you are unsure, ask your pharmacist for guidance.

  1. Blow your nose gently to clear the nasal passages before use
  2. Remove the protective cap from the nozzle
  3. Tilt your head slightly forward
  4. Insert the nozzle carefully into one nostril
  5. Press the pump firmly once while breathing in gently through your nose
  6. Breathe out through your mouth
  7. Repeat in the other nostril if needed
  8. Replace the cap after use and wipe the nozzle clean
Indication Age Group Dose Frequency
Nasal congestion (cold, sinusitis, rhinitis) Adults and children 12+ 1 spray per nostril Up to 3 times daily (every 8–10 hours)
Nasal congestion (cold, sinusitis, rhinitis) Under 12 years Not suitable — use 0.05% formulation N/A

 

What Are the Possible Side Effects of Otrivine Congestion Relief Nasal Spray?

 

Like all medicines, this spray can cause side effects, although not everyone experiences them. Most side effects are mild and affect the nose and throat locally.

Common side effects:

  • Nasal dryness or irritation
  • Burning or stinging sensation inside the nose
  • Sneezing after application
  • Increased nasal discharge initially

Less common side effects:

  • Headache
  • Nausea
  • Palpitations or increased heart rate
  • Rebound congestion (rhinitis medicamentosa) with use beyond 7 days
  • Raised blood pressure — more likely in those with pre-existing hypertension

If you experience any serious or unexpected side effects, stop using the spray and contact your GP or pharmacist. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

 

How Should You Store Otrivine Congestion Relief Nasal Spray?

 

Correct storage helps maintain the effectiveness and safety of the product. If you are also managing other health conditions alongside nasal congestion, our Pain Relief collection includes options for sinus headache and facial pain that may accompany a blocked nose.

  • Store below 25°C
  • Keep away from direct sunlight and heat sources
  • Do not freeze
  • Keep the bottle tightly capped when not in use
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the label
  • Do not share the spray with other people — this can spread infection
  • Dispose of any unused product safely after the recommended period of use

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Otrivine nasal spray online in the UK?

You can buy Otrivine Congestion Relief Nasal Spray 0.1% 10ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £5.70. No prescription is needed, as it is available over the counter. It is also available in most UK pharmacies and supermarkets.

How does Otrivine nasal spray work in the body?

Otrivine nasal spray contains xylometazoline hydrochloride, a sympathomimetic agent that stimulates alpha-adrenergic receptors in the nasal blood vessels. This causes vasoconstriction — the blood vessels narrow — which reduces swelling of the nasal lining and eases congestion. The effect is localised to the nose, so very little active ingredient enters the bloodstream.

How do I use Otrivine nasal spray step by step?

Blow your nose gently before use, then tilt your head slightly forward. Insert the nozzle into one nostril and press the pump once while breathing in gently through your nose, then repeat in the other nostril if needed. Use up to three times daily, leaving at least 8 to 10 hours between doses.

How quickly does Otrivine nasal spray start to work?

Otrivine nasal spray typically begins to relieve nasal congestion within a few minutes of application. The decongestant effect can last for up to 10 hours, making it suitable for use during the day or before sleep. Individual response times may vary slightly depending on the severity of congestion.

What is the correct dose of Otrivine nasal spray for adults?

The recommended dose for adults and children aged 12 and over is one spray into each nostril, up to three times daily. Doses should be spaced at least 8 to 10 hours apart. Do not exceed three doses in any 24-hour period.

Can children use Otrivine nasal spray 0.1%?

No — the 0.1% strength is not suitable for children under 12 years of age. A lower-strength formulation (0.05%) is available specifically for children aged 2 to 11 years. Always check the product label and speak to a pharmacist if you are unsure which strength is appropriate for your child.

How long can you use Otrivine nasal spray for?

Otrivine nasal spray should not be used for more than 7 consecutive days. Using it for longer than this can cause rebound congestion — a condition called rhinitis medicamentosa — where the nose becomes more blocked once the spray wears off. If your symptoms persist beyond a week, speak to your GP or pharmacist.

What happens if I use Otrivine nasal spray for too long?

Using Otrivine nasal spray for more than 7 days can lead to rhinitis medicamentosa, also known as rebound congestion. This means the nasal passages become dependent on the spray to stay open, and congestion returns — often worse than before — when the spray is not used. Stopping the spray gradually with medical guidance is usually recommended in this situation.

Can I use Otrivine nasal spray during pregnancy?

Otrivine nasal spray is not recommended during pregnancy without first seeking medical advice, as xylometazoline may affect placental blood flow. The NHS advises caution with all decongestant medicines during pregnancy. Speak to your GP or midwife before using this or any other decongestant if you are pregnant or breastfeeding.

What are the side effects of Otrivine nasal spray?

Common side effects include nasal dryness, a burning or stinging sensation inside the nose, and sneezing after use. Less commonly, some people experience headache, palpitations, or raised blood pressure. Rebound congestion can occur if the spray is used for more than 7 consecutive days.

Who should not use Otrivine nasal spray?

This spray is not suitable for children under 12, people with atrophic rhinitis, or those who have taken MAOIs within the last 14 days. People with high blood pressure, heart disease, hyperthyroidism, glaucoma, or diabetes should speak to a pharmacist or GP before use. Always read the full list of contraindications on the product label.

Does Otrivine nasal spray interact with other medicines?

Yes — Otrivine nasal spray can interact with MAOIs (monoamine oxidase inhibitors) and tricyclic antidepressants, potentially causing a dangerous rise in blood pressure. It may also interact with other sympathomimetic medicines. Always tell your pharmacist about all medicines you are taking before using this spray.

What are the alternatives to Otrivine nasal spray?

Alternatives include other xylometazoline-based sprays such as Sudafed Blocked Nose Spray, or oxymetazoline-based products. Saline nasal rinses are a non-medicated option suitable for longer-term use and are safe during pregnancy. You can also explore our Ear, Nose and Throat collection for a wider range of nasal and sinus products.

Can I use Otrivine nasal spray for hay fever congestion?

Yes — Otrivine nasal spray can provide short-term relief from nasal congestion caused by hay fever and allergic rhinitis. However, it does not treat the underlying allergic response, so you may also benefit from antihistamines or corticosteroid nasal sprays for longer-term hay fever management. Browse our Allergy and Hay Fever range for complementary options.

What is the latest research on xylometazoline nasal sprays?

Xylometazoline has been used as a nasal decongestant for decades and its efficacy and safety profile are well established in clinical literature. Current research continues to confirm that short-term use (up to 7 days) is effective and safe for most adults, while reinforcing the importance of avoiding prolonged use to prevent rebound congestion. No new safety concerns have been identified by the MHRA for this ingredient in recent years.

How Should You Use Otrivine Congestion Relief Nasal Spray?

Using Otrivine nasal spray correctly makes a real difference to how well it works. Always read the label before use, and if you have any questions, ask your pharmacist. The spray is designed for intranasal use only — never swallow it or use it in the eyes.

What Is the Correct Dose of Otrivine Congestion Relief Nasal Spray?

The dose depends on your age. Always follow the dosage instructions on the product label and never exceed the recommended amount. Using more than the stated dose will not improve relief and increases the risk of side effects.

When Is the Best Time to Use Otrivine Congestion Relief Nasal Spray?

You can use Otrivine nasal spray at any time of day when congestion is causing discomfort. Many people find it particularly helpful to use a dose before bed, as nasal congestion can significantly disrupt sleep. Using it in the morning can also help clear the airways before the day begins, making breathing easier throughout the day.

Space your doses evenly — at least 8 to 10 hours apart — to avoid exceeding the maximum of three doses in 24 hours. Try not to use it more frequently than needed, as this increases the risk of rebound congestion developing.

How Long Can You Use Otrivine Congestion Relief Nasal Spray For?

This spray is intended for short-term use only. Do not use it for more than 7 consecutive days. If your nasal congestion has not improved after a week, or if it worsens, stop using the spray and consult your GP or pharmacist. Prolonged use beyond 7 days can cause rhinitis medicamentosa — a form of rebound congestion where the nasal passages become reliant on the spray to stay open.

If you find yourself needing a decongestant nasal spray regularly over a longer period, this may indicate an underlying condition such as chronic rhinitis or sinusitis that requires a different treatment approach. Your GP can advise on longer-term management options, including corticosteroid nasal sprays.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Otrivine Congestion Relief Nasal Spray?

Most people tolerate Otrivine nasal spray well when used as directed. However, because the spray acts directly on the nasal mucosa, local side effects are the most frequently reported. These are generally mild and tend to resolve on their own.

  • Nasal dryness or a dry sensation inside the nose
  • Burning or stinging feeling after application
  • Sneezing shortly after use
  • Temporary increase in nasal discharge immediately after spraying

What Are the Less Common Side Effects of Otrivine Congestion Relief Nasal Spray?

Some people may experience side effects that go beyond the nose and throat. These are less common but worth being aware of, particularly if you have an underlying cardiovascular condition.

  • Headache
  • Nausea
  • Palpitations or a faster-than-normal heartbeat
  • Raised blood pressure — more likely in people with pre-existing hypertension
  • Insomnia or restlessness, particularly if used close to bedtime
  • Rebound nasal congestion (rhinitis medicamentosa) if used for more than 7 consecutive days

What Are the Serious Side Effects of Otrivine Congestion Relief Nasal Spray?

Serious side effects are rare when the spray is used correctly and for no longer than 7 days. However, in people with certain underlying conditions — particularly cardiovascular disease or hypertension — xylometazoline can occasionally cause a significant rise in blood pressure or heart rate. If you experience chest pain, severe headache, irregular heartbeat, or difficulty breathing after using this spray, stop use immediately and seek urgent medical attention.

Allergic reactions to xylometazoline are uncommon but possible. Signs of a serious allergic reaction include swelling of the face, lips, or throat, a widespread rash, or difficulty swallowing. If you notice any of these symptoms, call 999 or go to your nearest A&E department.

What Should You Do If You Experience Side Effects of Otrivine Congestion Relief Nasal Spray?

If you experience mild local side effects such as nasal dryness or stinging, these usually settle without any action needed. Reducing the frequency of use or ensuring you are not exceeding the recommended dose can help. If side effects are persistent or troublesome, stop using the spray and speak to your pharmacist or GP.

You can report any suspected side effects directly to the Medicines and Healthcare products Regulatory Agency (MHRA) via the Yellow Card scheme at yellowcard.mhra.gov.uk. Reporting side effects helps improve the safety information available for all medicines.

Can Otrivine Congestion Relief Nasal Spray Interact With Other Medicines?

Yes — there are some important drug interactions to be aware of. Xylometazoline should not be used alongside monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping them, as this combination can cause a dangerous rise in blood pressure. Tricyclic antidepressants may also enhance the cardiovascular effects of xylometazoline. If you are taking any prescription medicines, always check with your pharmacist before using this spray.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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